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Aliases for C18orf21 Gene

Aliases for C18orf21 Gene

  • Chromosome 18 Open Reading Frame 21 2 3 5
  • HBV X-Transactivated Gene 13 Protein 3 4
  • HBV XAg-Transactivated Protein 13 3 4
  • XTP13 3 4
  • HBV X-Transactivated Protein 13 3
  • UPF0711 Protein C18orf21 3
  • PNAS-124 3
  • PNAS-131 3
  • HsT3108 3

External Ids for C18orf21 Gene

Previous GeneCards Identifiers for C18orf21 Gene

  • GC18P031805
  • GC18P031806
  • GC18P033552
  • GC18P030411

Summaries for C18orf21 Gene

GeneCards Summary for C18orf21 Gene

C18orf21 (Chromosome 18 Open Reading Frame 21) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf21 Gene

Genomics for C18orf21 Gene

Regulatory Elements for C18orf21 Gene

Enhancers for C18orf21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G035495 1.4 ENCODE dbSUPER 10.1 -475.0 -475038 3.1 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 TBX21 ENSG00000268573 ZNF397 ELP2 ZSCAN30 ZNF271P ZNF396 C18orf21 INO80C ENSG00000267140 ENSG00000279074
GH18G035967 1.2 ENCODE 11 -1.2 -1225 5.8 HDGF PKNOX1 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ENSG00000268573 ZNF397 C18orf21 LOC105372066 ELP2 RPRD1A GC18P035965
GH18G035949 1.1 Ensembl ENCODE 11.7 -21.7 -21696 1.2 RAD21 YY1 GLIS2 ZNF143 ZNF654 REST ZBTB33 PRDM1 MYC CTCF LOC105372066 C18orf21 RPRD1A GC18P035965 MIR3929
GH18G036075 1.2 Ensembl ENCODE 10 +104.0 104023 1.3 ELF3 PKNOX1 FOXA2 NFRKB SIN3A RELB FOS IKZF2 THAP11 SMARCC1 RPRD1A MOCOS FHOD3 C18orf21 GC18P036078
GH18G036065 1.1 ENCODE 10.2 +94.7 94664 2.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF143 RPRD1A C18orf21 LOC105372066 GC18M035972
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C18orf21 on UCSC Golden Path with GeneCards custom track

Promoters for C18orf21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000102265 517 2001 HDGF PKNOX1 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for C18orf21 Gene

Chromosome:
18
Start:
35,972,083 bp from pter
End:
35,979,287 bp from pter
Size:
7,205 bases
Orientation:
Plus strand

Genomic View for C18orf21 Gene

Genes around C18orf21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C18orf21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C18orf21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf21 Gene

Proteins for C18orf21 Gene

  • Protein details for C18orf21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q32NC0-CR021_HUMAN
    Recommended name:
    UPF0711 protein C18orf21
    Protein Accession:
    Q32NC0
    Secondary Accessions:
    • Q6GW03
    • Q9BXV6
    • Q9BXW2

    Protein attributes for C18orf21 Gene

    Size:
    220 amino acids
    Molecular mass:
    24827 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK07541.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK07547.1; Type=Frameshift; Positions=216; Evidence={ECO:0000305};

    Alternative splice isoforms for C18orf21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C18orf21 Gene

Post-translational modifications for C18orf21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C18orf21 Gene

Domains & Families for C18orf21 Gene

Protein Domains for C18orf21 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C18orf21 Gene

Graphical View of Domain Structure for InterPro Entry

Q32NC0

UniProtKB/Swiss-Prot:

CR021_HUMAN :
  • Belongs to the UPF0711 family.
Family:
  • Belongs to the UPF0711 family.
genes like me logo Genes that share domains with C18orf21: view

No data available for Gene Families for C18orf21 Gene

Function for C18orf21 Gene

Phenotypes for C18orf21 Gene

GenomeRNAi human phenotypes for C18orf21:
genes like me logo Genes that share phenotypes with C18orf21: view

Animal Model Products

CRISPR Products

miRNA for C18orf21 Gene

miRTarBase miRNAs that target C18orf21

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C18orf21 Gene

Localization for C18orf21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C18orf21 gene
Compartment Confidence
nucleus 2
extracellular 1
mitochondrion 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C18orf21 Gene

Pathways & Interactions for C18orf21 Gene

SuperPathways for C18orf21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C18orf21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C18orf21 Gene

Transcripts for C18orf21 Gene

Unigene Clusters for C18orf21 Gene

Chromosome 18 open reading frame 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf21 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: -

Relevant External Links for C18orf21 Gene

GeneLoc Exon Structure for
C18orf21
ECgene alternative splicing isoforms for
C18orf21

Expression for C18orf21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C18orf21 Gene

Protein differential expression in normal tissues from HIPED for C18orf21 Gene

This gene is overexpressed in Lung (40.0) and Peripheral blood mononuclear cells (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C18orf21 Gene



Protein tissue co-expression partners for C18orf21 Gene

NURSA nuclear receptor signaling pathways regulating expression of C18orf21 Gene:

C18orf21

SOURCE GeneReport for Unigene cluster for C18orf21 Gene:

Hs.37883
genes like me logo Genes that share expression patterns with C18orf21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C18orf21 Gene

Orthologs for C18orf21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C18H18orf21 34
  • 99.69 (n)
C18ORF21 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C24H18orf21 34
  • 88.73 (n)
C18orf21 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C7H18orf21 34
  • 87.48 (n)
C18orf21 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2700062C07Rik 34 35
  • 79.28 (n)
Gm9182 16
rat
(Rattus norvegicus)
Mammalia MGC116121 34
  • 79.28 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia C18orf21 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves C18ORF21 34
  • 60.79 (n)
C18orf21 35
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C18orf21 35
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c18orf21 34
  • 54.07 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-184p18.2 34
  • 46.14 (n)
C19H18orf21 (1 of 2) 35
  • 33 (a)
OneToMany
C19H18orf21 (2 of 2) 35
  • 33 (a)
OneToMany
Species where no ortholog for C18orf21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C18orf21 Gene

ENSEMBL:
Gene Tree for C18orf21 (if available)
TreeFam:
Gene Tree for C18orf21 (if available)

Paralogs for C18orf21 Gene

Pseudogenes.org Pseudogenes for C18orf21 Gene

genes like me logo Genes that share paralogs with C18orf21: view

No data available for Paralogs for C18orf21 Gene

Variants for C18orf21 Gene

Sequence variations from dbSNP and Humsavar for C18orf21 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000292167 -- 35,976,370(+) TAGAC(C/T)TTTGA intron-variant
rs1000738221 -- 35,973,643(+) CAGCC(A/G)GGAGC intron-variant, upstream-variant-2KB
rs1000980384 -- 35,977,660(+) TTCCT(C/G)TGTTT intron-variant
rs1001521634 -- 35,974,866(+) TTGCT(A/G)AATTG intron-variant
rs1002286945 -- 35,970,876(+) TTCAC(C/T)GTGTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C18orf21 Gene

Variant ID Type Subtype PubMed ID
nsv1065113 CNV loss 25217958

Variation tolerance for C18orf21 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C18orf21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C18orf21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C18orf21 Gene

Disorders for C18orf21 Gene

Relevant External Links for C18orf21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C18orf21

No disorders were found for C18orf21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C18orf21 Gene

Publications for C18orf21 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes. (PMID: 24223155) Behr E.R. … Roden D.M. (PLoS ONE 2013) 3 64

Products for C18orf21 Gene

Sources for C18orf21 Gene

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