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Aliases for C19orf18 Gene

Aliases for C19orf18 Gene

  • Chromosome 19 Open Reading Frame 18 2 3 5

External Ids for C19orf18 Gene

Previous GeneCards Identifiers for C19orf18 Gene

  • GC19M063162
  • GC19M063163
  • GC19M058469
  • GC19M054780

Summaries for C19orf18 Gene

GeneCards Summary for C19orf18 Gene

C19orf18 (Chromosome 19 Open Reading Frame 18) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf18 Gene

Genomics for C19orf18 Gene

Regulatory Elements for C19orf18 Gene

Enhancers for C19orf18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G058045 0.5 FANTOM5 48.5 -70.6 -70589 0.1 HIC1 NRF1 C19orf18 ZSCAN18 ZNF329 ZSCAN1 GC19P058055 GC19P058057 LETM1P2 PIR58144
GH19G057934 0.8 ENCODE 10.9 +39.2 39240 1.5 CTCF MXI1 PKNOX1 NFIB SUZ12 WRNIP1 MAX ZBTB40 YY1 ETS1 LOC100128398 C19orf18 ZNF587 ZNF671 VN1R1 PIR52698 ZNF418
GH19G058203 0.8 FANTOM5 ENCODE 1.8 -229.8 -229833 1.0 AGO1 ZBTB33 ZNF311 RBFOX2 LOC105372483 ZNF837 ZNF544 C19orf18 GC19P058214 ZNF274
GH19G057990 0.5 FANTOM5 0.4 -16.2 -16150 0.3 ZSCAN18 YBX1 LOC100128398 ZNF606 ZSCAN4 ZSCAN1 ZIK1 ZSCAN18 ZNF418 ZNF134 ZNF549 ZNF132
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C19orf18 on UCSC Golden Path with GeneCards custom track

Genomic Location for C19orf18 Gene

Chromosome:
19
Start:
57,958,437 bp from pter
End:
57,974,534 bp from pter
Size:
16,098 bases
Orientation:
Minus strand

Genomic View for C19orf18 Gene

Genes around C19orf18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf18 Gene

Proteins for C19orf18 Gene

  • Protein details for C19orf18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEA5-CS018_HUMAN
    Recommended name:
    Uncharacterized protein C19orf18
    Protein Accession:
    Q8NEA5

    Protein attributes for C19orf18 Gene

    Size:
    215 amino acids
    Molecular mass:
    24151 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C19orf18 Gene

Post-translational modifications for C19orf18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C19orf18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C19orf18 Gene

Domains & Families for C19orf18 Gene

Protein Domains for C19orf18 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C19orf18: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C19orf18 Gene

Function for C19orf18 Gene

Gene Ontology (GO) - Molecular Function for C19orf18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C19orf18: view
genes like me logo Genes that share phenotypes with C19orf18: view

Animal Model Products

CRISPR Products

miRNA for C19orf18 Gene

miRTarBase miRNAs that target C19orf18

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C19orf18 Gene

Localization for C19orf18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C19orf18 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C19orf18 gene
Compartment Confidence
extracellular 5
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for C19orf18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with C19orf18: view

Pathways & Interactions for C19orf18 Gene

SuperPathways for C19orf18 Gene

No Data Available

Interacting Proteins for C19orf18 Gene

Selected Interacting proteins: Q8NEA5-CS018_HUMAN for C19orf18 Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for C19orf18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C19orf18: view

No data available for Pathways by source and SIGNOR curated interactions for C19orf18 Gene

Drugs & Compounds for C19orf18 Gene

No Compound Related Data Available

Transcripts for C19orf18 Gene

mRNA/cDNA for C19orf18 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(113) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C19orf18 Gene

Chromosome 19 open reading frame 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf18 Gene

No ASD Table

Relevant External Links for C19orf18 Gene

GeneLoc Exon Structure for
C19orf18
ECgene alternative splicing isoforms for
C19orf18

Expression for C19orf18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C19orf18 Gene

mRNA differential expression in normal tissues according to GTEx for C19orf18 Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for C19orf18 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C19orf18 Gene



Protein tissue co-expression partners for C19orf18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C19orf18 Gene:

C19orf18

SOURCE GeneReport for Unigene cluster for C19orf18 Gene:

Hs.134209
genes like me logo Genes that share expression patterns with C19orf18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C19orf18 Gene

Orthologs for C19orf18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C19orf18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf18 34
  • 99.53 (n)
C19orf18 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C19orf18 35
  • 71 (a)
OneToOne
C1H19orf18 34
  • 62.91 (n)
cow
(Bos Taurus)
Mammalia C18H19orf18 34
  • 70.43 (n)
mouse
(Mus musculus)
Mammalia 2900092C05Rik 34 16 35
  • 63.41 (n)
rat
(Rattus norvegicus)
Mammalia LOC691722 34
  • 62.56 (n)
Species where no ortholog for C19orf18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C19orf18 Gene

ENSEMBL:
Gene Tree for C19orf18 (if available)
TreeFam:
Gene Tree for C19orf18 (if available)

Paralogs for C19orf18 Gene

No data available for Paralogs for C19orf18 Gene

Variants for C19orf18 Gene

Sequence variations from dbSNP and Humsavar for C19orf18 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000145483 -- 57,973,548(+) GTGAA(A/T)CCCTG intron-variant
rs1000507352 -- 57,961,096(+) CGGGC(A/G)TGGTG intron-variant
rs1000931403 -- 57,960,125(+) ATAAA(C/T)AAATA intron-variant
rs1000953531 -- 57,960,299(+) CGGGT(A/G)CCTAT intron-variant
rs1001113375 -- 57,962,109(+) CACTG(A/C)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C19orf18 Gene

Variant ID Type Subtype PubMed ID
esv3644913 CNV gain 21293372
esv3644917 CNV loss 21293372
esv3644918 CNV gain 21293372
esv3893258 CNV gain 25118596
nsv1066059 CNV gain 25217958
nsv525611 CNV loss 19592680

Variation tolerance for C19orf18 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C19orf18 Gene

Human Gene Mutation Database (HGMD)
C19orf18
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C19orf18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf18 Gene

Disorders for C19orf18 Gene

Relevant External Links for C19orf18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C19orf18

No disorders were found for C19orf18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf18 Gene

Publications for C19orf18 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3 64

Products for C19orf18 Gene

Sources for C19orf18 Gene

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