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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C16orf92 Gene

protein-coding GIFtS: 38
GCID: GC16P030034 (predicted)

chromosome 16 open reading frame 92

Search for C16orf92
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 16 Open Reading Frame 92¹ ²
FLJ25404¹
Uncharacterized Protein C16orf92²

External Ids:	HGNC: 26346¹	Entrez Gene: 146378²	Ensembl: ENSG00000167194⁷	UniProtKB: Q96LL3³

Export aliases for C16orf92 gene to outside databases

Previous GC identifers: GC16P029944 GC16P027695

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C16orf92 gene promoter:
GR Egr-3 MAZR C/EBPalpha Evi-1 CHOP-10 RORalpha1 FOXO4 ARP-1 GR-alpha
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C16orf92

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2

C16orf92 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C16orf92 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P030034: view genomic region (about GC identifiers)

Start:	30,034,655 bp from pter	End:	30,039,057 bp from pter
Size:	4,403 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP092_HUMAN, Q96LL3 (See protein sequence)

Recommended Name: Uncharacterized protein C16orf92

Size: 132 amino acids; 14383 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Secondary accessions: Q494R8

Alternative splicing: 2 isoforms: Q96LL3-1 Q96LL3-2

Explore the universe of human proteins at neXtProt for C16orf92: NX_Q96LL3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96LL3

C16orf92 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001103129.1 NP_001103130.1

ENSEMBL proteins:

ENSP00000456798 ENSP00000300575 ENSP00000454560 ENSP00000458048

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

C16orf92 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96LL3

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C16orf92

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for C16orf92 gene (2 alternative transcripts):

NM_001109659.1 NM_001109660.1

Unigene Cluster for C16orf92:

Chromosome 16 open reading frame 92

Hs.651588 [show with all ESTs]

Unigene Representative Sequence: AK058133

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000561910 ENST00000300575(uc002dvr.2 uc002dvs.2) ENST00000569198

ENST00000567847

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Additional cDNA sequence:

AK058133.1 BC101433.1 BC101434.1 BC101435.1 BC101436.1 BC127955.1

4 DOTS entries:

DT.99935515 DT.120697024 DT.409775 DT.40234630

18 AceView cDNA sequences:

BM673918 BM664756 AK058133 BM676044 AA812801 BX444856 BE467245 AW196946

AA912420 AI187224 AA846409 AA860329 BM712944 BM703273 BM715434 BX433696

BM676198 BM712697

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for C16orf92 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4
SP1:
SP2:			-

ECgene alternative splicing isoforms for C16orf92

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C16orf92 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGGGCCCG

About this image

C16orf92 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Afferent Arteriole

Juxtaglomerular Cells

Kidney, Smooth Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C16orf92 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C16orf92

SOURCE GeneReport for Unigene cluster: Hs.651588

SABiosciences Custom PCR Arrays for C16orf92

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for C16orf92 gene from 1/4 species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	4930451I11Rik^{1 , 5}	RIKEN cDNA 4930451I11 gene^{1, 5}	73.39(n)¹ 66.06(a)¹		7 (69.25 cM)⁵ 78118¹ NM_183131.2¹ NP_898954.2¹ 126830474⁵

ENSEMBL Gene Tree for C16orf92 (if available)
TreeFam Gene Tree for C16orf92 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201065619^1,2	C	other	30035124(+)	`TTCTTC/TGATTA`	4	F	syn¹		0	--	--	--	--
rs138573795^1,2		--	30032659(+)	`GGTGGC/GATGGA`	2	--	us2k¹		0	--	--	--	--
rs191965463^1,2		--	30032689(+)	`GCCCAA/CCTGCC`	2	--	us2k¹		0	--	--	--	--
rs58753347^1,2		--	30032868(+)	`GATGTA/GCCTCG`	2	--	us2k¹		0	--	--	--	--
rs182831795^1,2		--	30032905(+)	`CAACCC/TCCGAC`	2	--	us2k¹		0	--	--	--	--
rs141039739^1,2		--	30033192(+)	`AGGAA-/CCCCCC`	2	--	us2k¹		0	--	--	--	--
rs187732188^1,2		--	30033365(+)	`AGGAGA/TTCAAG`	2	--	us2k¹		0	--	--	--	--
rs147970537^1,2		--	30033407(+)	`TCTACC/TAAAAG`	2	--	us2k¹		0	--	--	--	--
rs35605010^1,2	C,F	--	30033428(-)	`ACTGTT/CCGGCT`	2	--	us2k¹		8		NA CSA WA EA	367
rs141812320^1,2		--	30033493(+)	`AACCCA/GGGAGG`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for C16orf92 (30034655 - 30039057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C16orf92
1 CNV: 35383

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C16orf92 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C16orf92)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 146378	HGNC: 26346	AceView: FLJ25404	Ensembl:ENSG00000167194	euGenes: HUgn146378
ECgene: C16orf92	H-InvDB: C16orf92

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C16orf92	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C16orf92 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C16orf92 gene:
Search GeneIP for patents involving C16orf92

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	Browse SwitchGear 3'UTR luciferase reporter plasmids for C16orf92
	Browse SwitchGear Promoter luciferase reporter plasmids for C16orf92

Search ThermoFisher Antibodies for C16orf92

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf92

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for C16orf92

Sirion Biotech Customized:

	stable knockdown cell line services for C16orf92
	inducible knockdown cell line services for C16orf92
	design and validation of potent shRNA sequences against C16orf92
	adenovirus for potent knockdown of C16orf92
	adenovirus for overexpression of C16orf92
	stable overexpressing cell line services for C16orf92
	inducible overexpressing cell line services for C16orf92

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C16orf92 gene at Home site.

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C16orf92 Gene

chromosome 16 open reading frame 92

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C16orf92 Gene

chromosome 16 open reading frame 92

Aliasesfor C16orf92 gene

Summariesfor C16orf92 gene

Genomic Viewsfor C16orf92 gene

Proteinsfor C16orf92 gene

Protein Domains /Familiesfor C16orf92 gene

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Specialized Databases showing C16orf92 gene

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for C16orf92 gene

Summaries
for C16orf92 gene

Genomic Views
for C16orf92 gene

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for C16orf92 gene

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for C16orf92 gene

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for C16orf92 gene

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for C16orf92 gene

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for C16orf92 gene

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for C16orf92 gene

Expression
for C16orf92 gene

Orthologs
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for C16orf92 gene

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for C16orf92 gene

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for C16orf92 gene

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for C16orf92 gene

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