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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C17orf62 Gene

protein-coding   GIFtS: 44
GCID: GC17M080400

chromosome 17 open reading frame 62

  Search for C17orf62
in our new
 Human Malady Compendium 
Biological research products
for C17orf62
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 17 Open Reading Frame 621 2
FLJ904691
MGC43681
Uncharacterized Protein C17orf622

External Ids:    HGNC: 286721   Entrez Gene: 794152   Ensembl: ENSG000001789277   UniProtKB: Q9BQA93   
ORGUL members:         
NONCODE:n410075 n410077    

Export aliases for C17orf62 gene to outside databases

Previous GC identifers: GC17M077994 GC17M075798


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010663.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C17orf62 gene promoter:
         Pax-5   MyoD   RelA   NF-kappaB   NF-E2 p45   Roaz   Pax-3   NF-E2   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): C17orf62 promoter sequence
   Search SABiosciences Chromatin IP Primers for C17orf62

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf62


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

C17orf62 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C17orf62 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M080400:  view genomic region     (about GC identifiers)

Start:
80,400,462 bp from pter      End:
80,408,707 bp from pter
Size:
8,246 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

  • n410077
  • n410075
80400462 80404585 80408707 chr17

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CQ062_HUMAN, Q9BQA9 (See protein sequence)
Recommended Name: Uncharacterized protein C17orf62  
Size: 187 amino acids; 20774 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAB70818.1; Type=Miscellaneous discrepancy; Note=Wrong choice of frame;
Secondary accessions: E1B6X3 Q96NR1
Alternative splicing: 2 isoforms:  Q9BQA9-1   Q9BQA9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C17orf62: NX_Q9BQA9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BQA9

  • C17orf62 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (7 alternative transcripts): 
    NP_001028218.1  NP_001093877.1  NP_001093878.1  NP_001180582.1  NP_001180583.1  NP_001180584.1  NP_001180586.1  

    ENSEMBL proteins: 
     ENSP00000342228   ENSP00000307765   ENSP00000388909   ENSP00000462346   ENSP00000401626  
     ENSP00000463840   ENSP00000462956   ENSP00000462515   ENSP00000463306   ENSP00000464633  
     ENSP00000463846   ENSP00000463228   ENSP00000464080   ENSP00000462529   ENSP00000462410  
     ENSP00000464201   ENSP00000462997   ENSP00000463215   ENSP00000463475   ENSP00000464442  
     ENSP00000464531   ENSP00000337560  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: C17orf62
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    Uscn Proteins for C17orf62

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    C17orf62 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for C17orf62


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9BQA9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    Browse MicroRNA Expression Plasmids
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf62

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    C17orf62 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for C17orf62:
     Cell division defect  Increased G2M DNA content  Synthetic lethal with Ras 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for BC017643):
     hematopoietic system  immune system 

    C17orf62 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C17orf62

    2 Interacting proteins for C17orf62 (Q9BQA91, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETS1P149211, 3EBI-2680384,EBI-913209 I2D: score=1 
    CREB3O438893I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C17orf62
    Search CenterWatch for drugs/clinical trials and news about C17orf62 / CQ062 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C17orf62 gene (7 alternative transcripts): 
    NM_001033046.3  NM_001100407.2  NM_001100408.2  NM_001193653.1  NM_001193654.1  NM_001193655.1  NM_001193657.1  

    Unigene Cluster for C17orf62:

    Chromosome 17 open reading frame 62
    Hs.163113  [show with all ESTs]
    Unigene Representative Sequence: AK090484
    18/41 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 41):
    ENST00000342572 ENST00000536759(uc002kex.3) ENST00000306645(uc010dir.3 uc021ufr.1 uc002kfb.4 uc002kfc.4 uc002kfd.4 uc002kfe.4 uc021ufu.1)
    ENST00000578895 ENST00000585044(uc002key.3 uc021ufq.1) ENST00000437807(uc021ufs.1 uc002kfa.3 uc021uft.1)
    ENST00000584024 ENST00000434650 ENST00000582438 ENST00000579751 ENST00000583617
    ENST00000582725 ENST00000577436 ENST00000585064 ENST00000577732 ENST00000578919
    ENST00000580560 ENST00000581196

    miRNA
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    OriGene 3'-UTR Clone (see all 3): C17orf62
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    SwitchGear 3'UTR luciferase reporter plasmidC17orf62 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C17orf62 (see all 4)
    OriGene shRNA RFP: C17orf62
    OriGene siRNA: C17orf62
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    Clone
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    Additional cDNA sequence: 

    AF269290.1 AK027743.1 AK054876.1 AK056342.1 AK074950.1 AK090484.1 AK092865.1 AK225389.1 
    AK309201.1 BC003595.1 BC004171.2 NR_036514.1 NR_036516.1 NR_036517.1 NR_036518.1 NR_036519.1 

    24/29 DOTS entries (see all 29):

