C17orf75 Gene
protein-coding GIFtS: 41
GCID: GC17M030658
|
|
chromosome 17 open reading frame 75
| |
Aliases
for C17orf75 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 17 Open Reading Frame 751 2 | | NJMU-R11 2 | | Protein Njmu-R12 | | Spermatogenesis-Related Protein2 |
Export aliases for C17orf75 gene to outside databasesPrevious GC identifers: GC17M027683 GC17M026845 |
Summaries
for C17orf75 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NJMU_HUMAN, Q9HAS0Function: May have a role in spermatogenesis
|
Genomic Views
for C17orf75 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C17orf75 gene promoter:
HOXA9 Pax-2 Pax-2a AP-4 Ik-3 LCR-F1 CREB Pax-2b POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for C17orf75
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf75 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2C17orf75 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M030658: view genomic region
(about GC identifiers)
Start:
|
30,651,584 bp from pter |
End:
|
30,677,042 bp from pter |
Size:
|
25,459 bases |
Orientation:
|
minus strand |
|
Proteins
for C17orf75 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NJMU_HUMAN, Q9HAS0 (See
protein sequence)Recommended Name: Protein Njmu-R1 Size: 396 amino acids; 44622 Da
Sequence caution: Sequence=AAG23214.1; Type=Frameshift; Positions=362;
Secondary accessions: Q7Z2H4Explore the universe of human proteins at neXtProt for C17orf75: NX_Q9HAS0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HAS0
C17orf75 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071739.2
ENSEMBL proteins: ENSP00000462873 ENSP00000464275 ENSP00000464416 ENSP00000464759 ENSP00000462127 ENSP00000464845 ENSP00000463184 ENSP00000468451 ENSP00000225805
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
C17orf75 for ontologies About GeneDecksing
C17orf75 Antibody Products:
Assay Products for C17orf75: |
Protein
Domains /
Families
for C17orf75 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9HAS0 |
Function
for C17orf75 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NJMU_HUMAN, Q9HAS0Function: May have a role in spermatogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf75 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf75 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C17orf75 (NM_022344) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C17orf75 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf75 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf75 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
C17orf75 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for C17orf75:
|
Pathways & Interactions
for C17orf75 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C17orf75
2 Interacting proteins for C17orf75 (Q9HAS03) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007283 | spermatogenesis |
NAS | -- |
C17orf75 for ontologies About GeneDecksing
|
Drugs & Compounds
for C17orf75 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C17orf75
Search CenterWatch for drugs/clinical trials and news about C17orf75 / NJMU
|
Transcripts
for C17orf75 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C17orf75 gene: NM_022344.3 Unigene Cluster for C17orf75: Chromosome 17 open reading frame 75 Hs.655257 [show with all ESTs]Unigene Representative Sequence: NM_02234413 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000583104 ENST00000577809(uc002hhg.3) ENST00000582961 ENST00000580558
ENST00000583774 ENST00000581747 ENST00000578215 ENST00000583221 ENST00000583334
ENST00000582073 ENST00000580485 ENST00000580294 ENST00000225805
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf75 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf75 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C17orf75 (NM_022344) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C17orf75 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf75 |
Additional cDNA sequence: AB062437.1 AF052093.1 AF305686.1 BC026017.2 BC035715.1 BC047325.1 BC054035.1 16 DOTS entries: DT.97768150 DT.100744983 DT.100744985 DT.453479 DT.120901003 DT.95159872 DT.112050 DT.100695220 DT.91886036 DT.92427108 DT.86839290 DT.95268371 DT.120900987 DT.217110 DT.217113 DT.40115544 24/136 AceView cDNA sequences (see all 136): CR599009 AA554002 AA411708 BF108454 AI042561 BI489955 BC026017 AB062437 NM_022344 AA195290 CR618435 BE467546 CA307483 BC035715 AA886863 AA747754 AI697061 AA699397 AL521618 CN480580 AI583310 BM452519 AA699793 AI470795
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for C17orf75 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C17orf75
|
Expression
for C17orf75 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C17orf75 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGAAGCTC
About this image
See C17orf75 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C17orf75
SOURCE GeneReport for Unigene cluster: Hs.655257
UniProtKB/Swiss-Prot: NJMU_HUMAN, Q9HAS0Tissue specificity: Highly expressed in testis and also expressed in fetal testis
SABiosciences Custom PCR Arrays for C17orf75
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C17orf75
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf75 |
Orthologs
for C17orf75 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C17orf75 gene from 5/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
5730455P16Rik1 , 5 |
RIKEN cDNA 5730455P16 gene1, 5 |
89.29(n)1
90.05(a)1 |
|
11 (47.80 cM)5
705911 NM_027472.31 NP_081748.11
803604935 |
chicken
(Gallus gallus) |
Aves |
C18H17orf751 |
chromosome 18 open reading frame, human C17orf75 |
73.39(n)
73.21(a) |
|
417412 XM_415664.3 XP_415664.2 |
lizard
(Anolis carolinensis) |
Reptilia |
C17orf756 |
-- |
70(a) |
1 ↔ 1 |
GL343198.1(1806711-1822560) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.37852 |
Xenopus laevis transcribed sequence with weak similarity more |
76.07(n) |
|
BJ618144.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufj62a012 |
Transcribed sequence with weak similarity to protein more |
73.63(n) |
|
57077937 |
ENSEMBL Gene Tree for C17orf75 (if available)
TreeFam Gene Tree for C17orf75 (if available) |
Paralogs
for C17orf75 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C17orf75 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C17orf75 (30651584 - 30677042 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C17orf75: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C17orf75 |
|
Disorders
/ Diseases
for C17orf75 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C17orf75 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C17orf75 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with C17orf75) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
|
External Searches for C17orf75 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C17orf75 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C17orf75 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C17orf75 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C17orf75 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C17orf75 gene:
Search GeneIP for patents involving C17orf75
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C17orf75 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for C17orf75 | | OriGene shRNA RFP for C17orf75 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C17orf75 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C17orf75 | | | OriGene Protein Over-expression Lysate for C17orf75 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C17orf75 | | OriGene 3'-UTR Clone for C17orf75 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf75 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf75 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C17orf75 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C17orf75 | | OriGene Custom Protein Services for C17orf75 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C17orf75 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C17orf75 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf75 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C17orf75 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C17orf75 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C17orf75 |
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 | | | C17orf75 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf75 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf75 |
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