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Aliases for C18orf54 Gene

Aliases for C18orf54 Gene

  • Chromosome 18 Open Reading Frame 54 2 3 5
  • Lung Adenoma Susceptibility Protein 2 2 3
  • LAS2 3 4

External Ids for C18orf54 Gene

Previous GeneCards Identifiers for C18orf54 Gene

  • GC18P050140
  • GC18P051884
  • GC18P048741

Summaries for C18orf54 Gene

GeneCards Summary for C18orf54 Gene

C18orf54 (Chromosome 18 Open Reading Frame 54) is a Protein Coding gene. Diseases associated with C18orf54 include Lung Adenoma.

UniProtKB/Swiss-Prot for C18orf54 Gene

  • Might play a role in cell proliferation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf54 Gene

Genomics for C18orf54 Gene

Regulatory Elements for C18orf54 Gene

Enhancers for C18orf54 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G054250 1.2 Ensembl ENCODE 16.1 -105.1 -105085 5.5 FOXA2 ATF1 MLX ARID4B FEZF1 DMAP1 YY1 FOS JUNB PPARG POLI C18orf54 MBD2 SNORA37 STARD6 GC18P054260
GH18G054259 1.4 FANTOM5 Ensembl ENCODE 10.6 -96.7 -96700 3.5 PKNOX1 BACH1 CHD4 ZBTB40 RELA FOXM1 CTBP1 GATA3 ARID3A EGR1 POLI MBD2 SNORA37 C18orf54 GC18P054260
GH18G054246 1.2 Ensembl ENCODE dbSUPER 10.3 -110.5 -110547 2.6 CTCF FOXA2 RBBP5 EBF1 ZBTB40 ARID3A POLR2A ZNF143 RELB IKZF2 POLI MBD2 SNORA37 C18orf54 STARD6 ENSG00000264296 GC18P054260
GH18G054284 1.1 Ensembl ENCODE 10.8 -72.8 -72761 2.3 TBP PKNOX1 TBL1XR1 BMI1 EGR1 CBX5 RELB ETV6 IKZF2 CREM POLI MBD2 SNORA37 C18orf54 STARD6 GC18M054269 ENSG00000277324
GH18G054257 1.1 Ensembl ENCODE dbSUPER 10.6 -100.0 -99997 1.8 GATA3 CEBPA HLF TEAD4 CEBPB CEBPG NR2F6 POLI MBD2 SNORA37 C18orf54 STARD6 GC18P054260
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C18orf54 on UCSC Golden Path with GeneCards custom track

Promoters for C18orf54 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000103449 495 2401 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A ZNF2 ZNF48 YY1 GLIS2

Genomic Location for C18orf54 Gene

Chromosome:
18
Start:
54,357,905 bp from pter
End:
54,385,218 bp from pter
Size:
27,314 bases
Orientation:
Plus strand

Genomic View for C18orf54 Gene

Genes around C18orf54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C18orf54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C18orf54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf54 Gene

Proteins for C18orf54 Gene

  • Protein details for C18orf54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYD9-LAS2_HUMAN
    Recommended name:
    Lung adenoma susceptibility protein 2
    Protein Accession:
    Q8IYD9
    Secondary Accessions:
    • I7HFJ6
    • Q6MZU3
    • Q6ZTL6

    Protein attributes for C18orf54 Gene

    Size:
    372 amino acids
    Molecular mass:
    41811 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86570.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C18orf54 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C18orf54 Gene

Post-translational modifications for C18orf54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C18orf54 Gene

Domains & Families for C18orf54 Gene

Protein Domains for C18orf54 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C18orf54: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C18orf54 Gene

Function for C18orf54 Gene

Molecular function for C18orf54 Gene

UniProtKB/Swiss-Prot Function:
Might play a role in cell proliferation.

Phenotypes for C18orf54 Gene

GenomeRNAi human phenotypes for C18orf54:
genes like me logo Genes that share phenotypes with C18orf54: view

Animal Model Products

miRNA for C18orf54 Gene

miRTarBase miRNAs that target C18orf54

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C18orf54 Gene

Localization for C18orf54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C18orf54 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C18orf54 gene
Compartment Confidence
extracellular 4
nucleus 3
mitochondrion 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for C18orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C18orf54: view

Pathways & Interactions for C18orf54 Gene

SuperPathways for C18orf54 Gene

No Data Available

Interacting Proteins for C18orf54 Gene

Gene Ontology (GO) - Biological Process for C18orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with C18orf54: view

No data available for Pathways by source and SIGNOR curated interactions for C18orf54 Gene

Drugs & Compounds for C18orf54 Gene

No Compound Related Data Available

Transcripts for C18orf54 Gene

Unigene Clusters for C18orf54 Gene

Chromosome 18 open reading frame 54:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf54 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: - -

Relevant External Links for C18orf54 Gene

GeneLoc Exon Structure for
C18orf54
ECgene alternative splicing isoforms for
C18orf54

Expression for C18orf54 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C18orf54 Gene

mRNA differential expression in normal tissues according to GTEx for C18orf54 Gene

This gene is overexpressed in Testis (x5.8).

NURSA nuclear receptor signaling pathways regulating expression of C18orf54 Gene:

C18orf54

SOURCE GeneReport for Unigene cluster for C18orf54 Gene:

Hs.208701
genes like me logo Genes that share expression patterns with C18orf54: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C18orf54 Gene

Orthologs for C18orf54 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C18H18orf54 34
  • 99.31 (n)
C18orf54 35
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1H18orf54 34
  • 86.43 (n)
C18orf54 35
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930503L19Rik 34 16 35
  • 78.44 (n)
cow
(Bos Taurus)
Mammalia C18orf54 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C18orf54 35
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C18orf54 35
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C18orf54 35
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c18orf54 34
  • 51.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34873 34
zebrafish
(Danio rerio)
Actinopterygii C21H18orf54 35
  • 21 (a)
OneToOne
Species where no ortholog for C18orf54 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C18orf54 Gene

ENSEMBL:
Gene Tree for C18orf54 (if available)
TreeFam:
Gene Tree for C18orf54 (if available)

Paralogs for C18orf54 Gene

(4) SIMAP similar genes for C18orf54 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C18orf54: view

No data available for Paralogs for C18orf54 Gene

Variants for C18orf54 Gene

Sequence variations from dbSNP and Humsavar for C18orf54 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000008844 -- 54,381,572(+) CCCCC(A/G)AACTT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000032266 -- 54,367,090(+) GACAA(C/T)GTTAT intron-variant
rs1000124155 -- 54,380,152(+) ACGAA(C/T)CTAAG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000160433 -- 54,357,184(+) ACACC(A/G)ATTGG intron-variant, upstream-variant-2KB
rs1000249113 -- 54,381,933(+) AACTG(C/G)ATTTT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C18orf54 Gene

Variant ID Type Subtype PubMed ID
nsv828245 CNV gain 20364138

Variation tolerance for C18orf54 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C18orf54 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C18orf54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C18orf54 Gene

Disorders for C18orf54 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C18orf54 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung adenoma
  • adenoma of lung
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C18orf54

Genetic Association Database (GAD)
C18orf54
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C18orf54
genes like me logo Genes that share disorders with C18orf54: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C18orf54 Gene

Publications for C18orf54 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for C18orf54 Gene

Sources for C18orf54 Gene

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