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Aliases for C17orf75 Gene

Aliases for C17orf75 Gene

  • Chromosome 17 Open Reading Frame 75 2 3 5
  • Sensitization To Ricin Complex Subunit 2 2 3
  • Spermatogenesis-Related Protein 3
  • Protein Njmu-R1 3
  • NJMU-R1 3
  • SRI2 3

External Ids for C17orf75 Gene

Previous GeneCards Identifiers for C17orf75 Gene

  • GC17M027683
  • GC17M030658
  • GC17M026845

Summaries for C17orf75 Gene

GeneCards Summary for C17orf75 Gene

C17orf75 (Chromosome 17 Open Reading Frame 75) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C17orf75 Gene

  • May have a role in spermatogenesis.

Additional gene information for C17orf75 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C17orf75 Gene

Genomics for C17orf75 Gene

Regulatory Elements for C17orf75 Gene

Enhancers for C17orf75 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H032348 1.4 ENCODE dbSUPER 19.3 -0.6 -583 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 UTP6 SUZ12 ZNF207 PSMD11 C17orf75 LRRC37B ENSG00000266599 ENSG00000265337 ENSG00000264497 ENSG00000264300
GH17H032340 1.2 ENCODE 11.1 +8.0 7977 2 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A SSRP1 ZNF610 SUZ12 UTP6 ZNF207 ENSG00000266599 ENSG00000265337 ENSG00000264497 ENSG00000264300 ENSG00000265046 ENSG00000263567 ENSG00000264598
GH17H032288 1.2 Ensembl ENCODE dbSUPER 11.1 +60.6 60621 2 BCOR SMARCA5 HLF ZMYM3 NR2F2 ZNF664 POLR2A NR2C1 POU5F1 ZBTB33 RHBDL3 C17orf75 MIR632 ZNF207 LOC105371730 LOC105371732 PIR39108
GH17H032494 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.5 -146.4 -146429 4 CTCF ZNF687 L3MBTL2 NR3C1 REST RAD21 ZIC2 ZFP69B JUND ZNF341 PSMD11 CDK5R1 C17orf75 ENSG00000266718 ENSG00000280245
GH17H032443 1.1 ENCODE 11 -95.4 -95428 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 PSMD11 ZNF207 UTP6 SUZ12 ENSG00000265139 CDK5R1 TMEM98 RHBDL3 C17orf75 MIR632
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C17orf75 on UCSC Golden Path with GeneCards custom track

Promoters for C17orf75 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093226 -453 3001 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for C17orf75 Gene

Chromosome:
17
Start:
32,324,565 bp from pter
End:
32,350,047 bp from pter
Size:
25,483 bases
Orientation:
Minus strand

Genomic View for C17orf75 Gene

Genes around C17orf75 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf75 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf75 Gene

Proteins for C17orf75 Gene

  • Protein details for C17orf75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAS0-NJMU_HUMAN
    Recommended name:
    Protein Njmu-R1
    Protein Accession:
    Q9HAS0
    Secondary Accessions:
    • Q7Z2H4

    Protein attributes for C17orf75 Gene

    Size:
    396 amino acids
    Molecular mass:
    44622 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG23214.1; Type=Frameshift; Positions=362; Evidence={ECO:0000305};

neXtProt entry for C17orf75 Gene

Post-translational modifications for C17orf75 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for C17orf75 Gene

Domains & Families for C17orf75 Gene

Gene Families for C17orf75 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for C17orf75 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C17orf75 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C17orf75: view

No data available for UniProtKB/Swiss-Prot for C17orf75 Gene

Function for C17orf75 Gene

Molecular function for C17orf75 Gene

UniProtKB/Swiss-Prot Function:
May have a role in spermatogenesis.

Gene Ontology (GO) - Molecular Function for C17orf75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C17orf75: view
genes like me logo Genes that share phenotypes with C17orf75: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C17orf75
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C17orf75 Gene

Localization for C17orf75 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C17orf75 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C17orf75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C17orf75: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C17orf75 Gene

Pathways & Interactions for C17orf75 Gene

SuperPathways for C17orf75 Gene

No Data Available

Interacting Proteins for C17orf75 Gene

Gene Ontology (GO) - Biological Process for C17orf75 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C17orf75 Gene

Drugs & Compounds for C17orf75 Gene

No Compound Related Data Available

Transcripts for C17orf75 Gene

Unigene Clusters for C17orf75 Gene

Chromosome 17 open reading frame 75:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C17orf75
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf75 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for C17orf75 Gene

GeneLoc Exon Structure for
C17orf75
ECgene alternative splicing isoforms for
C17orf75

Expression for C17orf75 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C17orf75 Gene

Protein differential expression in normal tissues from HIPED for C17orf75 Gene

This gene is overexpressed in Pancreas (11.0), Skin (8.9), Bone (7.3), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C17orf75 Gene



NURSA nuclear receptor signaling pathways regulating expression of C17orf75 Gene:

C17orf75

SOURCE GeneReport for Unigene cluster for C17orf75 Gene:

Hs.655257

mRNA Expression by UniProt/SwissProt for C17orf75 Gene:

Q9HAS0-NJMU_HUMAN
Tissue specificity: Highly expressed in testis and also expressed in fetal testis.

Evidence on tissue expression from TISSUES for C17orf75 Gene

  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with C17orf75: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for C17orf75 Gene

Orthologs for C17orf75 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C17orf75 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf75 33
  • 99.49 (n)
C17orf75 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H17orf75 33
  • 91.58 (n)
C17orf75 34
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 5730455P16Rik 33 16 34
  • 89.29 (n)
rat
(Rattus norvegicus)
Mammalia RGD1310429 33
  • 88.35 (n)
cow
(Bos Taurus)
Mammalia C19H17orf75 33
  • 88.3 (n)
C17orf75 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C17orf75 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C17orf75 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves C18H17ORF75 33
  • 73.28 (n)
C17orf75 34
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C17orf75 34
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3785 33
zebrafish
(Danio rerio)
Actinopterygii zgc:153240 33
  • 59.89 (n)
C3H17orf75 34
  • 52 (a)
OneToOne
wufj62a01 33
Species where no ortholog for C17orf75 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C17orf75 Gene

ENSEMBL:
Gene Tree for C17orf75 (if available)
TreeFam:
Gene Tree for C17orf75 (if available)

Paralogs for C17orf75 Gene

(1) SIMAP similar genes for C17orf75 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with C17orf75: view

No data available for Paralogs for C17orf75 Gene

Variants for C17orf75 Gene

Sequence variations from dbSNP and Humsavar for C17orf75 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000211226 -- 32,334,483(+) AGAAC(C/T)GAGGC reference, missense
rs1000411272 -- 32,334,911(+) CTAAA(C/T)GTCCC intron-variant
rs1000748106 -- 32,327,979(+) AAGAG(A/C)ACTGG downstream-variant-500B
rs1000939445 -- 32,345,749(+) CCCCA(C/T)GTTCG intron-variant
rs1001251241 -- 32,329,192(+) CTCCC(A/G)AGTAG utr-variant-3-prime

Variation tolerance for C17orf75 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C17orf75 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C17orf75

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C17orf75 Gene

Disorders for C17orf75 Gene

Relevant External Links for C17orf75

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C17orf75

No disorders were found for C17orf75 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf75 Gene

Publications for C17orf75 Gene

  1. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. (PMID: 23394947) Bassik MC … Weissman JS (Cell 2013) 2 3 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for C17orf75 Gene

Sources for C17orf75 Gene

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