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Aliases for C17orf99 Gene

Aliases for C17orf99 Gene

  • Chromosome 17 Open Reading Frame 99 2 3 5
  • Uncharacterized Protein C17orf99 3
  • GLPG464 3
  • UNQ464 3

External Ids for C17orf99 Gene

Previous GeneCards Identifiers for C17orf99 Gene

  • GC17U901110
  • GC17P073655
  • GC17P076142
  • GC17P071566

Summaries for C17orf99 Gene

GeneCards Summary for C17orf99 Gene

C17orf99 (Chromosome 17 Open Reading Frame 99) is a Protein Coding gene.

Additional gene information for C17orf99 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C17orf99 Gene

Genomics for C17orf99 Gene

Regulatory Elements for C17orf99 Gene

Enhancers for C17orf99 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H078170 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +28.0 28019 6 HDGF YY1 GLIS2 ZNF143 KLF7 RUNX3 PAF1 SP3 ZHX2 REST AFMID C17orf99 TNRC6C-AS1 SYNGR2 TK1 TMC6 PGS1 SOCS3 GC17P078174
GH17H078197 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +52.8 52813 3 CTCF PKNOX1 BATF ZIC2 CTBP1 GATA3 POLR2A ZNF548 PAF1 SMARCE1 PGS1 USP36 TMEM235 SYNGR2 C17orf99 TNRC6C-AS1 ENSG00000200063 RNU6-625P SEPT9 SOCS3
GH17H078112 1.2 ENCODE dbSUPER 12.3 -32.4 -32412 2 HDGF ZFP64 ARID4B SIN3A ZNF2 SLC30A9 GLIS2 ZNF143 ZNF207 RUNX3 USP36 TK1 AFMID C17orf99 SYNGR2 RNU6-625P TNRC6C-AS1 TMC8
GH17H078226 1.2 Ensembl ENCODE dbSUPER 11.1 +81.3 81335 1 NFIB MAFG ZEB2 ZNF501 DPF2 ZKSCAN1 HIC1 ZNF316 MAFF POLR2A BIRC5 AFMID TK1 SYNGR2 TNRC6C-AS1 C17orf99 PGS1 ENSG00000200063 TMEM235 GC17M078223
GH17H078179 1.1 Ensembl ENCODE dbSUPER 11.9 +33.9 33936 2 SMARCC1 JUND NR2F1 CEBPB FOS ZNF600 NR2F2 C17orf99 TNRC6C-AS1 AFMID SYNGR2 GC17P078174
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C17orf99 on UCSC Golden Path with GeneCards custom track

Genomic Location for C17orf99 Gene

Chromosome:
17
Start:
78,146,040 bp from pter
End:
78,166,904 bp from pter
Size:
20,865 bases
Orientation:
Plus strand

Genomic View for C17orf99 Gene

Genes around C17orf99 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf99 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf99 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf99 Gene

Proteins for C17orf99 Gene

  • Protein details for C17orf99 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX52-CQ099_HUMAN
    Recommended name:
    Uncharacterized protein C17orf99
    Protein Accession:
    Q6UX52

    Protein attributes for C17orf99 Gene

    Size:
    265 amino acids
    Molecular mass:
    29091 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C17orf99 Gene

Post-translational modifications for C17orf99 Gene

  • Glycosylation at Asn86 and posLast=132132
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C17orf99 Gene

Domains & Families for C17orf99 Gene

Gene Families for C17orf99 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for C17orf99 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C17orf99: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C17orf99 Gene

Function for C17orf99 Gene

Phenotypes From GWAS Catalog for C17orf99 Gene

Phenotypes for C17orf99 Gene

MGI mutant phenotypes for C17orf99:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with C17orf99: view

Animal Models for C17orf99 Gene

MGI Knock Outs for C17orf99:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C17orf99
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C17orf99 Gene

Localization for C17orf99 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C17orf99 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C17orf99 gene
Compartment Confidence
extracellular 4
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C17orf99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C17orf99: view

Pathways & Interactions for C17orf99 Gene

SuperPathways for C17orf99 Gene

No Data Available

Interacting Proteins for C17orf99 Gene

Gene Ontology (GO) - Biological Process for C17orf99 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C17orf99 Gene

Drugs & Compounds for C17orf99 Gene

No Compound Related Data Available

Transcripts for C17orf99 Gene

mRNA/cDNA for C17orf99 Gene

(7) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C17orf99 Gene

Chromosome 17 open reading frame 99:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C17orf99
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf99 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: -
SP3:

Relevant External Links for C17orf99 Gene

GeneLoc Exon Structure for
C17orf99
ECgene alternative splicing isoforms for
C17orf99

Expression for C17orf99 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C17orf99 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C17orf99 Gene

This gene is overexpressed in Whole Blood (x8.3).

NURSA nuclear receptor signaling pathways regulating expression of C17orf99 Gene:

C17orf99

SOURCE GeneReport for Unigene cluster for C17orf99 Gene:

Hs.633034
genes like me logo Genes that share expression patterns with C17orf99: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C17orf99 Gene

Orthologs for C17orf99 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C17orf99 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf99 33
  • 97.99 (n)
C17orf99 34
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H17orf99 33
  • 77.14 (n)
C17orf99 34
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 6030468B19Rik 33 16 34
  • 70.35 (n)
rat
(Rattus norvegicus)
Mammalia LOC688282 33
  • 68.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C17orf99 34
  • 43 (a)
OneToOne
Species where no ortholog for C17orf99 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C17orf99 Gene

ENSEMBL:
Gene Tree for C17orf99 (if available)
TreeFam:
Gene Tree for C17orf99 (if available)

Paralogs for C17orf99 Gene

No data available for Paralogs for C17orf99 Gene

Variants for C17orf99 Gene

Sequence variations from dbSNP and Humsavar for C17orf99 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000005612 -- 78,157,525(+) CGGGC(C/G)CGGTG intron-variant
rs1000189467 -- 78,152,915(+) CATCT(C/T)TATTA intron-variant
rs1000583088 -- 78,163,653(+) TTGAG(C/T)CCAGG intron-variant
rs1000691176 -- 78,151,911(+) GAATT(C/T)CTAAG intron-variant
rs1000830242 -- 78,162,135(+) GCTGG(A/G)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C17orf99 Gene

Variant ID Type Subtype PubMed ID
nsv1141943 OTHER inversion 24896259
nsv470607 CNV loss 18288195
nsv833554 CNV gain+loss 17160897

Variation tolerance for C17orf99 Gene

Gene Damage Index Score: 3.57; 56.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C17orf99 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C17orf99

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf99 Gene

Disorders for C17orf99 Gene

Relevant External Links for C17orf99

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C17orf99

No disorders were found for C17orf99 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf99 Gene

Publications for C17orf99 Gene

  1. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 60
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 60
  4. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 60
  5. Identification of IL-40, a Novel B Cell-Associated Cytokine. (PMID: 28978694) Catalan-Dibene J … Zlotnik A (Journal of immunology (Baltimore, Md. : 1950) 2017) 3

Products for C17orf99 Gene

Sources for C17orf99 Gene

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