C17orf59 Gene
protein-coding GIFtS: 39
GCID: GC17M008091
|
|
chromosome 17 open reading frame 59
| |
Aliases
for C17orf59 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 17 Open Reading Frame 591 2 | | FLJ200141 | | PRO24722 | | Uncharacterized Protein C17orf592 |
Export aliases for C17orf59 gene to outside databasesPrevious GC identifers: GC17M008033 GC17M008038 GC17M007988 |
Summaries
for C17orf59 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C17orf59 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C17orf59 gene promoter:
Pbx1a SREBP-1c Olf-1 CUTL1 Nkx2-5 SREBP-1b SREBP-1a Zic3 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for C17orf59
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf59 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1C17orf59 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M008091: view genomic region
(about GC identifiers)
Start:
|
8,091,651 bp from pter |
End:
|
8,093,564 bp from pter |
Size:
|
1,914 bases |
Orientation:
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minus strand |
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Proteins
for C17orf59 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CQ059_HUMAN, Q96GS4 (See
protein sequence)Recommended Name: Uncharacterized protein C17orf59 Size: 357 amino acids; 37226 Da
Sequence caution: Sequence=AAH09261.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH18880.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH70272.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA90889.1; Type=Erroneous initiation;Note=Translation N-terminally extended; Sequence=BAD96226.1; Type=Erroneous initiation; Note=Translation N-terminallyextended;
Secondary accessions: Q53HS4 Q9NXW8Explore the universe of human proteins at neXtProt for C17orf59: NX_Q96GS4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96GS4
C17orf59 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060092.2
ENSEMBL proteins: ENSP00000373669
Human Recombinant Protein Products:
C17orf59 Antibody Products:
Assay Products for C17orf59: |
Protein
Domains /
Families
for C17orf59 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C17orf59 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96GS4ProtoNet protein and cluster: Q96GS4 |
Function
for C17orf59 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf59 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf59 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for C17orf59 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf59 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf59 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
C17orf59 for ontologies About GeneDecksing
|
Pathways & Interactions
for C17orf59 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C17orf59
2 Interacting proteins for C17orf59 (Q96GS43) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C17orf59 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C17orf59
Search CenterWatch for drugs/clinical trials and news about C17orf59 / CQ059
|
Transcripts
for C17orf59 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C17orf59 gene: NM_017622.2 Unigene Cluster for C17orf59: Chromosome 17 open reading frame 59 Hs.129563 [show with all ESTs]Unigene Representative Sequence: NM_0176221 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000389017(uc010vut.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf59 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf59 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C17orf59 (NM_017622) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C17orf59 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf59 |
Additional cDNA sequence: AK000021.1 AK222506.1 BC009261.2 BC018880.2 BC070272.1 3 DOTS entries: DT.100754930 DT.306506 DT.95290796 24/58 AceView cDNA sequences (see all 58): AI744756 CB528922 AI401164 AI380880 BF588575 AI992271 BU731516 AI380879 CA423621 AI251012 BC009261 AA604439 BU071884 AJ707590 BM819789 NM_017622 AW058624 BI911941 BF001228 AW016077 CB149568 BQ674127 AK000021 F29003
GeneLoc Exon Structure
|
Expression
for C17orf59 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C17orf59 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATCAGGAG
About this image
See C17orf59 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C17orf59
SOURCE GeneReport for Unigene cluster: Hs.129563
SABiosciences Custom PCR Arrays for C17orf59
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C17orf59
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C17orf59 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C17orf59 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C17orf59 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf59 |
Orthologs
for C17orf59 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C17orf59 gene from 7/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
2310047M10Rik1 , 5 |
RIKEN cDNA 2310047M10 gene1, 5 |
80.89(n)1
76.27(a)1 |
|
11 (42.33 cM)5
719231 NM_028005.31 NP_082281.21
690597175 |
chicken
(Gallus gallus) |
Aves |
C17orf596 |
Uncharacterized protein |
51(a) |
1 ↔ 1 |
3(78547748-78548398) |
lizard
(Anolis carolinensis) |
Reptilia |
C17orf596 |
-- |
64(a) |
1 ↔ 1 |
GL343516.1(222460-223059) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.116802 |
Xenopus laevis transcribed sequence with weak similarity more |
77.64(n) |
|
48012939 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkey-72l14.46 |
si:dkey-72l14.4 |
32(a) |
1 ↔ 1 |
8(26812883-26824495) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG171806 |
-- |
22(a) |
1 ↔ 1 |
3L(540851-542147) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y37E11B.36 |
Protein Y37E11B.3 |
30(a) |
1 ↔ 1 |
IV(3580964-3582904) |
ENSEMBL Gene Tree for C17orf59 (if available)
TreeFam Gene Tree for C17orf59 (if available) |
Paralogs
for C17orf59 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C17orf59 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C17orf59 (8091651 - 8093564 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C17orf59: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C17orf59 |
|
Disorders
/ Diseases
for C17orf59 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C17orf59 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C17orf59 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C17orf59) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for C17orf59 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C17orf59 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C17orf59 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C17orf59 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C17orf59 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C17orf59 gene:
Search GeneIP for patents involving C17orf59
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C17orf59 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C17orf59 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C17orf59 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C17orf59 | | | OriGene Protein Over-expression Lysate for C17orf59 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C17orf59 | | OriGene 3'-UTR Clone for C17orf59 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf59 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf59 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | C17orf59 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf59 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf59 |
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