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Aliases for C17orf75 Gene

Aliases for C17orf75 Gene

  • Chromosome 17 Open Reading Frame 75 2 3 5
  • Sensitization To Ricin Complex Subunit 2 2 3
  • Spermatogenesis-Related Protein 3
  • NJMU-R1 3
  • SRI2 3

External Ids for C17orf75 Gene

Previous GeneCards Identifiers for C17orf75 Gene

  • GC17M027683
  • GC17M030658
  • GC17M026845

Summaries for C17orf75 Gene

GeneCards Summary for C17orf75 Gene

C17orf75 (Chromosome 17 Open Reading Frame 75) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C17orf75 Gene

  • May have a role in spermatogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C17orf75 Gene

Genomics for C17orf75 Gene

Regulatory Elements for C17orf75 Gene

Genomic Location for C17orf75 Gene

Chromosome:
17
Start:
32,324,565 bp from pter
End:
32,350,047 bp from pter
Size:
25,483 bases
Orientation:
Minus strand

Genomic View for C17orf75 Gene

Genes around C17orf75 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf75 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf75 Gene

Proteins for C17orf75 Gene

  • Protein details for C17orf75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAS0-NJMU_HUMAN
    Recommended name:
    Protein Njmu-R1
    Protein Accession:
    Q9HAS0
    Secondary Accessions:
    • Q7Z2H4

    Protein attributes for C17orf75 Gene

    Size:
    396 amino acids
    Molecular mass:
    44622 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG23214.1; Type=Frameshift; Positions=362; Evidence={ECO:0000305};

neXtProt entry for C17orf75 Gene

Proteomics data for C17orf75 Gene at MOPED

Post-translational modifications for C17orf75 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for C17orf75 Gene

Domains & Families for C17orf75 Gene

Protein Domains for C17orf75 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C17orf75 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C17orf75: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C17orf75 Gene

Function for C17orf75 Gene

Molecular function for C17orf75 Gene

UniProtKB/Swiss-Prot Function:
May have a role in spermatogenesis.
genes like me logo Genes that share phenotypes with C17orf75: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C17orf75 Gene

Localization for C17orf75 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C17orf75 Gene COMPARTMENTS Subcellular localization image for C17orf75 gene
Compartment Confidence
cytosol 3
golgi apparatus 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C17orf75 Gene

Pathways & Interactions for C17orf75 Gene

SuperPathways for C17orf75 Gene

No Data Available

Interacting Proteins for C17orf75 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000225805%0d%0a9606.ENSP00000262854%0d%0a
Selected Interacting proteins: Q9HAS0-NJMU_HUMAN ENSP00000225805 for C17orf75 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for C17orf75 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C17orf75 Gene

Drugs & Compounds for C17orf75 Gene

No Compound Related Data Available

Transcripts for C17orf75 Gene

Unigene Clusters for C17orf75 Gene

Chromosome 17 open reading frame 75:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf75 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for C17orf75 Gene

GeneLoc Exon Structure for
C17orf75
ECgene alternative splicing isoforms for
C17orf75

Expression for C17orf75 Gene

mRNA expression in normal human tissues for C17orf75 Gene

Protein differential expression in normal tissues from HIPED for C17orf75 Gene

This gene is overexpressed in Pancreas (11.0), Skin (8.9), Bone (7.3), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C17orf75 Gene



SOURCE GeneReport for Unigene cluster for C17orf75 Gene Hs.655257

mRNA Expression by UniProt/SwissProt for C17orf75 Gene

Q9HAS0-NJMU_HUMAN
Tissue specificity: Highly expressed in testis and also expressed in fetal testis.
genes like me logo Genes that share expression patterns with C17orf75: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for C17orf75 Gene

Orthologs for C17orf75 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C17orf75 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf75 35
  • 99.49 (n)
  • 99.49 (a)
C17orf75 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C17orf75 36
  • 85 (a)
OneToOne
C19H17orf75 35
  • 88.3 (n)
  • 88.24 (a)
dog
(Canis familiaris)
Mammalia C9H17orf75 35
  • 91.58 (n)
  • 92.93 (a)
C17orf75 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 5730455P16Rik 16
5730455P16Rik 36
  • 90 (a)
OneToOne
5730455P16Rik 35
  • 89.29 (n)
  • 90.05 (a)
oppossum
(Monodelphis domestica)
Mammalia C17orf75 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C17orf75 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1310429 35
  • 88.35 (n)
  • 89.29 (a)
chicken
(Gallus gallus)
Aves C17orf75 36
  • 71 (a)
OneToOne
C18H17ORF75 35
  • 73.28 (n)
  • 73.54 (a)
lizard
(Anolis carolinensis)
Reptilia C17orf75 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3785 35
zebrafish
(Danio rerio)
Actinopterygii C3H17orf75 36
  • 52 (a)
OneToOne
wufj62a01 35
zgc:153240 35
  • 59.89 (n)
  • 53.95 (a)
Species with no ortholog for C17orf75:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C17orf75 Gene

ENSEMBL:
Gene Tree for C17orf75 (if available)
TreeFam:
Gene Tree for C17orf75 (if available)

Paralogs for C17orf75 Gene

(1) SIMAP similar genes for C17orf75 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with C17orf75: view

No data available for Paralogs for C17orf75 Gene

Variants for C17orf75 Gene

Sequence variations from dbSNP and Humsavar for C17orf75 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1127742 -- 32,334,591(-) TGTGG(A/C/T)CAGTC reference, missense
rs2041306 -- 32,338,656(+) AAAAG(C/G/T)ATGTT intron-variant
rs1019152 -- 32,331,987(+) GAAAA(A/T)GATTA intron-variant
rs7224742 -- 32,330,039(+) GGTTT(C/T)ACCAT utr-variant-3-prime
rs7501832 -- 32,340,962(+) aaaag(A/G)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C17orf75 Gene

Variant ID Type Subtype PubMed ID
nsv908068 CNV Gain 21882294
nsv908069 CNV Gain 21882294

Variation tolerance for C17orf75 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C17orf75 Gene

HapMap Linkage Disequilibrium report
C17orf75

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf75 Gene

Disorders for C17orf75 Gene

Relevant External Links for C17orf75

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C17orf75

No disorders were found for C17orf75 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf75 Gene

Publications for C17orf75 Gene

  1. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. (PMID: 23394947) Bassik M.C. … Weissman J.S. (Cell 2013) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for C17orf75 Gene

Sources for C17orf75 Gene

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