C18orf25 Gene
protein-coding GIFtS: 43
GCID: GC18P043753
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chromosome 18 open reading frame 25
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Aliases
for C18orf25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 18 Open Reading Frame 251 2 | | ARKL11 2 | | MGC129091 | | ARKadia-Like 12 | | Uncharacterized Protein C18orf252 |
Export aliases for C18orf25 gene to outside databasesPrevious GC identifers: GC18P042049 GC18P040611 |
Summaries
for C18orf25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C18orf25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C18orf25 gene promoter:
MEF-2A POU2F1 AML1a POU2F1a Nkx2-5 CUTL1 aMEF-2 Roaz
Other transcription factors
Search SABiosciences Chromatin IP Primers for C18orf25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C18orf25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q21.1 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q21.1C18orf25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P043753: view genomic region
(about GC identifiers)
Start:
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43,753,519 bp from pter |
End:
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43,846,955 bp from pter |
Size:
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93,437 bases |
Orientation:
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plus strand |
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Proteins
for C18orf25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CR025_HUMAN, Q96B23 (See
protein sequence)Recommended Name: Uncharacterized protein C18orf25 Size: 403 amino acids; 43324 Da
Secondary accessions: A8K123 A8KAB6 Q5XG78 Q6N058 Q86TB5 Q8TCQ5Alternative splicing: 2 isoforms: Q96B23-1 Q96B23-2 Explore the universe of human proteins at neXtProt for C18orf25: NX_Q96B23
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96B23
C18orf25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001008240.1 NP_659492.1
ENSEMBL proteins: ENSP00000467826 ENSP00000468128 ENSP00000282059 ENSP00000324294
Human Recombinant Protein Products for C18orf25:
C18orf25 Antibody Products:
Assay Products for C18orf25: |
Protein
Domains /
Families
for C18orf25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96B23 |
Function
for C18orf25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf25 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): C18orf25 (NM_145055) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C18orf25 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf25 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf25 |
|
Pathways & Interactions
for C18orf25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C18orf25
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for C18orf25 (Q96B232, 3 ENSP000002820594) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C18orf25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C18orf25
Search CenterWatch for drugs/clinical trials and news about C18orf25 / CR025
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Transcripts
for C18orf25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C18orf25 gene (2 alternative transcripts): NM_001008239.2 NM_145055.3 Unigene Cluster for C18orf25: Chromosome 18 open reading frame 25 Hs.116486 [show with all ESTs]Unigene Representative Sequence: NM_1450554 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000587591 ENST00000588730 ENST00000282059(uc002lbw.3) ENST00000321319(uc002lbx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf25 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C18orf25 (NM_145055) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C18orf25 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf25 |
Additional cDNA sequence: AK289738.1 AK292981.1 AL713661.1 AL832027.2 BC016149.1 BC084579.1 BX640683.1 6 DOTS entries: DT.413343 DT.110089 DT.100665942 DT.100766631 DT.40111533 DT.91649075 24/148 AceView cDNA sequences (see all 148): BM842994 AI742199 BM831606 BM977157 BG497739 AW675687 BU192741 AI026060 W49491 AI801785 BM564759 BM980424 BX090345 AA477381 AW473807 AI093177 CD672303 BM845545 CB146719 AA477133 BM752301 BQ028224 AI190947 AI187711
GeneLoc Exon Structure
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Expression
for C18orf25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C18orf25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGATATAAA
About this image
See C18orf25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C18orf25
SOURCE GeneReport for Unigene cluster: Hs.116486
SABiosciences Custom PCR Arrays for C18orf25
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C18orf25
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C18orf25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C18orf25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C18orf25 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf25 |
Orthologs
for C18orf25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C18orf25 gene from 5/11 species (see all 11) About this table
ENSEMBL Gene Tree for C18orf25 (if available)
TreeFam Gene Tree for C18orf25 (if available) |
Paralogs
for C18orf25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C18orf25 gene
1 SIMAP similar gene for C18orf25 using alignment to 3 protein entries: CR025_HUMAN (see all proteins):ARKL1
C18orf25 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for C18orf25
PGOHUM00000241044
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Genomic Variants
for C18orf25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C18orf25 (43753519 - 43846955 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C18orf25: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C18orf25 |
|
Disorders
/ Diseases
for C18orf25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C18orf25 for disorders About MalaCards
C18orf25 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: C18orf25 (1 document)
Export disorders for C18orf25 gene to outside databases
|
Publications
for C18orf25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C18orf25 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with C18orf25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18. (PubMed id 15722956)1, 3 Pickard B.S.... Muir W.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
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External Searches for C18orf25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing C18orf25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C18orf25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C18orf25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C18orf25 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for C18orf25 gene:
Search GeneIP for patents involving C18orf25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C18orf25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C18orf25 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C18orf25 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C18orf25 | | | OriGene Protein Over-expression Lysate for C18orf25 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C18orf25 | | OriGene 3'-UTR Clone for C18orf25 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf25 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf25 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C18orf25 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C18orf25 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C18orf25 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C18orf25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C18orf25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C18orf25 |
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 | | | C18orf25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf25 |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf25 |
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