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Aliases for C18orf21 Gene

Aliases for C18orf21 Gene

  • Chromosome 18 Open Reading Frame 21 2 3
  • HBV X-Transactivated Gene 13 Protein 3 4
  • HBV XAg-Transactivated Protein 13 3 4
  • XTP13 3 4
  • HBV X-Transactivated Protein 13 3
  • PNAS-124 3
  • PNAS-131 3
  • HsT3108 3

External Ids for C18orf21 Gene

Previous GeneCards Identifiers for C18orf21 Gene

  • GC18P031805
  • GC18P031806
  • GC18P033552
  • GC18P030411

Summaries for C18orf21 Gene

GeneCards Summary for C18orf21 Gene

C18orf21 (Chromosome 18 Open Reading Frame 21) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf21 Gene

Genomics for C18orf21 Gene

Regulatory Elements for C18orf21 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C18orf21 Gene

35,972,083 bp from pter
35,979,287 bp from pter
7,205 bases
Plus strand

Genomic View for C18orf21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C18orf21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf21 Gene

Proteins for C18orf21 Gene

  • Protein details for C18orf21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0711 protein C18orf21
    Protein Accession:
    Secondary Accessions:
    • Q6GW03
    • Q9BXV6
    • Q9BXW2

    Protein attributes for C18orf21 Gene

    220 amino acids
    Molecular mass:
    24827 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK07541.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK07547.1; Type=Frameshift; Positions=216; Evidence={ECO:0000305};

    Alternative splice isoforms for C18orf21 Gene


neXtProt entry for C18orf21 Gene

Proteomics data for C18orf21 Gene at MOPED

Post-translational modifications for C18orf21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C18orf21 Gene

Domains & Families for C18orf21 Gene

Protein Domains for C18orf21 Gene


Suggested Antigen Peptide Sequences for C18orf21 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0711 family.
  • Belongs to the UPF0711 family.
genes like me logo Genes that share domains with C18orf21: view

No data available for Gene Families for C18orf21 Gene

Function for C18orf21 Gene

Phenotypes for C18orf21 Gene

GenomeRNAi human phenotypes for C18orf21:
genes like me logo Genes that share phenotypes with C18orf21: view

Animal Model Products

CRISPR Products

miRNA for C18orf21 Gene

miRTarBase miRNAs that target C18orf21

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C18orf21

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for C18orf21 Gene

Localization for C18orf21 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C18orf21 Gene

Pathways & Interactions for C18orf21 Gene

SuperPathways for C18orf21 Gene

No Data Available

Interacting Proteins for C18orf21 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000465517 for C18orf21 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C18orf21 Gene


No data available for Pathways by source and SIGNOR curated interactions for C18orf21 Gene

Drugs & Compounds for C18orf21 Gene

No Compound Related Data Available

Transcripts for C18orf21 Gene

Unigene Clusters for C18orf21 Gene

Chromosome 18 open reading frame 21:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C18orf21

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf21 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - -
SP4: -
SP5: -

Relevant External Links for C18orf21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C18orf21 Gene

mRNA expression in normal human tissues for C18orf21 Gene

Protein differential expression in normal tissues from HIPED for C18orf21 Gene

This gene is overexpressed in Lung (40.0) and Peripheral blood mononuclear cells (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C18orf21 Gene

SOURCE GeneReport for Unigene cluster for C18orf21 Gene Hs.37883

genes like me logo Genes that share expression patterns with C18orf21: view

Protein tissue co-expression partners for C18orf21 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C18orf21 Gene

Orthologs for C18orf21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf21 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C24H18orf21 35
  • 88.73 (n)
  • 86.85 (a)
C18orf21 36
  • 85 (a)
(Canis familiaris)
Mammalia C7H18orf21 35
  • 87.48 (n)
  • 84.98 (a)
C18orf21 36
  • 84 (a)
(Mus musculus)
Mammalia 2700062C07Rik 35
  • 79.28 (n)
  • 74.77 (a)
2700062C07Rik 16
2700062C07Rik 36
  • 73 (a)
(Pan troglodytes)
Mammalia C18H18orf21 35
  • 99.69 (n)
  • 99.08 (a)
C18ORF21 36
  • 99 (a)
(Rattus norvegicus)
Mammalia MGC116121 35
  • 79.28 (n)
  • 73.36 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
-- 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia C18orf21 36
  • 49 (a)
(Gallus gallus)
Aves C18ORF21 35
  • 60.79 (n)
  • 49.52 (a)
C18orf21 36
  • 48 (a)
(Anolis carolinensis)
Reptilia C18orf21 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c18orf21 35
  • 54.07 (n)
  • 44.5 (a)
(Danio rerio)
Actinopterygii si:dkey-184p18.2 35
  • 46.14 (n)
  • 33.99 (a)
C19H18orf21 (1 of 2) 36
  • 33 (a)
C19H18orf21 (2 of 2) 36
  • 33 (a)
Species with no ortholog for C18orf21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C18orf21 Gene

Gene Tree for C18orf21 (if available)
Gene Tree for C18orf21 (if available)

Paralogs for C18orf21 Gene Pseudogenes for C18orf21 Gene

genes like me logo Genes that share paralogs with C18orf21: view

No data available for Paralogs for C18orf21 Gene

Variants for C18orf21 Gene

Sequence variations from dbSNP and Humsavar for C18orf21 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1540042 -- 35,975,273(+) GCTTA(C/T)TTTTA intron-variant
rs2276314 - 35,977,503(+) CTCCT(A/G)CAAGT reference, missense, intron-variant
rs4799831 -- 35,974,812(+) TTTCA(A/G)TATAC intron-variant
rs4799832 -- 35,979,683(+) TCCCA(C/T)ATCTG downstream-variant-500B
rs35122846 -- 35,977,234(+) AAAAA(-/A)TGTCT intron-variant

Variation tolerance for C18orf21 Gene

Residual Variation Intolerance Score: 67.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C18orf21 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C18orf21 Gene

Disorders for C18orf21 Gene

Relevant External Links for C18orf21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C18orf21: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C18orf21 Gene

Publications for C18orf21 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes. (PMID: 24223155) Behr E.R. … Roden D.M. (PLoS ONE 2013) 67
  4. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 67
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67

Products for C18orf21 Gene

Sources for C18orf21 Gene

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