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Aliases for C17orf99 Gene

Aliases for C17orf99 Gene

  • Chromosome 17 Open Reading Frame 99 2 3 5
  • GLPG464 3
  • UNQ464 3

External Ids for C17orf99 Gene

Previous GeneCards Identifiers for C17orf99 Gene

  • GC17U901110
  • GC17P073655
  • GC17P076142
  • GC17P071566

Summaries for C17orf99 Gene

GeneCards Summary for C17orf99 Gene

C17orf99 (Chromosome 17 Open Reading Frame 99) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C17orf99 Gene

Genomics for C17orf99 Gene

Regulatory Elements for C17orf99 Gene

Genomic Location for C17orf99 Gene

Chromosome:
17
Start:
78,146,040 bp from pter
End:
78,166,904 bp from pter
Size:
20,865 bases
Orientation:
Plus strand

Genomic View for C17orf99 Gene

Genes around C17orf99 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf99 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf99 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf99 Gene

Proteins for C17orf99 Gene

  • Protein details for C17orf99 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX52-CQ099_HUMAN
    Recommended name:
    Uncharacterized protein C17orf99
    Protein Accession:
    Q6UX52

    Protein attributes for C17orf99 Gene

    Size:
    265 amino acids
    Molecular mass:
    29091 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C17orf99 Gene

Proteomics data for C17orf99 Gene at MOPED

Post-translational modifications for C17orf99 Gene

  • Glycosylation at Asn 86 and Asn 132
  • Modification sites at PhosphoSitePlus

Other Protein References for C17orf99 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C17orf99 Gene

Domains & Families for C17orf99 Gene

Protein Domains for C17orf99 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C17orf99: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C17orf99 Gene

Function for C17orf99 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C17orf99 Gene

Localization for C17orf99 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C17orf99 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C17orf99 Gene COMPARTMENTS Subcellular localization image for C17orf99 gene
Compartment Confidence
extracellular 4
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for C17orf99 Gene

Pathways & Interactions for C17orf99 Gene

SuperPathways for C17orf99 Gene

No Data Available

Interacting Proteins for C17orf99 Gene

Gene Ontology (GO) - Biological Process for C17orf99 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C17orf99 Gene

Drugs & Compounds for C17orf99 Gene

No Compound Related Data Available

Transcripts for C17orf99 Gene

mRNA/cDNA for C17orf99 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C17orf99 Gene

Chromosome 17 open reading frame 99:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf99 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: -
SP3:

Relevant External Links for C17orf99 Gene

GeneLoc Exon Structure for
C17orf99
ECgene alternative splicing isoforms for
C17orf99

Expression for C17orf99 Gene

mRNA expression in normal human tissues for C17orf99 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C17orf99 Gene

This gene is overexpressed in Whole Blood (x8.3).

SOURCE GeneReport for Unigene cluster for C17orf99 Gene Hs.633034

genes like me logo Genes that share expression patterns with C17orf99: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C17orf99 Gene

Orthologs for C17orf99 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C17orf99 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf99 35
  • 97.99 (n)
  • 95.47 (a)
C17orf99 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C17orf99 36
  • 55 (a)
OneToOne
C9H17orf99 35
  • 77.14 (n)
  • 62.3 (a)
mouse
(Mus musculus)
Mammalia 6030468B19Rik 35
  • 70.35 (n)
  • 57.21 (a)
6030468B19Rik 36
  • 48 (a)
OneToOne
6030468B19Rik 16
platypus
(Ornithorhynchus anatinus)
Mammalia C17orf99 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC688282 35
  • 68.25 (n)
  • 56.32 (a)
Species with no ortholog for C17orf99:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C17orf99 Gene

ENSEMBL:
Gene Tree for C17orf99 (if available)
TreeFam:
Gene Tree for C17orf99 (if available)

Paralogs for C17orf99 Gene

No data available for Paralogs for C17orf99 Gene

Variants for C17orf99 Gene

Sequence variations from dbSNP and Humsavar for C17orf99 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4789017 - 78,160,076(+) ggtgt(A/G)tgtct intron-variant, reference, missense
rs3642 -- 78,166,097(-) GTGCA(C/T)GCTGA utr-variant-3-prime
rs560 -- 78,166,054(+) TGAAC(C/T)GTCCA utr-variant-3-prime
rs748708 -- 78,146,714(-) TTGCG(C/T)CCCTC intron-variant
rs2310998 -- 78,146,321(-) GCTCC(C/T)TGGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C17orf99 Gene

Variant ID Type Subtype PubMed ID
nsv833554 CNV Gain+Loss 17160897
nsv908860 CNV Loss 21882294
dgv3275n71 CNV Loss 21882294
dgv3276n71 CNV Loss 21882294
dgv3277n71 CNV Loss 21882294
dgv3278n71 CNV Loss 21882294
nsv908871 CNV Loss 21882294
nsv470607 CNV Loss 18288195
nsv908872 CNV Gain 21882294
dgv3279n71 CNV Loss 21882294

Variation tolerance for C17orf99 Gene

Gene Damage Index Score: 3.57; 56.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C17orf99 Gene

HapMap Linkage Disequilibrium report
C17orf99

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf99 Gene

Disorders for C17orf99 Gene

Relevant External Links for C17orf99

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C17orf99

No disorders were found for C17orf99 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf99 Gene

Publications for C17orf99 Gene

  1. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3
  3. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for C17orf99 Gene

Sources for C17orf99 Gene

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