C17orf85 Gene
protein-coding GIFtS: 45
GCID: GC17M003724
|
|
chromosome 17 open reading frame 85
| |
Aliases
for C17orf85 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 17 Open Reading Frame 851 2 | | ELG1 2 | | HSA2778411 2 | | Uncharacterized Protein C17orf852 | | Protein ELG3 |
Export aliases for C17orf85 gene to outside databasesPrevious GC identifers: GC17M003662 GC17M003604 GC17M003715 GC17M003720 |
Summaries
for C17orf85 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C17orf85 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C17orf85 gene promoter:
STAT5B STAT1 STAT4 STAT1beta STAT5A STAT1alpha AREB6 STAT2 STAT3 TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for C17orf85
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf85 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.2C17orf85 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M003724: view genomic region
(about GC identifiers)
Start:
|
3,714,460 bp from pter |
End:
|
3,749,545 bp from pter |
Size:
|
35,086 bases |
Orientation:
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minus strand |
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Proteins
for C17orf85 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CQ085_HUMAN, Q53F19 (See
protein sequence)Recommended Name: Uncharacterized protein C17orf85 Size: 620 amino acids; 70593 Da
Sequence caution: Sequence=BAD97190.1; Type=Erroneous initiation;
Secondary accessions: B3KWG7 Q7L406 Q96FK1 Q9NXZ4Alternative splicing: 2 isoforms: Q53F19-1 Q53F19-2 Explore the universe of human proteins at neXtProt for C17orf85: NX_Q53F19
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q53F19
C17orf85 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001107590.1
ENSEMBL proteins: ENSP00000467742 ENSP00000373657 ENSP00000466165 ENSP00000158149
Human Recombinant Protein Products:
C17orf85 Antibody Products:
Assay Products for C17orf85: |
Protein
Domains /
Families
for C17orf85 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C17orf85 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q53F19ProtoNet protein and cluster: Q53F19 |
Function
for C17orf85 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf85 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf85 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for C17orf85 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf85 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf85 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- |
C17orf85 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for C17orf85:
|
Pathways & Interactions
for C17orf85 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C17orf85
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for C17orf85 (Q53F192, 3 ENSP000003736574) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for C17orf85 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C17orf85
Search CenterWatch for drugs/clinical trials and news about C17orf85 / CQ085
|
Transcripts
for C17orf85 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C17orf85 gene (2 alternative transcripts): NM_018553.3 NM_001114118.2 Unigene Cluster for C17orf85: Chromosome 17 open reading frame 85 Hs.120963 [show with all ESTs]Unigene Representative Sequence: NM_0011141187 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000574911 ENST00000575815(uc002fwr.2) ENST00000389005 ENST00000576523
ENST00000574379 ENST00000577169 ENST00000158149(uc002fwq.2 uc010ckl.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf85 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf85 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C17orf85 (NM_001114118) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C17orf85 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf85 |
Additional cDNA sequence: AJ277841.1 AK056724.1 AK223470.1 BC010707.1 BC011733.2 13 DOTS entries: DT.86854135 DT.409549 DT.100723236 DT.91700920 DT.121004291 DT.100653334 DT.101967753 DT.40250614 DT.91698135 DT.86839741 DT.91637696 DT.86859574 DT.91933195 24/114 AceView cDNA sequences (see all 114): AA887937 BI041684 BM681344 AI189982 BC010707 CF529779 AA884163 CD652060 AI933559 AI804370 BQ011979 CF227220 BI062143 AA706815 CF227216 CF227218 AK125048 BE220254 AI131055 BM728166 AA693932 AW340034 BF512666 F01447
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for C17orf85 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C17orf85
|
Expression
for C17orf85 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C17orf85 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCGTTAGAG
About this image
See C17orf85 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C17orf85
SOURCE GeneReport for Unigene cluster: Hs.120963
SABiosciences Custom PCR Arrays for C17orf85
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C17orf85
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C17orf85 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C17orf85 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C17orf85 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf85 |
Orthologs
for C17orf85 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C17orf85 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
1200014J11Rik1 , 5 |
RIKEN cDNA 1200014J11 gene1, 5 |
90.08(n)1
95.28(a)1 |
|
11 (45.16 cM)5
668741 NM_025818.31 NP_080094.31
730477835 |
chicken
(Gallus gallus) |
Aves |
C19H17orf851 |
chromosome 19 open reading frame, human C17orf85 |
76.67(n)
82.67(a) |
|
417552 NM_001012805.1 NP_001012823.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.334632 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.16(n) |
|
BJ038719.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc558702 |
hypothetical protein MGC55870 |
75.46(n) |
|
393112 BC044520.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
25(a) |
1 ↔ 1 |
GroupUn.653(24405-26910) |
ENSEMBL Gene Tree for C17orf85 (if available)
TreeFam Gene Tree for C17orf85 (if available) |
Paralogs
for C17orf85 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C17orf85 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C17orf85 (3714460 - 3749545 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for C17orf85
3 CNVs: 88318 88319 4983 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C17orf85 |
|
Disorders
/ Diseases
for C17orf85 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C17orf85 for disorders About GeneDecksing
2  diseases for C17orf85: About MalaCardsabdominal aortic aneurysm aortic aneurysm
2 diseases from the University of Copenhagen DISEASES database for C17orf85:Vertebral artery insufficiency Abdominal aortic aneurysm Export disorders for C17orf85 gene to outside databases
|
Publications
for C17orf85 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C17orf85 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with C17orf85) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Studies on transcriptional regulation of the mucosal T-cell integrin alphaEbeta7 (CD103). (PubMed id 11412301)1, 3 Robinson P.W....Kilshaw P.J. (2001)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
|
External Searches for C17orf85 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C17orf85 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C17orf85 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C17orf85 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C17orf85 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C17orf85 gene:
Search GeneIP for patents involving C17orf85
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C17orf85 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C17orf85 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C17orf85 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C17orf85 | | | OriGene Protein Over-expression Lysate for C17orf85 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C17orf85 | | OriGene 3'-UTR Clone for C17orf85 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf85 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf85 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C17orf85 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C17orf85 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf85 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C17orf85 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C17orf85 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C17orf85 |
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 | | | C17orf85 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf85 |
|  |  |  | | | | Search ThermoFisher Antibodies for C17orf85 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf85 |
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