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Aliases for C17orf67 Gene

Aliases for C17orf67 Gene

  • Chromosome 17 Open Reading Frame 67 2 3 5

External Ids for C17orf67 Gene

Previous GeneCards Identifiers for C17orf67 Gene

  • GC17M052225
  • GC17M054869
  • GC17M050230

Summaries for C17orf67 Gene

GeneCards Summary for C17orf67 Gene

C17orf67 (Chromosome 17 Open Reading Frame 67) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C17orf67 Gene

Genomics for C17orf67 Gene

Regulatory Elements for C17orf67 Gene

Enhancers for C17orf67 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G056784 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +52.2 52235 3.6 PKNOX1 ARID4B SIN3A FEZF1 YY1 ZNF766 GATA2 FOS DEK ZNF623 C17orf67 NOG TRIM25 SCPEP1 GC17M056800 GC17M056765
GH17G056808 1 ENCODE dbSUPER 17.1 +30.0 30012 1.5 FEZF1 ZNF697 ZNF664 ZFHX2 GLI2 ZNF547 NFE2 EGR2 ZNF426 REST C17orf67 DGKE RNU6-1158P ENSG00000283209 PIR41486
GH17G056793 0.8 ENCODE 17.9 +44.2 44187 1.8 TBP PKNOX1 MAX FEZF1 RFX5 CTBP1 GATA3 ZNF366 ZNF350 RCOR1 C17orf67 GC17M056800 GC17M056765
GH17G056889 1.1 dbSUPER 11.2 -52.3 -52337 2.3 HDGF PKNOX1 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A ZBTB7B YY1 TRIM25 C17orf67 SCPEP1 MIR3614 ENSG00000262112
GH17G056885 1.1 ENCODE dbSUPER 11 -48.2 -48247 2.6 ELF3 TBP HDGF FOXA2 ARID4B RAD21 RARA SLC30A9 ZNF121 CBX5 C17orf67 MTVR2 ENSG00000262112
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C17orf67 on UCSC Golden Path with GeneCards custom track

Genomic Location for C17orf67 Gene

Chromosome:
17
Start:
56,791,913 bp from pter
End:
56,838,773 bp from pter
Size:
46,861 bases
Orientation:
Minus strand

Genomic View for C17orf67 Gene

Genes around C17orf67 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf67 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf67 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf67 Gene

Proteins for C17orf67 Gene

  • Protein details for C17orf67 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0P5P2-CQ067_HUMAN
    Recommended name:
    Uncharacterized protein C17orf67
    Protein Accession:
    Q0P5P2

    Protein attributes for C17orf67 Gene

    Size:
    114 amino acids
    Molecular mass:
    13463 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH93905.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH93907.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C17orf67 Gene

Post-translational modifications for C17orf67 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C17orf67 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C17orf67 Gene

Domains & Families for C17orf67 Gene

Protein Domains for C17orf67 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C17orf67: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C17orf67 Gene

Function for C17orf67 Gene

Gene Ontology (GO) - Molecular Function for C17orf67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C17orf67: view
genes like me logo Genes that share phenotypes with C17orf67: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C17orf67

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C17orf67 Gene

Localization for C17orf67 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C17orf67 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C17orf67 gene
Compartment Confidence
extracellular 4
plasma membrane 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for C17orf67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C17orf67: view

Pathways & Interactions for C17orf67 Gene

SuperPathways for C17orf67 Gene

No Data Available

Interacting Proteins for C17orf67 Gene

Selected Interacting proteins: Q0P5P2-CQ067_HUMAN for C17orf67 Gene via UniProtKB IID

Gene Ontology (GO) - Biological Process for C17orf67 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C17orf67 Gene

Drugs & Compounds for C17orf67 Gene

No Compound Related Data Available

Transcripts for C17orf67 Gene

mRNA/cDNA for C17orf67 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C17orf67 Gene

Chromosome 17 open reading frame 67:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf67 Gene

No ASD Table

Relevant External Links for C17orf67 Gene

GeneLoc Exon Structure for
C17orf67
ECgene alternative splicing isoforms for
C17orf67

Expression for C17orf67 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C17orf67 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of C17orf67 Gene:

C17orf67

SOURCE GeneReport for Unigene cluster for C17orf67 Gene:

Hs.658949

Evidence on tissue expression from TISSUES for C17orf67 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with C17orf67: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C17orf67 Gene

Orthologs for C17orf67 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C17orf67 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf67 34
  • 98.52 (n)
C17ORF67 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm525 34 16 35
  • 84.93 (n)
dog
(Canis familiaris)
Mammalia C9H17orf67 34
  • 84.68 (n)
C17orf67 35
  • 70 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C19H17orf67 34
  • 82.59 (n)
C17orf67 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves C18H17ORF67 34 35
  • 71.62 (n)
lizard
(Anolis carolinensis)
Reptilia C17orf67 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c17orf67 34
  • 67.41 (n)
zebrafish
(Danio rerio)
Actinopterygii C6H17orf67 35
  • 53 (a)
OneToOne
Species where no ortholog for C17orf67 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C17orf67 Gene

ENSEMBL:
Gene Tree for C17orf67 (if available)
TreeFam:
Gene Tree for C17orf67 (if available)

Paralogs for C17orf67 Gene

No data available for Paralogs for C17orf67 Gene

Variants for C17orf67 Gene

Sequence variations from dbSNP and Humsavar for C17orf67 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs398123008 Pathogenic 56,834,922(+) GCCTC(C/T)AGCGG nc-transcript-variant, upstream-variant-2KB, reference, stop-gained
rs148605410 Likely pathogenic 56,834,827(+) GGGCT(A/C/G)GCCCT nc-transcript-variant, upstream-variant-2KB, reference, missense, stop-gained
rs146866423 Likely benign 56,834,830(+) CTCGC(C/T)CTCCG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs775112986 Uncertain significance 56,814,916(+) CTGTC(A/G)CCGAG reference, stop-gained
rs312262694 other 56,834,983(+) GTGGC(C/G)CGACA nc-transcript-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for C17orf67 Gene

Variant ID Type Subtype PubMed ID
dgv954e212 CNV loss 25503493
esv1366533 CNV insertion 17803354
esv2633698 CNV deletion 19546169
esv2657521 CNV deletion 23128226
esv32884 CNV loss 17666407
esv3640858 CNV loss 21293372
nsv833495 CNV loss 17160897
nsv962344 CNV duplication 23825009

Variation tolerance for C17orf67 Gene

Gene Damage Index Score: 1.18; 23.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C17orf67 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C17orf67

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf67 Gene

Disorders for C17orf67 Gene

Relevant External Links for C17orf67

Human Genome Epidemiology (HuGE) Navigator
C17orf67
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C17orf67

No disorders were found for C17orf67 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf67 Gene

Publications for C17orf67 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Molecular and clinical delineation of the 17q22 microdeletion phenotype. (PMID: 23361222) Laurell T. … Nordgren A. (Eur. J. Hum. Genet. 2013) 3 64
  5. Association between genetic determinants of peak height velocity during puberty and predisposition to adolescent idiopathic scoliosis. (PMID: 23354108) Mao S. … Qiu Y. (Spine 2013) 3 64

Products for C17orf67 Gene

Sources for C17orf67 Gene

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