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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C17orf76-AS1 Gene

RNA gene   GIFtS: 37
GCID: GC17P016366

C17orf76 Antisense RNA 1

(Previous names: chromosome 17 open reading frame 45, non-protein coding...)
(Previous symbols: C17orf45, NCRNA00188)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Subcategory (RNA class): processed_transcript

Quality score for this RNA gene is 3

Aliases
C17orf76 Antisense RNA 11 2 3     Chromosome 17 Open Reading Frame 451
C17orf451 2 3     Non-Protein Coding RNA 1881
NCRNA001881 2 3     TSAP192
C17orf76 Antisense RNA 1 (Non-Protein Coding)1     C17orf76 Antisense Gene Protein 13

External Ids:    HGNC: 286191   Entrez Gene: 1251442   Ensembl: ENSG000001750617   UniProtKB: Q8N1F13   

Export aliases for C17orf76-AS1 gene to outside databases

Previous GC identifers: GC17P016348 GC17P016350 GC17P016354 GC17P016358


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C17orf76-AS1 Gene: 
C17orf76-AS1 (C17orf76 antisense RNA 1) is an RNA gene, and is affiliated with the processed_transcript RNA class. Diseases associated with C17orf76-AS1 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for C17orf76-AS1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC17orf76-AS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for C17orf76-AS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf76-AS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

C17orf76-AS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C17orf76-AS1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P016366:  view genomic region     (about GC identifiers)

Start:
16,342,136 bp from pter      End:
16,381,992 bp from pter
Size:
39,857 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: C1AS1_HUMAN, Q8N1F1 (See protein sequence)
Recommended Name: Putative uncharacterized protein C17orf76-AS1, mitochondrial precursor  
Size: 130 amino acids; 13824 Da
Subcellular location: Mitochondrion (Potential)
Caution: Product of a dubious CDS prediction. Probable non-coding RNA

Explore the universe of human proteins at neXtProt for C17orf76-AS1: NX_Q8N1F1

C17orf76-AS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

Human Recombinant Protein Products for C17orf76-AS1: 

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IEA--

C17orf76-AS1 for ontologies           About GeneDecksing



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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q8N1F1


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for C17orf76-AS1 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C17orf76-AS1 
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miRNA
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Inhib. RNA
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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf76-AS1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C17orf76-AS1

1 Interacting protein for C17orf76-AS1 (Q8N1F12, 3) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
KLF10Q131182, 3MINT-8259172 I2D: score=1 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C17orf76-AS1 (C1AS1)

Search CenterWatch for drugs/clinical trials and news about C17orf76-AS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C17orf76-AS1 gene: 
NM_152350.3  

Unigene Cluster for C17orf76-AS1:

C17orf76 antisense RNA 1
Hs.368934  [show with all ESTs]
Unigene Representative Sequence: BG027878
18/33 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
ENST00000584177 ENST00000487066 ENST00000580180 ENST00000475947 ENST00000481898(uc002gqb.4 uc010vwk.2 uc021tqx.1 uc010vwi.2 uc002gqa.4)
ENST00000497774(uc021tqu.1 uc021tqv.1 uc021tqw.1 uc010vwh.2 uc010cpd.3 uc021tqy.1 uc010vwg.2 uc010vwj.2)
ENST00000582911 ENST00000584141 ENST00000584926 ENST00000581361(uc010cpe.2)
ENST00000581718 ENST00000580770 ENST00000578757(uc010vwf.2) ENST00000492250
ENST00000579473 ENST00000475953(uc021tqt.1 uc002gqc.3 uc021tqz.1)
ENST00000583400(uc010vwo.1 uc010vwp.1 uc010vwl.1 uc010vwm.1 uc010vwn.1 uc021tra.1 uc021trb.1 uc021trc.1)
ENST00000578380
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidC17orf76-AS1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for C17orf76-AS1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C17orf76-AS1
Clone
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OriGene clones in human, mouse for C17orf76-AS1 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for C17orf76-AS1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for C17orf76-AS1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf76-AS1
Sirion Biotech Customized lentivirus for stable overexpression of C17orf76-AS1 
                     Customized lentivirus expression plasmids for stable overexpression of C17orf76-AS1 
Primer
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OriGene qPCR primer pairs and template standards for C17orf76-AS1
OriGene qSTAR qPCR primer pairs in human, mouse for C17orf76-AS1
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat C17orf76-AS1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C17orf76-AS1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C17orf76-AS1

