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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C17orf67 Gene

protein-coding   GIFtS: 35
GCID: GC17M054869

Chromosome 17 Open Reading Frame 67

  Search for C17orf67
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 17 Open Reading Frame 671 2
Uncharacterized Protein C17orf672

External Ids:    HGNC: 279001   Entrez Gene: 3392102   Ensembl: ENSG000002142267   UniProtKB: Q0P5P23   

Export aliases for C17orf67 gene to outside databases

Previous GC identifers: GC17M052225 GC17M050230


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C17orf67 Gene: 
C17orf67 (chromosome 17 open reading frame 67) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C17orf67 gene promoter:
         RFX1   Pax-5   FOXO3   MIF-1   FOXO3b   HEN1   SRY   Pax-3   NRF-2   FOXO3a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C17orf67

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf67


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.2

C17orf67 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C17orf67 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M054869:  view genomic region     (about GC identifiers)

Start:
54,869,274 bp from pter      End:
54,916,134 bp from pter
Size:
46,861 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CQ067_HUMAN, Q0P5P2 (See protein sequence)
Recommended Name: Uncharacterized protein C17orf67 precursor  
Size: 114 amino acids; 13463 Da
Subcellular location: Secreted (Potential)
Caution: It is uncertain whether Met-1 or Met-25 is the initiator
Sequence caution: Sequence=AAH93905.1; Type=Erroneous initiation; Sequence=AAH93907.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for C17orf67: NX_Q0P5P2

Explore proteomics data for C17orf67 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q0P5P2

  • C17orf67 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C17orf67 Protein Expression
    REFSEQ proteins: NP_001078899.2  
    ENSEMBL proteins: 
     ENSP00000380959   ENSP00000461483   ENSP00000380960  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    C17orf67 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q0P5P2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for C17orf67:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C17orf67

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C17orf67 (CQ067)

    Search CenterWatch for drugs/clinical trials and news about C17orf67 / CQ067

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C17orf67 gene: 
    NM_001085430.2  

    Unigene Cluster for C17orf67:

    Chromosome 17 open reading frame 67
    Hs.658949  [show with all ESTs]
    Unigene Representative Sequence: NM_001085430
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570754 ENST00000397861(uc010dci.3 uc002iuq.3) ENST00000487705
    ENST00000575658 ENST00000397862
    miRNA
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    Additional mRNA sequence: 

    BC041467.1 BC093905.1 BC093907.1 

    5 DOTS entries:

    DT.427773  DT.100019384  DT.95092470  DT.310317  DT.91726285 

    17 AceView cDNA sequences:

    CR612053 AI288950 CA308560 BX415418 AW300396 BQ230340 BE463822 BC041467 
    BI770408 AI205518 AI689580 BF592860 AA627202 BI907789 H92155 BI772271 
    BE173202 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C17orf67 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCACCTGC
    C17orf67 Expression
    About this image


    See C17orf67 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C17orf67

    SOURCE GeneReport for Unigene cluster: Hs.658949
        SABiosciences Custom PCR Arrays for C17orf67
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf67

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C17orf67 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves C17ORF676
    Uncharacterized protein
    65(a)
    1 ↔ 1
    18(6230180-6235911)
    lizard
    (Anolis carolinensis)
    Reptilia C17ORF676
    Uncharacterized protein
    71(a)
    1 ↔ 1
    GL343198.1(584797-590356)
    zebrafish
    (Danio rerio)
    Actinopterygii C6H17orf676
    chromosome 17 open reading frame 67
    53(a)
    1 ↔ 1
    6(19544140-19546365)
            Species with no ortholog for C17orf67

    ENSEMBL Gene Tree for C17orf67 (if available)
    TreeFam Gene Tree for C17orf67 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/848 SNPs in C17orf67 are shown (see all 848)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72095991,2
    C,F,A,H--54868990(+) CAAGGT/CGGGTG 1 -- int16Minor allele frequency- C:0.17NA WA 12
    rs1501936811,2
    C--54869049(+) ACCCCA/GTCTCT 1 -- int10--------
    rs1389227461,2
    --54869094(+) GTGCAC/TCTGTA 1 -- int10--------
    rs1407255551,2
    C--54869152(+) GAGGCA/GGAGGT 1 -- int10--------
    rs1923726461,2
    --54869191(+) CTCCAA/GACTGA 1 -- int10--------
    rs1822709431,2
    --54869273(+) TAAAAA/GTAAAT 1 -- spd10--------
    rs562682001,2
    --54869422(+) TCCTGA/GTCTGG 1 -- ut310--------
    rs733230511,2
    C,F--54869453(+) CCAGGT/AAAGAT 1 -- ut312Minor allele frequency- A:0.11WA 120
    rs178224031,2
    C,F,H--54869473(+) TCCCAC/TTCTTG 1 -- ut3120Minor allele frequency- T:0.12NA NS EA WA 2482
    rs733230521,2
    C,F--54869495(+) GAAGAC/ACTTTG 1 -- ut313Minor allele frequency- A:0.15WA 122

    HapMap Linkage Disequilibrium report for C17orf67 (54869274 - 54916134 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for C17orf67:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2633698CNV Deletion19546169
    esv1366533CNV Insertion17803354
    nsv833495CNV Loss17160897
    esv32884CNV Loss17666407
    nsv908632CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C17orf67 for disorders           About MalaCards

    C17orf67 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: C17orf67 (1 document)

    Export disorders for C17orf67 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C17orf67 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C17orf67)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PubMed id 19266077)1 Sovio U....Jarvelin M.R. (2009)
    3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339210 HGNC: 27900 AceView: LOC339210 Ensembl:ENSG00000214226 euGenes: HUgn339210
    ECgene: C17orf67 H-InvDB: C17orf67

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C17orf67 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C17orf67 gene:
    Search GeneIP for patents involving C17orf67

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for C17orf67
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf67
     inGenious Targeting Laboratory - Custom generated mouse model solutions for C17orf67
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C17orf67
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     Search LSBio for Antibodies for C17orf67
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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