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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C17orf105 Gene

protein-coding   GIFtS: 32
GCID: GC17P041857          (predicted)

Chromosome 17 Open Reading Frame 105

  Search for C17orf105
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 17 Open Reading Frame 1051 2
Uncharacterized Protein C17orf1052

External Ids:    HGNC: 372411   Entrez Gene: 2840672   Ensembl: ENSG000002312567   UniProtKB: B2RV133   

Export aliases for C17orf105 gene to outside databases

Previous GC identifers: GC17P039214 GC17P037621


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C17orf105 Gene: 
C17orf105 (chromosome 17 open reading frame 105) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for C17orf105
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C17orf105

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C17orf105


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

C17orf105 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C17orf105 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P041857:  view genomic region     (about GC identifiers)

Start:
41,857,803 bp from pter      End:
41,864,980 bp from pter
Size:
7,178 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CQ105_HUMAN, B2RV13 (See protein sequence)
Recommended Name: Uncharacterized protein C17orf105  
Size: 164 amino acids; 19546 Da

Explore the universe of human proteins at neXtProt for C17orf105: NX_B2RV13

Explore proteomics data for C17orf105 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_B2RV13

  • C17orf105 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C17orf105 Protein Expression
    REFSEQ proteins: NP_001129955.1  
    ENSEMBL proteins: 
     ENSP00000415662   ENSP00000468141  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: B2RV13


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C17orf105

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C17orf105 (CQ105)

    Search CenterWatch for drugs/clinical trials and news about C17orf105 / CQ105

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for C17orf105 gene: 
    NM_001136483.1  

    Unigene Cluster for C17orf105:

    Chromosome 17 open reading frame 105
    Hs.252707  [show with all ESTs]
    Unigene Representative Sequence: AK125817
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449302(uc002ieg.3) ENST00000590148
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    Additional mRNA sequence: 

    AK125817.1 BC054872.1 BC070324.1 BC146971.1 

    2 DOTS entries:

    DT.408412  DT.120892141 

    24 AceView cDNA sequences:

    AA913745 AW469550 AI023564 AA628992 AA913754 BC054872 AA913253 AI247398 
    AI684443 AW629499 AI633771 AI126165 AW236514 AK125817 BX118909 AW182374 
    AI809525 BU193659 AI028293 BU561134 BC070324 AA843576 AI808307 AA913260 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C17orf105 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAGATAC
    C17orf105 Expression
    About this image


    See C17orf105 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C17orf105

    SOURCE GeneReport for Unigene cluster: Hs.252707
        SABiosciences Custom PCR Arrays for C17orf105
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C17orf105

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C17orf105 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1700006E09Rik1 , 5 RIKEN cDNA 1700006E09 gene1, 5 87.8(n)1
    85.98(a)1
      11 (65.48 cM)5
    754371  NM_029287.11  NP_083563.11 
     1019842795 
    chicken
    (Gallus gallus)
    Aves C17ORF1056
    Uncharacterized protein
    36(a)
    1 ↔ 1
    27(3268629-3270317)
    lizard
    (Anolis carolinensis)
    Reptilia C17orf1056
    --
    --
    40(a)
    28(a)
    1 ↔ 1
    possible ortholog
    6(78163988-78177141)
    3(106740876-106755992)
    zebrafish
    (Danio rerio)
    Actinopterygii BX005109.16
    C9H17orf1056
    chromosome 17 open reading frame 105
    23(a)
    21(a)
    possible ortholog
    1 ↔ 1
    25(611578-616429)
    9(33103265-33104738)


    ENSEMBL Gene Tree for C17orf105 (if available)
    TreeFam Gene Tree for C17orf105 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/89 SNPs in C17orf105 are shown (see all 89)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739870871,2
    C,F--41858383(+) TAATTC/TGAAAT 1 -- int12Minor allele frequency- T:0.11WA 120
    rs713829951,2
    C,F--41858623(+) CTAAAG/AAGGTT 1 -- int13Minor allele frequency- A:0.08NA 124
    rs1119116831,2
    C--41858722(+) CCCCCT/-GATAC 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1135554291,2
    C,F--41858742(+) CTCTGT/CTGCCT 1 -- int14Minor allele frequency- C:0.11CSA WA NA EA 360
    rs1128886001,2
    C--41858810(+) TCTCCC/TGCCTC 1 -- int10--------
    rs1893731181,2
    --41858854(+) GCACCA/GTGCCC 1 -- int10--------
    rs1814631871,2
    --41858983(+) CCACCA/GTGCCC 1 -- int10--------
    rs572276601,2
    C,F--41858984(+) CACCGT/CGCCCG 1 -- int16Minor allele frequency- C:0.22WA CSA NA EA 246
    rs1155820341,2
    F--41858989(+) TGCCCG/AGCCGC 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1430344011,2
    C--41859001(+) CAGTC-/TTTTAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for C17orf105 (41857803 - 41864980 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for C17orf105:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908265CNV Gain21882294
    nsv908267CNV Gain21882294
    esv27934CNV Gain19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C17orf105 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C17orf105)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284067 HGNC: 37241 AceView: LOC284067 Ensembl:ENSG00000231256 euGenes: HUgn284067
    ECgene: C17orf105 H-InvDB: C17orf105

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C17orf105 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C17orf105 gene:
    Search GeneIP for patents involving C17orf105

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for C17orf105
     Browse SwitchGear Promoter luciferase reporter plasmids for C17orf105
     Search ThermoFisher Antibodies for C17orf105
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C17orf105
     inGenious Targeting Laboratory - Custom generated mouse model solutions for C17orf105
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C17orf105
    Customized:
     lentivirus for stable overexpression of C17orf105
     lentivirus expression plasmids for stable overexpression of C17orf105
     adenovirus for overexpression of C17orf105
     Search LSBio for Antibodies for C17orf105
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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