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Aliases for C16orf91 Gene

Aliases for C16orf91 Gene

  • Chromosome 16 Open Reading Frame 91 2 3 5
  • Cattle Cerebrum And Skeletal Muscle-Specific Protein 1 Family Member 2 3
  • CCSMST1 3 4
  • Up-Regulated In Lung Cancer 5 3
  • Protein CCSMST1 3
  • URLC5 3
  • Gs103 3

External Ids for C16orf91 Gene

Previous GeneCards Identifiers for C16orf91 Gene

  • GC16M001411
  • GC16M001469
  • GC16M001396
  • GC16M001433
  • GC16M001438
  • GC16M001443
  • GC16M001451
  • GC16M001457
  • GC16M001463

Summaries for C16orf91 Gene

GeneCards Summary for C16orf91 Gene

C16orf91 (Chromosome 16 Open Reading Frame 91) is a Protein Coding gene.

Additional gene information for C16orf91 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf91 Gene

Genomics for C16orf91 Gene

Regulatory Elements for C16orf91 Gene

Enhancers for C16orf91 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H000635 1.4 ENCODE dbSUPER 11 +783.7 783728 4.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 METTL26 WDR90 CRAMP1 WFIKKN1 JMJD8 ENSG00000261505 UBE2I TELO2 NARFL ENSG00000226890
GH16H001308 1.4 ENCODE dbSUPER 10.6 +110.0 110046 5.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 MCM3 NFYC WDR90 CRAMP1 ENSG00000261505 TELO2 UBE2I E4F1 TSC2 ENSG00000260051 JMJD8 RHOT2
GH16H000981 1.2 ENCODE dbSUPER 10.5 +439.3 439325 0.2 ZNF493 ZNF133 GLI4 ZNF2 GLIS2 ZNF416 KLF7 ZNF548 SP3 MCM3 WDR90 CRAMP1 ENSG00000261505 UBE2I JMJD8 TELO2 ENSG00000260954 UNKL ENSG00000260051 WDR24
GH16H000986 1.2 ENCODE dbSUPER 10.5 +439.7 439655 0 ZNF473 ZNF493 ZSCAN4 ZNF133 GLI4 ZNF2 EGR1 ZNF366 SCRT2 ZNF416 ENSG00000261505 CRAMP1 WDR90 UBE2I TBL3 ENSG00000260051 ENSG00000260954 ENSG00000255513 SNORA64 UNKL
GH16H001271 1.1 ENCODE 10.6 +149.0 148974 1.6 PKNOX1 SIN3A FEZF1 ZNF2 ZNF302 ZNF416 SP3 REST ZNF662 ZNF592 CRAMP1 WDR90 TELO2 IFT140 ENSG00000261505 TSC2 E4F1 WDR24 ENSG00000260646 UBE2I
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C16orf91 on UCSC Golden Path with GeneCards custom track

Promoters for C16orf91 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082341 0 1601 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Locations for C16orf91 Gene

Genomic Locations for C16orf91 Gene
chr16:1,419,744-1,420,800
(GRCh38/hg38)
Size:
1,057 bases
Orientation:
Minus strand
chr16:1,469,745-1,479,345
(GRCh37/hg19)

Genomic View for C16orf91 Gene

Genes around C16orf91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf91 Gene

Proteins for C16orf91 Gene

  • Protein details for C16orf91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0I0-CSMT1_HUMAN
    Recommended name:
    Protein CCSMST1
    Protein Accession:
    Q4G0I0
    Secondary Accessions:
    • Q96RZ0

    Protein attributes for C16orf91 Gene

    Size:
    132 amino acids
    Molecular mass:
    15004 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK61280.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW85657.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for C16orf91 Gene

Post-translational modifications for C16orf91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C16orf91 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C16orf91 Gene

Domains & Families for C16orf91 Gene

Gene Families for C16orf91 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for C16orf91 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C16orf91 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0I0

UniProtKB/Swiss-Prot:

