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C17orf70 Gene

protein-coding   GIFtS: 50
GCID: GC17M079506

Chromosome 17 Open Reading Frame 70

  See C17orf70-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 17 Open Reading Frame 701 2     Fanconi Anemia Associated Protein 100 KDa Subunit2
FAAP1002 5     Fanconi Anemia Core Complex 100 KDa Subunit2
100kDa1     Fanconi Anemia-Associated Protein Of 100 KDa2
Fanconi Anemia-Associated Protein1     Fanconi Anemia-Associated Protein, 100kDa2

External Ids:    HGNC: 261711   Entrez Gene: 802332   Ensembl: ENSG000001855047   OMIM: 6113015   UniProtKB: Q0VG063   

Export aliases for C17orf70 gene to outside databases

Previous GC identifers: GC17M077118 GC17M074954


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for C17orf70 Gene:
FAAP100 is a component of the Fanconi anemia (FA; MIM 277650) core complex and is required for core complex
stability and FANCD2 (see MIM 227646) monoubiquitination (Ling et al., 2007 (PubMed 17396147)).(supplied by OMIM,
Mar 2008)

GeneCards Summary for C17orf70 Gene:
C17orf70 (chromosome 17 open reading frame 70) is a protein-coding gene. Diseases associated with C17orf70 include fanconi anemia, complementation group m, and fanconi's anemia.

UniProtKB/Swiss-Prot: FP100_HUMAN, Q0VG06
Function: Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2
monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as
hypersensitivity to DNA cross-linking agents, when repressed




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C17orf70 gene promoter:
         PPAR-gamma1   CUTL1   PPAR-gamma2   Tal-1beta   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C17orf70

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C17orf70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

C17orf70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C17orf70 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079506:  view genomic region     (about GC identifiers)

Start:
79,506,911 bp from pter      End:
79,520,987 bp from pter
Size:
14,077 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for C17orf70

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FP100_HUMAN, Q0VG06 (See protein sequence)
Recommended Name: Fanconi anemia-associated protein of 100 kDa  
Size: 881 amino acids; 93433 Da
Subunit: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9,
FANCM, FAAP24 and FAAP100. Forms a subcomplex with FANCB and FANCL
Sequence caution: Sequence=AAH21968.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15251.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD39037.2;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NNM1 Q8N3F7 Q9BV13 Q9H6K7 Q9H7E8
Alternative splicing: 3 isoforms:  Q0VG06-1   Q0VG06-2   Q0VG06-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C17orf70: NX_Q0VG06

Explore proteomics data for C17orf70 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C17orf70 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079437.5  
    ENSEMBL proteins: 
     ENSP00000395348   ENSP00000333283   ENSP00000399674   ENSP00000459776   ENSP00000438149  
     ENSP00000444241   ENSP00000443415   ENSP00000440151  
    Reactome Protein details: Q0VG06

    C17orf70 Human Recombinant Protein Products:

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    Novus Biologicals C17orf70 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for C17orf70 

     
    antibodies-online proteins for C17orf70 

     
    antibodies-online peptides for C17orf70

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    antibodies-online antibodies for C17orf70 (3 products) 

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    antibodies-online kits for C17orf70 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q0VG06


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FP100_HUMAN, Q0VG06
    Function: Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2
    monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as
    hypersensitivity to DNA cross-linking agents, when repressed

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI17396147
         
    Find genes that share ontologies with C17orf70           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for C17orf70

    miRNA
    Products:
        
    miRTarBase miRNAs that target C17orf70:
    hsa-mir-186-5p (MIRT045137), hsa-mir-423-3p (MIRT042474), hsa-mir-744-5p (MIRT037454)

    Block miRNA regulation of human, mouse, rat C17orf70 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate C17orf70:
    hsa-miR-9 hsa-miR-3065-3p hsa-miR-128 hsa-miR-3681* hsa-miR-512-3p hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidC17orf70 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat C17orf70

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    GenScript: all cDNA clones in your preferred vector: C17orf70 (NM_025161)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf70


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FP100_HUMAN, Q0VG06: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0045111intermediate filament cytoskeleton IDA--

    Find genes that share ontologies with C17orf70           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for C17orf70 About    
    See pathways by source

