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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C17orf76-AS1 Gene

RNA gene GIFtS: 38
GCID: GC17P016358

C17orf76 antisense RNA 1

(Previous names: chromosome 17 open reading frame 45, non-protein coding...)
(Previous symbols: C17orf45, NCRNA00188)

Explore 2 diseases affiliated with
C17orf76-AS1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Subcategory (RNA class): processed_transcript

Quality score for this RNA gene is 3

Aliases
C17orf76 Antisense RNA 1¹ ² ³		Chromosome 17 Open Reading Frame 45¹
C17orf45¹ ² ³		Non-Protein Coding RNA 188¹
NCRNA00188¹ ² ³		TSAP19²
MGC40157¹		C17orf76 Antisense Gene Protein 1³
C17orf76 Antisense RNA 1 (Non-Protein Coding)¹

External Ids:	HGNC: 28619¹	Entrez Gene: 125144²	Ensembl: ENSG00000175061⁷	UniProtKB: Q8N1F1³

Export aliases for C17orf76-AS1 gene to outside databases

Previous GC identifers: GC17P016348 GC17P016350 GC17P016354

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for C17orf76-AS1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C17orf76-AS1 promoter sequence

Search SABiosciences Chromatin IP Primers for C17orf76-AS1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf76-AS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2

C17orf76-AS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C17orf76-AS1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P016358: view genomic region (about GC identifiers)

Start:	16,342,136 bp from pter	End:	16,381,992 bp from pter
Size:	39,857 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: C1AS1_HUMAN, Q8N1F1 (See protein sequence)

Recommended Name: Putative uncharacterized protein C17orf76-AS1, mitochondrial precursor

Size: 130 amino acids; 13824 Da

Subcellular location: Mitochondrion (Potential)

Caution: Product of a dubious CDS prediction. Probable non-coding RNA

Explore the universe of human proteins at neXtProt for C17orf76-AS1: NX_Q8N1F1

C17orf76-AS1 Protein expression data from MOPED and PaxDb: --

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--

C17orf76-AS1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8N1F1

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C17orf76-AS1

1 Interacting protein for C17orf76-AS1 (Q8N1F1^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KLF10	Q13118²^,³	MINT-8259172 I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C17orf76-AS1
Search CenterWatch for drugs/clinical trials and news about C17orf76-AS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C17orf76-AS1 gene:

NM_152350.3

Unigene Cluster for C17orf76-AS1:

C17orf76 antisense RNA 1

Hs.368934 [show with all ESTs]

Unigene Representative Sequence: BG027878

18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):

ENST00000584177 ENST00000487066 ENST00000580180 ENST00000475947 ENST00000481898(uc002gqb.4 uc010vwk.2 uc021tqx.1 uc010vwi.2 uc002gqa.4)

ENST00000497774(uc021tqu.1 uc021tqv.1 uc021tqw.1 uc010vwh.2 uc010cpd.3 uc021tqy.1 uc010vwg.2 uc010vwj.2)

ENST00000582911 ENST00000584141 ENST00000584926 ENST00000581361(uc010cpe.2)

ENST00000581718 ENST00000580770 ENST00000578757(uc010vwf.2) ENST00000492250

ENST00000472293 ENST00000579473 ENST00000475953(uc021tqt.1 uc002gqc.3 uc021tqz.1)

ENST00000578380

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C17orf76-AS1

Additional cDNA sequence:

AJ012499.1 AK098643.1 AK307982.1 AK308482.1 AK309961.1 AK311247.1 BC012396.1 BC019833.1

BC027986.1 BC040159.1 BX538291.1 NR_027158.1 NR_027159.1 NR_027160.1 NR_027161.1 NR_027162.1

NR_027163.1 NR_027164.1 NR_027165.1 NR_027166.1 NR_027167.1 NR_027168.2 NR_027169.1 NR_027170.1

NR_027171.1 NR_027172.2 NR_027173.1 NR_027174.1 NR_027175.1 NR_027176.1 NR_027177.1 NR_027178.1

NR_027179.1 NR_027667.1 NR_045021.1 NR_045022.1 NR_045023.1 NR_045024.1 NR_045025.1 NR_045026.1

NR_045027.1 NR_045028.1 NR_045029.1

24/74 DOTS entries (see all 74):

