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Aliases for C17orf80 Gene

Aliases for C17orf80 Gene

  • Chromosome 17 Open Reading Frame 80 2 3 5
  • Cell Migration-Inducing Gene 3 Protein 3 4
  • Human Lung Cancer Oncogene 8 Protein 3 4
  • Sperm-Expressed Protein 1 2 3
  • HLC-8 3 4
  • Uncharacterized Protein C17orf80 3
  • Lung Cancer-Related Protein 8 3
  • Migration-Inducing Protein 3 2
  • SPEP1 3
  • MIG3 3

External Ids for C17orf80 Gene

Previous GeneCards Identifiers for C17orf80 Gene

  • GC17P068741
  • GC17P071228
  • GC17P066637

Summaries for C17orf80 Gene

GeneCards Summary for C17orf80 Gene

C17orf80 (Chromosome 17 Open Reading Frame 80) is a Protein Coding gene.

Additional gene information for C17orf80 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C17orf80 Gene

Genomics for C17orf80 Gene

Regulatory Elements for C17orf80 Gene

Enhancers for C17orf80 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H072444 1.8 FANTOM5 Ensembl ENCODE dbSUPER 28 -786.2 -786225 3 FOXA2 ATF1 ZNF493 ZFP64 ARID4B SIN3A DMAP1 ZNF202 SP5 ZC3H11A C17orf80 CDC42EP4 COG1 SOX9 GC17P072434 GC17M072441
GH17H073191 1.1 ENCODE 26.5 -39.4 -39416 2 HNRNPUL1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 SP3 SP5 C17orf80 SSTR2 FAM104A CDC42EP4 COG1 ENSG00000277728
GH17H073303 1.8 FANTOM5 ENCODE dbSUPER 15.1 +75.9 75939 9 MLX DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 MCM3 NFYC PPARGC1A C17orf80 ENSG00000265935 LINC02092 ENSG00000266765 ENSG00000265927 FAM104A SSTR2 CDC42EP4 GC17M073290
GH17H073287 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.2 +59.5 59518 7 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF143 CDC42EP4 CPSF4L FAM104A C17orf80 GC17P073281 GC17M073288
GH17H072586 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -642.3 -642274 6 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 FOS SP3 MYL6P5 ENSG00000225818 C17orf80 GC17P072592 GC17M072441
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C17orf80 on UCSC Golden Path with GeneCards custom track

Promoters for C17orf80 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098068 167 2401 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143

Genomic Location for C17orf80 Gene

Chromosome:
17
Start:
73,232,233 bp from pter
End:
73,248,959 bp from pter
Size:
16,727 bases
Orientation:
Plus strand

Genomic View for C17orf80 Gene

Genes around C17orf80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf80 Gene

Proteins for C17orf80 Gene

  • Protein details for C17orf80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSJ5-CQ080_HUMAN
    Recommended name:
    Uncharacterized protein C17orf80
    Protein Accession:
    Q9BSJ5
    Secondary Accessions:
    • A8K9X3
    • Q5JB45
    • Q6YAU3
    • Q9H0L9
    • Q9H5E6
    • Q9NWN5

    Protein attributes for C17orf80 Gene

    Size:
    609 amino acids
    Molecular mass:
    67315 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP72185.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91344.1; Type=Frameshift; Positions=121; Evidence={ECO:0000305}; Sequence=BAB15680.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C17orf80 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C17orf80 Gene

Post-translational modifications for C17orf80 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C17orf80 Gene

Domains & Families for C17orf80 Gene

Gene Families for C17orf80 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for C17orf80 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C17orf80 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C17orf80: view

No data available for UniProtKB/Swiss-Prot for C17orf80 Gene

Function for C17orf80 Gene

Phenotypes From GWAS Catalog for C17orf80 Gene

Gene Ontology (GO) - Molecular Function for C17orf80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C17orf80: view

Phenotypes for C17orf80 Gene

GenomeRNAi human phenotypes for C17orf80:
genes like me logo Genes that share phenotypes with C17orf80: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C17orf80 Gene

