C18orf32 Gene
protein-coding GIFtS: 41
GCID: GC18M047008
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|
chromosome 18 open reading frame 32
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Aliases
for C18orf32 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 18 Open Reading Frame 321 2 | | Putative NF-Kappa-B-Activating Protein 2002 3 | | FLJ234581 | | Putative NFkB Activating Protein2 | | UPF0729 Protein C18orf322 |
Export aliases for C18orf32 gene to outside databasesPrevious GC identifers: GC18M045264 GC18M043861 |
Summaries
for C18orf32 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CR032_HUMAN, Q8TCD1Function: May activate the NF-kappa-B signaling pathway
|
Genomic Views
for C18orf32 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C18orf32 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 CREB POU2F1 deltaCREB POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for C18orf32
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C18orf32 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q21.1 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q21.1C18orf32 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M047008: view genomic region
(about GC identifiers)
Start:
|
47,008,028 bp from pter |
End:
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47,013,622 bp from pter |
Size:
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5,595 bases |
Orientation:
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minus strand |
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Proteins
for C18orf32 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CR032_HUMAN, Q8TCD1 (See
protein sequence)Recommended Name: UPF0729 protein C18orf32 Size: 76 amino acids; 8669 DaExplore the universe of human proteins at neXtProt for C18orf32: NX_Q8TCD1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TCD1
C18orf32 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001030177.1 NP_001186275.1
ENSEMBL proteins: ENSP00000464411 ENSP00000323199 ENSP00000462538
Human Recombinant Protein Products:
C18orf32 Antibody Products:
Assay Products for C18orf32: |
Protein
Domains /
Families
for C18orf32 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C18orf32 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TCD1ProtoNet protein and cluster: Q8TCD1 UniProtKB/Swiss-Prot: CR032_HUMAN, Q8TCD1Similarity: Belongs to the UPF0729 family |
Function
for C18orf32 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CR032_HUMAN, Q8TCD1Function: May activate the NF-kappa-B signaling pathway
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf32 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf32
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): C18orf32 (NM_001199346) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C18orf32 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf32 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf32 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
C18orf32 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for C18orf32:
|
Pathways & Interactions
for C18orf32 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C18orf32
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/35 Interacting proteins for C18orf32 (Q8TCD13 ENSP000003231994) via UniProtKB, MINT, STRING, and/or I2D (see all 35)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
C18orf32 for ontologies About GeneDecksing
|
Drugs & Compounds
for C18orf32 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C18orf32
Search CenterWatch for drugs/clinical trials and news about C18orf32 / CR032
|
Transcripts
for C18orf32 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C18orf32 gene (2 alternative transcripts): NM_001035005.3 NM_001199346.1 Unigene Cluster for C18orf32: Chromosome 18 open reading frame 32 Hs.603040 [show with all ESTs]Unigene Representative Sequence: NM_0011993563 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000579820(uc002ldl.3) ENST00000318240(uc002ldk.2) ENST00000582392
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf32 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf32
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C18orf32 (NM_001199346) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C18orf32 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf32 |
Additional cDNA sequence: AB097012.1 AK027111.1 AK291882.1 BC022357.1 BC093004.1 21 DOTS entries: DT.100891790 DT.95182723 DT.452028 DT.121105090 DT.100891783 DT.121104983 DT.95182721 DT.100891774 DT.95182728 DT.75196436 DT.100809496 DT.121105078 DT.121105088 DT.121105135 DT.95182730 DT.97765301 DT.100035658 DT.100891762 DT.121105133 DT.91832582 DT.92471784
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for C18orf32 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|
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| SP1: | | | | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C18orf32
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Expression
for C18orf32 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C18orf32 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGGATTAC
About this image
See C18orf32 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C18orf32
SOURCE GeneReport for Unigene cluster: Hs.603040
SABiosciences Custom PCR Arrays for C18orf32
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C18orf32
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C18orf32 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C18orf32 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C18orf32 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf32 |
Orthologs
for C18orf32 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C18orf32 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for C18orf32 (if available)
TreeFam Gene Tree for C18orf32 (if available) |
Paralogs
for C18orf32 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C18orf32 gene
C18orf32 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for C18orf32
PGOHUM00000248886 PGOHUM00000245118 PGOHUM00000240961 PGOHUM00000241082 PGOHUM00000237737
|
Genomic Variants
for C18orf32 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C18orf32 (47008028 - 47013622 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C18orf32
1 CNV: 35573 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C18orf32 |
|
Disorders
/ Diseases
for C18orf32 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C18orf32 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C18orf32 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C18orf32) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (2003)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for C18orf32 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C18orf32 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C18orf32 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C18orf32 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C18orf32 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C18orf32 gene:
Search GeneIP for patents involving C18orf32
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C18orf32 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C18orf32 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C18orf32 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C18orf32 | | | OriGene Protein Over-expression Lysate for C18orf32 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C18orf32 | | OriGene 3'-UTR Clone for C18orf32 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf32 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf32 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C18orf32 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C18orf32 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C18orf32 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C18orf32 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C18orf32 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C18orf32 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C18orf32 |
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 | | | C18orf32 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf32 |
|  |  |  | | | | Search ThermoFisher Antibodies for C18orf32 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf32 |
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