C19orf10 Gene
protein-coding GIFtS: 52
GCID: GC19M004608
|
|
chromosome 19 open reading frame 10(Previous name: interleukin 27 working designation )
(Previous symbols: IL27, IL27w)
| |
Aliases
for C19orf10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 19 Open Reading Frame 101 2 | | Stromal Cell-Derived Growth Factor SF202 3 | | IL251 2 3 5 | | IL-271 | | SF201 2 5 | | EUROIMAGE18753352 | | IL271 2 | | Interleukin 252 | | IL27w1 2 | | Interleukin-253 | | R33729_11 2 | | UPF0556 Protein C19orf102 | | Interleukin 27 Working Designation1 2 | | Interleukin-253 | | IL-251 3 | | |
Export aliases for C19orf10 gene to outside databasesPrevious GC identifers: GC19M004581 GC19M004417 |
Summaries
for C19orf10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for C19orf10:
The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was consideredan interleukin. However, this activity has not been reproducible and the function of this protein is currentlyunknown. (provided by RefSeq, Jul 2008)
|
Genomic Views
for C19orf10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C19orf10 gene promoter:
ER-alpha Spz1 MyoD CUTL1 XBP-1 Tal-1beta E47 FAC1 PPAR-gamma1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for C19orf10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C19orf10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3C19orf10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M004608: view genomic region
(about GC identifiers)
Start:
|
4,657,557 bp from pter |
End:
|
4,670,415 bp from pter |
Size:
|
12,859 bases |
Orientation:
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minus strand |
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Proteins
for C19orf10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CS010_HUMAN, Q969H8 (See
protein sequence)Recommended Name: UPF0556 protein C19orf10 precursor Size: 173 amino acids; 18795 Da
Subcellular location: Secreted. Endoplasmic reticulum-Golgi intermediate compartment
Caution: Was originally (PubMed:11714798) thought to signal lymphoid cells to proliferate via thymic shared antigen 1,but this work has been later retracted
Sequence caution: Sequence=AAC27824.1; Type=Erroneous gene model prediction; Sequence=AAC33800.1; Type=Erroneous genemodel prediction;
Secondary accessions: D6W628 O75256 O75272 Q9BTK7 Q9NP69Explore the universe of human proteins at neXtProt for C19orf10: NX_Q969H8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969H8
C19orf10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061980.1
ENSEMBL proteins: ENSP00000262947 Reactome Protein details: Q969H8
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005788 | endoplasmic reticulum lumen |
TAS | -- | | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
IEA | -- |
C19orf10 for ontologies About GeneDecksing
C19orf10 Antibody Products:
Assay Products for C19orf10: |
Protein
Domains /
Families
for C19orf10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C19orf10 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q969H8ProtoNet protein and cluster: Q969H8 UniProtKB/Swiss-Prot: CS010_HUMAN, Q969H8Similarity: Belongs to the UPF0556 family |
Function
for C19orf10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf10 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf10 |
|
Pathways & Interactions
for C19orf10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of Chaperone Genes by XBP1(S) | | | 2 | Expression of C19orf10 | | | 3 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for C19orf10
C19orf10 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C19orf10
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/8 Interacting proteins for C19orf10 (Q969H82, 3 ENSP000002629474) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006987 | activation of signaling protein activity involved in unfolded protein response |
TAS | -- | | GO:0030968 | endoplasmic reticulum unfolded protein response |
TAS | -- |
C19orf10 for ontologies About GeneDecksing
|
Drugs & Compounds
for C19orf10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
C19orf10 for compounds About GeneDecksing
 Browse Tocris compounds for C19orf10
3 Novoseek chemical compound relationships for C19orf10 gene About this table
Search CenterWatch for drugs/clinical trials and news about C19orf10 / CS010
|
Transcripts
for C19orf10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C19orf10 gene: NM_019107.3 Unigene Cluster for C19orf10: Chromosome 19 open reading frame 10 Hs.465645 [show with all ESTs]Unigene Representative Sequence: BM9161961 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000262947(uc002may.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf10 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C19orf10 (NM_019107) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C19orf10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf10 |
Additional cDNA sequence: AF282264.1 AK098829.1 AL365373.1 AL365374.1 BC003639.2 BC010129.2 BC014655.1 13 DOTS entries: DT.455776 DT.97856355 DT.95325965 DT.100826657 DT.121478177 DT.95224176 DT.95224189 DT.121478128 DT.418993 DT.100825760 DT.120943892 DT.121638060 DT.121638061 24/467 AceView cDNA sequences (see all 467): AW516332 R64566 AI394156 BQ928431 CA430873 AI370474 CD368570 AI360482 AI491961 CB160854 BM562483 BM766297 AW069781 AI356216 CA865945 AA872246 BE301831 BM700385 BC010129 BU856726 CD368852 AA359669 CR606625 NM_019107
