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Aliases for C18orf8 Gene

Aliases for C18orf8 Gene

  • Chromosome 18 Open Reading Frame 8 2 3 5
  • Colon Cancer-Associated Protein Mic1 3 4
  • Macrophage Inhibitory Cytokine 1 2 3
  • Mic-1 3 4
  • MIC1 3 4
  • Colon Cancer Associated Protein Mic1 2
  • Uncharacterized Protein C18orf8 3
  • HsT2591 3

External Ids for C18orf8 Gene

Previous GeneCards Identifiers for C18orf8 Gene

  • GC18P019335
  • GC18P019337
  • GC18P021083
  • GC18P017938

Summaries for C18orf8 Gene

Entrez Gene Summary for C18orf8 Gene

  • This gene encodes a colon cancer associated protein. [provided by RefSeq, Jan 2013]

GeneCards Summary for C18orf8 Gene

C18orf8 (Chromosome 18 Open Reading Frame 8) is a Protein Coding gene.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf8 Gene

Genomics for C18orf8 Gene

Regulatory Elements for C18orf8 Gene

Enhancers for C18orf8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G023582 1.8 FANTOM5 ENCODE dbSUPER 28.8 +81.5 81521 5.8 HDGF PKNOX1 FOXA2 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 YY1 NPC1 C18orf8 ANKRD29 CABLES1 TMEM241 CABYR ENSG00000199366 GC18M023583
GH18G023539 1.4 Ensembl ENCODE dbSUPER 29.2 +37.8 37832 3.1 HDAC1 ATF1 TBL1XR1 TCF12 ZNF766 GATA2 ELK1 RELB IKZF2 USF2 NPC1 C18orf8 ANKRD29 GC18M023583 ENSG00000199366
GH18G023528 1.3 ENCODE dbSUPER 29.4 +25.9 25910 2.7 PKNOX1 CREB3L1 ARNT FEZF1 ZNF766 FOS JUNB REST ZNF592 MEF2D C18orf8 ENSG00000199366 GC18M023583
GH18G023578 1.3 Ensembl ENCODE dbSUPER 26.7 +76.5 76489 3.5 CEBPG ZNF664 HIC1 ZFHX2 ZNF366 FOS PRDM10 MAFK EGR2 ZNF362 C18orf8 LAMA3 ANKRD29 TMEM241 GC18M023583 ENSG00000199366
GH18G023502 1.4 ENCODE dbSUPER 22.3 +0.2 211 2.9 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 KLF13 NPC1 C18orf8 TMEM241 GC18M023583 ENSG00000199366
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C18orf8 on UCSC Golden Path with GeneCards custom track

Promoters for C18orf8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000101443 230 1801 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 KLF13

Genomic Location for C18orf8 Gene

Chromosome:
18
Start:
23,503,470 bp from pter
End:
23,531,807 bp from pter
Size:
28,338 bases
Orientation:
Plus strand

Genomic View for C18orf8 Gene

Genes around C18orf8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C18orf8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C18orf8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf8 Gene

Proteins for C18orf8 Gene

  • Protein details for C18orf8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DM3-MIC1_HUMAN
    Recommended name:
    Uncharacterized protein C18orf8
    Protein Accession:
    Q96DM3
    Secondary Accessions:
    • Q9BU17
    • Q9Y5M0

    Protein attributes for C18orf8 Gene

    Size:
    657 amino acids
    Molecular mass:
    74975 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD33909.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C18orf8 Gene

Post-translational modifications for C18orf8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for C18orf8
  • Santa Cruz Biotechnology (SCBT) Antibodies for C18orf8

No data available for DME Specific Peptides for C18orf8 Gene

Domains & Families for C18orf8 Gene

Protein Domains for C18orf8 Gene

Suggested Antigen Peptide Sequences for C18orf8 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DM3

UniProtKB/Swiss-Prot:

MIC1_HUMAN :
  • Belongs to the Mic1 family.
Family:
  • Belongs to the Mic1 family.
genes like me logo Genes that share domains with C18orf8: view

No data available for Gene Families for C18orf8 Gene

Function for C18orf8 Gene

genes like me logo Genes that share phenotypes with C18orf8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C18orf8 Gene

Localization for C18orf8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C18orf8 gene
Compartment Confidence
lysosome 5
nucleus 3
cytosol 2
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for C18orf8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
genes like me logo Genes that share ontologies with C18orf8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C18orf8 Gene

Pathways & Interactions for C18orf8 Gene

SuperPathways for C18orf8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C18orf8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C18orf8 Gene

