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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C17orf59 Gene

protein-coding   GIFtS: 40
GCID: GC17M008091

Chromosome 17 Open Reading Frame 59

  Search for C17orf59
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 17 Open Reading Frame 591 2
PRO24722
Uncharacterized Protein C17orf592

External Ids:    HGNC: 259391   Entrez Gene: 547852   Ensembl: ENSG000001965447   UniProtKB: Q96GS43   

Export aliases for C17orf59 gene to outside databases

Previous GC identifers: GC17M008033 GC17M008038 GC17M007988


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C17orf59 Gene: 
C17orf59 (chromosome 17 open reading frame 59) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C17orf59 gene promoter:
         Pbx1a   SREBP-1c   Olf-1   CUTL1   Nkx2-5   SREBP-1b   SREBP-1a   Zic3   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C17orf59

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf59


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

C17orf59 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C17orf59 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M008091:  view genomic region     (about GC identifiers)

Start:
8,091,651 bp from pter      End:
8,093,564 bp from pter
Size:
1,914 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CQ059_HUMAN, Q96GS4 (See protein sequence)
Recommended Name: Uncharacterized protein C17orf59  
Size: 357 amino acids; 37226 Da
Sequence caution: Sequence=AAH09261.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH18880.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH70272.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA90889.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAD96226.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: Q53HS4 Q9NXW8

Explore the universe of human proteins at neXtProt for C17orf59: NX_Q96GS4

Explore proteomics data for C17orf59 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96GS4

  • C17orf59 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C17orf59 Protein Expression
    REFSEQ proteins: NP_060092.2  
    ENSEMBL proteins: 
     ENSP00000373669  

    Human Recombinant Protein Products for C17orf59: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019314 DUF2365

    Graphical View of Domain Structure for InterPro Entry Q96GS4

    ProtoNet protein and cluster: Q96GS4


    C17orf59 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    C17orf59 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidC17orf59 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C17orf59

    2 Interacting proteins for C17orf59 (Q96GS43) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KNSTRNQ9Y4483I2D: score=3 
    NDE1Q9NXR13I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C17orf59 (CQ059)

    Search CenterWatch for drugs/clinical trials and news about C17orf59 / CQ059

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C17orf59 gene: 
    NM_017622.2  

    Unigene Cluster for C17orf59:

    Chromosome 17 open reading frame 59
    Hs.129563  [show with all ESTs]
    Unigene Representative Sequence: NM_017622
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000389017(uc010vut.2)
    miRNA
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate C17orf59 (see all 29):
    hsa-miR-125a-5p hsa-miR-185* hsa-miR-15a hsa-miR-1224-3p hsa-miR-331-3p hsa-miR-548v hsa-miR-1260b hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidC17orf59 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for C17orf59
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C17orf59
    Clone
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    OriGene clones in human, mouse for C17orf59 (see all 10)
    OriGene ORF clones in mouse, rat for C17orf59
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    GenScript: all cDNA clones in your preferred vector: C17orf59 (NM_017622)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C17orf59
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf59
    Sirion Biotech Customized lentivirus for stable overexpression of C17orf59 
                         Customized lentivirus expression plasmids for stable overexpression of C17orf59 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C17orf59
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C17orf59

    Additional mRNA sequence: 

    AK000021.1 AK222506.1 BC009261.2 BC018880.2 BC070272.1 

    3 DOTS entries:

    DT.100754930  DT.306506  DT.95290796 

    24/58 AceView cDNA sequences (see all 58):

    AI380880 BU071884 AI744756 BU731516 AI401164 BC009261 AI380879 AA604439 
    AJ707590 BF588575 AI992271 AI251012 CB528922 CA423621 BI911941 BQ669483 
    AI989738 BM998432 BF001228 BC018880 BM819789 BG503122 BF062824 BF445145 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C17orf59 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATCAGGAG
    C17orf59 Expression
    About this image


    See C17orf59 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C17orf59

    SOURCE GeneReport for Unigene cluster: Hs.129563
        SABiosciences Custom PCR Arrays for C17orf59
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C17orf59
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf59

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for C17orf59 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2310047M10Rik1 , 5 RIKEN cDNA 2310047M10 gene1, 5 80.89(n)1
    76.27(a)1
      11 (42.33 cM)5
    719231  NM_028005.31  NP_082281.21 
     690597175 
    chicken
    (Gallus gallus)
    Aves C17ORF596
    Uncharacterized protein
    51(a)
    1 ↔ 1
    3(75238660-75241744)
    lizard
    (Anolis carolinensis)
    Reptilia C17ORF596
    Uncharacterized protein
    63(a)
    1 ↔ 1
    GL343516.1(222460-223059)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.116802 Xenopus laevis transcribed sequence with weak similarity more 77.64(n)    48012939 
    zebrafish
    (Danio rerio)
    Actinopterygii C8H17orf596
    chromosome 17 open reading frame 59
    29(a)
    1 ↔ 1
    8(26812883-26824495)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG171806
    --
    23(a)
    1 ↔ 1
    3L(540851-542147)
    worm
    (Caenorhabditis elegans)
    Secernentea Y37E11B.36
    Protein Y37E11B.3
    28(a)
    1 ↔ 1
    IV(3580969-3582909)


    ENSEMBL Gene Tree for C17orf59 (if available)
    TreeFam Gene Tree for C17orf59 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/90 SNPs in C17orf59 are shown (see all 90)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30272691,2
    H--8091209(+) TTACTG/ATGTGA 1 -- int14Minor allele frequency- A:0.00NS EA 416
    rs1899388081,2
    --8091264(+) GGCACC/TGATCT 1 -- int10--------
    rs1165486541,2
    F--8091273(+) CTGCAG/AAGTGT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs30272701,2
    C,F,H--8091313(+) TGTTCC/TCAGTC 1 -- int113Minor allele frequency- T:0.04NS EA NA WA CSA 1197
    rs1813952951,2
    --8091329(+) CCAGAC/GGTAAG 1 -- int10--------
    rs1862514671,2
    --8091356(+) CCCAGC/TCCCTG 1 -- int10--------
    rs22337581,2
    C,F,H--8091438(+) GTTACC/TGGATC 1 -- int18Minor allele frequency- T:0.04NS EA NA 850
    rs1897840011,2
    --8091448(+) CTCTGA/GGCCCC 1 -- int10--------
    rs22337591,2
    C,F,H--8091451(+) TGGGCC/TCCTGT 1 -- int15Minor allele frequency- T:0.01NS EA WA 480
    rs728464111,2
    --8091471(+) TCTGTG/TTCCTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for C17orf59 (8091651 - 8093564 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for C17orf59:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv527475CNV Loss19592680
    nsv833353CNV Loss17160897
    nsv907658CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C17orf59 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C17orf59)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    3. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54785 HGNC: 25939 AceView: FLJ20014 Ensembl:ENSG00000196544 euGenes: HUgn54785
    ECgene: C17orf59 H-InvDB: C17orf59

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C17orf59 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C17orf59 gene:
    Search GeneIP for patents involving C17orf59

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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