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C17orf97 Gene

protein-coding   GIFtS: 37
GCID: GC17P000261

Chromosome 17 Open Reading Frame 97

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 17 Open Reading Frame 971 2
Uncharacterized Protein C17orf972

External Ids:    HGNC: 338001   Entrez Gene: 4005662   Ensembl: ENSG000001876247   UniProtKB: Q6ZQX73   

Export aliases for C17orf97 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C17orf97 Gene:
C17orf97 (chromosome 17 open reading frame 97) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_024972.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the C17orf97 gene promoter:
         NCX/Ncx   Nkx2-2   CUTL1   GATA-1   FOXC1   HFH-1   FOXJ2 (long isoform)   c-Myb   FOXJ2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C17orf97

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C17orf97


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

C17orf97 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C17orf97 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P000261:  view genomic region     (about GC identifiers)

Start:
260,118 bp from pter      End:
273,510 bp from pter
Size:
13,393 bases      Orientation:
plus strand

1 alternative location:
Chr17+,NW_003315951 7,690-12,029     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CQ097_HUMAN, Q6ZQX7 (See protein sequence)
Recommended Name: Uncharacterized protein C17orf97  
Size: 453 amino acids; 49656 Da
Secondary accessions: A5D8T6 Q6NSI2 Q6PFW9
Alternative splicing: 4 isoforms:  Q6ZQX7-1   Q6ZQX7-2   Q6ZQX7-3   Q6ZQX7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C17orf97: NX_Q6ZQX7

Explore proteomics data for C17orf97 at MOPED


See C17orf97 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001013694.4  
ENSEMBL proteins: 
 ENSP00000353245   ENSP00000458320   ENSP00000419482   ENSP00000466848  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q6ZQX7


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 MGI phenotypic allele for 1700016K19Rik (no phenotypes)

Find genes that share phenotypes with C17orf97           About GenesLikeMe

Animal Models:
     MGI mouse knock-out 1700016K19Riktm1(KOMP)Vlcg for C17orf97

   genOway: Develop your customized and physiologically relevant rodent model for C17orf97

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C17orf97
Interactions:

    Search GeneGlobe Interaction Network for C17orf97

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C17orf97 (CQ097)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C17orf97 gene: 
NM_001013672.4  

Unigene Cluster for C17orf97:

Chromosome 17 open reading frame 97
Hs.499607  [show with all ESTs]
Unigene Representative Sequence: BC057385
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000360127(uc021tna.1) ENST00000571106 ENST00000491373 ENST00000575151(uc010vpz.1)

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SwitchGear 3'UTR luciferase reporter plasmidC17orf97 3' UTR sequence
Inhib. RNA
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Additional mRNA sequence: 

AK128660.1 BC057385.1 BC070116.1 BC141806.1 

6 DOTS entries:

DT.100670332  DT.112919  DT.99986889  DT.112918  DT.97765530  DT.97778396 

Selected AceView cDNA sequences (see all 65):

AA398562 AA417326 BE466454 BE552331 BE467721 AI589189 BU148800 BF061796 
BM560032 BC057385 BG056786 BI461399 H46053 AL044401 BQ448081 AA843459 
BG236810 AW956653 CB305397 H42912 BM677979 BQ045333 AA417339 H20793 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C17orf97 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCTGCCTTT
C17orf97 Expression
About this image

C17orf97 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C17orf97 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.499607
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for C17orf97 gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 1700016K19Rik1 , 5 RIKEN cDNA 1700016K19 gene1, 5 74.59(n)1
66.83(a)1
  11 (45.92 cM)5
742301  NM_198637.21  NP_941039.11 
 759999125 


ENSEMBL Gene Tree for C17orf97 (if available)
TreeFam Gene Tree for C17orf97 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C17orf97 (see all 243)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1432109381,2
C--258132(+) TGTCAC/TCCAGG 1 -- us2k10--------
rs129497881,2
C--258223(+) aatagC/Ttggga 1 -- us2k1 tfbs36Minor allele frequency- T:0.00NA WA CSA 11
rs1401274381,2
C--258235(+) TACATA/GCACCC 1 -- us2k10--------
rs1503142631,2
C--258253(+) TGCCCA/GGCTAA 1 -- us2k10--------
rs1379937661,2
C--258370(+) TACAGA/GCGTGA 1 -- us2k10--------
rs1431617971,2
--258420(+) CAATCG/TGTGGA 1 -- us2k10--------
rs1914844031,2
--258710(+) CTGAGA/GCAGAA 1 -- us2k10--------
rs129497551,2
C,F,A--258807(+) tctccC/Aaaaaa 1 -- us2k1 trp36Minor allele frequency- A:0.50NA EA 248
rs1849657451,2
C--258868(+) GGTGCA/GATCTC 1 -- us2k10--------
rs98954471,2
C,F,A,H--258914(+) CCTCAG/ACGCAG 1 -- us2k121Minor allele frequency- A:0.22NS EA NA WA CSA 2062

HapMap Linkage Disequilibrium report for C17orf97 (260118 - 273510 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for C17orf97:    About this table    
Variant IDTypeSubtypePubMed ID
esv2715302CNV Deletion23290073
esv1210692CNV Deletion17803354
esv2715298CNV Deletion23290073
esv2715301CNV Deletion23290073
esv998391CNV Deletion20482838
esv2422420CNV Duplication17116639
nsv827849CNV Gain20364138
nsv907452CNV Gain21882294
nsv457627CNV Gain19166990

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C17orf97 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C17orf97)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
  3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 400566 HGNC: 33800 AceView: LOC400566 Ensembl:ENSG00000187624 euGenes: HUgn400566
ECgene: C17orf97 H-InvDB: C17orf97

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C17orf97 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C17orf97 gene:
Search GeneIP for patents involving C17orf97

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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