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Aliases for C18orf54 Gene

Aliases for C18orf54 Gene

  • Chromosome 18 Open Reading Frame 54 2 3
  • LAS2 3 4 6
  • Lung Adenoma Susceptibility Protein 2 2 3

External Ids for C18orf54 Gene

Summaries for C18orf54 Gene

GeneCards Summary for C18orf54 Gene

C18orf54 (Chromosome 18 Open Reading Frame 54) is a Protein Coding gene. Diseases associated with C18orf54 include adenoma and inferior myocardial infarction.

UniProtKB/Swiss-Prot for C18orf54 Gene

  • Might play a role in cell proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf54 Gene

Genomics for C18orf54 Gene

Genomic Location for C18orf54 Gene

Start:
54,357,914 bp from pter
End:
54,385,218 bp from pter
Size:
27,305 bases
Orientation:
Plus strand

Genomic View for C18orf54 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C18orf54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf54 Gene

Regulatory Elements for C18orf54 Gene

Proteins for C18orf54 Gene

  • Protein details for C18orf54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYD9-LAS2_HUMAN
    Recommended name:
    Lung adenoma susceptibility protein 2
    Protein Accession:
    Q8IYD9
    Secondary Accessions:
    • I7HFJ6
    • Q6MZU3
    • Q6ZTL6

    Protein attributes for C18orf54 Gene

    Size:
    372 amino acids
    Molecular mass:
    41811 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86570.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C18orf54 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C18orf54 Gene

Proteomics data for C18orf54 Gene at MOPED

Post-translational modifications for C18orf54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C18orf54 Gene

No data available for DME Specific Peptides for C18orf54 Gene

Domains for C18orf54 Gene

Protein Domains for C18orf54 Gene

ProtoNet:
genes like me logo Genes that share domains with C18orf54: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C18orf54 Gene

Function for C18orf54 Gene

Molecular function for C18orf54 Gene

UniProtKB/Swiss-Prot Function: Might play a role in cell proliferation.

Phenotypes for C18orf54 Gene

GenomeRNAi human phenotypes for C18orf54:
genes like me logo Genes that share phenotypes with C18orf54: view

miRNA for C18orf54 Gene

miRTarBase miRNAs that target C18orf54

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for C18orf54 Gene

Localization for C18orf54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C18orf54 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C18orf54 Gene COMPARTMENTS Subcellular localization image for C18orf54 gene
Compartment Confidence
extracellular 3
nucleus 3
mitochondrion 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C18orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C18orf54: view

Pathways for C18orf54 Gene

SuperPathways for C18orf54 Gene

No Data Available

Interacting Proteins for C18orf54 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000300091%0d%0a9606.ENSP00000250416%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q8IYD9-LAS2_HUMAN ENSP00000300091 for C18orf54 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for C18orf54 Gene

None

No data available for Pathways by source for C18orf54 Gene

Transcripts for C18orf54 Gene

Unigene Clusters for C18orf54 Gene

Chromosome 18 open reading frame 54:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf54 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: - -

Relevant External Links for C18orf54 Gene

GeneLoc Exon Structure for
C18orf54
ECgene alternative splicing isoforms for
C18orf54

Expression for C18orf54 Gene

mRNA expression in normal human tissues for C18orf54 Gene

mRNA differential expression in normal tissues according to GTEx for C18orf54 Gene

This gene is overexpressed in Testis (5.8).

SOURCE GeneReport for Unigene cluster for C18orf54 Gene Hs.208701

genes like me logo Genes that share expressions with C18orf54: view

Orthologs for C18orf54 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C18H18orf54 36
  • 99.31 (n)
  • 98.69 (a)
C18orf54 37
  • 69 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C18orf54 37
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C18orf54 37
  • 54 (a)
OneToOne
C1H18orf54 36
  • 86.43 (n)
  • 78.8 (a)
mouse
(Mus musculus)
Mammalia 4930503L19Rik 36
  • 78.44 (n)
  • 66.41 (a)
4930503L19Rik 16
4930503L19Rik 37
  • 47 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C18orf54 37
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C18orf54 37
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C18orf54 37
  • 31 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34873 36
tropical clawed frog
(Silurana tropicalis)
Amphibia c18orf54 36
  • 51.6 (n)
  • 42.14 (a)
zebrafish
(Danio rerio)
Actinopterygii C21H18orf54 37
  • 21 (a)
OneToOne
Species with no ortholog for C18orf54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C18orf54 Gene

ENSEMBL:
Gene Tree for C18orf54 (if available)
TreeFam:
Gene Tree for C18orf54 (if available)

Paralogs for C18orf54 Gene

Selected SIMAP similar genes for C18orf54 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C18orf54: view

No data available for Paralogs for C18orf54 Gene

Variants for C18orf54 Gene

Sequence variations from dbSNP and Humsavar for C18orf54 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1046699 -- 54,380,767(+) GAAGA(G/T)AAATC utr-variant-3-prime, nc-transcript-variant
rs1061830 -- 54,381,697(-) GGGAC(A/G)AAATA utr-variant-3-prime, nc-transcript-variant
rs1344883 -- 54,382,033(+) TTACT(C/T)ATGTG utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs1344884 -- 54,382,036(+) CTCAT(A/G)TGAGG downstream-variant-500B
rs1347662 -- 54,377,025(+) TTTTT(A/T)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C18orf54 Gene

Variant ID Type Subtype PubMed ID
nsv909656 CNV Loss 21882294
nsv828245 CNV Gain 20364138

Relevant External Links for C18orf54 Gene

HapMap Linkage Disequilibrium report
C18orf54

Disorders for C18orf54 Gene

(2) University of Copenhagen DISEASES for C18orf54 Gene

Relevant External Links for C18orf54

Genetic Association Database (GAD)
C18orf54
genes like me logo Genes that share disorders with C18orf54: view

No data available for UniProtKB/Swiss-Prot for C18orf54 Gene

Publications for C18orf54 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for C18orf54 Gene

Sources for C18orf54 Gene

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