C18orf54 Gene
protein-coding GIFtS: 48
GCID: GC18P051884
|
|
chromosome 18 open reading frame 54
| |
Aliases
for C18orf54 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 18 Open Reading Frame 541 2 | | Hypothetical Protein V32 | | LAS21 2 5 | | Hypothetical Protein V42 | | MGC333821 | | Hypothetical Protein V52 | | Hypothetical Protein V12 | | Lung Adenoma Susceptibility Protein 22 |
Export aliases for C18orf54 gene to outside databasesPrevious GC identifers: GC18P050140 GC18P048741 |
Summaries
for C18orf54 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: LAS2_HUMAN, Q8IYD9Function: Might play a role in cell proliferation (By similarity)
|
Genomic Views
for C18orf54 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C18orf54 gene promoter:
TBP AML1a SRF (504 AA) POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) CUTL1 STAT5A POU3F2 GATA-1 RORalpha2
Other transcription factors
Search SABiosciences Chromatin IP Primers for C18orf54
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C18orf54 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q21.2 Ensembl cytogenetic band: 18q21.2 HGNC cytogenetic band: 18q21C18orf54 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P051884: view genomic region
(about GC identifiers)
Start:
|
51,884,287 bp from pter |
End:
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51,911,588 bp from pter |
Size:
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27,302 bases |
Orientation:
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plus strand |
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Proteins
for C18orf54 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LAS2_HUMAN, Q8IYD9 (See
protein sequence)Recommended Name: Lung adenoma susceptibility protein 2 precursor Size: 372 amino acids; 41811 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=BAC86570.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6MZU3 Q6ZTL6Alternative splicing: 2 isoforms: Q8IYD9-1 Q8IYD9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C18orf54: NX_Q8IYD9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYD9
C18orf54 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775800.3
ENSEMBL proteins: ENSP00000462317 ENSP00000372368 ENSP00000300091 ENSP00000462201
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
C18orf54 for ontologies About GeneDecksing
C18orf54 Antibody Products:
Assay Products for C18orf54: |
Protein
Domains /
Families
for C18orf54 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8IYD9 |
Function
for C18orf54 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LAS2_HUMAN, Q8IYD9Function: Might play a role in cell proliferation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf54 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf54
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf54 |
1 GenomeRNAi human phenotype for C18orf54:
|
Pathways & Interactions
for C18orf54 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C18orf54
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for C18orf54 (Q8IYD92, 3 ENSP000003000914) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C18orf54 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C18orf54
Search CenterWatch for drugs/clinical trials and news about C18orf54 / LAS2
|
Transcripts
for C18orf54 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C18orf54 gene: NM_173529.4 Unigene Cluster for C18orf54: Chromosome 18 open reading frame 54 Hs.208701 [show with all ESTs]Unigene Representative Sequence: AB2679065 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000578138 ENST00000382911 ENST00000300091(uc002lfn.4 uc002lfo.4)
ENST00000582188 ENST00000579594
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf54 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf54
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C18orf54 (NM_173529) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C18orf54 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf54 |
Additional cDNA sequence: AB267906.1 AB330143.1 AB330144.1 AB353076.1 AB353077.1 AK126503.1 BC036054.2 BC043651.2 BX640877.1 4 DOTS entries: DT.112011 DT.92029918 DT.91739043 DT.100017463 24/61 AceView cDNA sequences (see all 61): AA629335 BM979842 BX090828 AA281260 BF513703 AA831399 AA741180 BX088973 AK126503 AA831040 AA281744 AI191017 BU623030 AA587685 BX640877 AW182245 AI809253 AI753538 AA281309 AA626254 AL704560 CB961249 BX344497 BQ432491
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for C18orf54 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C18orf54
|
Expression
for C18orf54 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C18orf54 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAAATATT
About this image
See C18orf54 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C18orf54
SOURCE GeneReport for Unigene cluster: Hs.208701
SABiosciences Custom PCR Arrays for C18orf54
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C18orf54
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C18orf54 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C18orf54 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C18orf54 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf54 |
Orthologs
for C18orf54 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C18orf54 gene from 4/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
4930503L19Rik5 |
RIKEN cDNA 4930503L19 gene |
-- |
|
18 (44.42 cM) 70453140 |
lizard
(Anolis carolinensis) |
Reptilia |
C18orf546 |
-- |
31(a) |
1 ↔ 1 |
GL343213.1(148307-158159) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.348732 |
Xenopus laevis transcribed sequence |
73.15(n) |
|
BX847761.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1529486 |
zgc:152948 |
24(a) |
1 ↔ 1 |
21(1952470-1967162) |
ENSEMBL Gene Tree for C18orf54 (if available)
TreeFam Gene Tree for C18orf54 (if available) |
Paralogs
for C18orf54 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C18orf54 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C18orf54 (51884287 - 51911588 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for C18orf54
6 CNVs: 77891 88857 77892 88859 88855 88858 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C18orf54 |
|
Disorders
/ Diseases
for C18orf54 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C18orf54 for disorders About GeneDecksing
OMIM gene information: 613258
OMIM disorders: --
4  diseases for C18orf54: About MalaCardslung adenoma adenoma inferior myocardial infarction myocardial infarction
2 diseases from the University of Copenhagen DISEASES database for C18orf54:Lung adenoma Inferior myocardial infarction Export disorders for C18orf54 gene to outside databases
|
Publications
for C18orf54 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C18orf54 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C18orf54) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for C18orf54 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C18orf54 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C18orf54 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C18orf54 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C18orf54 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C18orf54 gene:
Search GeneIP for patents involving C18orf54
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C18orf54 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | C18orf54 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf54 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf54 |
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