Additional mRNA sequence: 

AJ012499.1 AK098643.1 AK307982.1 AK308482.1 AK309961.1 AK311247.1 BC012396.1 BC019833.1 
BC027986.1 BC040159.1 BX538291.1 NR_027158.1 NR_027159.1 NR_027160.1 NR_027161.1 NR_027162.1 
NR_027163.1 NR_027164.1 NR_027165.1 NR_027166.1 NR_027167.1 NR_027168.2 NR_027169.1 NR_027170.1 
NR_027171.1 NR_027172.2 NR_027173.1 NR_027174.1 NR_027175.1 NR_027176.1 NR_027177.1 NR_027178.1 
NR_027179.1 NR_027667.1 NR_045021.1 NR_045022.1 NR_045023.1 NR_045024.1 NR_045025.1 NR_045026.1 
NR_045027.1 NR_045028.1 NR_045029.1 

24/74 DOTS entries (see all 74):

DT.99926865  DT.97869724  DT.100801729  DT.100741270  DT.91781339  DT.91781349  DT.100741310  DT.319228 
DT.91952129  DT.97869733  DT.99982909  DT.100741313  DT.319230  DT.100741208  DT.91781321  DT.97869730 
DT.101987484  DT.120965729  DT.91781357  DT.95258739  DT.97869732  DT.99926870  DT.100844786  DT.120965556 

21 AceView cDNA sequences:

AJ012499 CR619468 BC012396 CR609832 CR591104 CR596984 CR617187 CR608772 
CR622208 CR592897 CR617966 CR616072 CR604967 BC027986 AK098643 NM_152350 
BC019833 BX538291 BC040159 CR596839 CR590510 

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for C17orf76-AS1 (see all 21)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1:                    -     -     -     -                 -                       -     -     -                 -     -     -                                 
SP2:                                -     -                 -     -     -     -     -     -     -                 -     -     -                                 
SP3:                                                        -     -                 -     -     -                 -     -     -                                 
SP4:                                                                                -     -     -                 -     -     -                                 
SP5:                                                                                -     -                       -     -     -                                 


ECgene alternative splicing isoforms for C17orf76-AS1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for C17orf76-AS1:none

C17orf76-AS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AACTAATACT
C17orf76-AS1 Expression
About this image


Genevestigator expression for C17orf76-AS1

SOURCE GeneReport for Unigene cluster: Hs.368934
    SABiosciences Custom PCR Arrays for C17orf76-AS1
Primer
Products:
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C17orf76-AS1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf76-AS1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for C17orf76-AS1 (if available)
TreeFam Gene Tree for C17orf76-AS1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for C17orf76-AS1 gene
2 SIMAP similar genes for C17orf76-AS1 using alignment to 1 protein entry:     C1AS1_HUMAN:
DKFZp686I23148    C17orf45

C17orf76-AS1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

1 SNPs in C17orf76-AS1 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs711528131,2
----16348538(-) TCTCC-/TCCTCTTC 10 -- int11Minor allele frequency- TCC:0.00NA 2

HapMap Linkage Disequilibrium report for C17orf76-AS1 (16342136 - 16381992 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for C17orf76-AS1:    About this table     
Variant IDTypeSubtypePubMed ID
esv2715702CNV Deletion23290073

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for C17orf76-AS1:    About MalaCards
intrahepatic cholangiocarcinoma    cholangiocarcinoma


C17orf76-AS1 for disorders           About GeneDecksing


Export disorders for C17orf76-AS1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C17orf76-AS1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with C17orf76-AS1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  2. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  5. Distinct class of putative 'non-conserved' promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PubMed id 17567985)1 Tsuritani K....Suzuki Y. (2007)
  6. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
  7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  10. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 125144 HGNC: 28619 AceView: MGC40157.1 Ensembl:ENSG00000175061 euGenes: HUgn125144
ECgene: C17orf76-AS1 H-InvDB: C17orf76-AS1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C17orf76-AS1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C17orf76-AS1 gene:
Search GeneIP for patents involving C17orf76-AS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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