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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C17orf74 Gene

protein-coding   GIFtS: 37
GCID: GC17P007340

Chromosome 17 Open Reading Frame 74

  Search for C17orf74
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 17 Open Reading Frame 741 2
Uncharacterized Protein C17orf742

External Ids:    HGNC: 273151   Entrez Gene: 2012432   Ensembl: ENSG000001845607   UniProtKB: Q0P6703   

Export aliases for C17orf74 gene to outside databases

Previous GC identifers: GC17P007270 GC17P007331 GC17P007222 GC17P007333 GC17P007336


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C17orf74 Gene: 
C17orf74 (chromosome 17 open reading frame 74) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C17orf74 gene promoter:
         Max1   CUTL1   POU3F2   Tal-1beta   GATA-1   Evi-1   C/EBPalpha   PPAR-gamma2   ITF-2   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C17orf74

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf74


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

C17orf74 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C17orf74 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007340:  view genomic region     (about GC identifiers)

Start:
7,328,934 bp from pter      End:
7,330,887 bp from pter
Size:
1,954 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CQ074_HUMAN, Q0P670 (See protein sequence)
Recommended Name: Uncharacterized protein C17orf74  
Size: 501 amino acids; 57131 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for C17orf74: NX_Q0P670

Explore proteomics data for C17orf74 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q0P670

  • C17orf74 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C17orf74 Protein Expression
    REFSEQ proteins: NP_783861.3  
    ENSEMBL proteins: 
     ENSP00000328061   ENSP00000458799  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    C17orf74 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q0P670


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for C17orf74:
     Decreased POU5F1-GFP protein e 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C17orf74

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C17orf74 (CQ074)

    Search CenterWatch for drugs/clinical trials and news about C17orf74 / CQ074

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for C17orf74 gene: 
    NM_175734.4  

    Unigene Cluster for C17orf74:

    Chromosome 17 open reading frame 74
    Hs.380704  [show with all ESTs]
    Unigene Representative Sequence: NM_175734
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333870(uc002ggw.3) ENST00000574034
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    Additional mRNA sequence: 

    BC044816.1 BC048010.1 

    2 DOTS entries:

    DT.100746899  DT.75167020 

    24/27 AceView cDNA sequences (see all 27):

    BC031286 BC048010 NM_175734 BX106288 BC044816 AW236480 AA769816 AW172409 
    AI243482 BX093638 BI825604 AW590745 BI560613 AA992955 BI827149 BI562077 
    AA435882 AI652816 AA454173 BF115340 AA397600 BI560786 AI217124 AA451831 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C17orf74 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGAGAGG
    C17orf74 Expression
    About this image


    See C17orf74 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C17orf74

    SOURCE GeneReport for Unigene cluster: Hs.380704
        SABiosciences Custom PCR Arrays for C17orf74
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf74

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for C17orf74 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 4933402P03Rik1 , 5 RIKEN cDNA 4933402P03 gene1, 5 74.44(n)1
    64.42(a)1
      11 (42.89 cM)5
    1088031  NM_175368.11  NP_780577.11 
     698165665 


    ENSEMBL Gene Tree for C17orf74 (if available)
    TreeFam Gene Tree for C17orf74 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/118 SNPs in C17orf74 are shown (see all 118)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0321464
    ----see VAR_0321462 Q R mis40--------
    rs1855054561,2
    C--7326975(+) CTAAGG/TGTCTT 1 -- us2k11Minor allele frequency- T:0.00EU 503
    rs1168905581,2
    C,F--7327019(+) CATGGC/TCTCAG 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs775193071,2
    C,F--7327089(+) GTTCAC/ACATGT 1 -- us2k12Minor allele frequency- A:0.05WA EA 238
    rs1898708531,2
    --7327141(+) TTCTGC/TTACAC 1 -- us2k10--------
    rs1503137111,2
    --7327148(+) ACACAA/GTTGGG 1 -- us2k10--------
    rs559543331,2
    C,F--7327183(+) CCACTC/TGAGAA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1872950101,2
    --7327209(+) GTGAGC/TCCAGG 1 -- us2k10--------
    rs1114988171,2
    C,F--7327228(+) GCTGGA/TCTTCA 1 -- us2k12Minor allele frequency- T:0.04NA 122
    rs37445481,2
    C,F,H--7327234(-) GGAAGG/ATGAAG 1 -- us2k19Minor allele frequency- A:0.01EA NS NA 2112

    HapMap Linkage Disequilibrium report for C17orf74 (7328934 - 7330887 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for C17orf74:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    dgv3054n71CNV Loss21882294
    nsv470575CNV Loss18288195
    nsv907644CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv523672CNV Loss19592680
    nsv526176CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C17orf74 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C17orf74)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 201243 HGNC: 27315 AceView: LOC201243 Ensembl:ENSG00000184560 euGenes: HUgn201243
    ECgene: C17orf74 H-InvDB: C17orf74

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C17orf74 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C17orf74 gene:
    Search GeneIP for patents involving C17orf74

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf74
     Browse SwitchGear 3'UTR luciferase reporter plasmids for C17orf74
     Browse SwitchGear Promoter luciferase reporter plasmids for C17orf74
     Search ThermoFisher Antibodies for C17orf74
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C17orf74
     inGenious Targeting Laboratory - Custom generated mouse model solutions for C17orf74
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C17orf74
    Customized:
     lentivirus for stable overexpression of C17orf74
     lentivirus expression plasmids for stable overexpression of C17orf74
     adenovirus for overexpression of C17orf74
     LSBio Antibodies in human, mouse, rat for C17orf74
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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