C17orf58 Gene
protein-coding GIFtS: 38
GCID: GC17M065987
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chromosome 17 open reading frame 58
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Aliases
for C17orf58 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 17 Open Reading Frame 581 2 | | UPF0450 Protein C17orf582 |
Export aliases for C17orf58 gene to outside databasesPrevious GC identifers: GC17M063418 GC17M061371 |
Summaries
for C17orf58 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C17orf58 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C17orf58 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 Pax-2 POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for C17orf58
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf58 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q24.2 Ensembl cytogenetic band: 17q24.2 HGNC cytogenetic band: 17q24.2C17orf58 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M065987: view genomic region
(about GC identifiers)
Start:
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65,987,217 bp from pter |
End:
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65,989,765 bp from pter |
Size:
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2,549 bases |
Orientation:
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minus strand |
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Proteins
for C17orf58 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CQ058_HUMAN, Q2M2W7 (See
protein sequence)Recommended Name: UPF0450 protein C17orf58 Size: 97 amino acids; 11219 Da
Secondary accessions: A8MQV2Alternative splicing: 2 isoforms: Q2M2W7-1 Q2M2W7-2 (Ref.1 (AL556320) and Ref.2 (AK026583) sequences are in conflict in position: 72:E->G)Explore the universe of human proteins at neXtProt for C17orf58: NX_Q2M2W7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2M2W7
C17orf58 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_858041.2 NP_858042.2
ENSEMBL proteins: ENSP00000402020 ENSP00000443680 ENSP00000334741
Human Recombinant Protein Products for C17orf58:
C17orf58 Antibody Products:
Assay Products for C17orf58: |
Protein
Domains /
Families
for C17orf58 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C17orf58 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q2M2W7ProtoNet protein and cluster: Q2M2W7 UniProtKB/Swiss-Prot: CQ058_HUMAN, Q2M2W7Similarity: Belongs to the UPF0450 family |
Function
for C17orf58 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf58 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf58 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): C17orf58 (NM_181655) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C17orf58 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf58 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf58 |
|
Pathways & Interactions
for C17orf58 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C17orf58
|
Drugs & Compounds
for C17orf58 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C17orf58
Search CenterWatch for drugs/clinical trials and news about C17orf58 / CQ058
|
Transcripts
for C17orf58 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C17orf58 gene (2 alternative transcripts): NM_181655.2 NM_181656.3 Unigene Cluster for C17orf58: Chromosome 17 open reading frame 58 Hs.90790 [show with all ESTs]Unigene Representative Sequence: NM_1816563 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000449250 ENST00000536693 ENST00000334461(uc002jgj.4 uc002jgi.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf58 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf58 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C17orf58 (NM_181655) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C17orf58 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf58 |
Additional cDNA sequence: AK026583.1 BC021702.1 BC036760.1 BC105124.1 BC112073.1 5 DOTS entries: DT.100781627 DT.442873 DT.92423357 DT.95192797 DT.121608847 24/69 AceView cDNA sequences (see all 69): AA868096 AI492828 CA308257 CR594326 CR592488 CA443532 BF435372 BC036760 BX369525 BF511946 AK026583 BX396661 BI224193 NM_181655 R22334 BX369526 BM764858 BG529487 BG475090 BM544218 CA443050 BF439607 BC021702 F10593
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for C17orf58 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c |
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| SP1: | | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C17orf58
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Expression
for C17orf58 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C17orf58 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCCCTGCT
About this image
See C17orf58 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C17orf58
SOURCE GeneReport for Unigene cluster: Hs.90790
SABiosciences Custom PCR Arrays for C17orf58
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C17orf58
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C17orf58 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C17orf58 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C17orf58 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf58 |
Orthologs
for C17orf58 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C17orf58 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for C17orf58 (if available)
TreeFam Gene Tree for C17orf58 (if available) |
Paralogs
for C17orf58 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C17orf58 gene
C17orf58 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for C17orf58
PGOHUM00000237415 PGOHUM00000247406
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Genomic Variants
for C17orf58 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C17orf58 (65987217 - 65989765 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for C17orf58
3 CNVs: 73006 73007 22953 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C17orf58 |
|
Disorders
/ Diseases
for C17orf58 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C17orf58 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C17orf58 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C17orf58) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for C17orf58 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing C17orf58 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C17orf58 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C17orf58 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C17orf58 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C17orf58 gene:
Search GeneIP for patents involving C17orf58
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C17orf58 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C17orf58 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C17orf58 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C17orf58 | | | OriGene Protein Over-expression Lysate for C17orf58 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C17orf58 | | OriGene 3'-UTR Clone for C17orf58 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf58 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C17orf58 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C17orf58 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C17orf58 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf58 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C17orf58 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C17orf58 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C17orf58 |
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 | | | C17orf58 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf58 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for C17orf58 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf58 |
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