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Aliases for C19orf25 Gene

Aliases for C19orf25 Gene

  • Chromosome 19 Open Reading Frame 25 2 3 5

External Ids for C19orf25 Gene

Previous GeneCards Identifiers for C19orf25 Gene

  • GC19M001425
  • GC19M001426
  • GC19M001247
  • GC19M001473

Summaries for C19orf25 Gene

GeneCards Summary for C19orf25 Gene

C19orf25 (Chromosome 19 Open Reading Frame 25) is a Protein Coding gene.

Gene Wiki entry for C19orf25 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf25 Gene

Genomics for C19orf25 Gene

Regulatory Elements for C19orf25 Gene

Enhancers for C19orf25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F001442 1.4 FANTOM5 ENCODE 12.2 +35.3 35255 3.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 APC2 ENSG00000266990 RNA5SP462 C19orf24 C19orf25 PCSK4 REEP6 SCAMP4 MUM1 CBARP
GH19F001546 1.2 Ensembl ENCODE 11.6 -66.8 -66802 0.5 HDAC1 KLF17 ZNF2 RAD21 ZEB1 SCRT2 ZNF143 ZNF391 CREM ZNF654 ATP8B3 MIR1909 REXO1 TCF3 PCSK4 REEP6 C19orf25 RNU6-1223P DAZAP1 GAMT
GH19F001441 0.8 ENCODE 12.2 +37.3 37341 0.6 ARNT TAL1 INSM2 ZNF384 HIC1 GLIS2 POLR2A NCOR1 PATZ1 ZNF600 C19orf25 PCSK4 REEP6 ENSG00000268798 APC2
GH19F001236 1.6 FANTOM5 ENCODE 6 +222.7 222698 41.1 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SF3A2 TMEM259 LOC100288123 C19orf24 MIER2 ENSG00000267317 MIDN CIRBP MUM1 RPS15
GH19F001464 1.2 Ensembl ENCODE 5.8 +9.4 9369 10.5 ZFP64 GLI4 ZNF2 GLIS2 KLF7 KLF13 SP3 REST SMARCB1 SSRP1 CIRBP RPS15 ATP8B3 MIR1909 REXO1 TCF3 REEP6 C19orf25 PIR35020 ENSG00000267317
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C19orf25 on UCSC Golden Path with GeneCards custom track

Promoters for C19orf25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000213894 556 2001 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for C19orf25 Gene

Chromosome:
19
Start:
1,461,143 bp from pter
End:
1,479,556 bp from pter
Size:
18,414 bases
Orientation:
Minus strand

Genomic View for C19orf25 Gene

Genes around C19orf25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf25 Gene

Proteins for C19orf25 Gene

  • Protein details for C19orf25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UFG5-CS025_HUMAN
    Recommended name:
    UPF0449 protein C19orf25
    Protein Accession:
    Q9UFG5
    Secondary Accessions:
    • B3KQN6
    • Q8N9R7
    • Q8WV94

    Protein attributes for C19orf25 Gene

    Size:
    118 amino acids
    Molecular mass:
    12878 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C19orf25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C19orf25 Gene

Post-translational modifications for C19orf25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C19orf25 Gene

Domains & Families for C19orf25 Gene

Protein Domains for C19orf25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C19orf25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UFG5

UniProtKB/Swiss-Prot:

CS025_HUMAN :
  • Belongs to the UPF0449 family.
Family:
  • Belongs to the UPF0449 family.
genes like me logo Genes that share domains with C19orf25: view

No data available for Gene Families for C19orf25 Gene

Function for C19orf25 Gene

Gene Ontology (GO) - Molecular Function for C19orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with C19orf25: view
genes like me logo Genes that share phenotypes with C19orf25: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C19orf25 Gene

Localization for C19orf25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C19orf25 gene
Compartment Confidence
nucleus 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C19orf25 Gene

Pathways & Interactions for C19orf25 Gene

SuperPathways for C19orf25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C19orf25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C19orf25 Gene

Transcripts for C19orf25 Gene

Unigene Clusters for C19orf25 Gene

Chromosome 19 open reading frame 25:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf25 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - - -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for C19orf25 Gene

GeneLoc Exon Structure for
C19orf25
ECgene alternative splicing isoforms for
C19orf25

Expression for C19orf25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C19orf25 Gene

Protein differential expression in normal tissues from HIPED for C19orf25 Gene

This gene is overexpressed in Bone (28.0) and Peripheral blood mononuclear cells (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C19orf25 Gene



NURSA nuclear receptor signaling pathways regulating expression of C19orf25 Gene:

C19orf25

SOURCE GeneReport for Unigene cluster for C19orf25 Gene:

Hs.532840
genes like me logo Genes that share expression patterns with C19orf25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C19orf25 Gene

Orthologs for C19orf25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C19orf25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf25 34
  • 98.87 (n)
C19orf25 35
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf25 34
  • 79.66 (n)
cow
(Bos Taurus)
Mammalia C7H19orf25 34 35
  • 75.71 (n)
mouse
(Mus musculus)
Mammalia 2310011J03Rik 34 16 35
  • 74.04 (n)
rat
(Rattus norvegicus)
Mammalia RGD1359127 34
  • 74.04 (n)
oppossum
(Monodelphis domestica)
Mammalia C19orf25 35
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf25 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves C19orf25 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C19orf25 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c19orf25 34
  • 52.75 (n)
zebrafish
(Danio rerio)
Actinopterygii C11H19orf25 (1 of 2) 35
  • 43 (a)
OneToMany
C11H19orf25 (2 of 2) 35
  • 36 (a)
OneToMany
Species where no ortholog for C19orf25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C19orf25 Gene

ENSEMBL:
Gene Tree for C19orf25 (if available)
TreeFam:
Gene Tree for C19orf25 (if available)

Paralogs for C19orf25 Gene

genes like me logo Genes that share paralogs with C19orf25: view

No data available for Paralogs for C19orf25 Gene

Variants for C19orf25 Gene

Sequence variations from dbSNP and Humsavar for C19orf25 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1047854 -- 1,481,482(-) GTCCG(C/T)CTCGG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs11084894 -- 1,473,153(+) GTCCT(C/T)CCCTA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs11084895 -- 1,480,910(+) CTGGC(C/T)AACAT upstream-variant-2KB
rs111412232 -- 1,474,643(+) ACCTC(A/G)ATCCC utr-variant-3-prime
rs111865101 -- 1,472,949(+) GCTGA(A/G)CTCGG intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C19orf25 Gene

Variant ID Type Subtype PubMed ID
nsv953942 CNV deletion 24416366
nsv833705 CNV loss 17160897
nsv817811 CNV loss 17921354
nsv578295 CNV gain 21841781
nsv578279 CNV gain 21841781
nsv470106 CNV loss 18288195
nsv470105 CNV gain 18288195
nsv1113954 CNV deletion 24896259
esv32942 CNV gain+loss 17666407
esv2758743 CNV gain+loss 17122850

Variation tolerance for C19orf25 Gene

Gene Damage Index Score: 0.81; 16.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C19orf25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C19orf25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf25 Gene

Disorders for C19orf25 Gene

Relevant External Links for C19orf25

Human Genome Epidemiology (HuGE) Navigator
C19orf25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C19orf25

No disorders were found for C19orf25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf25 Gene

Publications for C19orf25 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 64
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3 64

Products for C19orf25 Gene

Sources for C19orf25 Gene

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