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Aliases for C17orf64 Gene

Aliases for C17orf64 Gene

  • Chromosome 17 Open Reading Frame 64 2 3 5

External Ids for C17orf64 Gene

Previous GeneCards Identifiers for C17orf64 Gene

  • GC17P055855
  • GC17P058469
  • GC17P053870

Summaries for C17orf64 Gene

GeneCards Summary for C17orf64 Gene

C17orf64 (Chromosome 17 Open Reading Frame 64) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C17orf64 Gene

Genomics for C17orf64 Gene

Regulatory Elements for C17orf64 Gene

Enhancers for C17orf64 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F060354 0.5 Ensembl ENCODE 12.1 -36.2 -36229 4.4 PKNOX1 ARID4B ZNF121 CBX5 FOS JUNB ZNF264 ETV4 PBX2 RCOR2 PPM1D RPS6KB1 C17orf64 USP32 NDUFB8P2 DHX40 HEATR6 GC17M060371 ENSG00000271626
GH17F060420 0.4 ENCODE 11.8 +29.1 29106 1.4 PKNOX1 ARID4B SIN3A ZNF48 RAD21 ZNF143 ZNF207 FOS KLF11 MIER3 C17orf64 LOC105371850 USP32
GH17F060249 0.5 ENCODE 11.2 -142.9 -142896 0.8 IKZF1 REST C17orf64 USP32 HEATR6 RPL32P32 LOC100418753
GH17F060435 0.8 Ensembl ENCODE 10.9 +43.7 43674 1.1 HDGF PKNOX1 WRNIP1 SIN3A ARID4B ZNF2 SLC30A9 GLIS2 ZNF143 DEK C17orf64 HEATR6 CA4 RPL12P38 GC17M060489
GH17F060269 0.2 ENCODE 10.6 -122.8 -122825 0.1 PKNOX1 SCARNA20 C17orf64 USP32 HEATR6 LOC100418753 GC17M060304
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C17orf64 on UCSC Golden Path with GeneCards custom track

Promoters for C17orf64 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001350343 -629 3601 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for C17orf64 Gene

Chromosome:
17
Start:
60,392,429 bp from pter
End:
60,431,426 bp from pter
Size:
38,998 bases
Orientation:
Plus strand

Genomic View for C17orf64 Gene

Genes around C17orf64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf64 Gene

Proteins for C17orf64 Gene

  • Protein details for C17orf64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WR6-CQ064_HUMAN
    Recommended name:
    Uncharacterized protein C17orf64
    Protein Accession:
    Q86WR6
    Secondary Accessions:
    • Q8IY87

    Protein attributes for C17orf64 Gene

    Size:
    236 amino acids
    Molecular mass:
    27182 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36356.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH48806.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for C17orf64 Gene

Post-translational modifications for C17orf64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C17orf64 Gene

No data available for DME Specific Peptides for C17orf64 Gene

Domains & Families for C17orf64 Gene

Protein Domains for C17orf64 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C17orf64: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C17orf64 Gene

Function for C17orf64 Gene

genes like me logo Genes that share phenotypes with C17orf64: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C17orf64 Gene

Localization for C17orf64 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C17orf64 Gene COMPARTMENTS Subcellular localization image for C17orf64 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C17orf64 Gene

Pathways & Interactions for C17orf64 Gene

SuperPathways for C17orf64 Gene

No Data Available

Interacting Proteins for C17orf64 Gene

Gene Ontology (GO) - Biological Process for C17orf64 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C17orf64 Gene

Transcripts for C17orf64 Gene

mRNA/cDNA for C17orf64 Gene

Unigene Clusters for C17orf64 Gene

Chromosome 17 open reading frame 64:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf64 Gene

No ASD Table

Relevant External Links for C17orf64 Gene

GeneLoc Exon Structure for
C17orf64
ECgene alternative splicing isoforms for
C17orf64

Expression for C17orf64 Gene

mRNA expression in normal human tissues for C17orf64 Gene

mRNA differential expression in normal tissues according to GTEx for C17orf64 Gene

This gene is overexpressed in Testis (x51.3).

Protein differential expression in normal tissues from HIPED for C17orf64 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C17orf64 Gene



Protein tissue co-expression partners for C17orf64 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C17orf64 Gene:

C17orf64

SOURCE GeneReport for Unigene cluster for C17orf64 Gene:

Hs.129312
genes like me logo Genes that share expression patterns with C17orf64: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C17orf64 Gene

Orthologs for C17orf64 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C17orf64 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf64 34
  • 99.01 (n)
C17orf64 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C19H17orf64 34
  • 82.04 (n)
C17orf64 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H17orf64 34
  • 81.77 (n)
C17orf64 35
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1310166 34
  • 79.4 (n)
mouse
(Mus musculus)
Mammalia 1700125H20Rik 34 16 35
  • 78.77 (n)
oppossum
(Monodelphis domestica)
Mammalia C17orf64 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C17orf64 35
  • 29 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17orf64 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C17orf64 35
  • 52 (a)
OneToOne
Species where no ortholog for C17orf64 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C17orf64 Gene

ENSEMBL:
Gene Tree for C17orf64 (if available)
TreeFam:
Gene Tree for C17orf64 (if available)

Paralogs for C17orf64 Gene

(1) SIMAP similar genes for C17orf64 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C17orf64: view

No data available for Paralogs for C17orf64 Gene

Variants for C17orf64 Gene

Sequence variations from dbSNP and Humsavar for C17orf64 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10595433 -- 60,430,148(+) TTTTT(-/T)ACATT intron-variant
rs10709335 -- 60,428,495(+) CTGAA(-/T)TTTTT intron-variant
rs11079398 -- 60,419,862(+) ATTAT(A/T)TTATT intron-variant, upstream-variant-2KB
rs111278617 -- 60,426,082(+) AGACC(A/G)GTGTG intron-variant
rs111330712 -- 60,422,013(+) CCAGT(-/ACCCAGC)ACCCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C17orf64 Gene

Variant ID Type Subtype PubMed ID
dgv3273n100 CNV gain 25217958
nsv519929 CNV loss 19592680
nsv521420 CNV loss 19592680

Variation tolerance for C17orf64 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C17orf64 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C17orf64

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf64 Gene

Disorders for C17orf64 Gene

Relevant External Links for C17orf64

Genetic Association Database (GAD)
C17orf64
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C17orf64

No disorders were found for C17orf64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf64 Gene

Publications for C17orf64 Gene

  1. The Chromatin Remodelling Protein CHD1 Contains a Previously Unrecognised C-Terminal Helical Domain. (PMID: 27591891) Mohanty B. … Ryan D.P. (J. Mol. Biol. 2016) 2 3 64
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C17orf64 Gene

Sources for C17orf64 Gene

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