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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C17orf97 Gene

protein-coding   GIFtS: 36
GCID: GC17P000261

chromosome 17 open reading frame 97
  Search for C17orf97
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C17orf97    

Aliases
for C17orf97 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 17 Open Reading Frame 971 2
LOC4005661
Uncharacterized Protein C17orf972

External Ids:    HGNC: 338001   Entrez Gene: 4005662   Ensembl: ENSG000001876247   UniProtKB: Q6ZQX73   

Export aliases for C17orf97 gene to outside databases


Summaries
for C17orf97 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C17orf97 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_024972.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C17orf97 gene promoter:
         NCX/Ncx   Nkx2-2   CUTL1   GATA-1   FOXC1   HFH-1   FOXJ2 (long isoform)   c-Myb   FOXJ2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C17orf97

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf97


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

C17orf97 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C17orf97 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P000261:  view genomic region     (about GC identifiers)

Start:
 260,118 bp from pter      End:
 273,510 bp from pter
Size:
 13,393 bases      Orientation:
 plus strand

1 alternative location:
Chr17+,PATCHES 260,118-264,457     

Proteins
for C17orf97 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CQ097_HUMAN, Q6ZQX7 (See protein sequence)
Recommended Name: Uncharacterized protein C17orf97  
Size: 453 amino acids; 49656 Da
Secondary accessions: A5D8T6 Q6NSI2 Q6PFW9
Alternative splicing: 4 isoforms:  Q6ZQX7-1   Q6ZQX7-2   Q6ZQX7-3   Q6ZQX7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C17orf97: NX_Q6ZQX7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZQX7

    • C17orf97 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001013694.4  
    ENSEMBL proteins: 
     ENSP00000353245   ENSP00000458320   ENSP00000419482   ENSP00000466848  

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    Protein Domains /
    Families
    for C17orf97 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6ZQX7


    Function
    for C17orf97 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for C17orf97 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C17orf97

    Drugs & Compounds
    for C17orf97 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for C17orf97
    Search CenterWatch for drugs/clinical trials and news about C17orf97 / CQ097 

    Transcripts
    for C17orf97 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for C17orf97 gene: 
    NM_001013672.4  

    Unigene Cluster for C17orf97:

    Chromosome 17 open reading frame 97
    Hs.499607  [show with all ESTs]
    Unigene Representative Sequence: BC057385
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360127(uc021tna.1) ENST00000571106 ENST00000491373 ENST00000575151(uc010vpz.1)


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    Inhib. RNA
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    Additional cDNA sequence: 

    AK128660.1 BC057385.1 BC070116.1 BC141806.1 

    6 DOTS entries:

    DT.100670332  DT.112919  DT.99986889  DT.112918  DT.97765530  DT.97778396 

    24/65 AceView cDNA sequences (see all 65):

    AI589189 BU148800 BE466454 BE467721 BE552331 BM560032 AA398562 AA417326 
    BF061796 AA417339 H42912 BX119789 AI738578 BG772141 AA405991 BM725863 
    AA393166 BU687907 AA405740 BQ045333 H46053 BM685723 BQ448081 AW515801 

    GeneLoc Exon Structure


    Expression
    for C17orf97 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C17orf97 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTGCCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    C17orf97 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C17orf97 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C17orf97

    SOURCE GeneReport for Unigene cluster: Hs.499607
        SABiosciences Custom PCR Arrays for C17orf97
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    In Situ
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    Orthologs
    for C17orf97 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for C17orf97 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia 1700016K19Rik1 , 5 RIKEN cDNA 1700016K19 gene1, 5 73.65(n)1
    65.5(a)1    		   11 (45.92 cM)5
    742301  NM_198637.21  NP_941039.11 
     759999125 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 41(a)
    40(a)
    		 many → 1
    many → 1
    		 AAWZ02041952(1977-3125)
    GL343494.1(163248-164424)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-274p24.26
    		 si:ch211-274p24.2
    		 24(a)
    		 1 ↔ 1
    		 21(38127129-38133979)


    ENSEMBL Gene Tree for C17orf97 (if available)
    TreeFam Gene Tree for C17orf97 (if available) 

    Paralogs
    for C17orf97 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C17orf97 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/201 NCBI SNPs in C17orf97 are shown (see all 201)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1432109381,2
    		--258132(+) TGTCAC/TCCAGG 1 -- us2k10--------
    rs129497881,2
    		C,--258223(+) AATAGC/TTGGGA 1 -- us2k1 tfbs36Minor allele frequency- T:0.00NA WA CSA 11
    rs1401274381,2
    		--258235(+) TACATA/GCACCC 1 -- us2k10--------
    rs1503142631,2
    		--258253(+) TGCCCA/GGCTAA 1 -- us2k10--------
    rs1379937661,2
    		--258370(+) TACAGA/GCGTGA 1 -- us2k10--------
    rs1431617971,2
    		--258420(+) CAATCG/TGTGGA 1 -- us2k10--------
    rs1914844031,2
    		--258710(+) CTGAGA/GCAGAA 1 -- us2k10--------
    rs129497551,2
    		C,F,A,--258807(+) TCTCCC/AAAAAA 1 -- us2k1 trp36Minor allele frequency- A:0.50NA EA 248
    rs355431461,2
    		C--258808(+) AAAAA-/AGAGAG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1849657451,2
    		--258868(+) GGTGCA/GATCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C17orf97 (260118 - 273510 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for C17orf97: --

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    Disorders / Diseases
    for C17orf97 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C17orf97 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C17orf97 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C17orf97)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    External Searches for C17orf97 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C17orf97 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 400566 HGNC: 33800 AceView: LOC400566 Ensembl:ENSG00000187624 euGenes: HUgn400566
    ECgene: C17orf97 H-InvDB: C17orf97

    Other Databases showing C17orf97 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C17orf97 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C17orf97 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C17orf97 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C17orf97 gene:
    Search GeneIP for patents involving C17orf97

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for C17orf97 gene

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    About This Section

     
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