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Aliases for C18orf54 Gene

Aliases for C18orf54 Gene

  • Chromosome 18 Open Reading Frame 54 2 3 5
  • LAS2 3 4
  • Lung Adenoma Susceptibility Protein 2 2

External Ids for C18orf54 Gene

Previous GeneCards Identifiers for C18orf54 Gene

  • GC18P050140
  • GC18P051884
  • GC18P048741

Summaries for C18orf54 Gene

GeneCards Summary for C18orf54 Gene

C18orf54 (Chromosome 18 Open Reading Frame 54) is a Protein Coding gene. Diseases associated with C18orf54 include lung adenoma and adenoma.

UniProtKB/Swiss-Prot for C18orf54 Gene

  • Might play a role in cell proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf54 Gene

Genomics for C18orf54 Gene

Regulatory Elements for C18orf54 Gene

Promoters for C18orf54 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C18orf54 on UCSC Golden Path with GeneCards custom track

Genomic Location for C18orf54 Gene

Chromosome:
18
Start:
54,357,905 bp from pter
End:
54,385,218 bp from pter
Size:
27,314 bases
Orientation:
Plus strand

Genomic View for C18orf54 Gene

Genes around C18orf54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C18orf54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C18orf54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf54 Gene

Proteins for C18orf54 Gene

  • Protein details for C18orf54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYD9-LAS2_HUMAN
    Recommended name:
    Lung adenoma susceptibility protein 2
    Protein Accession:
    Q8IYD9
    Secondary Accessions:
    • I7HFJ6
    • Q6MZU3
    • Q6ZTL6

    Protein attributes for C18orf54 Gene

    Size:
    372 amino acids
    Molecular mass:
    41811 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86570.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C18orf54 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C18orf54 Gene

Proteomics data for C18orf54 Gene at MOPED

Post-translational modifications for C18orf54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C18orf54 Gene

Antibody Products

No data available for DME Specific Peptides for C18orf54 Gene

Domains & Families for C18orf54 Gene

Protein Domains for C18orf54 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C18orf54: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C18orf54 Gene

Function for C18orf54 Gene

Molecular function for C18orf54 Gene

UniProtKB/Swiss-Prot Function:
Might play a role in cell proliferation.

Phenotypes for C18orf54 Gene

GenomeRNAi human phenotypes for C18orf54:
genes like me logo Genes that share phenotypes with C18orf54: view

Animal Model Products

miRNA for C18orf54 Gene

miRTarBase miRNAs that target C18orf54

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C18orf54 Gene

Localization for C18orf54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C18orf54 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C18orf54 Gene COMPARTMENTS Subcellular localization image for C18orf54 gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 2
mitochondrion 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for C18orf54 Gene

Pathways & Interactions for C18orf54 Gene

SuperPathways for C18orf54 Gene

No Data Available

Interacting Proteins for C18orf54 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000300091%0d%0a9606.ENSP00000250416%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q8IYD9-LAS2_HUMAN ENSP00000300091 for C18orf54 Gene via I2D MINT STRING

Gene Ontology (GO) - Biological Process for C18orf54 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C18orf54 Gene

Drugs & Compounds for C18orf54 Gene

No Compound Related Data Available

Transcripts for C18orf54 Gene

Unigene Clusters for C18orf54 Gene

Chromosome 18 open reading frame 54:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf54 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: - -

Relevant External Links for C18orf54 Gene

GeneLoc Exon Structure for
C18orf54
ECgene alternative splicing isoforms for
C18orf54

Expression for C18orf54 Gene

mRNA expression in normal human tissues for C18orf54 Gene

mRNA differential expression in normal tissues according to GTEx for C18orf54 Gene

This gene is overexpressed in Testis (x5.8).

SOURCE GeneReport for Unigene cluster for C18orf54 Gene Hs.208701

genes like me logo Genes that share expression patterns with C18orf54: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C18orf54 Gene

Orthologs for C18orf54 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C18orf54 36
  • 69 (a)
OneToOne
C18H18orf54 35
  • 99.31 (n)
  • 98.69 (a)
cow
(Bos Taurus)
Mammalia C18orf54 36
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C18orf54 36
  • 54 (a)
OneToOne
C1H18orf54 35
  • 86.43 (n)
  • 78.8 (a)
mouse
(Mus musculus)
Mammalia 4930503L19Rik 36
  • 47 (a)
OneToOne
4930503L19Rik 16
4930503L19Rik 35
  • 78.44 (n)
  • 66.41 (a)
oppossum
(Monodelphis domestica)
Mammalia C18orf54 36
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C18orf54 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C18orf54 36
  • 31 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34873 35
tropical clawed frog
(Silurana tropicalis)
Amphibia c18orf54 35
  • 51.6 (n)
  • 42.14 (a)
zebrafish
(Danio rerio)
Actinopterygii C21H18orf54 36
  • 21 (a)
OneToOne
Species with no ortholog for C18orf54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C18orf54 Gene

ENSEMBL:
Gene Tree for C18orf54 (if available)
TreeFam:
Gene Tree for C18orf54 (if available)

Paralogs for C18orf54 Gene

(4) SIMAP similar genes for C18orf54 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C18orf54: view

No data available for Paralogs for C18orf54 Gene

Variants for C18orf54 Gene

Sequence variations from dbSNP and Humsavar for C18orf54 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1046699 -- 54,380,767(+) GAAGA(G/T)AAATC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1608517 -- 54,383,399(-) cagag(A/G)cagat intron-variant
rs1787834 -- 54,363,897(-) GAAAA(G/T)GGCAG intron-variant
rs1787835 -- 54,363,858(-) CAATG(C/T)CTACA intron-variant
rs1657910 -- 54,366,048(+) TGATG(G/T)GATAC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C18orf54 Gene

Variant ID Type Subtype PubMed ID
nsv909656 CNV Loss 21882294
nsv828245 CNV Gain 20364138

Variation tolerance for C18orf54 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C18orf54 Gene

HapMap Linkage Disequilibrium report
C18orf54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C18orf54 Gene

Disorders for C18orf54 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C18orf54 Gene - From: GeneCards

Disorder Aliases PubMed IDs
lung adenoma
  • adenoma of lung
adenoma
  • acinar cell adenoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C18orf54

Genetic Association Database (GAD)
C18orf54
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C18orf54
genes like me logo Genes that share disorders with C18orf54: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C18orf54 Gene

Publications for C18orf54 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for C18orf54 Gene

Sources for C18orf54 Gene

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