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Aliases for C18orf25 Gene

Aliases for C18orf25 Gene

  • Chromosome 18 Open Reading Frame 25 2 3 5
  • ARKadia-Like 1 2 3
  • Uncharacterized Protein C18orf25 3
  • RNF111L1 3
  • ARKL1 3

External Ids for C18orf25 Gene

Previous GeneCards Identifiers for C18orf25 Gene

  • GC18P042049
  • GC18P043753
  • GC18P040611

Summaries for C18orf25 Gene

GeneCards Summary for C18orf25 Gene

C18orf25 (Chromosome 18 Open Reading Frame 25) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf25 Gene

Genomics for C18orf25 Gene

Regulatory Elements for C18orf25 Gene

Enhancers for C18orf25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C18orf25 on UCSC Golden Path with GeneCards custom track

Promoters for C18orf25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C18orf25 on UCSC Golden Path with GeneCards custom track

Genomic Location for C18orf25 Gene

46,173,553 bp from pter
46,266,992 bp from pter
93,440 bases
Plus strand

Genomic View for C18orf25 Gene

Genes around C18orf25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C18orf25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C18orf25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf25 Gene

Proteins for C18orf25 Gene

  • Protein details for C18orf25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C18orf25
    Protein Accession:
    Secondary Accessions:
    • A8K123
    • A8KAB6
    • Q5XG78
    • Q6N058
    • Q86TB5
    • Q8TCQ5

    Protein attributes for C18orf25 Gene

    403 amino acids
    Molecular mass:
    43324 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C18orf25 Gene


neXtProt entry for C18orf25 Gene

Post-translational modifications for C18orf25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C18orf25 Gene

No data available for DME Specific Peptides for C18orf25 Gene

Domains & Families for C18orf25 Gene

Protein Domains for C18orf25 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C18orf25: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C18orf25 Gene

Function for C18orf25 Gene

Gene Ontology (GO) - Molecular Function for C18orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with C18orf25: view
genes like me logo Genes that share phenotypes with C18orf25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C18orf25 Gene

Localization for C18orf25 Gene

Subcellular locations from

Jensen Localization Image for C18orf25 Gene COMPARTMENTS Subcellular localization image for C18orf25 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C18orf25 Gene

Pathways & Interactions for C18orf25 Gene

SuperPathways for C18orf25 Gene

No Data Available

Interacting Proteins for C18orf25 Gene

Selected Interacting proteins: Q96B23-CR025_HUMAN for C18orf25 Gene via MINT IID

Gene Ontology (GO) - Biological Process for C18orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with C18orf25: view

No data available for Pathways by source and SIGNOR curated interactions for C18orf25 Gene

Drugs & Compounds for C18orf25 Gene

No Compound Related Data Available

Transcripts for C18orf25 Gene

Unigene Clusters for C18orf25 Gene

Chromosome 18 open reading frame 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf25 Gene

No ASD Table

Relevant External Links for C18orf25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C18orf25 Gene

mRNA expression in normal human tissues for C18orf25 Gene

Protein differential expression in normal tissues from HIPED for C18orf25 Gene

This gene is overexpressed in Lung (18.2), Testis (17.5), Retina (11.8), Blymphocyte (11.1), and Frontal cortex (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C18orf25 Gene

Protein tissue co-expression partners for C18orf25 Gene

NURSA nuclear receptor signaling pathways regulating expression of C18orf25 Gene:


SOURCE GeneReport for Unigene cluster for C18orf25 Gene:

genes like me logo Genes that share expression patterns with C18orf25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C18orf25 Gene

Orthologs for C18orf25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf25 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia C7H18orf25 34
  • 95.46 (n)
  • 98.27 (a)
C18orf25 35
  • 98 (a)
(Pan troglodytes)
Mammalia C18H18orf25 34
  • 99.59 (n)
  • 100 (a)
C18orf25 35
  • 100 (a)
(Rattus norvegicus)
Mammalia RGD1308601 34
  • 90.56 (n)
  • 93.98 (a)
(Bos Taurus)
Mammalia C24H18orf25 35
  • 97 (a)
(Monodelphis domestica)
Mammalia C18orf25 35
  • 91 (a)
(Mus musculus)
Mammalia 8030462N17Rik 35
  • 95 (a)
8030462N17Rik 16
8030462N17Rik 34
  • 92.23 (n)
  • 95.24 (a)
(Ornithorhynchus anatinus)
Mammalia C18orf25 35
  • 90 (a)
(Gallus gallus)
Aves CZH18ORF25 34
  • 82.38 (n)
  • 86.6 (a)
-- 35
  • 56 (a)
-- 35
  • 86 (a)
(Anolis carolinensis)
Reptilia C18orf25 35
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c18orf25 34
  • 74.01 (n)
  • 80.51 (a)
Str.15922 34
African clawed frog
(Xenopus laevis)
Amphibia mgc12909-prov 34
(Danio rerio)
Actinopterygii zgc:77838 34
  • 58.06 (n)
  • 58.67 (a)
C21H18orf25 35
  • 50 (a)
Species where no ortholog for C18orf25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C18orf25 Gene

Gene Tree for C18orf25 (if available)
Gene Tree for C18orf25 (if available)

Paralogs for C18orf25 Gene

(1) SIMAP similar genes for C18orf25 Gene using alignment to 3 proteins: Pseudogenes for C18orf25 Gene

genes like me logo Genes that share paralogs with C18orf25: view

No data available for Paralogs for C18orf25 Gene

Variants for C18orf25 Gene

Sequence variations from dbSNP and Humsavar for C18orf25 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs7239202 -- 46,220,771(+) GTTAT(A/G)CGTTC intron-variant
rs7239657 -- 46,220,313(+) CCCAC(C/T)TCAAG intron-variant
rs7240076 -- 46,248,891(+) ATACT(C/G)TTACG intron-variant
rs7240354 -- 46,229,648(+) gtctc(A/G)ctcta intron-variant
rs7240461 -- 46,208,102(+) tttaa(G/T)ttcat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C18orf25 Gene

Variant ID Type Subtype PubMed ID
esv2675609 CNV deletion 23128226
esv3309689 CNV mobile element insertion 20981092
esv3350079 CNV insertion 20981092
esv3555318 CNV deletion 23714750
esv3642420 CNV gain 21293372
esv3642424 CNV gain 21293372
esv3642429 CNV loss 21293372
nsv1064031 CNV gain 25217958
nsv1110718 CNV insertion 24896259
nsv2278 CNV insertion 18451855
nsv953535 CNV duplication 24416366
nsv960275 CNV duplication 23825009

Variation tolerance for C18orf25 Gene

Residual Variation Intolerance Score: 26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C18orf25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C18orf25 Gene

Disorders for C18orf25 Gene

Relevant External Links for C18orf25

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C18orf25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C18orf25 Gene

Publications for C18orf25 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65
  2. Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18. (PMID: 15722956) Pickard B.S. … Muir W.J. (Psychiatr. Genet. 2005) 2 3 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 65

Products for C18orf25 Gene

Sources for C18orf25 Gene