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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C16orf93 Gene

protein-coding   GIFtS: 36
GCID: GC16M030768

chromosome 16 open reading frame 93
  Search for C16orf93
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C16orf93    

Aliases
for C16orf93 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 16 Open Reading Frame 931 2
MGC1047061
Coiled-Coil Domain-Containing Protein C16orf932

External Ids:    HGNC: 280781   Entrez Gene: 908352   Ensembl: ENSG000001961187   UniProtKB: A1A4V93   

Export aliases for C16orf93 gene to outside databases

Previous GC identifers: GC16M030677 GC16M030678 GC16M028331


Summaries
for C16orf93 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C16orf93 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C16orf93 gene promoter:
         NF-1   NF-1/L   ATF-2   Nkx2-5   c-Ets-1   Pax-3   PPAR-gamma1   Ik-2   c-Jun   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C16orf93

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C16orf93


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

C16orf93 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C16orf93 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030768:  view genomic region     (about GC identifiers)

Start:
 30,768,744 bp from pter      End:
 30,774,031 bp from pter
Size:
 5,288 bases      Orientation:
 minus strand

Proteins
for C16orf93 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CP093_HUMAN, A1A4V9 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein C16orf93  
Size: 331 amino acids; 37921 Da
Secondary accessions: A1A4V8 F5GX13 Q569G2
Alternative splicing: 4 isoforms:  A1A4V9-1   A1A4V9-2   A1A4V9-3   A1A4V9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C16orf93: NX_A1A4V9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A1A4V9

    • C16orf93 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001014979.2  NP_001182549.1  

    ENSEMBL proteins: 
     ENSP00000455034   ENSP00000442644   ENSP00000457287   ENSP00000437532   ENSP00000441164  
     ENSP00000442648  

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    Uscn ELISAs and CLIAs for C16orf93

    Protein Domains /
    Families
    for C16orf93 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: A1A4V9


    Function
    for C16orf93 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for C16orf93 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C16orf93

    Drugs & Compounds
    for C16orf93 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C16orf93
    Search CenterWatch for drugs/clinical trials and news about C16orf93 / CP093 

    Transcripts
    for C16orf93 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for C16orf93 gene (2 alternative transcripts): 
    NM_001014979.2  NM_001195620.1  

    Unigene Cluster for C16orf93:

    Chromosome 16 open reading frame 93
    Hs.724010  [show with all ESTs]
    Unigene Representative Sequence: BC092491
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544613 ENST00000546006 ENST00000544643 ENST00000535476 ENST00000543128(uc002dzo.3 uc002dzm.3)
    ENST00000537986 ENST00000544487(uc021tgp.1) ENST00000433909 ENST00000541260
    ENST00000543610 ENST00000545825(uc002dzp.3) ENST00000545809

    miRNA
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK307279.1 BC073881.1 BC092491.1 BC128129.1 

    13 DOTS entries:

    DT.99933835  DT.95266485  DT.86853373  DT.95269850  DT.40131703  DT.95269851  DT.100887020  DT.95266484 
    DT.100755025  DT.100806357  DT.102838764  DT.120714206  DT.40113268 

    24/64 AceView cDNA sequences (see all 64):

    BC042548 BG742636 AL122109 AI419128 AI493459 BC063391 BE222577 BC073881 
    BM849219 BX115932 BX457439 CR598994 BX424406 BM845163 BI826855 BM543508 
    BM763228 R58937 BM847406 BI520182 AA515275 BU533782 AI744490 AI809251 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for C16orf93 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                      -                 -     -           -     -                                             
    SP2:                                                        -     -                                               -               
    SP3:                                                        -     -     -     -     -     -                                       
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for C16orf93

    Expression
    for C16orf93 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C16orf93 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGCTACAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    C16orf93 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneEndochondral Facial BonesBone
    BoneStylopod Long BoneBone
    BoneThoracic RibBone
    BoneZeugopod Long BoneBone
    CartilageMeckel's CartilageCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    Genevestigator expression for C16orf93

    SOURCE GeneReport for Unigene cluster: Hs.724010
        SABiosciences Custom PCR Arrays for C16orf93
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    In Situ
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    Orthologs
    for C16orf93 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for C16orf93 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Gm1661 , 5 predicted gene 1661, 5 77.61(n)1
    73.25(a)1    		   7 (69.61 cM)5
    2338991  NM_001033040.31  NP_001028212.11 
     1275823845 
    chicken
    (Gallus gallus)    		 Aves C16orf936
    		 Uncharacterized protein
    		 34(a)
    		 1 ↔ 1
    		 17(620188-623896)
    lizard
    (Anolis carolinensis)    		 Reptilia C16orf936
    		 --
    		 50(a)
    		 1 ↔ 1
    		 GL343516.1(83756-94883)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1001515161 coiled-coil domain-containing protein C16orf93 homolog 48.38(n)
    34.24(a)    		   100151516  XM_001920593.3  XP_001920628.2 


    ENSEMBL Gene Tree for C16orf93 (if available)
    TreeFam Gene Tree for C16orf93 (if available) 

    Paralogs
    for C16orf93 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C16orf93 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for C16orf93
         2 CNVs: 30780 2209
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for C16orf93 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C16orf93 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C16orf93 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C16orf93)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for C16orf93 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C16orf93 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90835 HGNC: 28078 AceView: LOC90835 Ensembl:ENSG00000196118 euGenes: HUgn90835
    ECgene: C16orf93 H-InvDB: C16orf93

    Other Databases showing C16orf93 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C16orf93 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C16orf93 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C16orf93 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C16orf93 gene:
    Search GeneIP for patents involving C16orf93

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for C16orf93 gene

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    About This Section

     
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