    SuperPathContained pathways About
    1DNA Repair
    DNA Repair0.45
    2Fanconi Anemia pathway (REACTOME)
    Fanconi Anemia pathway
    3Fanconi anemia pathway (KEGG)
    Fanconi anemia pathway


    Find genes that share SuperPaths with C17orf70           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for C17orf70
        Fanconi Anemia pathway


    1 Kegg Pathway  (Kegg details for C17orf70):
        Fanconi anemia pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C17orf70
    Interactions:

        Search GeneGlobe Interaction Network for C17orf70

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for C17orf70 (Q0VG061, 2, 3 ENSP000003332834) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FANCBQ8NB911, 2, 3, ENSP000003268194EBI-2557990,EBI-2557983 MINT-4789189 MINT-4789279 MINT-4789226 MINT-4789371 MINT-4789347 I2D: score=2 STRING: ENSP00000326819
    FANCAO153601, 2, 3, ENSP000003739524EBI-2557990,EBI-81570 MINT-4789089 MINT-4789189 MINT-4789226 MINT-4789325 I2D: score=2 STRING: ENSP00000373952
    FANCGO152872, 3, ENSP000003679104MINT-4789189 MINT-4789226 MINT-4789325 I2D: score=1 STRING: ENSP00000367910
    FANCLQ9NW382, 3, ENSP000003850214MINT-4789189 MINT-4789279 MINT-4789226 MINT-4789371 MINT-4789325 I2D: score=1 STRING: ENSP00000385021
    FANCMQ8IYD82, 3, ENSP000002674304MINT-4789189 MINT-4789279 MINT-4789226 I2D: score=1 STRING: ENSP00000267430
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--

    Find genes that share ontologies with C17orf70           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C17orf70 (FP100)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C17orf70 gene: 
    NM_025161.5  

    Unigene Cluster for C17orf70:

    Chromosome 17 open reading frame 70
    Hs.313905  [show with all ESTs]
    Unigene Representative Sequence: NR_033338
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000443656(uc002kap.3) ENST00000327787(uc010wuq.1) ENST00000425898(uc002kao.1)
    ENST00000545865 ENST00000541246 ENST00000544302 ENST00000536161 ENST00000537152(uc002kaq.3)

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate C17orf70:
    hsa-miR-9 hsa-miR-3065-3p hsa-miR-128 hsa-miR-3681* hsa-miR-512-3p hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidC17orf70 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat C17orf70
      QuantiFast Probe-based Assays in human, mouse, rat C17orf70

    Additional mRNA sequence: 

    AK024644.1 AK025828.1 AK054713.1 AK225370.1 AL834374.1 BC001724.1 BC008883.2 BC021968.2 
    BC117139.1 BC117141.1 BC128596.1 BC143861.1 DQ989324.1 NR_033338.1 

    12 DOTS entries:

    DT.441219  DT.120915111  DT.95349326  DT.100787681  DT.100808135  DT.100787682  DT.100787685  DT.92430447 
    DT.95178378  DT.215301  DT.95349328  DT.92430446 

    Selected AceView cDNA sequences (see all 264):

    AI005424 CK821618 AI199033 AA773000 CK821619 AW051371 BG055793 BQ678927 
    BF196574 CA943362 CF125979 BF000394 AW007487 BG056076 AI571176 BC021968 
    AI417229 BI766057 BF439311 BE044443 BU784786 AA401977 AW169911 BM700445 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for C17orf70 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11
    SP1:                                                                                            -                                 
    SP2:                                -     -           -     -     -     -     -     -           -                                 
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:        -     -     -           -     -                                                                                       


    ECgene alternative splicing isoforms for C17orf70

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C17orf70 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGGAGCTC
    C17orf70 Expression
    About this image


    C17orf70 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Rib
     
     Dermis (Integumentary System)
    C17orf70 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C17orf70 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.313905
        Custom PCR Arrays for C17orf70
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf70