GeneLoc Exon Structure
|
Expression
for C19orf10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C19orf10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCTGCAGA
About this image
See C19orf10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C19orf10
SOURCE GeneReport for Unigene cluster: Hs.465645
UniProtKB/Swiss-Prot: CS010_HUMAN, Q969H8Tissue specificity: Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties
SABiosciences Custom PCR Arrays for C19orf10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C19orf10
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf10 |
Orthologs
for C19orf10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C19orf10 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
D17Wsu104e1 , 5 |
DNA segment, Chr 17, Wayne State University 104, expressed1, 5 |
84.14(n)1
87.35(a)1 |
|
17 (29.20 cM)5
281061 NM_080837.21 NP_543027.11
561757445 |
chicken
(Gallus gallus) |
Aves |
C28H19orf101 |
chromosome 28 open reading frame, human C19orf10 |
67.07(n)
62.28(a) |
|
420161 NM_001006342.1 NP_001006342.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.167992 |
Xenopus laevis transcribed sequence with weak similarity more |
73.76(n) |
|
48055822 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:928711 |
zgc:92871 |
58.77(n)
55.92(a) |
|
436753 NM_001002480.1 NP_001002480.1 |
ENSEMBL Gene Tree for C19orf10 (if available)
TreeFam Gene Tree for C19orf10 (if available) |
Paralogs
for C19orf10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C19orf10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C19orf10 (4657557 - 4670415 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C19orf10
1 Indel: 73298 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C19orf10 |
|
Disorders
/ Diseases
for C19orf10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C19orf10 for disorders About GeneDecksing
OMIM gene information: 606746
OMIM disorders: --
17  diseases for C19orf10: About MalaCardsgrowth hormone deficiency inflammatory bowel disease gastric ulcer encephalomyelitis
endometrial cancer liver disease hepatocellular carcinoma immunodeficiency
pancreatic cancer prostate carcinoma prostatitis breast cancer
asthma pancreatitis ataxia carcinoma
hepatitis
7 Novoseek disease relationships for C19orf10 gene About this table
Genetic Association Database (GAD): C19orf10
Human Genome Epidemiology (HuGE) Navigator: C19orf10 (1 document)
Export disorders for C19orf10 gene to outside databases
|
Publications
for C19orf10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C19orf10 gene, integrated from 9 sources (see all 81):
(articles sorted by number of sources associating them with C19orf10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The identification and characterization of a novel protein, c19orf10, in the synovium. (PubMed id 17362502)1, 2, 3 Weiler T....Wilkins J.A. (2007)
- Identification of a secretory protein c19orf10 activa ted in hepatocellular carcinoma. (PubMed id 21128247)1, 3 Sunagozaka H....Kaneko S. (2011)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The interleukin-25 gene located in the inflammatory bowel disease (IBD) 4 region: no association with inflammatory bowel disease. (PubMed id 14641539)1, 4 Buning C....Schmidt H. (2003)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Global profiling of protease cleavage sites by chemos elective labeling of protein N-termini. (PubMed id 19892738)2 Xu G....Jaffrey S.R. (2009)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
|
External Searches for C19orf10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C19orf10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C19orf10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C19orf10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C19orf10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C19orf10 gene:
Search GeneIP for patents involving C19orf10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C19orf10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C19orf10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C19orf10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C19orf10 | | | OriGene Protein Over-expression Lysate for C19orf10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C19orf10 | | OriGene 3'-UTR Clone for C19orf10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C19orf10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C19orf10 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C19orf10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C19orf10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C19orf10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C19orf10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C19orf10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C19orf10 |
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 | | | C19orf10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C19orf10 |
|  |  |  | | | | Search ThermoFisher Antibodies for C19orf10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C19orf10 |
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