Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C17orf75 Gene

Aliases for C17orf75 Gene

  • Chromosome 17 Open Reading Frame 75 2 3 5
  • Sensitization To Ricin Complex Subunit 2 2 3
  • Spermatogenesis-Related Protein 3
  • Protein Njmu-R1 3
  • NJMU-R1 3
  • SRI2 3

External Ids for C17orf75 Gene

Previous GeneCards Identifiers for C17orf75 Gene

  • GC17M027683
  • GC17M030658
  • GC17M026845

Summaries for C17orf75 Gene

GeneCards Summary for C17orf75 Gene

C17orf75 (Chromosome 17 Open Reading Frame 75) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C17orf75 Gene

  • May have a role in spermatogenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C17orf75 Gene

Genomics for C17orf75 Gene

Regulatory Elements for C17orf75 Gene

Enhancers for C17orf75 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G032494 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.4 -146.4 -146429 4.2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF143 PSMD11 UTP6 SUZ12 TMEM98 CDK5R1 C17orf75 ENSG00000266718 ENSG00000280245
GH17G032557 1.5 FANTOM5 Ensembl ENCODE 10.4 -208.5 -208513 2.3 HDGF TBP PKNOX1 ZFP64 ZNF121 CBX5 FOS RELB ETV6 IKZF2 SUZ12 UTP6 CDK5R1 SH3GL1P1 C17orf75 GC17M032557 ENSG00000265337
GH17G032348 1.4 ENCODE dbSUPER 10.3 -0.6 -583 4.1 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SUZ12 UTP6 PSMD11 LRRC37B RHBDL3 C17orf75 ZNF207 ENSG00000274341
GH17G032288 1.2 Ensembl ENCODE dbSUPER 11.1 +60.6 60621 2.4 BCOR TEAD4 ZMYM3 CHD7 ZNF664 NR2F6 SMARCA5 RNF2 HLF NR2F1 RHBDL3 C17orf75 ZNF207 MIR632 LOC105371730 LOC105371732 PIR39108
GH17G032323 1 Ensembl ENCODE 12.3 +25.8 25847 0.8 CTCF ESRRA ZFP64 NR2F1 ZEB2 EBF1 ZIC2 RELA YY1 ZEB1 RHBDL3 C17orf75 ZNF207 MIR632 ENSG00000265794 PIR39108
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C17orf75 on UCSC Golden Path with GeneCards custom track

Genomic Location for C17orf75 Gene

Chromosome:
17
Start:
32,324,565 bp from pter
End:
32,350,047 bp from pter
Size:
25,483 bases
Orientation:
Minus strand

Genomic View for C17orf75 Gene

Genes around C17orf75 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf75 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf75 Gene

Proteins for C17orf75 Gene

  • Protein details for C17orf75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAS0-NJMU_HUMAN
    Recommended name:
    Protein Njmu-R1
    Protein Accession:
    Q9HAS0
    Secondary Accessions:
    • Q7Z2H4

    Protein attributes for C17orf75 Gene

    Size:
    396 amino acids
    Molecular mass:
    44622 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG23214.1; Type=Frameshift; Positions=362; Evidence={ECO:0000305};

neXtProt entry for C17orf75 Gene

Post-translational modifications for C17orf75 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for C17orf75 Gene

Domains & Families for C17orf75 Gene

Protein Domains for C17orf75 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C17orf75 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C17orf75: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C17orf75 Gene

Function for C17orf75 Gene

Molecular function for C17orf75 Gene

UniProtKB/Swiss-Prot Function:
May have a role in spermatogenesis.

Gene Ontology (GO) - Molecular Function for C17orf75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C17orf75: view
genes like me logo Genes that share phenotypes with C17orf75: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C17orf75 Gene

Localization for C17orf75 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C17orf75 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for C17orf75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C17orf75: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C17orf75 Gene

Pathways & Interactions for C17orf75 Gene

SuperPathways for C17orf75 Gene

No Data Available

Interacting Proteins for C17orf75 Gene

Gene Ontology (GO) - Biological Process for C17orf75 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C17orf75 Gene

Transcripts for C17orf75 Gene

Unigene Clusters for C17orf75 Gene

Chromosome 17 open reading frame 75:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf75 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for C17orf75 Gene

GeneLoc Exon Structure for
C17orf75
ECgene alternative splicing isoforms for
C17orf75

Expression for C17orf75 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C17orf75 Gene

Protein differential expression in normal tissues from HIPED for C17orf75 Gene

This gene is overexpressed in Pancreas (11.0), Skin (8.9), Bone (7.3), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C17orf75 Gene



NURSA nuclear receptor signaling pathways regulating expression of C17orf75 Gene:

C17orf75

SOURCE GeneReport for Unigene cluster for C17orf75 Gene:

Hs.655257

mRNA Expression by UniProt/SwissProt for C17orf75 Gene:

Q9HAS0-NJMU_HUMAN
Tissue specificity: Highly expressed in testis and also expressed in fetal testis.

Evidence on tissue expression from TISSUES for C17orf75 Gene

  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with C17orf75: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for C17orf75 Gene

Orthologs for C17orf75 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C17orf75 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf75 34
  • 99.49 (n)
C17orf75 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H17orf75 34
  • 91.58 (n)
C17orf75 35
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 5730455P16Rik 34 16 35
  • 89.29 (n)
rat
(Rattus norvegicus)
Mammalia RGD1310429 34
  • 88.35 (n)
cow
(Bos Taurus)
Mammalia C19H17orf75 34
  • 88.3 (n)
C17orf75 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C17orf75 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C17orf75 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves C18H17ORF75 34
  • 73.28 (n)
C17orf75 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C17orf75 35
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3785 34
zebrafish
(Danio rerio)
Actinopterygii zgc:153240 34
  • 59.89 (n)
C3H17orf75 35
  • 52 (a)
OneToOne
wufj62a01 34
Species where no ortholog for C17orf75 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C17orf75 Gene

ENSEMBL:
Gene Tree for C17orf75 (if available)
TreeFam:
Gene Tree for C17orf75 (if available)

Paralogs for C17orf75 Gene

(1) SIMAP similar genes for C17orf75 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with C17orf75: view

No data available for Paralogs for C17orf75 Gene

Variants for C17orf75 Gene

Sequence variations from dbSNP and Humsavar for C17orf75 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000211226 -- 32,334,483(+) AGAAC(C/T)GAGGC reference, missense
rs1000411272 -- 32,334,911(+) CTAAA(C/T)GTCCC intron-variant
rs1000748106 -- 32,327,979(+) AAGAG(A/C)ACTGG downstream-variant-500B
rs1000939445 -- 32,345,749(+) CCCCA(C/T)GTTCG intron-variant
rs1001251241 -- 32,329,192(+) CTCCC(A/G)AGTAG utr-variant-3-prime

Variation tolerance for C17orf75 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C17orf75 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C17orf75

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C17orf75 Gene

Disorders for C17orf75 Gene

Relevant External Links for C17orf75

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C17orf75

No disorders were found for C17orf75 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf75 Gene

Publications for C17orf75 Gene

  1. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. (PMID: 23394947) Bassik M.C. … Weissman J.S. (Cell 2013) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for C17orf75 Gene

Sources for C17orf75 Gene

Content
Loading form....