    DT.100838255  DT.100813438  DT.95100082  DT.97815349  DT.100838265  DT.100030066  DT.91769567  DT.91769562 
    DT.87015923  DT.100030062  DT.100838261  DT.100838258  DT.91675866  DT.100686697  DT.101957420  DT.120922220 
    DT.97848314  DT.120922269  DT.120922281  DT.95258882  DT.100030064  DT.100838264  DT.91769570  DT.99995960 

    24/289 AceView cDNA sequences (see all 289):

    BQ214997 BU542155 BQ882160 CD370025 AI627847 BQ948958 BM762505 AK090484 
    AU280357 AW080044 BQ935219 BM833838 BM801484 AA282408 BQ070931 BX364112 
    AI695766 BU161915 BM988786 BM701579 BM479923 T07931 AW166121 N79577 

    GeneLoc Exon Structure

    5/23 Alternative Splicing Database (ASD) splice patterns (SP) for C17orf62 (see all 23)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^
    SP1:                                -     -     -     -     -                 -     -     -           -                 -     -     -                 -         
    SP2:                          -     -     -     -     -     -     -           -     -     -           -                 -     -     -                 -         
    SP3:                                                                          -     -     -           -                 -     -     -                 -         
    SP4:                          -     -     -     -     -     -     -           -     -     -     -     -                 -     -     -                 -         
    SP5:                          -     -     -     -     -     -     -           -     -     -           -     -           -     -     -                 -         

    ExUns: 11a · 11b · 11c · 11d · 11e · 11f
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for C17orf62

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C17orf62 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAGTAATCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See C17orf62 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C17orf62

    SOURCE GeneReport for Unigene cluster: Hs.163113
        SABiosciences Custom PCR Arrays for C17orf62
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf62

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C17orf62 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia BC0176431 , 5 cDNA sequence BC0176431, 5 86.99(n)1
    88.77(a)1
      11 (85.10 cM)5
    2173701  NM_144832.21  NP_659081.11 
     1212225885 
    chicken
    (Gallus gallus)
    Aves C18H17orf621 chromosome 18 open reading frame, human C17orf62 71.09(n)
    70.72(a)
      417342  XM_415607.3  XP_415607.1 
    lizard
    (Anolis carolinensis)
    Reptilia C17orf626
    --
    70(a)
    1 ↔ 1
    2(109526094-109534044)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:919401 zgc:91940 62.04(n)
    62.78(a)
      436942  NM_001002669.1  NP_001002669.1 


    ENSEMBL Gene Tree for C17orf62 (if available)
    TreeFam Gene Tree for C17orf62 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/212 NCBI SNPs in C17orf62 are shown (see all 212    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs761468851,2
    C--80400537(+) GTTATG/TTATGG 12 -- nc-transcript-variantint1 ut310--------
    rs96481,2
    C,F,H,--80400586(-) TCCTCA/CGTAGT 12 -- nc-transcript-variantut31 int1 ese314Minor allele frequency- C:0.10MN NS EA NA 1694
    rs119511,2
    C,F,--80400626(+) TCACCG/CAGGTC 12 -- nc-transcript-variantint1 ut31 ese31Minor allele frequency- C:0.03NA 120
    rs1827874651,2
    --80400641(+) CCAGAC/GGTGGG 12 -- nc-transcript-variantut31 int10--------
    rs80081,2
    C,F,A,H,--80400755(-) GCACCG/AAGCGC 12 -- nc-transcript-variantint1 ut3118Minor allele frequency- A:0.17EA MN NS NA 3888
    rs1889528921,2
    --80400811(+) ACTGGC/TGGGTC 12 -- nc-transcript-variantint1 ut310--------
    rs1455134791,2
    --80400865(+) TAGCCA/GAGAGC 12 -- int1 ut31 nc-transcript-variant0--------
    rs1402723011,2
    --80401045(+) GCCTCC/TGAAAG 11 -- nc-transcript-variantut310--------
    rs1131133401,2
    C,--80401097(+) TCCCGG/ATTTTT 11 -- nc-transcript-variantut311Minor allele frequency- A:0.50NA 2
    rs1172725201,2
    C,F,--80401220(+) GTCTAT/CGCGCC 11 -- nc-transcript-variantut311Minor allele frequency- C:0.05NA 120

    HapMap Linkage Disequilibrium report for C17orf62 (80400462 - 80408707 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for C17orf62
         2 CNVs: 5043 73078
         3 Indels: 88659 77764 34352

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C17orf62
    DNA2.0 Custom Variant and Variant Library Synthesis for C17orf62

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C17orf62 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with C17orf62)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. [Study on the mechanism of C17orf62 induced cell death ]. (PubMed id 21503106)1 Deng X....Shi T.P. (2011)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1 Melzer D....Ferrucci L. (2008)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    10. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79415 HGNC: 28672 AceView: MGC4368 Ensembl:ENSG00000178927 euGenes: HUgn79415
    ECgene: C17orf62 H-InvDB: C17orf62

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C17orf62 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C17orf62 gene:
    Search GeneIP for patents involving C17orf62

    GeneCards and IP:
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