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C17orf89 Gene

protein-coding   GIFtS: 35
GCID: GC17P079213          (predicted)

Chromosome 17 Open Reading Frame 89

  Search for C17orf89
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 17 Open Reading Frame 891 2
Uncharacterized Protein C17orf892

External Ids:    HGNC: 335511   Entrez Gene: 2841842   Ensembl: ENSG000002248777   UniProtKB: A1L1883   
ORGUL members:         

Export aliases for C17orf89 gene to outside databases

Previous GC identifers: GC17P076828 GC17P074649


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C17orf89 Gene:
C17orf89 (chromosome 17 open reading frame 89) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the C17orf89 gene promoter:
         AhR   C/EBPbeta   Sp1   p53   LCR-F1   HEN1   Pax-3   ARP-1   Pax-4a   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C17orf89

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C17orf89


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

C17orf89 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C17orf89 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P079213:  view genomic region     (about GC identifiers)

Start:
79,213,039 bp from pter      End:
79,215,098 bp from pter
Size:
2,060 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CQ089_HUMAN, A1L188 (See protein sequence)
Recommended Name: Uncharacterized protein C17orf89  
Size: 74 amino acids; 7756 Da

Explore the universe of human proteins at neXtProt for C17orf89: NX_A1L188

Explore proteomics data for C17orf89 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C17orf89 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001079990.1  
    ENSEMBL proteins: 
     ENSP00000400184   ENSP00000458326   ENSP00000461155  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: A1L188


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C17orf89
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    mitochondrion2
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    C17orf89 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C17orf89
    Interactions:

        Search GeneGlobe Interaction Network for C17orf89

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C17orf89 (CQ089)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for C17orf89 gene: 
    NM_001086521.1  

    Unigene Cluster for C17orf89:

    Chromosome 17 open reading frame 89
    Hs.356545  [show with all ESTs]
    Unigene Representative Sequence: BI457009
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431388(uc010dib.1 uc002jzx.2) ENST00000577158 ENST00000573090
    ENST00000576002 ENST00000575067 ENST00000573173
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    Additional mRNA sequence: 

    BC079831.1 BC127837.1 BC141912.1 BC141913.1 

    7 DOTS entries:

    DT.320393  DT.91815322  DT.103225  DT.87016497  DT.120911131  DT.91655604  DT.91872961 

    Selected AceView cDNA sequences (see all 145):

    BE048354 AI217819 BI225218 BU541024 BF446894 AW182347 BQ424151 AI421097 
    BM315054 AI590080 AW072001 AI302111 AI244458 BG942823 AI589610 BG944744 
    AA495720 AV701859 AI924162 BF438512 BM672987 BE270803 BQ631538 AW269777 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C17orf89 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGCAGAGC
    C17orf89 Expression
    About this image

    C17orf89 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C17orf89 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356545
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C17orf89 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1810043H04Rik1 , 5 RIKEN cDNA 1810043H04 gene1, 5 85.39(n)1
    87.67(a)1
      11 (83.96 cM)5
    2085011  NM_001110242.11  NP_001103712.11 
     1200989285 
    zebrafish
    (Danio rerio)
    Actinopterygii C12H17orf896
    chromosome 17 open reading frame 89
    51(a)
    1 ↔ 1
    12(36496011-36498426) ENSDARG00000096749


    ENSEMBL Gene Tree for C17orf89 (if available)
    TreeFam Gene Tree for C17orf89 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C17orf89 gene

    C17orf89 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for C17orf89
    PGOHUM00000262427


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C17orf89 (see all 18)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134901481,2
    C--79214894(+) CATATA/C/TGAATG 2 -- ut311CSA 2
    rs762215651,2
    C,F--79214927(+) AATGGC/TGAAGA 1 -- ut311Minor allele frequency- T:0.03EA 120
    rs1379792371,2
    --79214928(+) ATGGCA/GAAGAT 1 -- ut310--------
    rs30878771,2
    F--79214963(+) TGTTTT/CTTCTT 1 -- ut311Minor allele frequency- C:0.20MN 184
    rs1919156861,2
    --79214984(+) GGCGTA/GGGTAG 1 -- ut310--------
    rs1124178481,2
    C--79215019(+) GTGTCC/TGTAAA 1 -- ut312Minor allele frequency- T:0.06NA 122
    rs1121023811,2
    C--79215101(+) GTGTGC/TAGACT 1 -- ds50012Minor allele frequency- T:0.05CSA WA 120
    rs1494739801,2
    C--79215148(+) GGGCCC/TAGAGC 1 -- ds50010--------
    rs766096161,2
    C,F--79215161(+) TTCCCC/TCAAAG 1 -- ds50012Minor allele frequency- T:0.05CSA WA 120
    rs1837794611,2
    C--79215192(+) GGACAA/CCCTGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for C17orf89 (79213039 - 79215098 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for C17orf89 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2161CNV Insertion18451855
    nsv509677CNV Insertion20534489
    dgv3318n71CNV Loss21882294
    dgv3316n71CNV Loss21882294
    dgv3317n71CNV Loss21882294
    dgv46n68CNV Loss17160897
    dgv3308n71CNV Loss21882294
    nsv457971CNV Loss19166990
    dgv3321n71CNV Loss21882294
    nsv470619CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C17orf89
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C17orf89 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C17orf89)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. (PubMed id 17287340)1, 3 Molina H.... Pandey A. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284184 HGNC: 33551 AceView: LOC284184 Ensembl:ENSG00000224877 euGenes: HUgn284184
    ECgene: C17orf89 H-InvDB: C17orf89

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for C17orf89 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C17orf89 gene:
    Search GeneIP for patents involving C17orf89

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse SwitchGear Promoter luciferase reporter plasmids for C17orf89
     Search ThermoFisher Antibodies for C17orf89
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf89
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C17orf89
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C17orf89
     Search LSBio for Antibodies for C17orf89
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