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Aliases for C19orf33 Gene

Aliases for C19orf33 Gene

  • Chromosome 19 Open Reading Frame 33 2 3 5
  • Hepatocyte Growth Factor Activator Inhibitor Type 2-Related Small Protein 2 3 4
  • Immortalization-Upregulated Protein 2 3
  • HAI-2 Related Small Protein 2 3
  • H2RSP 3 4
  • IMUP 3 4
  • Immortalization Up-Regulated Protein 3
  • HAI-2-Related Small Protein 4
  • IMUP-1 3
  • IMUP-2 3

External Ids for C19orf33 Gene

Previous GeneCards Identifiers for C19orf33 Gene

  • GC19P043489
  • GC19P043490
  • GC19P038794
  • GC19P035242

Summaries for C19orf33 Gene

Entrez Gene Summary for C19orf33 Gene

  • The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for C19orf33 Gene

C19orf33 (Chromosome 19 Open Reading Frame 33) is a Protein Coding gene. Diseases associated with C19orf33 include Eclampsia. GO annotations related to this gene include double-stranded DNA binding and single-stranded DNA binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf33 Gene

Genomics for C19orf33 Gene

Regulatory Elements for C19orf33 Gene

Enhancers for C19orf33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F038299 1.7 FANTOM5 Ensembl ENCODE 63.5 -1.2 -1216 6.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF121 GLIS2 KLF7 FOS C19orf33 CATSPERG ZNF793 ZNF607 ENSG00000200209
GH19F038279 0.2 ENCODE 59.1 -23.5 -23513 1.4 ZFHX2 RBAK ZNF169 PRDM2 C19orf33 SPINT2 PPP1R14A YIF1B KCNK6 CATSPERG ENSG00000267748 GC19M038269
GH19F038282 0.4 Ensembl 58.6 -21.7 -21661 1.0 SRF KLF1 PKNOX1 ZNF335 ZFHX2 ZFP3 ZBTB33 SP7 C19orf33 PPP1R14A SPINT2 YIF1B KCNK6 CATSPERG ENSG00000267748 GC19M038269
GH19F038312 1 FANTOM5 Ensembl ENCODE 56.7 +13.4 13431 10.0 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 C19orf33 ENSG00000266963 CATSPERG SPINT2 ENSG00000269445 ENSG00000267375 ENSG00000269172 ENSG00000269688 PPP1R14A ACTN4
GH19F038336 1.1 ENCODE 50.5 +32.3 32264 2.5 HDGF PKNOX1 MLX ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 ZNF302 C19orf33 ZNF793 ZNF573 ZNF607 ENSG00000266963 ENSG00000269688 CATSPERG ENSG00000267152 ENSG00000269445 ENSG00000267375
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C19orf33 on UCSC Golden Path with GeneCards custom track

Promoters for C19orf33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000346261 539 1401 HDGF PKNOX1 SIN3A ZNF48 GLIS2 KLF7 FOS KLF13 SP3 SP5

Genomic Location for C19orf33 Gene

Chromosome:
19
Start:
38,304,161 bp from pter
End:
38,305,009 bp from pter
Size:
849 bases
Orientation:
Plus strand

Genomic View for C19orf33 Gene

Genes around C19orf33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf33 Gene

Proteins for C19orf33 Gene

  • Protein details for C19orf33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZP8-IMUP_HUMAN
    Recommended name:
    Immortalization up-regulated protein
    Protein Accession:
    Q9GZP8
    Secondary Accessions:
    • Q0P6G2
    • Q96H58
    • Q9HCR4

    Protein attributes for C19orf33 Gene

    Size:
    106 amino acids
    Molecular mass:
    10897 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C19orf33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C19orf33 Gene

Post-translational modifications for C19orf33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C19orf33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C19orf33 Gene

Domains & Families for C19orf33 Gene

Protein Domains for C19orf33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C19orf33 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C19orf33: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C19orf33 Gene

Function for C19orf33 Gene

genes like me logo Genes that share phenotypes with C19orf33: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C19orf33 Gene

Localization for C19orf33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C19orf33 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C19orf33 Gene COMPARTMENTS Subcellular localization image for C19orf33 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for C19orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11606055
genes like me logo Genes that share ontologies with C19orf33: view

