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Aliases for C18orf32 Gene

Aliases for C18orf32 Gene

  • Chromosome 18 Open Reading Frame 32 2 3
  • Putative NF-Kappa-B-Activating Protein 200 4

External Ids for C18orf32 Gene

Summaries for C18orf32 Gene

GeneCards Summary for C18orf32 Gene

C18orf32 (Chromosome 18 Open Reading Frame 32) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity.

UniProtKB/Swiss-Prot for C18orf32 Gene

  • May activate the NF-kappa-B signaling pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf32 Gene

Genomics for C18orf32 Gene

Genomic Location for C18orf32 Gene

Start:
49,477,250 bp from pter
End:
49,492,565 bp from pter
Size:
15,316 bases
Orientation:
Minus strand

Genomic View for C18orf32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C18orf32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf32 Gene

Regulatory Elements for C18orf32 Gene

Proteins for C18orf32 Gene

  • Protein details for C18orf32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCD1-CR032_HUMAN
    Recommended name:
    UPF0729 protein C18orf32
    Protein Accession:
    Q8TCD1
    Secondary Accessions:

    Protein attributes for C18orf32 Gene

    Size:
    76 amino acids
    Molecular mass:
    8669 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C18orf32 Gene

Proteomics data for C18orf32 Gene at MOPED

Post-translational modifications for C18orf32 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys38 and Lys39

Other Protein References for C18orf32 Gene

No data available for DME Specific Peptides for C18orf32 Gene

Domains for C18orf32 Gene

Protein Domains for C18orf32 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CR032_HUMAN
Family:
  • Belongs to the UPF0729 family.:
    • Q8TCD1
genes like me logo Genes that share domains with C18orf32: view

No data available for Gene Families for C18orf32 Gene

Function for C18orf32 Gene

Molecular function for C18orf32 Gene

UniProtKB/Swiss-Prot Function: May activate the NF-kappa-B signaling pathway.

Gene Ontology (GO) - Molecular Function for C18orf32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome --
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with C18orf32: view

Phenotypes for C18orf32 Gene

GenomeRNAi human phenotypes for C18orf32:
genes like me logo Genes that share phenotypes with C18orf32: view

miRNA for C18orf32 Gene

miRTarBase miRNAs that target C18orf32

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C18orf32 Gene

Localization for C18orf32 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C18orf32 Gene COMPARTMENTS Subcellular localization image for C18orf32 gene
Compartment Confidence
extracellular 3
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C18orf32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005840 ribosome --
GO:0015934 large ribosomal subunit --
genes like me logo Genes that share ontologies with C18orf32: view

Pathways for C18orf32 Gene

SuperPathways for C18orf32 Gene

No Data Available

Interacting Proteins for C18orf32 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000323199%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000363970%0d%0a
Selected Interacting proteins: ENSP00000323199 Q8TCD1-CR032_HUMAN for C18orf32 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for C18orf32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0007165 signal transduction IMP 12761501
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with C18orf32: view

No data available for Pathways by source for C18orf32 Gene

Transcripts for C18orf32 Gene

mRNA/cDNA for C18orf32 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C18orf32 Gene

Chromosome 18 open reading frame 32:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf32 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for C18orf32 Gene

GeneLoc Exon Structure for
C18orf32
ECgene alternative splicing isoforms for
C18orf32

Expression for C18orf32 Gene

mRNA expression in normal human tissues for C18orf32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C18orf32 Gene

SOURCE GeneReport for Unigene cluster for C18orf32 Gene Hs.603040

genes like me logo Genes that share expressions with C18orf32: view

Orthologs for C18orf32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C18H18orf32 36
  • 97.81 (n)
  • 96.05 (a)
C18orf32 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C24H18orf32 36
  • 91.23 (n)
  • 84.21 (a)
C24H18orf32 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C18orf32 37
  • 80 (a)
OneToOne
C7H18orf32 36
  • 88.16 (n)
  • 80.26 (a)
mouse
(Mus musculus)
Mammalia BC031181 36
  • 81.94 (n)
  • 80.56 (a)
BC031181 16
BC031181 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C18orf32 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C18orf32 37
  • 22 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562987 36
  • 80.56 (n)
  • 76.39 (a)
chicken
(Gallus gallus)
Aves C18orf32 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C18orf32 37
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
OneToOne
Species with no ortholog for C18orf32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C18orf32 Gene

ENSEMBL:
Gene Tree for C18orf32 (if available)
TreeFam:
Gene Tree for C18orf32 (if available)

Paralogs for C18orf32 Gene

genes like me logo Genes that share paralogs with C18orf32: view

No data available for Paralogs for C18orf32 Gene

Variants for C18orf32 Gene

Sequence variations from dbSNP and Humsavar for C18orf32 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
VAR_039374 -

Structural Variations from Database of Genomic Variants (DGV) for C18orf32 Gene

Variant ID Type Subtype PubMed ID
nsv2294 CNV Loss 18451855
nsv2295 CNV Insertion 18451855

Relevant External Links for C18orf32 Gene

HapMap Linkage Disequilibrium report
C18orf32

Disorders for C18orf32 Gene

No disorders were found for C18orf32 Gene.

No data available for UniProtKB/Swiss-Prot for C18orf32 Gene

Publications for C18orf32 Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 3 4
  2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3
  5. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PMID: 23864651) Huang X. … Wheeler M.B. (Mol. Endocrinol. 2013) 3

Products for C18orf32 Gene

Sources for C18orf32 Gene

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