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Aliases for C17orf105 Gene

Aliases for C17orf105 Gene

  • Chromosome 17 Open Reading Frame 105 2 3 5

External Ids for C17orf105 Gene

Previous GeneCards Identifiers for C17orf105 Gene

  • GC17P039214
  • GC17P041857
  • GC17P037621

Summaries for C17orf105 Gene

GeneCards Summary for C17orf105 Gene

C17orf105 (Chromosome 17 Open Reading Frame 105) is a Protein Coding gene.

Additional gene information for C17orf105 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C17orf105 Gene

Genomics for C17orf105 Gene

Regulatory Elements for C17orf105 Gene

Enhancers for C17orf105 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H043926 1.2 FANTOM5 Ensembl ENCODE 23.8 +149.8 149817 2.8 SOX5 SOX13 GATAD2A TFAP4 TCF7 HMG20A PRDM10 SMAD4 LSM12 C17orf105 MPP2 NAGS PYY ENSG00000221044 CD300LG LOC102724183 LINC01976
GH17H044024 0.5 FANTOM5 25.2 +246.1 246074 0.4 KLF9 RCOR1 C17orf105 LSM12 NAGS CD300LG ENSG00000221044 TMEM101 PYY
GH17H043839 1.1 Ensembl ENCODE 10.9 +61.8 61756 1.6 TBP NFIB RAD21 YY1 ZNF366 SCRT2 RCOR1 ZNF391 ELK4 SMARCC1 DUSP3 C17orf105 MPP2 MPP3 MEOX1 CD300LG
GH17H043841 1 Ensembl ENCODE 10.7 +64.1 64134 1.2 PKNOX1 SP3 KLF1 MTA2 ZBTB2 KLF17 MNT SP1 ZFHX2 EGR1 MPP2 DUSP3 C17orf105 MPP3 CD300LG
GH17H043846 0.9 ENCODE 10.9 +68.2 68199 0.8 RB1 ARID4B ZNF2 RAD21 SCRT2 ZNF143 THAP11 EGR2 ZNF654 REST DUSP3 C17orf105 SOST ENSG00000221044 CD300LG MPP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C17orf105 on UCSC Golden Path with GeneCards custom track

Promoters for C17orf105 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094656 309 1401 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9

Genomic Locations for C17orf105 Gene

Genomic Locations for C17orf105 Gene
chr17:43,778,391-43,787,612
(GRCh38/hg38)
Size:
9,222 bases
Orientation:
Plus strand
chr17:41,857,803-41,864,980
(GRCh37/hg19)

Genomic View for C17orf105 Gene

Genes around C17orf105 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf105 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf105 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf105 Gene

Proteins for C17orf105 Gene

  • Protein details for C17orf105 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B2RV13-CQ105_HUMAN
    Recommended name:
    Uncharacterized protein C17orf105
    Protein Accession:
    B2RV13

    Protein attributes for C17orf105 Gene

    Size:
    164 amino acids
    Molecular mass:
    19546 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C17orf105 Gene

Post-translational modifications for C17orf105 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C17orf105 Gene

No data available for DME Specific Peptides for C17orf105 Gene

Domains & Families for C17orf105 Gene

Gene Families for C17orf105 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C17orf105 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C17orf105: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C17orf105 Gene

Function for C17orf105 Gene

Phenotypes From GWAS Catalog for C17orf105 Gene

miRNA for C17orf105 Gene

miRTarBase miRNAs that target C17orf105

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C17orf105 Gene

Localization for C17orf105 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C17orf105 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C17orf105 Gene

Pathways & Interactions for C17orf105 Gene

SuperPathways for C17orf105 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C17orf105 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C17orf105 Gene

Drugs & Compounds for C17orf105 Gene

No Compound Related Data Available

Transcripts for C17orf105 Gene

Unigene Clusters for C17orf105 Gene

Chromosome 17 open reading frame 105:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf105 Gene

No ASD Table

Relevant External Links for C17orf105 Gene

GeneLoc Exon Structure for
C17orf105
ECgene alternative splicing isoforms for
C17orf105

Expression for C17orf105 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C17orf105 Gene

mRNA differential expression in normal tissues according to GTEx for C17orf105 Gene

This gene is overexpressed in Testis (x48.0).

Protein differential expression in normal tissues from HIPED for C17orf105 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C17orf105 Gene



Protein tissue co-expression partners for C17orf105 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C17orf105 Gene:

C17orf105

SOURCE GeneReport for Unigene cluster for C17orf105 Gene:

Hs.252707

Evidence on tissue expression from TISSUES for C17orf105 Gene

  • Blood(2)
genes like me logo Genes that share expression patterns with C17orf105: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C17orf105 Gene

Orthologs for C17orf105 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C17orf105 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf105 33
  • 99.19 (n)
C17orf105 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H17orf105 33
  • 91.67 (n)
C17orf105 34
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C19H17orf105 33
  • 90.45 (n)
C17orf105 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700006E09Rik 33 16 34
  • 87.8 (n)
rat
(Rattus norvegicus)
Mammalia RGD1565533 33
  • 86.59 (n)
oppossum
(Monodelphis domestica)
Mammalia C17orf105 34
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C17orf105 34
  • 29 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17orf105 34
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C17orf105 34
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C25H17orf105 (1 of 2) 34
  • 23 (a)
OneToMany
C9H17orf105 (2 of 2) 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToOne
Species where no ortholog for C17orf105 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C17orf105 Gene

ENSEMBL:
Gene Tree for C17orf105 (if available)
TreeFam:
Gene Tree for C17orf105 (if available)

Paralogs for C17orf105 Gene

No data available for Paralogs for C17orf105 Gene

Variants for C17orf105 Gene

Sequence variations from dbSNP and Humsavar for C17orf105 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000602014 -- 43,778,777(+) CGGGG(C/T)CGGGC intron-variant, upstream-variant-2KB
rs1000972813 -- 43,778,936(+) GGCGG(A/G)GCCCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001088813 -- 43,779,011(+) GAGCC(C/G)CCCCG intron-variant, upstream-variant-2KB
rs1001236686 -- 43,778,873(+) GCCGT(C/T)CGAGA intron-variant, upstream-variant-2KB, reference, missense
rs1001251253 -- 43,784,691(+) TGGAA(G/T)AAGAA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C17orf105 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv1060861 CNV gain 25217958
esv3640637 CNV gain 21293372
esv27934 CNV gain 19812545

Variation tolerance for C17orf105 Gene

Gene Damage Index Score: 0.89; 18.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C17orf105 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C17orf105

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf105 Gene

Disorders for C17orf105 Gene

Relevant External Links for C17orf105

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C17orf105

No disorders were found for C17orf105 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf105 Gene

Publications for C17orf105 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for C17orf105 Gene

Sources for C17orf105 Gene

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