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Aliases for C18orf32 Gene

Aliases for C18orf32 Gene

  • Chromosome 18 Open Reading Frame 32 2 3 5
  • Putative NF-Kappa-B-Activating Protein 200 4

External Ids for C18orf32 Gene

Previous GeneCards Identifiers for C18orf32 Gene

  • GC18M045264
  • GC18M047008
  • GC18M043861

Summaries for C18orf32 Gene

GeneCards Summary for C18orf32 Gene

C18orf32 (Chromosome 18 Open Reading Frame 32) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity and structural constituent of ribosome.

UniProtKB/Swiss-Prot for C18orf32 Gene

  • May activate the NF-kappa-B signaling pathway.

Additional gene information for C18orf32 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf32 Gene

Genomics for C18orf32 Gene

Regulatory Elements for C18orf32 Gene

Enhancers for C18orf32 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H049485 1.2 ENCODE 16.4 -2.6 -2592 8 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 C18orf32 DYM CXXC1 ENSG00000252139 SCARNA17 ACAA2 LIPG MBD1 ENSG00000265496 GC18M049515
GH18H049476 1.1 Ensembl ENCODE 11.8 +10.3 10279 1 FEZF1 BATF ZNF121 ELK1 FOS ATF7 RUNX3 CEBPB JUNB REST C18orf32 GC18P049470 ENSG00000263916
GH18H049514 0.9 ENCODE 13.3 -27.5 -27482 0 ZNF493 ZFP64 RAD21 ZEB1 ZNF155 ZNF121 ZNF302 ZNF138 ZNF366 ZNF354C CXXC1 RPL17 MBD1 ENSG00000264269 C18orf32 LIPG DYM LOC101928144 GC18M049549
GH18H049560 1 ENCODE 10 -75.0 -74995 3 ATF1 ARID4B ZNF2 YY1 ZNF416 FOS SP3 NFYC REST SREBF1 ENSG00000266696 LOC101928144 SRP72P1 ENSG00000263895 ENSG00000267196 ENSG00000265128 ENSG00000267591 RN7SL310P LOC105372107 ENSG00000267695
GH18H049520 0.9 ENCODE 10.1 -34.0 -33978 0 ZSCAN4 INSM2 KLF17 FEZF1 ZEB1 GLIS2 ZNF366 ZNF416 EGR2 ZNF362 MBD1 LIPG SNORD58A RPL17-C18orf32 SNORD58C DYM C18orf32 LOC101928144 GC18M049549
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C18orf32 on UCSC Golden Path with GeneCards custom track

Promoters for C18orf32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000103215 374 1401 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 ZNF143

Genomic Location for C18orf32 Gene

Chromosome:
18
Start:
49,477,250 bp from pter
End:
49,487,274 bp from pter
Size:
10,025 bases
Orientation:
Minus strand

Genomic View for C18orf32 Gene

Genes around C18orf32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C18orf32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C18orf32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf32 Gene

Proteins for C18orf32 Gene

  • Protein details for C18orf32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCD1-CR032_HUMAN
    Recommended name:
    UPF0729 protein C18orf32
    Protein Accession:
    Q8TCD1

    Protein attributes for C18orf32 Gene

    Size:
    76 amino acids
    Molecular mass:
    8669 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C18orf32 Gene

Post-translational modifications for C18orf32 Gene

  • Ubiquitination at Lys39
  • Modification sites at PhosphoSitePlus

Other Protein References for C18orf32 Gene

No data available for DME Specific Peptides for C18orf32 Gene

Domains & Families for C18orf32 Gene

Gene Families for C18orf32 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C18orf32 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C18orf32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCD1

UniProtKB/Swiss-Prot:

CR032_HUMAN :
  • Belongs to the UPF0729 family.
Family:
  • Belongs to the UPF0729 family.
genes like me logo Genes that share domains with C18orf32: view

Function for C18orf32 Gene

Molecular function for C18orf32 Gene

UniProtKB/Swiss-Prot Function:
May activate the NF-kappa-B signaling pathway.

