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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C17orf97 Gene

protein-coding   GIFtS: 37
GCID: GC17P000261

Chromosome 17 Open Reading Frame 97

  Search for C17orf97
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 17 Open Reading Frame 971 2
Uncharacterized Protein C17orf972

External Ids:    HGNC: 338001   Entrez Gene: 4005662   Ensembl: ENSG000001876247   UniProtKB: Q6ZQX73   

Export aliases for C17orf97 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C17orf97 Gene: 
C17orf97 (chromosome 17 open reading frame 97) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_024972.8  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C17orf97 gene promoter:
         NCX/Ncx   Nkx2-2   CUTL1   GATA-1   FOXC1   HFH-1   FOXJ2 (long isoform)   c-Myb   FOXJ2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C17orf97

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf97


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

C17orf97 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C17orf97 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P000261:  view genomic region     (about GC identifiers)

Start:
260,118 bp from pter      End:
273,510 bp from pter
Size:
13,393 bases      Orientation:
plus strand

1 alternative location:
Chr17+,NW_003315951 7,690-12,029     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CQ097_HUMAN, Q6ZQX7 (See protein sequence)
Recommended Name: Uncharacterized protein C17orf97  
Size: 453 amino acids; 49656 Da
Secondary accessions: A5D8T6 Q6NSI2 Q6PFW9
Alternative splicing: 4 isoforms:  Q6ZQX7-1   Q6ZQX7-2   Q6ZQX7-3   Q6ZQX7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C17orf97: NX_Q6ZQX7

Explore proteomics data for C17orf97 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZQX7

  • C17orf97 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C17orf97 Protein Expression
    REFSEQ proteins: NP_001013694.4  
    ENSEMBL proteins: 
     ENSP00000353245   ENSP00000458320   ENSP00000419482   ENSP00000466848  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6ZQX7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C17orf97

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C17orf97 (CQ097)

    Search CenterWatch for drugs/clinical trials and news about C17orf97 / CQ097

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for C17orf97 gene: 
    NM_001013672.4  

    Unigene Cluster for C17orf97:

    Chromosome 17 open reading frame 97
    Hs.499607  [show with all ESTs]
    Unigene Representative Sequence: BC057385
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360127(uc021tna.1) ENST00000571106 ENST00000491373 ENST00000575151(uc010vpz.1)

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    Additional mRNA sequence: 

    AK128660.1 BC057385.1 BC070116.1 BC141806.1 

    6 DOTS entries:

    DT.100670332  DT.112919  DT.99986889  DT.112918  DT.97765530  DT.97778396 

    24/65 AceView cDNA sequences (see all 65):

    AI589189 BE467721 BU148800 BF061796 BE552331 BE466454 AA398562 BM560032 
    AA417326 BQ448081 BM685723 BM725863 BC057385 H20793 H46053 AL044401 
    BM677979 AA405740 H42912 CB305397 AW956653 AW515801 BQ045333 BG236810 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C17orf97 expression in normal human tissues (normalized intensities)      C17orf97 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGCCTTT
    C17orf97 Expression
    About this image


    C17orf97 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Lung (Respiratory System)

    See C17orf97 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C17orf97

    SOURCE GeneReport for Unigene cluster: Hs.499607
        SABiosciences Custom PCR Arrays for C17orf97
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf97

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C17orf97 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1700016K19Rik1 , 5 RIKEN cDNA 1700016K19 gene1, 5 73.65(n)1
    65.5(a)1
      11 (45.92 cM)5
    742301  NM_198637.21  NP_941039.11 
     759999125 
    zebrafish
    (Danio rerio)
    Actinopterygii C21H17orf976
    chromosome 17 open reading frame 97
    26(a)
    1 ↔ 1
    21(38127129-38133979)


    ENSEMBL Gene Tree for C17orf97 (if available)
    TreeFam Gene Tree for C17orf97 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/243 SNPs in C17orf97 are shown (see all 243)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432109381,2
    C--258132(+) TGTCAC/TCCAGG 1 -- us2k10--------
    rs129497881,2
    C--258223(+) aatagC/Ttggga 1 -- us2k1 tfbs36Minor allele frequency- T:0.00NA WA CSA 11
    rs1401274381,2
    C--258235(+) TACATA/GCACCC 1 -- us2k10--------
    rs1503142631,2
    C--258253(+) TGCCCA/GGCTAA 1 -- us2k10--------
    rs1379937661,2
    C--258370(+) TACAGA/GCGTGA 1 -- us2k10--------
    rs1431617971,2
    --258420(+) CAATCG/TGTGGA 1 -- us2k10--------
    rs1914844031,2
    --258710(+) CTGAGA/GCAGAA 1 -- us2k10--------
    rs129497551,2
    C,F,A--258807(+) tctccC/Aaaaaa 1 -- us2k1 trp36Minor allele frequency- A:0.50NA EA 248
    rs1849657451,2
    C--258868(+) GGTGCA/GATCTC 1 -- us2k10--------
    rs98954471,2
    C,F,A,H--258914(+) CCTCAG/ACGCAG 1 -- us2k121Minor allele frequency- A:0.22NS EA NA WA CSA 2062

    HapMap Linkage Disequilibrium report for C17orf97 (260118 - 273510 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for C17orf97:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715302CNV Deletion23290073
    esv1210692CNV Deletion17803354
    esv2715298CNV Deletion23290073
    esv2715301CNV Deletion23290073
    esv998391CNV Deletion20482838
    esv2422420CNV Duplication17116639
    nsv827849CNV Gain20364138
    nsv907452CNV Gain21882294
    nsv457627CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C17orf97 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C17orf97)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 400566 HGNC: 33800 AceView: LOC400566 Ensembl:ENSG00000187624 euGenes: HUgn400566
    ECgene: C17orf97 H-InvDB: C17orf97

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C17orf97 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C17orf97 gene:
    Search GeneIP for patents involving C17orf97

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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