C18orf8 Gene
protein-coding GIFtS: 48
GCID: GC18P021083
|
|
chromosome 18 open reading frame 8
| |
Aliases
for C18orf8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 18 Open Reading Frame 81 2 | | MIC11 2 3 | | HsT25911 2 | | Colon Cancer-Associated Protein Mic12 3 | | Mic-12 3 | | Uncharacterized Protein C18orf82 |
Export aliases for C18orf8 gene to outside databasesPrevious GC identifers: GC18P019335 GC18P019337 GC18P017938 |
Summaries
for C18orf8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for C18orf8:
This gene encodes a colon cancer associated protein. (provided by RefSeq, Jan 2013)
|
Genomic Views
for C18orf8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C18orf8 gene promoter:
USF1 ATF-2 USF2 USF-1:USF-2 POU6F1 (c2) Roaz GATA-1 RORalpha1 USF-1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for C18orf8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C18orf8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q11.2 Ensembl cytogenetic band: 18q11.2 HGNC cytogenetic band: 18q11.2C18orf8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P021083: view genomic region
(about GC identifiers)
Start:
|
21,083,462 bp from pter |
End:
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21,111,746 bp from pter |
Size:
|
28,285 bases |
Orientation:
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plus strand |
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Proteins
for C18orf8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MIC1_HUMAN, Q96DM3 (See
protein sequence)Recommended Name: Uncharacterized protein C18orf8 Size: 657 amino acids; 74975 Da
Sequence caution: Sequence=AAD33909.1; Type=Erroneous initiation;
Secondary accessions: Q9BU17 Q9Y5M0Explore the universe of human proteins at neXtProt for C18orf8: NX_Q96DM3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96DM3
C18orf8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001263271.1 NP_037458.3
ENSEMBL proteins: ENSP00000269221 ENSP00000467852 ENSP00000467007 ENSP00000467692 ENSP00000465956 ENSP00000464875 ENSP00000465696
Human Recombinant Protein Products for C18orf8:
C18orf8 Antibody Products:
Assay Products for C18orf8: |
Protein
Domains /
Families
for C18orf8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C18orf8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96DM3ProtoNet protein and cluster: Q96DM3 UniProtKB/Swiss-Prot: MIC1_HUMAN, Q96DM3Similarity: Belongs to the Mic1 familySimilarity: Contains 1 Mic1 domain |
Function
for C18orf8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf8 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C18orf8 (NM_013326) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C18orf8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf8 |
|
Pathways & Interactions
for C18orf8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C18orf8
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
4 Interacting proteins for C18orf8 (Q96DM33 ENSP000002692214) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C18orf8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C18orf8
Search CenterWatch for drugs/clinical trials and news about C18orf8 / MIC1
|
Transcripts
for C18orf8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C18orf8 gene (2 alternative transcripts): NM_001276342.1 NM_013326.4 Unigene Cluster for C18orf8: Chromosome 18 open reading frame 8 Hs.464779 [show with all ESTs]Unigene Representative Sequence: AK02437013 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000269221(uc010xau.1 uc010xav.1 uc010xaw.1 uc021uie.1 uc010xay.2)
ENST00000589215 ENST00000587153 ENST00000590868 ENST00000587690 ENST00000589860
ENST00000590870 ENST00000592119 ENST00000590387 ENST00000591367 ENST00000593081
ENST00000592682 ENST00000589409
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf8 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C18orf8 (NM_013326) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C18orf8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf8 |
Additional cDNA sequence: AF143536.1 AK024370.1 AK027106.1 AK057192.1 AK294169.1 AK295246.1 AK296230.1 BC002950.1 BC008305.1 24/28 DOTS entries (see all 28): DT.452148 DT.100813642 DT.121085254 DT.40304003 DT.100816573 DT.100813641 DT.85105210 DT.97847518 DT.319097 DT.97847519 DT.100813636 DT.75136867 DT.92427261 DT.100849442 DT.121085292 DT.75129934 DT.100046040 DT.100733386 DT.100733427 DT.100813643 DT.101973162 DT.102834494 DT.319093 DT.97847520 24/196 AceView cDNA sequences (see all 196): AI334292 CA306996 AA380463 AA402027 F10365 CN481504 AL526340 AA810829 BU740353 BQ688572 AI271551 BU629425 BU159289 CR626373 AI800688 BI907653 BM836549 AA424047 BU678437 BP429585 AI275852 BM696414 BQ686230 BC002950
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for C18orf8 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · |
|---|
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| SP1: | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19b | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 |
|---|
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| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for C18orf8
|
Expression
for C18orf8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C18orf8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCTTTTTT
About this image
See C18orf8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C18orf8
SOURCE GeneReport for Unigene cluster: Hs.464779
SABiosciences Custom PCR Arrays for C18orf8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C18orf8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C18orf8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C18orf8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C18orf8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf8 |
Orthologs
for C18orf8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for C18orf8 gene from 9/26 species (see all 26) About this table
ENSEMBL Gene Tree for C18orf8 (if available)
TreeFam Gene Tree for C18orf8 (if available) |
Paralogs
for C18orf8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C18orf8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C18orf8 (21083462 - 21111746 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C18orf8
1 CNV: 47911 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C18orf8 |
|
Disorders
/ Diseases
for C18orf8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C18orf8 for disorders About GeneDecksing
3  diseases for C18orf8: About MalaCardscolon cancer prostate cancer prostatitis
Genetic Association Database (GAD): C18orf8
Human Genome Epidemiology (HuGE) Navigator: C18orf8 (1 document)
Export disorders for C18orf8 gene to outside databases
|
Publications
for C18orf8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C18orf8 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with C18orf8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
- H6D polymorphism in macrophage-inhibitory cytokine-1 gene associated with prostate cancer. (PubMed id 15316060)4 Lindmark F....Xu J. (2004)
- Antibody-based approach to high-volume genotyping for MIC-1 polymorphism. (PubMed id 12139236)4 Brown D.A....Breit S.N. (2002)
|
External Searches for C18orf8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C18orf8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C18orf8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C18orf8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for C18orf8 gene:
Search GeneIP for patents involving C18orf8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C18orf8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for C18orf8 | | OriGene shRNA RFP for C18orf8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C18orf8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C18orf8 | | | OriGene Protein Over-expression Lysate for C18orf8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C18orf8 | | OriGene 3'-UTR Clone for C18orf8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C18orf8 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C18orf8 | | OriGene Custom Protein Services for C18orf8 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C18orf8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C18orf8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C18orf8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C18orf8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C18orf8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C18orf8 |
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| | | | Search Tocris compounds for C18orf8 |
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 | | | C18orf8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf8 |
|  |  |  |  | | | | ThermoFisher Antibodies for C18orf8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf8 |
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