C18orf21 Gene
protein-coding GIFtS: 36
GCID: GC18P033552
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chromosome 18 open reading frame 21
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Aliases
for C18orf21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 18 Open Reading Frame 211 2 | | HBV XAg-Transactivated Protein 132 3 | | HsT31081 2 | | PNAS-1241 | | PNAS-1311 2 | | HBV X-Transactivated Protein 132 | | XTP132 3 | | UPF0711 Protein C18orf212 | | HBV X-Transactivated Gene 13 Protein2 3 | | |
Export aliases for C18orf21 gene to outside databasesPrevious GC identifers: GC18P031805 GC18P031806 GC18P030411 |
Summaries
for C18orf21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C18orf21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010966.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C18orf21 gene promoter:
AhR RP58 Nkx2-2 NF-E2 p45 Evi-1 Arnt YY1 GATA-1 Pax-4a NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for C18orf21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C18orf21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q12.2 Ensembl cytogenetic band: 18q12.2 HGNC cytogenetic band: 18q12.2C18orf21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P033552: view genomic region
(about GC identifiers)
Start:
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33,552,046 bp from pter |
End:
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33,559,241 bp from pter |
Size:
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7,196 bases |
Orientation:
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plus strand |
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Proteins
for C18orf21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CR021_HUMAN, Q32NC0 (See
protein sequence)Recommended Name: UPF0711 protein C18orf21 Size: 220 amino acids; 24827 Da
Sequence caution: Sequence=AAK07541.1; Type=Erroneous initiation; Sequence=AAK07547.1; Type=Frameshift; Positions=216;
Secondary accessions: Q6GW03 Q9BXV6 Q9BXW2Explore the universe of human proteins at neXtProt for C18orf21: NX_Q32NC0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q32NC0
C18orf21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001188403.1 NP_001188404.1 NP_001188405.1 NP_113634.3
ENSEMBL proteins: ENSP00000465517 ENSP00000269194 ENSP00000466400 ENSP00000329492
Human Recombinant Protein Products:
C18orf21 Antibody Products:
Assay Products for C18orf21: |
Protein
Domains /
Families
for C18orf21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q32NC0 UniProtKB/Swiss-Prot: CR021_HUMAN, Q32NC0Similarity: Belongs to the UPF0711 family |
Function
for C18orf21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf21 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf21 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for C18orf21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf21 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf21 |
|
Pathways & Interactions
for C18orf21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C18orf21
|
Drugs & Compounds
for C18orf21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C18orf21
Search CenterWatch for drugs/clinical trials and news about C18orf21 / CR021
|
Transcripts
for C18orf21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C18orf21 gene (4 alternative transcripts): NM_001201474.1 NM_001201475.1 NM_001201476.1 NM_031446.4 Unigene Cluster for C18orf21: Chromosome 18 open reading frame 21 Hs.37883 [show with all ESTs]Unigene Representative Sequence: NM_0012014756 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000592875 ENST00000269194 ENST00000587719 ENST00000587873 ENST00000593210
ENST00000333234(uc002kzc.3 uc002kzd.3 uc021uit.1 uc021uiu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf21 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf21 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): C18orf21 (NM_031446) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C18orf21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf21 |
Additional cDNA sequence: AF277182.1 AF277189.1 AK311536.1 AY631401.1 BC025950.1 BC108730.1 BC119765.1 BC119766.1 6 DOTS entries: DT.415320 DT.100749668 DT.121084241 DT.121084245 DT.121084248 DT.75175063 24/93 AceView cDNA sequences (see all 93): AA776764 AA287109 AA383059 AA719476 BQ279004 AI741440 AA383058 CR613371 BU622514 CA314152 AA758507 AA889614 BU539192 BM313795 CR608062 W87660 BM726912 AA766092 BQ130789 AA648431 BM712459 AA459936 AA768308 AW246709
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for C18orf21 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|
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| SP1: | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for C18orf21
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Expression
for C18orf21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C18orf21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAACTAGAT
About this image
See C18orf21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C18orf21
SOURCE GeneReport for Unigene cluster: Hs.37883
SABiosciences Custom PCR Arrays for C18orf21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C18orf21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C18orf21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C18orf21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C18orf21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf21 |
Orthologs
for C18orf21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C18orf21 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for C18orf21 (if available)
TreeFam Gene Tree for C18orf21 (if available) |
Paralogs
for C18orf21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C18orf21 gene
C18orf21 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for C18orf21
PGOHUM00000245617 PGOHUM00000243428
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Genomic Variants
for C18orf21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C18orf21 (33552046 - 33559241 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C18orf21: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C18orf21 |
|
Disorders
/ Diseases
for C18orf21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C18orf21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C18orf21 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C18orf21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1 Beausoleil S.A.... Gygi S.P. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for C18orf21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C18orf21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C18orf21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C18orf21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C18orf21 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C18orf21 gene:
Search GeneIP for patents involving C18orf21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C18orf21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C18orf21 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C18orf21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C18orf21 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C18orf21 | | OriGene 3'-UTR Clone for C18orf21 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C18orf21 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C18orf21 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C18orf21 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C18orf21 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C18orf21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C18orf21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C18orf21 |
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 | | | C18orf21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C18orf21 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C18orf21 |
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