Gene Ontology (GO) - Molecular Function for C18orf32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP 12761501
genes like me logo Genes that share ontologies with C18orf32: view

Phenotypes for C18orf32 Gene

GenomeRNAi human phenotypes for C18orf32:
genes like me logo Genes that share phenotypes with C18orf32: view

Animal Model Products

CRISPR Products

miRNA for C18orf32 Gene

miRTarBase miRNAs that target C18orf32

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C18orf32
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C18orf32 Gene

Localization for C18orf32 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C18orf32 gene
Compartment Confidence
extracellular 3
nucleus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C18orf32 Gene

Pathways & Interactions for C18orf32 Gene

SuperPathways for C18orf32 Gene

No Data Available

Interacting Proteins for C18orf32 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000323199%0d%0a9606.ENSP00000362353%0d%0a
Selected Interacting proteins: Q8TCD1-CR032_HUMAN ENSP00000323199 for C18orf32 Gene via IID STRING

Gene Ontology (GO) - Biological Process for C18orf32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 12761501
genes like me logo Genes that share ontologies with C18orf32: view

No data available for Pathways by source and SIGNOR curated interactions for C18orf32 Gene

Drugs & Compounds for C18orf32 Gene

No Compound Related Data Available

Transcripts for C18orf32 Gene

mRNA/cDNA for C18orf32 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C18orf32 Gene

Chromosome 18 open reading frame 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C18orf32
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf32 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for C18orf32 Gene

GeneLoc Exon Structure for
C18orf32
ECgene alternative splicing isoforms for
C18orf32

Expression for C18orf32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C18orf32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C18orf32 Gene

This gene is overexpressed in Breast (35.3) and Peripheral blood mononuclear cells (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C18orf32 Gene



NURSA nuclear receptor signaling pathways regulating expression of C18orf32 Gene:

C18orf32

SOURCE GeneReport for Unigene cluster for C18orf32 Gene:

Hs.603040

Evidence on tissue expression from TISSUES for C18orf32 Gene

  • Lung(4.3)
  • Muscle(4.3)
  • Nervous system(3.9)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with C18orf32: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C18orf32 Gene

Orthologs for C18orf32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C18H18orf32 33
  • 97.81 (n)
C18orf32 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C24H18orf32 33 34
  • 91.23 (n)
dog
(Canis familiaris)
Mammalia C7H18orf32 33
  • 88.16 (n)
C18orf32 34
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC031181 33 16 34
  • 81.94 (n)
rat
(Rattus norvegicus)
Mammalia RGD1562987 33
  • 80.56 (n)
oppossum
(Monodelphis domestica)
Mammalia C18orf32 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C18orf32 34
  • 22 (a)
OneToOne
chicken
(Gallus gallus)
Aves C18orf32 34
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C18orf32 34
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToOne
Species where no ortholog for C18orf32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C18orf32 Gene

ENSEMBL:
Gene Tree for C18orf32 (if available)
TreeFam:
Gene Tree for C18orf32 (if available)

Paralogs for C18orf32 Gene

genes like me logo Genes that share paralogs with C18orf32: view

No data available for Paralogs for C18orf32 Gene

Variants for C18orf32 Gene

Sequence variations from dbSNP and Humsavar for C18orf32 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000167975 -- 49,483,504(+) AAAAC(C/T)TGTCC intron-variant
rs1000261753 -- 49,488,623(+) TGGAG(A/G)ACTTC intron-variant, upstream-variant-2KB
rs1000314483 -- 49,488,255(+) TTTTT(A/T)ACAGA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000460489 -- 49,486,700(+) GACAG(C/T)TAAAG intron-variant, upstream-variant-2KB
rs1000599285 -- 49,487,575(+) GCTAT(C/T)AGTTT intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C18orf32 Gene

Variant ID Type Subtype PubMed ID
nsv1065279 CNV gain 25217958
nsv1160523 CNV deletion 26073780
nsv2294 CNV deletion 18451855
nsv2295 CNV insertion 18451855
nsv978629 CNV duplication 23825009

Variation tolerance for C18orf32 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C18orf32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C18orf32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C18orf32 Gene

Disorders for C18orf32 Gene

Relevant External Links for C18orf32

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C18orf32

No disorders were found for C18orf32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C18orf32 Gene

Publications for C18orf32 Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 3 4 60
  2. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 60
  3. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PMID: 23864651) Huang X … Wheeler MB (Molecular endocrinology (Baltimore, Md.) 2013) 3 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for C18orf32 Gene

Sources for C18orf32 Gene

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