C19orf25 Gene
protein-coding GIFtS: 44
GCID: GC19M001469
|
|
chromosome 19 open reading frame 25
| |
Aliases
for C19orf25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 19 Open Reading Frame 251 2 | | FLJ366661 | | UPF0449 Protein C19orf252 |
Export aliases for C19orf25 gene to outside databasesPrevious GC identifers: GC19M001425 GC19M001426 GC19M001247 GC19M001473 |
Summaries
for C19orf25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for C19orf25
|
Genomic Views
for C19orf25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C19orf25 gene promoter:
Spz1 AML1a SREBP-1c LUN-1 E47 SREBP-1b YY1 Max SREBP-1a c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for C19orf25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C19orf25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3C19orf25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M001469: view genomic region
(about GC identifiers)
Start:
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1,461,142 bp from pter |
End:
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1,479,555 bp from pter |
Size:
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18,414 bases |
Orientation:
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minus strand |
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Proteins
for C19orf25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CS025_HUMAN, Q9UFG5 (See
protein sequence)Recommended Name: UPF0449 protein C19orf25 Size: 118 amino acids; 12878 Da
Secondary accessions: B3KQN6 Q8N9R7 Q8WV94Alternative splicing: 2 isoforms: Q9UFG5-1 Q9UFG5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C19orf25: NX_Q9UFG5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UFG5
C19orf25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689695.2
ENSEMBL proteins: ENSP00000468000 ENSP00000397394 ENSP00000465469 ENSP00000389254 ENSP00000466283 ENSP00000466372 ENSP00000468064 ENSP00000467861 ENSP00000468688 ENSP00000466994
Human Recombinant Protein Products:
C19orf25 Antibody Products:
Assay Products for C19orf25: |
Protein
Domains /
Families
for C19orf25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9UFG5 UniProtKB/Swiss-Prot: CS025_HUMAN, Q9UFG5Similarity: Belongs to the UPF0449 family |
Function
for C19orf25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf25 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf25
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C19orf25 (NM_152482) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C19orf25 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf25 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf25 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
C19orf25 for ontologies About GeneDecksing
|
Pathways & Interactions
for C19orf25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C19orf25
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for C19orf25 (Q9UFG51, 3 ENSP000003973944) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for C19orf25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C19orf25
Search CenterWatch for drugs/clinical trials and news about C19orf25 / CS025
|
Transcripts
for C19orf25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C19orf25 gene: NM_152482.2 Unigene Cluster for C19orf25: Chromosome 19 open reading frame 25 Hs.532840 [show with all ESTs]Unigene Representative Sequence: AK05600414 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000588427 ENST00000436106(uc010xgn.1 uc010dsk.3 uc010xgo.2)
ENST00000588871 ENST00000427685 ENST00000592486 ENST00000588849 ENST00000586564
ENST00000590621 ENST00000592872 ENST00000585675 ENST00000591027 ENST00000592605
ENST00000589421 ENST00000589529
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf25 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf25
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C19orf25 (NM_152482) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C19orf25 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf25 |
Additional cDNA sequence: AK056004.1 AK075267.1 AK093985.1 AK297944.1 AL122089.1 AY007120.1 BC018441.1 FJ423750.1 11 DOTS entries: DT.213740 DT.99987621 DT.91949899 DT.95095042 DT.100783936 DT.100783934 DT.115077 DT.75150865 DT.95095046 DT.97845826 DT.99936512 24/228 AceView cDNA sequences (see all 228): BU844522 BM544503 BF725558 BQ891673 BE297507 BQ070444 BI333332 BI061865 CF130943 CR623802 BM785712 BF204675 BU680846 AY007120 CB106842 NM_152482 AK093985 CR591126 BE298776 BF724242 AK075267 BI029468 BX375457 BM769266
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for C19orf25 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for C19orf25
|
Expression
for C19orf25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C19orf25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGAGTTGGT
About this image
See C19orf25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C19orf25
SOURCE GeneReport for Unigene cluster: Hs.532840
SABiosciences Custom PCR Arrays for C19orf25
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C19orf25
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C19orf25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C19orf25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C19orf25 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf25 |
Orthologs
for C19orf25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C19orf25 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for C19orf25 (if available)
TreeFam Gene Tree for C19orf25 (if available) |
Paralogs
for C19orf25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C19orf25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C19orf25 (1461142 - 1479555 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for C19orf25
5 CNVs: 10541 7191 4066 30059 5066 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C19orf25 |
|
Disorders
/ Diseases
for C19orf25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C19orf25 for disorders About MalaCards
C19orf25 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: C19orf25 (3 documents)
Export disorders for C19orf25 gene to outside databases
|
Publications
for C19orf25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C19orf25 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with C19orf25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
|
External Searches for C19orf25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C19orf25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C19orf25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C19orf25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C19orf25 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for C19orf25 gene:
Search GeneIP for patents involving C19orf25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C19orf25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C19orf25 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C19orf25 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C19orf25 | | | OriGene Protein Over-expression Lysate for C19orf25 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for C19orf25 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf25 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf25 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C19orf25 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C19orf25 | | OriGene Custom Protein Services for C19orf25 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C19orf25 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C19orf25 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C19orf25 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C19orf25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C19orf25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C19orf25 |
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 | | | C19orf25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf25 |
|  |  |  | | | | Search ThermoFisher Antibodies for C19orf25 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf25 |
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