Localization for C17orf80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C17orf80 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C17orf80 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C17orf80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with C17orf80: view

Pathways & Interactions for C17orf80 Gene

SuperPathways for C17orf80 Gene

No Data Available

Interacting Proteins for C17orf80 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000351937%0d%0a9606.ENSP00000330433%0d%0a9606.ENSP00000237201%0d%0a
Selected Interacting proteins: Q9BSJ5-CQ080_HUMAN ENSP00000351937 for C17orf80 Gene via IID STRING

Gene Ontology (GO) - Biological Process for C17orf80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C17orf80: view

No data available for Pathways by source and SIGNOR curated interactions for C17orf80 Gene

Drugs & Compounds for C17orf80 Gene

No Compound Related Data Available

Transcripts for C17orf80 Gene

Unigene Clusters for C17orf80 Gene

Chromosome 17 open reading frame 80:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf80 Gene

No ASD Table

Relevant External Links for C17orf80 Gene

GeneLoc Exon Structure for
C17orf80
ECgene alternative splicing isoforms for
C17orf80

Expression for C17orf80 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C17orf80 Gene

mRNA differential expression in normal tissues according to GTEx for C17orf80 Gene

This gene is overexpressed in Testis (x5.0).

Protein differential expression in normal tissues from HIPED for C17orf80 Gene

This gene is overexpressed in Kidney (25.6), Liver (13.8), Lung (6.9), and Breast (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C17orf80 Gene



NURSA nuclear receptor signaling pathways regulating expression of C17orf80 Gene:

C17orf80

SOURCE GeneReport for Unigene cluster for C17orf80 Gene:

Hs.12929

Evidence on tissue expression from TISSUES for C17orf80 Gene

  • Kidney(4.2)
  • Lung(4.2)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with C17orf80: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C17orf80 Gene

Orthologs for C17orf80 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C17orf80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf80 33 34
  • 98.74 (n)
dog
(Canis familiaris)
Mammalia C9H17orf80 33
  • 78.02 (n)
C17orf80 34
  • 64 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C19H17orf80 33
  • 73.02 (n)
C17orf80 34
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D11Wsu47e 33 16 34
  • 65.38 (n)
rat
(Rattus norvegicus)
Mammalia MGC95210 33
  • 65.38 (n)
oppossum
(Monodelphis domestica)
Mammalia C17orf80 34
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C17orf80 34
  • 31 (a)
OneToOne
Species where no ortholog for C17orf80 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C17orf80 Gene

ENSEMBL:
Gene Tree for C17orf80 (if available)
TreeFam:
Gene Tree for C17orf80 (if available)

Paralogs for C17orf80 Gene

Pseudogenes.org Pseudogenes for C17orf80 Gene

genes like me logo Genes that share paralogs with C17orf80: view

No data available for Paralogs for C17orf80 Gene

Variants for C17orf80 Gene

Sequence variations from dbSNP and Humsavar for C17orf80 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs776418014 Uncertain significance 73,236,455(+) AGGAA(C/T)GGACT intron-variant, reference, missense
rs1000011998 -- 73,239,086(+) TATGC(A/G)CCACC intron-variant
rs1000087812 -- 73,244,762(+) AGTGC(C/T)TAGTG intron-variant
rs1000147716 -- 73,245,599(+) TACAG(A/G)AAAGT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000524839 -- 73,244,982(+) TGAAA(A/G)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C17orf80 Gene

Variant ID Type Subtype PubMed ID
nsv2138 CNV insertion 18451855
nsv833534 CNV loss 17160897

Variation tolerance for C17orf80 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C17orf80 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C17orf80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf80 Gene

Disorders for C17orf80 Gene

Relevant External Links for C17orf80

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C17orf80

No disorders were found for C17orf80 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf80 Gene

Publications for C17orf80 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales PA … Knepper MA (Journal of the American Society of Nephrology : JASN 2009) 3 60

Products for C17orf80 Gene

Sources for C17orf80 Gene

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