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C17orf70 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2310003H01Rik1 , 5 RIKEN cDNA 2310003H01 gene1, 5 78.21(n)1
    73.58(a)1
      11 (84.08 cM)5
    718851  NM_027980.21  NP_082256.21 
     1203690555 
    chicken
    (Gallus gallus)
    Aves C18H17orf701 FancA associated protein of 100 kDa 66.16(n)
    57.49(a)
      100049617  NM_001098610.1  NP_001092080.1 
    lizard
    (Anolis carolinensis)
    Reptilia C17orf706
    chromosome 17 open reading frame 70
    53(a)
    1 ↔ 1
    2(98593391-98624214)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004889041 chromosome unknown open reading frame, human C17orf7 more 46.37(n)
    35.38(a)
      100488904  XM_004916351.1  XP_004916408.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-57h18.11 si:dkey-57h18.1 45.29(n)
    33.75(a)
      100001169  XM_001341191.4  XP_001341227.3 


    ENSEMBL Gene Tree for C17orf70 (if available)
    TreeFam Gene Tree for C17orf70 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C17orf70 gene
    1 SIMAP similar gene for C17orf70 using alignment to 6 protein entries:     E7EVV8_HUMAN (see all proteins):
    FAAP100

    Find genes that share paralogs with C17orf70           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C17orf70 (see all 451)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1132337871,2
    C--79506601(+) GGCCGA/GGTTTG 2 -- int10--------
    rs743202301,2
    F--79506611(+) GGAGTG/ATCATC 2 -- int11Minor allele frequency- A:0.01WA 118
    rs606299561,2
    C,F--79506622(+) AGGGCG/AGCCGT 2 -- int11Minor allele frequency- A:0.17WA 118
    rs1170102031,2
    C,F--79506626(+) CGGCCG/ATGCTC 2 -- int11Minor allele frequency- A:0.03NA 120
    rs778877581,2
    C,F--79506670(+) CCTGAC/ATAGGA 2 -- int11Minor allele frequency- A:0.04NA 120
    rs74055221,2
    C,F,A--79506761(+) CCTTGG/CAGCAG 2 -- int18Minor allele frequency- C:0.48WA CSA NA EA 366
    rs1499878771,2
    C--79506800(+) GGGACA/GCGTCT 2 -- int10--------
    rs74055321,2
    C,F,A--79506811(+) TCCTCG/AGAGGC 2 -- int17Minor allele frequency- A:0.44WA CSA NA EA 365
    rs1156177901,2
    F--79506848(+) AGCGCC/AAGGGC 2 -- int11Minor allele frequency- A:0.02WA 118
    rs1995349931,2
    --79506871(+) CCAGT-/GAGAGAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for C17orf70 (79506911 - 79520987 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for C17orf70 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2164CNV Insertion18451855
    nsv833568CNV Loss17160897
    dgv3318n71CNV Loss21882294
    dgv3330n71CNV Loss21882294
    dgv3331n71CNV Loss21882294
    nsv909000CNV Loss21882294
    nsv833567CNV Loss17160897
    nsv828128CNV Loss20364138
    nsv909052CNV Loss21882294
    dgv3320n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C17orf70
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611301    OMIM disorders: --

    2 diseases for C17orf70:    
    About MalaCards
    fanconi anemia, complementation group m    fanconi's anemia

    1 disease from the University of Copenhagen DISEASES database for C17orf70:
    Fanconi's anemia

    Find genes that share disorders with C17orf70           About GenesLikeMe


    Export disorders for C17orf70 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C17orf70 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with C17orf70)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway. (PubMed id 17396147)1, 2, 3 Ling C....Wang W. (EMBO J. 2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. (PubMed id 22705371)1 Yan Z.... Wang W. (Mol. Cell 2012)
    4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    5. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. (PubMed id 20347428)1 Yan Z....Wang W. (Mol. Cell 2010)
    6. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    7. MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. (PubMed id 20347429)1 Singh T.R....Meetei A.R. (Mol. Cell 2010)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair. (PubMed id 18285517)1 Xue Y....Wang W. (Hum. Mol. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80233 HGNC: 26171 AceView: FLJ22175 Ensembl:ENSG00000185504 euGenes: HUgn80233
    ECgene: C17orf70 Kegg: 80233 H-InvDB: C17orf70

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for C17orf70 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for C17orf70 gene:
    Search GeneIP for patents involving C17orf70

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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