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Aliases for C17orf58 Gene

Aliases for C17orf58 Gene

  • Chromosome 17 Open Reading Frame 58 2 3 5

External Ids for C17orf58 Gene

Previous GeneCards Identifiers for C17orf58 Gene

  • GC17M063418
  • GC17M065987
  • GC17M061371

Summaries for C17orf58 Gene

GeneCards Summary for C17orf58 Gene

C17orf58 (Chromosome 17 Open Reading Frame 58) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C17orf58 Gene

Genomics for C17orf58 Gene

Regulatory Elements for C17orf58 Gene

Enhancers for C17orf58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F067992 1.5 FANTOM5 ENCODE 16.3 +2.0 1991 4.5 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 ZNF302 NOL11 LRRC37A16P HELZ C17orf58 ENSG00000265100 ENSG00000267731 WIPI1 LOC440461 AMZ2 BPTF
GH17F067973 0.9 Ensembl ENCODE 12.6 +21.9 21886 2.8 CTCF HLF NFRKB TEAD4 MAX CEBPB CEBPG MNT ZBTB40 JUND SH3GL1P3 C17orf58 WIPI1 ENSG00000279880 RN7SL622P
GH17F068045 0.5 FANTOM5 11.4 -48.5 -48519 0.4 PAF1 ZNF592 C17orf58 KPNA2 FBXO36P1
GH17F067977 0.9 ENCODE 0.3 +18.2 18239 1.4 PKNOX1 INSM2 KLF17 FEZF1 ZNF2 ZEB1 ZNF366 SCRT2 RCOR1 KLF7 LRRC37A16P WIPI1 RN7SL622P C17orf58
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C17orf58 on UCSC Golden Path with GeneCards custom track

Genomic Location for C17orf58 Gene

Chromosome:
17
Start:
67,991,099 bp from pter
End:
67,996,784 bp from pter
Size:
5,686 bases
Orientation:
Minus strand

Genomic View for C17orf58 Gene

Genes around C17orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf58 Gene

Proteins for C17orf58 Gene

  • Protein details for C17orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2W7-CQ058_HUMAN
    Recommended name:
    UPF0450 protein C17orf58
    Protein Accession:
    Q2M2W7
    Secondary Accessions:
    • A8MQV2

    Protein attributes for C17orf58 Gene

    Size:
    97 amino acids
    Molecular mass:
    11219 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C17orf58 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C17orf58 Gene

Post-translational modifications for C17orf58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C17orf58 Gene

No data available for DME Specific Peptides for C17orf58 Gene

Domains & Families for C17orf58 Gene

Protein Domains for C17orf58 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C17orf58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2M2W7

UniProtKB/Swiss-Prot:

CQ058_HUMAN :
  • Belongs to the UPF0450 family.
Family:
  • Belongs to the UPF0450 family.
genes like me logo Genes that share domains with C17orf58: view

No data available for Gene Families for C17orf58 Gene

Function for C17orf58 Gene

Phenotypes for C17orf58 Gene

GenomeRNAi human phenotypes for C17orf58:
genes like me logo Genes that share phenotypes with C17orf58: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C17orf58 Gene

Localization for C17orf58 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C17orf58 gene
Compartment Confidence
cytosol 3
plasma membrane 2
extracellular 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C17orf58 Gene

Pathways & Interactions for C17orf58 Gene

SuperPathways for C17orf58 Gene

No Data Available

Interacting Proteins for C17orf58 Gene

Gene Ontology (GO) - Biological Process for C17orf58 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C17orf58 Gene

Transcripts for C17orf58 Gene

Unigene Clusters for C17orf58 Gene

Chromosome 17 open reading frame 58:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf58 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - -
SP2: -
SP3:

Relevant External Links for C17orf58 Gene

GeneLoc Exon Structure for
C17orf58
ECgene alternative splicing isoforms for
C17orf58

Expression for C17orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C17orf58 Gene

Protein differential expression in normal tissues from HIPED for C17orf58 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C17orf58 Gene



Protein tissue co-expression partners for C17orf58 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C17orf58 Gene:

C17orf58

SOURCE GeneReport for Unigene cluster for C17orf58 Gene:

Hs.90790
genes like me logo Genes that share expression patterns with C17orf58: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C17orf58 Gene

Orthologs for C17orf58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C17orf58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf58 34
  • 100 (n)
C17ORF58 35
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C17orf58 35
  • 92 (a)
OneToOne
C9H17orf58 34
  • 89 (n)
cow
(Bos Taurus)
Mammalia C19H17orf58 34
  • 88.32 (n)
mouse
(Mus musculus)
Mammalia 1810010H24Rik 34 16
  • 84.54 (n)
rat
(Rattus norvegicus)
Mammalia RGD1565033 34
  • 82.82 (n)
oppossum
(Monodelphis domestica)
Mammalia C17orf58 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C17orf58 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17orf58 35
  • 74 (a)
OneToOne
C17ORF58 34
  • 72.92 (n)
lizard
(Anolis carolinensis)
Reptilia C17orf58 35
  • 48 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14404 34
Species where no ortholog for C17orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C17orf58 Gene

ENSEMBL:
Gene Tree for C17orf58 (if available)
TreeFam:
Gene Tree for C17orf58 (if available)

Paralogs for C17orf58 Gene

No data available for Paralogs for C17orf58 Gene

Variants for C17orf58 Gene

Sequence variations from dbSNP and Humsavar for C17orf58 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111513651 -- 67,993,106(+) GGACT(A/C/T)GGAAG reference, missense
rs112612674 -- 67,992,964(+) CGACC(C/T)ACAGC intron-variant, reference, synonymous-codon
rs113012247 -- 67,994,514(+) TGTGT(A/G)TGTAT upstream-variant-2KB
rs113421199 -- 67,991,385(+) TAAGT(A/G)TAAAA utr-variant-3-prime
rs113985803 -- 67,993,855(+) CGCGG(A/G)CGGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C17orf58 Gene

Variant ID Type Subtype PubMed ID
dgv5754n54 CNV gain 21841781
dgv5755n54 CNV loss 21841781
esv22750 CNV gain 19812545
esv26540 CNV loss 19812545
esv2716136 CNV deletion 23290073
esv3641102 CNV gain 21293372
nsv1118767 CNV deletion 24896259
nsv1120054 OTHER inversion 24896259
nsv436233 CNV deletion 17901297
nsv471405 CNV gain 19718026

Variation tolerance for C17orf58 Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.70; 78.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C17orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C17orf58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf58 Gene

Disorders for C17orf58 Gene

Relevant External Links for C17orf58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C17orf58

No disorders were found for C17orf58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf58 Gene

Publications for C17orf58 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for C17orf58 Gene

Sources for C17orf58 Gene

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