Transcripts for C18orf8 Gene

Unigene Clusters for C18orf8 Gene

Chromosome 18 open reading frame 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19a ·
SP1: - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: -
SP6: - - - - -
SP7: - -
SP8: -
SP9: - - - - - -
SP10:
SP11:
SP12:
SP13:

ExUns: 19b ^ 20 ^ 21a · 21b ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for C18orf8 Gene

GeneLoc Exon Structure for
C18orf8
ECgene alternative splicing isoforms for
C18orf8

Expression for C18orf8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C18orf8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C18orf8 Gene

This gene is overexpressed in Breast (29.5) and Fetal Brain (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C18orf8 Gene



Protein tissue co-expression partners for C18orf8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C18orf8 Gene:

C18orf8

SOURCE GeneReport for Unigene cluster for C18orf8 Gene:

Hs.464779

Evidence on tissue expression from TISSUES for C18orf8 Gene

  • Lung(4.2)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with C18orf8: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C18orf8 Gene

Orthologs for C18orf8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for C18orf8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C18orf8 35
  • 100 (a)
OneToOne
C18H18orf8 34
  • 99.14 (n)
cow
(Bos Taurus)
Mammalia C18orf8 35
  • 93 (a)
OneToOne
C24H18orf8 34
  • 87.77 (n)
oppossum
(Monodelphis domestica)
Mammalia C18orf8 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C18orf8 35
  • 90 (a)
OneToOne
C7H18orf8 34
  • 88.59 (n)
mouse
(Mus musculus)
Mammalia 3110002H16Rik 34 16 35
  • 86.96 (n)
rat
(Rattus norvegicus)
Mammalia RGD1311805 34
  • 86.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C18orf8 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves C18orf8 35
  • 85 (a)
OneToOne
C18ORF8 34
  • 79.12 (n)
lizard
(Anolis carolinensis)
Reptilia C18orf8 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c18orf8 34
  • 75.7 (n)
Str.18235 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68745 34
zebrafish
(Danio rerio)
Actinopterygii C24H18orf8 35
  • 76 (a)
OneToOne
zgc:101800 34
  • 70.61 (n)
Dr.18809 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007576 34
  • 49.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8270 34 35
  • 48.73 (n)
worm
(Caenorhabditis elegans)
Secernentea Y50D4A.4 34 35
  • 43.35 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G12010 34
  • 40.43 (n)
rice
(Oryza sativa)
Liliopsida Os10g0400900 34
  • 41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8232 35
  • 46 (a)
OneToOne
Species where no ortholog for C18orf8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C18orf8 Gene

ENSEMBL:
Gene Tree for C18orf8 (if available)
TreeFam:
Gene Tree for C18orf8 (if available)

Paralogs for C18orf8 Gene

genes like me logo Genes that share paralogs with C18orf8: view

No data available for Paralogs for C18orf8 Gene

Variants for C18orf8 Gene

Sequence variations from dbSNP and Humsavar for C18orf8 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1805084 Likely benign 23,532,242(-) AGAGC(A/G)ATACA intron-variant, downstream-variant-500B, reference, missense
rs8086463 Likely benign 23,532,038(+) AGTCA(A/G)CTGTG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs145236115 Uncertain significance 23,531,887(+) TTGGC(-/CTTTACA)GAGTG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs188980155 Uncertain significance 23,532,093(+) AACCG(A/C)TGGTT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs534888589 Uncertain significance 23,532,011(+) CTCCA(G/T)ATCTA intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C18orf8 Gene

Variant ID Type Subtype PubMed ID
esv34149 CNV loss 18971310
esv3641971 CNV loss 21293372
nsv509688 CNV insertion 20534489
nsv576572 CNV loss 21841781

Variation tolerance for C18orf8 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C18orf8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C18orf8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C18orf8 Gene

Disorders for C18orf8 Gene

Relevant External Links for C18orf8

Genetic Association Database (GAD)
C18orf8
Human Genome Epidemiology (HuGE) Navigator
C18orf8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C18orf8

No disorders were found for C18orf8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C18orf8 Gene

Publications for C18orf8 Gene

  1. Knockdown of macrophage inhibitory cytokine-1 in RPMI-8226 human multiple myeloma cells inhibits osteoclastic differentiation through inhibiting the RANKL-Erk1/2 signaling pathway. (PMID: 27779672) Yuan M. … Zeng Z. (Mol Med Rep 2016) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for C18orf8 Gene

Sources for C18orf8 Gene

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