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Aliases for C18orf63 Gene

Aliases for C18orf63 Gene

  • Chromosome 18 Open Reading Frame 63 2 3 5
  • Uncharacterized Protein C18orf63 3
  • DKFZP781G0119 3

External Ids for C18orf63 Gene

Previous GeneCards Identifiers for C18orf63 Gene

  • GC18P071985

Summaries for C18orf63 Gene

GeneCards Summary for C18orf63 Gene

C18orf63 (Chromosome 18 Open Reading Frame 63) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf63 Gene

Genomics for C18orf63 Gene

Regulatory Elements for C18orf63 Gene

Enhancers for C18orf63 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G074288 1.6 Ensembl ENCODE dbSUPER 11.4 -25.2 -25204 4.9 HDGF HNRNPUL1 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 CYB5A ZNF407 C18orf63 GC18M074253 GC18M074254
GH18G074280 1.4 Ensembl ENCODE dbSUPER 12.1 -32.1 -32060 6.1 TBP ZSCAN4 ZBTB40 RAD21 YY1 ETS1 THAP11 CEBPB ZNF398 PPARG CYB5A C18orf63 GC18M074254 GC18M074253
GH18G074248 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.7 -65.5 -65491 4.6 PKNOX1 MLX ARID4B SIN3A ZNF48 YY1 SLC30A9 FOS ZNF263 SP5 CYB5A C18orf63 CNDP2 GC18M074253 GC18M074254 ENSG00000260569
GH18G074741 0.3 FANTOM5 48.4 +425.4 425393 0.4 C18orf63 GC18M074636 GC18M074659
GH18G074277 1.2 Ensembl ENCODE dbSUPER 11.4 -37.7 -37707 1.0 NFIA MAX REST FOXA1 JUND ZNF316 ATF3 SMARCA4 HNF4G NFE2 C18orf63 CYB5A GC18M074253 GC18M074254
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C18orf63 on UCSC Golden Path with GeneCards custom track

Genomic Location for C18orf63 Gene

Chromosome:
18
Start:
74,315,813 bp from pter
End:
74,359,187 bp from pter
Size:
43,375 bases
Orientation:
Plus strand

Genomic View for C18orf63 Gene

Genes around C18orf63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C18orf63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C18orf63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf63 Gene

Proteins for C18orf63 Gene

  • Protein details for C18orf63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DL7-CR063_HUMAN
    Recommended name:
    Uncharacterized protein C18orf63
    Protein Accession:
    Q68DL7
    Secondary Accessions:
    • A6NME8

    Protein attributes for C18orf63 Gene

    Size:
    685 amino acids
    Molecular mass:
    77230 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C18orf63 Gene

Post-translational modifications for C18orf63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C18orf63 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C18orf63 Gene

Domains & Families for C18orf63 Gene

Protein Domains for C18orf63 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C18orf63: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C18orf63 Gene

Function for C18orf63 Gene

Phenotypes for C18orf63 Gene

GenomeRNAi human phenotypes for C18orf63:
genes like me logo Genes that share phenotypes with C18orf63: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C18orf63 Gene

Localization for C18orf63 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C18orf63 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C18orf63 Gene

Pathways & Interactions for C18orf63 Gene

SuperPathways for C18orf63 Gene

No Data Available

Interacting Proteins for C18orf63 Gene

Selected Interacting proteins: Q68DL7-CR063_HUMAN for C18orf63 Gene via IID

Symbol External ID(s) Details
JUN

Gene Ontology (GO) - Biological Process for C18orf63 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C18orf63 Gene

Drugs & Compounds for C18orf63 Gene

No Compound Related Data Available

Transcripts for C18orf63 Gene

mRNA/cDNA for C18orf63 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C18orf63 Gene

Chromosome 18 open reading frame 63:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf63 Gene

No ASD Table

Relevant External Links for C18orf63 Gene

GeneLoc Exon Structure for
C18orf63
ECgene alternative splicing isoforms for
C18orf63

Expression for C18orf63 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C18orf63 Gene

mRNA differential expression in normal tissues according to GTEx for C18orf63 Gene

This gene is overexpressed in Testis (x50.3).

Protein differential expression in normal tissues from HIPED for C18orf63 Gene

This gene is overexpressed in Rectum (18.1), Gallbladder (10.8), Prostate (7.0), and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C18orf63 Gene



NURSA nuclear receptor signaling pathways regulating expression of C18orf63 Gene:

C18orf63

SOURCE GeneReport for Unigene cluster for C18orf63 Gene:

Hs.465414
genes like me logo Genes that share expression patterns with C18orf63: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C18orf63 Gene

Orthologs for C18orf63 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf63 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C18H18orf63 34
  • 99.08 (n)
C18orf63 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1H18orf63 34
  • 82.89 (n)
C18orf63 35
  • 71 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C24H18orf63 34
  • 80.56 (n)
C18orf63 35
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm17266 34 16
  • 74.78 (n)
rat
(Rattus norvegicus)
Mammalia LOC100359752 34
  • 73.95 (n)
oppossum
(Monodelphis domestica)
Mammalia C18orf63 35
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C18orf63 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H18orf63 34
  • 57.27 (n)
C18orf63 35
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C18orf63 35
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C24H18orf63 35
  • 34 (a)
OneToOne
Species where no ortholog for C18orf63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C18orf63 Gene

ENSEMBL:
Gene Tree for C18orf63 (if available)
TreeFam:
Gene Tree for C18orf63 (if available)

Paralogs for C18orf63 Gene

No data available for Paralogs for C18orf63 Gene

Variants for C18orf63 Gene

Sequence variations from dbSNP and Humsavar for C18orf63 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000056148 -- 74,342,494(+) CTTAG(A/G)ATATC intron-variant
rs1000086806 -- 74,341,936(+) TAGTT(A/G)TTGAA intron-variant
rs1000141760 -- 74,356,489(+) TGAGC(A/G)TTCTG utr-variant-3-prime
rs1000270555 -- 74,349,946(+) CTGCA(A/G)AAGAT intron-variant
rs1000315581 -- 74,334,737(+) ATTTC(C/T)CCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C18orf63 Gene

Variant ID Type Subtype PubMed ID
dgv3401n100 CNV gain 25217958
esv2659011 CNV deletion 23128226
esv3643111 CNV loss 21293372
esv3643113 CNV loss 21293372
esv3643114 CNV gain 21293372
nsv1057441 CNV gain 25217958
nsv1065204 CNV loss 25217958
nsv2356 CNV insertion 18451855
nsv819427 CNV loss 19587683

Variation tolerance for C18orf63 Gene

Gene Damage Index Score: 4.13; 61.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C18orf63 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C18orf63

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C18orf63 Gene

Disorders for C18orf63 Gene

Relevant External Links for C18orf63

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C18orf63

No disorders were found for C18orf63 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C18orf63 Gene

Publications for C18orf63 Gene

  1. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  2. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 4 64

Products for C18orf63 Gene

Sources for C18orf63 Gene

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