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Aliases for C17orf74 Gene

Aliases for C17orf74 Gene

  • Chromosome 17 Open Reading Frame 74 2 3 5

External Ids for C17orf74 Gene

Previous GeneCards Identifiers for C17orf74 Gene

  • GC17P007270
  • GC17P007331
  • GC17P007222
  • GC17P007333
  • GC17P007336
  • GC17P007340
  • GC17P007450
  • GC17P007468
  • GC17P007503
  • GC17P007538
  • GC17P007547

Summaries for C17orf74 Gene

GeneCards Summary for C17orf74 Gene

C17orf74 (Chromosome 17 Open Reading Frame 74) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C17orf74 Gene

Genomics for C17orf74 Gene

Regulatory Elements for C17orf74 Gene

Enhancers for C17orf74 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G007712 0.9 FANTOM5 29.2 +287.5 287454 0.2 ATF1 MXI1 ZMYM3 CHD4 BMI1 KMT2B YY1 ZNF335 GLIS2 ZNF366 SPEM1 TMEM95 C17orf74 YBX2 DLG4 SLC35G6 CNTROB ELP5 GC17M007714 DNAH2
GH17G007474 1.8 FANTOM5 ENCODE dbSUPER 11.5 +55.7 55709 12.5 CREB3L1 AGO1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DVL2 CHRNB1 SNORD10 PFAS SNORA48 KCTD11 NEURL4 CTC1 CD68 FGF11
GH17G007454 1.3 ENCODE dbSUPER 11.4 +31.1 31100 2.0 HDGF PKNOX1 ATF1 CREB3L1 AGO1 ZNF493 ZFP64 SIN3A FEZF1 YY1 DVL2 CHRNB1 NLGN2 NEURL4 ENSG00000265749 PFAS SENP3 FGF11 CTC1 ZBTB4
GH17G007465 1.3 Ensembl ENCODE dbSUPER 11.4 +42.1 42147 2.2 HDAC1 ESRRA ZNF175 BCL11B YY1 HIC1 POLR2A NCOR1 RCOR1 NR2F6 CHRNB1 FGF11 TMEM102 C17orf74 SPEM1 TNFSF12 TNFSF12-TNFSF13 NLGN2 TMEM256 PLSCR3
GH17G007401 1.1 ENCODE 11.8 -20.8 -20756 4.8 HNRNPUL1 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 DVL2 PFAS SNORD10 CNTROB CTC1 SNORA48 ENSG00000262089 ENSG00000265749 C17orf74 CHRNB1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C17orf74 on UCSC Golden Path with GeneCards custom track

Genomic Location for C17orf74 Gene

Chromosome:
17
Start:
7,424,881 bp from pter
End:
7,427,568 bp from pter
Size:
2,688 bases
Orientation:
Plus strand

Genomic View for C17orf74 Gene

Genes around C17orf74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf74 Gene

Proteins for C17orf74 Gene

  • Protein details for C17orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0P670-CQ074_HUMAN
    Recommended name:
    Uncharacterized protein C17orf74
    Protein Accession:
    Q0P670

    Protein attributes for C17orf74 Gene

    Size:
    501 amino acids
    Molecular mass:
    57131 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C17orf74 Gene

Post-translational modifications for C17orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C17orf74 Gene

No data available for DME Specific Peptides for C17orf74 Gene

Domains & Families for C17orf74 Gene

Protein Domains for C17orf74 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C17orf74: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C17orf74 Gene

Function for C17orf74 Gene

genes like me logo Genes that share phenotypes with C17orf74: view

Animal Model Products

CRISPR Products

miRNA for C17orf74 Gene

miRTarBase miRNAs that target C17orf74

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C17orf74 Gene

Localization for C17orf74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C17orf74 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C17orf74 gene
Compartment Confidence
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C17orf74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C17orf74: view

Pathways & Interactions for C17orf74 Gene

SuperPathways for C17orf74 Gene

No Data Available

Interacting Proteins for C17orf74 Gene

Gene Ontology (GO) - Biological Process for C17orf74 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C17orf74 Gene

Drugs & Compounds for C17orf74 Gene

No Compound Related Data Available

Transcripts for C17orf74 Gene

mRNA/cDNA for C17orf74 Gene

Unigene Clusters for C17orf74 Gene

Chromosome 17 open reading frame 74:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf74 Gene

No ASD Table

Relevant External Links for C17orf74 Gene

GeneLoc Exon Structure for
C17orf74
ECgene alternative splicing isoforms for
C17orf74

Expression for C17orf74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C17orf74 Gene

mRNA differential expression in normal tissues according to GTEx for C17orf74 Gene

This gene is overexpressed in Testis (x52.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C17orf74 Gene



NURSA nuclear receptor signaling pathways regulating expression of C17orf74 Gene:

C17orf74

SOURCE GeneReport for Unigene cluster for C17orf74 Gene:

Hs.380704
genes like me logo Genes that share expression patterns with C17orf74: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C17orf74 Gene

Orthologs for C17orf74 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C17orf74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf74 34
  • 97.92 (n)
C17orf74 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H17orf74 34
  • 76.42 (n)
C17orf74 35
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC497938 34
  • 72.85 (n)
mouse
(Mus musculus)
Mammalia 4933402P03Rik 34 16 35
  • 72.79 (n)
Species where no ortholog for C17orf74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C17orf74 Gene

ENSEMBL:
Gene Tree for C17orf74 (if available)
TreeFam:
Gene Tree for C17orf74 (if available)

Paralogs for C17orf74 Gene

No data available for Paralogs for C17orf74 Gene

Variants for C17orf74 Gene

Sequence variations from dbSNP and Humsavar for C17orf74 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1001511596 -- 7,425,541(+) CACAT(G/T)GTGAC upstream-variant-2KB, utr-variant-5-prime
rs1001942494 -- 7,425,305(+) AAAAG(A/G)ACAAT upstream-variant-2KB, utr-variant-5-prime
rs1002372128 -- 7,424,422(+) CCAAC(A/C)TGCCC upstream-variant-2KB
rs1002545419 -- 7,424,038(+) TGAAT(C/T)TACTC upstream-variant-2KB
rs1003361594 -- 7,427,783(+) ATTCT(C/T)CCTGT intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C17orf74 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv3639869 CNV loss 21293372
nsv457659 CNV loss 19166990
nsv470575 CNV loss 18288195
nsv523672 CNV loss 19592680
nsv526176 CNV gain 19592680
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for C17orf74 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C17orf74 Gene

Human Gene Mutation Database (HGMD)
C17orf74
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C17orf74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf74 Gene

Disorders for C17orf74 Gene

Relevant External Links for C17orf74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C17orf74

No disorders were found for C17orf74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf74 Gene

Publications for C17orf74 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for C17orf74 Gene

Sources for C17orf74 Gene

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