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Aliases for C18orf42 Gene

Aliases for C18orf42 Gene

  • Chromosome 18 Open Reading Frame 42 2 3

External Ids for C18orf42 Gene

Summaries for C18orf42 Gene

GeneCards Summary for C18orf42 Gene

C18orf42 (Chromosome 18 Open Reading Frame 42) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C18orf42 Gene

  • Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf42 Gene

Genomics for C18orf42 Gene

Genomic Location for C18orf42 Gene

Start:
5,143,673 bp from pter
End:
5,197,503 bp from pter
Size:
53,831 bases
Orientation:
Minus strand

Genomic View for C18orf42 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C18orf42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf42 Gene

No data available for Regulatory Elements for C18orf42 Gene

Proteins for C18orf42 Gene

  • Protein details for C18orf42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CW23-CR042_HUMAN
    Recommended name:
    A-kinase anchor protein C18orf42
    Protein Accession:
    P0CW23
    Secondary Accessions:

    Protein attributes for C18orf42 Gene

    Size:
    69 amino acids
    Molecular mass:
    7848 Da
    Quaternary structure:
    • Binds cAMP-dependent protein kinase (PKA). Interacts specifically with RII-regulatory subunits of PKA (PRKAR2A and PRKAR2B) (PubMed:25653177).

neXtProt entry for C18orf42 Gene

Proteomics data for C18orf42 Gene at MOPED

Post-translational modifications for C18orf42 Gene

No Post-translational modifications

Other Protein References for C18orf42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C18orf42 Gene

Domains for C18orf42 Gene

Protein Domains for C18orf42 Gene

Graphical View of Domain Structure for InterPro Entry

P0CW23

UniProtKB/Swiss-Prot:

CR042_HUMAN :
  • P0CW23
Domain:
  • The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer
genes like me logo Genes that share domains with C18orf42: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for C18orf42 Gene

Function for C18orf42 Gene

Molecular function for C18orf42 Gene

UniProtKB/Swiss-Prot Function:
Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177).

Gene Ontology (GO) - Molecular Function for C18orf42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051018 protein kinase A binding IDA 25653177
genes like me logo Genes that share ontologies with C18orf42: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C18orf42 Gene

Localization for C18orf42 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C18orf42 Gene

Pathways for C18orf42 Gene

SuperPathways for C18orf42 Gene

No Data Available

Interacting Proteins for C18orf42 Gene

Gene Ontology (GO) - Biological Process for C18orf42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008104 protein localization IDA 25653177
genes like me logo Genes that share ontologies with C18orf42: view

No data available for Pathways by source for C18orf42 Gene

Transcripts for C18orf42 Gene

mRNA/cDNA for C18orf42 Gene

(0) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C18orf42 Gene

Chromosome 18 open reading frame 42:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C18orf42

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf42 Gene

No ASD Table

Relevant External Links for C18orf42 Gene

GeneLoc Exon Structure for
C18orf42
ECgene alternative splicing isoforms for
C18orf42

Expression for C18orf42 Gene

mRNA expression in normal human tissues for C18orf42 Gene

mRNA differential expression in normal tissues according to GTEx for C18orf42 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (21.2), Brain - Cerebellum (18.2), and Brain - Hippocampus (4.3).

SOURCE GeneReport for Unigene cluster for C18orf42 Gene Hs.437160

mRNA Expression by UniProt/SwissProt for C18orf42 Gene

P0CW23-CR042_HUMAN
Tissue specificity: Preferentially expressed in the neural tissues (PubMed:25653177).
genes like me logo Genes that share expressions with C18orf42: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for C18orf42 Gene

Orthologs for C18orf42 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf42 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia A330050F15Rik 35
  • 79.71 (n)
  • 76.81 (a)
A330050F15Rik 16
A330050F15Rik 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C18H18orf42 35
  • 99.03 (n)
  • 97.1 (a)
C18orf42 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100362606 35
  • 79.23 (n)
  • 79.71 (a)
dog
(Canis familiaris)
Mammalia C18orf42 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves C18orf42 36
  • 72 (a)
OneToOne
Species with no ortholog for C18orf42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C18orf42 Gene

ENSEMBL:
Gene Tree for C18orf42 (if available)
TreeFam:
Gene Tree for C18orf42 (if available)

Paralogs for C18orf42 Gene

Selected SIMAP similar genes for C18orf42 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C18orf42: view

No data available for Paralogs for C18orf42 Gene

Variants for C18orf42 Gene

Sequence variations from dbSNP and Humsavar for C18orf42 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs184123 -- 5,164,119(-) TTGCT(C/T)TAGAT intron-variant
rs186042 -- 5,165,644(+) TCCTT(A/C)ACAGA intron-variant
rs292264 -- 5,183,007(+) CTATT(A/T)TGCAA intron-variant
rs292265 -- 5,183,863(-) aatga(A/G)tcaac intron-variant
rs292266 -- 5,184,634(-) ctccc(C/T)ggtta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C18orf42 Gene

Variant ID Type Subtype PubMed ID
dgv184n21 CNV Gain 19592680
esv2670046 CNV Deletion 23128226
nsv523963 CNV Loss 19592680

Relevant External Links for C18orf42 Gene

HapMap Linkage Disequilibrium report
C18orf42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C18orf42 Gene

Disorders for C18orf42 Gene

No disorders were found for C18orf42 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for C18orf42 Gene

Publications for C18orf42 Gene

  1. Hypothetical gene C18orf42 encodes a novel protein kinase A-binding protein. (PMID: 25653177) Fukuda M. … Aizawa Y. (Genes Cells 2015) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for C18orf42 Gene

Sources for C18orf42 Gene

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