Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C19orf35 Gene

Aliases for C19orf35 Gene

  • Chromosome 19 Open Reading Frame 35 2 3 5

External Ids for C19orf35 Gene

Previous GeneCards Identifiers for C19orf35 Gene

  • GC19M002227
  • GC19M002228
  • GC19M002045

Summaries for C19orf35 Gene

GeneCards Summary for C19orf35 Gene

C19orf35 (Chromosome 19 Open Reading Frame 35) is a Protein Coding gene. An important paralog of this gene is PEAK1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf35 Gene

Genomics for C19orf35 Gene

Regulatory Elements for C19orf35 Gene

Enhancers for C19orf35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F002615 1.8 FANTOM5 Ensembl ENCODE 10.8 -345.4 -345444 24.4 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 GADD45B SF3A2 GNG7 DIRAS1 LOC100288123 CACTIN-AS1 RNU6-993P SLC39A3 C19orf35 LOC101928631
GH19F002598 1.7 FANTOM5 Ensembl ENCODE 10.9 -317.2 -317156 1.5 HDGF ATF1 PKNOX1 ZFP64 ARID4B SIN3A GLI4 FEZF1 DMAP1 ZNF2 RNU6-993P SLC39A3 C19orf35 LSM7 SPPL2B GADD45B DOT1L RN7SL121P ENSG00000267412
GH19F002038 1.7 FANTOM5 ENCODE 9.8 +231.2 231157 24.2 MLX CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MKNK2 ENSG00000261526 CIRBP SF3A2 SCAMP4 RPS15 ZNF77 LOC100288123 C19orf35 MOB3A
GH19F001894 1.7 FANTOM5 Ensembl ENCODE 9.7 +385.5 385482 4.2 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 KLF16 ARHGAP45 C19orf35 LOC100288123 DOT1L ABHD17A CSNK1G2 OAZ1 SCAMP4
GH19F003150 1.7 FANTOM5 Ensembl ENCODE 9.7 -871.2 -871207 6.0 HDGF PKNOX1 ARNT CREB3L1 SIN3A YBX1 ZNF766 FOS DEK ZNF263 CACTIN ZNF77 GNA15 FZR1 NCLN GNA11 AES C19orf35 S1PR4 GC19P003153
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C19orf35 on UCSC Golden Path with GeneCards custom track

Promoters for C19orf35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001417341 -518 201 ZBTB11 NBN ZBTB33 ZIC2 GABPA EZH2

Genomic Location for C19orf35 Gene

2,274,622 bp from pter
2,282,182 bp from pter
7,561 bases
Minus strand

Genomic View for C19orf35 Gene

Genes around C19orf35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf35 Gene

Proteins for C19orf35 Gene

  • Protein details for C19orf35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative uncharacterized protein C19orf35
    Protein Accession:

    Protein attributes for C19orf35 Gene

    473 amino acids
    Molecular mass:
    50509 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C19orf35 Gene

Post-translational modifications for C19orf35 Gene

No Post-translational modifications

Other Protein References for C19orf35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C19orf35 Gene

Domains & Families for C19orf35 Gene

Protein Domains for C19orf35 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C19orf35: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C19orf35 Gene

Function for C19orf35 Gene

Gene Ontology (GO) - Molecular Function for C19orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IBA --
genes like me logo Genes that share ontologies with C19orf35: view
genes like me logo Genes that share phenotypes with C19orf35: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C19orf35 Gene

Localization for C19orf35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C19orf35 gene
Compartment Confidence
cytoskeleton 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C19orf35 Gene

Pathways & Interactions for C19orf35 Gene

SuperPathways for C19orf35 Gene

No Data Available

Interacting Proteins for C19orf35 Gene

Gene Ontology (GO) - Biological Process for C19orf35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with C19orf35: view

No data available for Pathways by source and SIGNOR curated interactions for C19orf35 Gene

Transcripts for C19orf35 Gene

mRNA/cDNA for C19orf35 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C19orf35 Gene

Chromosome 19 open reading frame 35:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf35 Gene

No ASD Table

Relevant External Links for C19orf35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C19orf35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C19orf35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C19orf35 Gene

This gene is overexpressed in Whole Blood (x38.8).

Protein differential expression in normal tissues from HIPED for C19orf35 Gene

This gene is overexpressed in NK cells (34.6), Monocytes (10.1), Prostate (9.3), and Urinary Bladder (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C19orf35 Gene

Protein tissue co-expression partners for C19orf35 Gene

NURSA nuclear receptor signaling pathways regulating expression of C19orf35 Gene:


SOURCE GeneReport for Unigene cluster for C19orf35 Gene:

genes like me logo Genes that share expression patterns with C19orf35: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for C19orf35 Gene

Orthologs for C19orf35 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C19orf35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C19orf35 35
  • 99 (a)
C19H19orf35 34
  • 98.6 (n)
(Bos Taurus)
Mammalia C7H19orf35 34
  • 78.55 (n)
C19orf35 35
  • 70 (a)
(Canis familiaris)
Mammalia C20H19orf35 34
  • 78.3 (n)
C19orf35 35
  • 68 (a)
(Monodelphis domestica)
Mammalia C19orf35 35
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia C19orf35 35
  • 43 (a)
Species where no ortholog for C19orf35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C19orf35 Gene

Gene Tree for C19orf35 (if available)
Gene Tree for C19orf35 (if available)

Paralogs for C19orf35 Gene

Paralogs for C19orf35 Gene

genes like me logo Genes that share paralogs with C19orf35: view

Variants for C19orf35 Gene

Sequence variations from dbSNP and Humsavar for C19orf35 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10407772 -- 2,282,367(+) AAGTC(A/G)ATAGC upstream-variant-2KB
rs10409063 -- 2,276,711(+) GATGT(C/T)CCTGG intron-variant
rs10415285 -- 2,274,948(+) aaaaa(A/G)aaaaa utr-variant-3-prime
rs10419306 -- 2,280,444(+) ggctc(A/G)aggga intron-variant
rs10420010 -- 2,280,777(+) CACCC(A/C)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C19orf35 Gene

Variant ID Type Subtype PubMed ID
nsv833707 CNV loss 17160897
nsv578383 CNV loss 21841781
esv2717882 CNV deletion 23290073
dgv6218n54 CNV loss 21841781

Variation tolerance for C19orf35 Gene

Gene Damage Index Score: 8.19; 84.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C19orf35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf35 Gene

Disorders for C19orf35 Gene

Relevant External Links for C19orf35

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C19orf35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf35 Gene

Publications for C19orf35 Gene

  1. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A. … Haiman C.A. (PLoS Genet. 2011) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C19orf35 Gene

Sources for C19orf35 Gene

Loading form....