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C17orf59 Gene

protein-coding   GIFtS: 42
GCID: GC17M008091

Chromosome 17 Open Reading Frame 59

  Search for C17orf59
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 17 Open Reading Frame 591 2
PRO24722
Uncharacterized Protein C17orf592

External Ids:    HGNC: 259391   Entrez Gene: 547852   Ensembl: ENSG000001965447   UniProtKB: Q96GS43   

Export aliases for C17orf59 gene to outside databases

Previous GC identifers: GC17M008033 GC17M008038 GC17M007988


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C17orf59 Gene:
C17orf59 (chromosome 17 open reading frame 59) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the C17orf59 gene promoter:
         Pbx1a   SREBP-1c   Olf-1   CUTL1   Nkx2-5   SREBP-1b   SREBP-1a   Zic3   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C17orf59

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C17orf59


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

C17orf59 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C17orf59 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M008091:  view genomic region     (about GC identifiers)

Start:
8,091,651 bp from pter      End:
8,093,564 bp from pter
Size:
1,914 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CQ059_HUMAN, Q96GS4 (See protein sequence)
Recommended Name: Uncharacterized protein C17orf59  
Size: 357 amino acids; 37226 Da
Sequence caution: Sequence=AAH09261.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH18880.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH70272.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA90889.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAD96226.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: Q53HS4 Q9NXW8

Explore the universe of human proteins at neXtProt for C17orf59: NX_Q96GS4

Explore proteomics data for C17orf59 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C17orf59 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060092.2  
    ENSEMBL proteins: 
     ENSP00000373669  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019314 DUF2365

    Graphical View of Domain Structure for InterPro Entry Q96GS4

    ProtoNet protein and cluster: Q96GS4


    C17orf59 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    C17orf59 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    hsa-mir-26b-5p (MIRT028984)

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    hsa-miR-125a-5p hsa-miR-185* hsa-miR-15a hsa-miR-1224-3p hsa-miR-331-3p hsa-miR-548v hsa-miR-1260b hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidC17orf59 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    nucleus2
    cytosol1
    lysosome1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C17orf59
    Interactions:

        Search GeneGlobe Interaction Network for C17orf59

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for C17orf59 (Q96GS43 ENSP000003736694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KNSTRNQ9Y4483I2D: score=3 
    NDE1Q9NXR13I2D: score=3 
    KXD1ENSP000002223074STRING: ENSP00000222307
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C17orf59 (CQ059)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for C17orf59 gene: 
    NM_017622.2  

    Unigene Cluster for C17orf59:

    Chromosome 17 open reading frame 59
    Hs.129563  [show with all ESTs]
    Unigene Representative Sequence: NM_017622
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000389017(uc010vut.2)
    miRNA
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    hsa-miR-125a-5p hsa-miR-185* hsa-miR-15a hsa-miR-1224-3p hsa-miR-331-3p hsa-miR-548v hsa-miR-1260b hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidC17orf59 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat C17orf59
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf59
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat C17orf59
      QuantiFast Probe-based Assays in human, mouse, rat C17orf59

    Additional mRNA sequence: 

    AK000021.1 AK222506.1 BC009261.2 BC018880.2 BC070272.1 

    3 DOTS entries:

    DT.100754930  DT.306506  DT.95290796 

    Selected AceView cDNA sequences (see all 58):

    AJ707590 AI380880 AI744756 CA423621 BU731516 CB528922 BC009261 BF588575 
    AI380879 AI401164 AI251012 BU071884 AI992271 AA604439 AI332442 BF001228 
    BP382515 BQ674127 AW058624 BC070272 CB149568 AK000021 BM708837 H27353 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C17orf59 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATCAGGAG
    C17orf59 Expression
    About this image

    C17orf59 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C17orf59 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129563
        Custom PCR Arrays for C17orf59
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf59

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for C17orf59 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2310047M10Rik1 , 5 RIKEN cDNA 2310047M10 gene1, 5 80.28(n)1
    74.37(a)1
      11 (42.33 cM)5
    719231  NM_028005.31  NP_082281.21 
     690597175 
    chicken
    (Gallus gallus)
    Aves C17orf596
    chromosome 17 open reading frame 59
    55(a)
    1 ↔ 1
    3(75238660-75241744)
    lizard
    (Anolis carolinensis)
    Reptilia C17orf596
    chromosome 17 open reading frame 59
    62(a)
    1 ↔ 1
    GL343516.1(222460-223059)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.116802 Xenopus laevis transcribed sequence with weak similarity more 77.64(n)    48012939 
    zebrafish
    (Danio rerio)
    Actinopterygii C8H17orf596
    chromosome 17 open reading frame 59
    30(a)
    1 ↔ 1
    8(26812883-26824495) ENSDARG00000061023
    fruit fly
    (Drosophila melanogaster)
    Insecta CG171806
    --
    23(a)
    1 ↔ 1
    3L(540851-542147)
    worm
    (Caenorhabditis elegans)
    Secernentea Y37E11B.36
    Protein Y37E11B.3 (Y37E11B.3) mRNA, complete cds
    31(a)
    1 ↔ 1
    IV(3580969-3582909) WBGene00021376


    ENSEMBL Gene Tree for C17orf59 (if available)
    TreeFam Gene Tree for C17orf59 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C17orf59 (see all 90)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30272691,2
    H--8091209(+) TTACTG/ATGTGA 1 -- int14Minor allele frequency- A:0.00NS EA 416
    rs1899388081,2
    --8091264(+) GGCACC/TGATCT 1 -- int10--------
    rs1165486541,2
    F--8091273(+) CTGCAG/AAGTGT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs30272701,2
    C,F,H--8091313(+) TGTTCC/TCAGTC 1 -- int113Minor allele frequency- T:0.04NS EA NA WA CSA 1197
    rs1813952951,2
    --8091329(+) CCAGAC/GGTAAG 1 -- int10--------
    rs1862514671,2
    --8091356(+) CCCAGC/TCCCTG 1 -- int10--------
    rs22337581,2
    C,F,H--8091438(+) GTTACC/TGGATC 1 -- int18Minor allele frequency- T:0.04NS EA NA 850
    rs1897840011,2
    --8091448(+) CTCTGA/GGCCCC 1 -- int10--------
    rs22337591,2
    C,F,H--8091451(+) TGGGCC/TCCTGT 1 -- int15Minor allele frequency- T:0.01NS EA WA 480
    rs728464111,2
    --8091471(+) TCTGTG/TTCCTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for C17orf59 (8091651 - 8093564 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for C17orf59:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527475CNV Loss19592680
    nsv833353CNV Loss17160897
    nsv907658CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C17orf59
    DNA2.0 Custom Variant and Variant Library Synthesis for C17orf59

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C17orf59 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C17orf59)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    3. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54785 HGNC: 25939 AceView: FLJ20014 Ensembl:ENSG00000196544 euGenes: HUgn54785
    ECgene: C17orf59 H-InvDB: C17orf59

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C17orf59 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C17orf59 gene:
    Search GeneIP for patents involving C17orf59

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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