Pathways & Interactions for C19orf33 Gene

SuperPathways for C19orf33 Gene

No Data Available

Interacting Proteins for C19orf33 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000301246%0d%0a9606.ENSP00000347858%0d%0a
Selected Interacting proteins: ENSP00000301246 Q9GZP8-IMUP_HUMAN for C19orf33 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C19orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C19orf33: view

No data available for Pathways by source and SIGNOR curated interactions for C19orf33 Gene

Transcripts for C19orf33 Gene

Unigene Clusters for C19orf33 Gene

Chromosome 19 open reading frame 33:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf33 Gene

No ASD Table

Relevant External Links for C19orf33 Gene

GeneLoc Exon Structure for
C19orf33
ECgene alternative splicing isoforms for
C19orf33

Expression for C19orf33 Gene

mRNA expression in normal human tissues for C19orf33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C19orf33 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.5).

Protein differential expression in normal tissues from HIPED for C19orf33 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.7), Cervix (19.4), and Amniocyte (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C19orf33 Gene



NURSA nuclear receptor signaling pathways regulating expression of C19orf33 Gene:

C19orf33

SOURCE GeneReport for Unigene cluster for C19orf33 Gene:

Hs.631544
genes like me logo Genes that share expression patterns with C19orf33: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C19orf33 Gene

Orthologs for C19orf33 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C19orf33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19ORF33 35
  • 98 (a)
OneToMany
Species where no ortholog for C19orf33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C19orf33 Gene

ENSEMBL:
Gene Tree for C19orf33 (if available)
TreeFam:
Gene Tree for C19orf33 (if available)

Paralogs for C19orf33 Gene

No data available for Paralogs for C19orf33 Gene

Variants for C19orf33 Gene

Sequence variations from dbSNP and Humsavar for C19orf33 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1054383 -- 38,305,168(-) AGGCC(A/C)CCGCC intron-variant, utr-variant-3-prime
rs1063980 -- 38,305,156(-) CAGGG(C/G)GTGGC intron-variant, utr-variant-3-prime
rs1064154 -- 38,304,932(-) cttct(C/G)cttct downstream-variant-500B, reference, missense, utr-variant-3-prime
rs1064155 -- 38,304,930(-) tctcc(G/T)tcttg downstream-variant-500B, reference, missense, utr-variant-3-prime
rs111400805 -- 38,303,331(+) ATCCA(-/CCTG)CCTGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C19orf33 Gene

Variant ID Type Subtype PubMed ID
nsv833822 CNV loss 17160897

Variation tolerance for C19orf33 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.09; 87.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C19orf33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C19orf33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf33 Gene

Disorders for C19orf33 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C19orf33 Gene - From: GeneCards

Disorder Aliases PubMed IDs
eclampsia
  • eclampsia in puerperium
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C19orf33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C19orf33
genes like me logo Genes that share disorders with C19orf33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C19orf33 Gene

Publications for C19orf33 Gene

  1. Identification of cDNAs encoding two novel nuclear proteins, IMUP-1 and IMUP-2, upregulated in SV40-immortalized human fibroblasts. (PMID: 11080599) Kim J.K. … Kato S. (Gene 2000) 2 3 4 22 64
  2. Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes. (PMID: 11606055) Itoh H.K. … Koono M.R. (Biochem. Biophys. Res. Commun. 2001) 3 4 22 64
  3. Increased immortalization-upregulated protein 2 (IMUP-2) by hypoxia induces apoptosis of the trophoblast and pre-eclampsia. (PMID: 20432246) Jeon S.Y. … Kim G.J. (J. Cell. Biochem. 2010) 3 22 64
  4. Imup-1 and imup-2 overexpression in endometrial carcinoma in Korean and Japanese populations. (PMID: 18507030) Kim S.J. … Kim J.K. (Anticancer Res. 2008) 3 22 64
  5. Enhanced expression of hepatocyte growth factor activator inhibitor type 2-related small peptide at the invasive front of colon cancers. (PMID: 16809422) Uchiyama S. … Kataoka H. (Gut 2007) 3 22 64

Products for C19orf33 Gene

Sources for C19orf33 Gene

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