DT.99926865 DT.97869724 DT.100801729 DT.100741270 DT.91781339 DT.91781349 DT.100741310 DT.319228

DT.91952129 DT.97869733 DT.99982909 DT.100741313 DT.319230 DT.100741208 DT.91781321 DT.97869730

DT.101987484 DT.120965729 DT.91781357 DT.95258739 DT.97869732 DT.99926870 DT.100844786 DT.120965556

21 AceView cDNA sequences:

AJ012499 CR608772 CR609832 CR591104 CR619468 CR617187 BC012396 CR622208

CR596984 CR592897 CR617966 CR616072 CR604967 AK098643 NM_152350 BC019833

BC040159 BC027986 BX538291 CR596839 CR590510

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for C17orf76-AS1 (see all 21) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	·	5e	·	5f	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	·	8e	·	8f
SP1:							-		-		-		-						-								-		-		-						-		-		-
SP2:											-		-						-		-		-		-		-		-		-						-		-		-
SP3:																			-		-						-		-		-						-		-		-
SP4:																											-		-		-						-		-		-
SP5:																											-		-								-		-		-

ECgene alternative splicing isoforms for C17orf76-AS1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for C17orf76-AS1:none

C17orf76-AS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTAATACT

About this image

C17orf76-AS1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for C17orf76-AS1

SOURCE GeneReport for Unigene cluster: Hs.368934

SABiosciences Custom PCR Arrays for C17orf76-AS1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for C17orf76-AS1 (if available)
TreeFam Gene Tree for C17orf76-AS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143429880^1,2		--	16340895(+)	`CTCCAC/TCTCTG`	33	--	us2k¹		0	--	--	--	--
rs148060918^1,2		--	16340981(+)	`TCTTGC/TTGGAA`	33	--	us2k¹		0	--	--	--	--
rs182096372^1,2		--	16341025(+)	`GGTGGA/GGGGAG`	33	--	us2k¹		0	--	--	--	--
rs186819549^1,2		--	16341046(+)	`AGGAGA/CTATAC`	33	--	us2k¹		0	--	--	--	--
rs141765001^1,2		--	16341054(+)	`TACCTA/GATGTA`	33	--	us2k¹		0	--	--	--	--
rs150151183^1,2		--	16341185(+)	`TTGCCA/GGGCGC`	33	--	us2k¹		0	--	--	--	--
rs192405436^1,2		--	16341260(+)	`AGCCTC/GACCAA`	33	--	us2k¹		0	--	--	--	--
rs7210291^1,2	C,F,A,H,	--	16341335(+)	`ATCCCG/AGCTAC`	33	--	us2k¹		7		NA WA CSA	17
rs12452054^1,2	H	--	16343933(+)	`gctaaA/Ggtggg`	33	--	int¹ us2k¹		0	--	--	--	--
rs143177731^1,2		--	16344094(+)	`AACCCA/GGGAGG`	33	--	int¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for C17orf76-AS1 (16342136 - 16381992 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C17orf76-AS1: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C17orf76-AS1 for disorders About GeneDecksing

2 diseases for C17orf76-AS1: About MalaCards

intrahepatic cholangiocarcinoma cholangiocarcinoma

Export disorders for C17orf76-AS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C17orf76-AS1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with C17orf76-AS1)

Utopia: connect your pdf to the dynamic
world of online information

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Distinct class of putative 'non-conserved' promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PubMed id 17567985)¹ Tsuritani K....Suzuki Y. (2007)
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)¹ Wang A.G....Kim N.S. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 125144	HGNC: 28619	AceView: MGC40157.1	Ensembl:ENSG00000175061	euGenes: HUgn125144
ECgene: C17orf76-AS1	H-InvDB: C17orf76-AS1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C17orf76-AS1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C17orf76-AS1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C17orf76-AS1 gene:
Search GeneIP for patents involving C17orf76-AS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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C17orf76-AS1 Gene

C17orf76 antisense RNA 1

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C17orf76-AS1 Gene

C17orf76 antisense RNA 1

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