CSMT1_HUMAN :
  • Belongs to the CCSMST1 family.
Family:
  • Belongs to the CCSMST1 family.
genes like me logo Genes that share domains with C16orf91: view

Function for C16orf91 Gene

genes like me logo Genes that share phenotypes with C16orf91: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf91 Gene

Localization for C16orf91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C16orf91 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf91 gene
Compartment Confidence
nucleus 3
mitochondrion 2
plasma membrane 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for C16orf91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C16orf91: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C16orf91 Gene

Pathways & Interactions for C16orf91 Gene

SuperPathways for C16orf91 Gene

No Data Available

Interacting Proteins for C16orf91 Gene

Gene Ontology (GO) - Biological Process for C16orf91 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C16orf91 Gene

Drugs & Compounds for C16orf91 Gene

No Compound Related Data Available

Transcripts for C16orf91 Gene

mRNA/cDNA for C16orf91 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C16orf91 Gene

Chromosome 16 open reading frame 91:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf91 Gene

No ASD Table

Relevant External Links for C16orf91 Gene

GeneLoc Exon Structure for
C16orf91
ECgene alternative splicing isoforms for
C16orf91

Expression for C16orf91 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf91 Gene

Protein differential expression in normal tissues from HIPED for C16orf91 Gene

This gene is overexpressed in Adrenal (37.7), Bone (12.5), and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C16orf91 Gene



Protein tissue co-expression partners for C16orf91 Gene

NURSA nuclear receptor signaling pathways regulating expression of C16orf91 Gene:

C16orf91

SOURCE GeneReport for Unigene cluster for C16orf91 Gene:

Hs.58373
genes like me logo Genes that share expression patterns with C16orf91: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf91 Gene

Orthologs for C16orf91 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C16orf91 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C16orf91 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C25H16orf91 33
  • 75.76 (n)
CCSMST1 34
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565784 33
  • 73.99 (n)
mouse
(Mus musculus)
Mammalia BC003965 33 16 34
  • 73.74 (n)
dog
(Canis familiaris)
Mammalia C6H16orf91 33
  • 70.11 (n)
C16orf91 34
  • 44 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C16orf91 34
  • 43 (a)
OneToOne
Species where no ortholog for C16orf91 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C16orf91 Gene

ENSEMBL:
Gene Tree for C16orf91 (if available)
TreeFam:
Gene Tree for C16orf91 (if available)

Paralogs for C16orf91 Gene

(1) SIMAP similar genes for C16orf91 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C16orf91: view

No data available for Paralogs for C16orf91 Gene

Variants for C16orf91 Gene

Sequence variations from dbSNP and Humsavar for C16orf91 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000318633 -- 1,422,451(+) TGTCC(C/T)GCACA upstream-variant-2KB
rs1001819866 -- 1,422,636(+) CCAAG(C/T)CTGGC upstream-variant-2KB
rs1002578574 -- 1,422,109(+) GCAGT(A/G)AGCCA upstream-variant-2KB
rs1003213206 -- 1,420,339(+) CACTG(C/G)TCCGC reference, missense
rs1003267625 -- 1,420,131(+) CCAGC(C/G)AAGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C16orf91 Gene

Variant ID Type Subtype PubMed ID
nsv952899 CNV deletion 24416366
nsv819844 CNV gain 19587683
nsv819259 CNV gain 19587683
nsv571160 CNV loss 21841781
nsv471066 CNV loss 18288195
nsv457331 CNV loss 19166990
nsv1046314 CNV loss 25217958
esv2762143 CNV gain 21179565
esv2422427 CNV duplication 17116639

Variation tolerance for C16orf91 Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C16orf91 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C16orf91

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf91 Gene

Disorders for C16orf91 Gene

Relevant External Links for C16orf91

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C16orf91

No disorders were found for C16orf91 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf91 Gene

Publications for C16orf91 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for C16orf91 Gene

Sources for C16orf91 Gene

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