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Aliases for C16orf89 Gene

Aliases for C16orf89 Gene

  • Chromosome 16 Open Reading Frame 89 2 3

External Ids for C16orf89 Gene

Summaries for C16orf89 Gene

Entrez Gene Summary for C16orf89 Gene

  • This gene is expressed predominantly in the thyroid. Based on expression patterns similar to thyroid transcription factors and proteins, this gene may function in the development and function of the thyroid. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for C16orf89 Gene

C16orf89 (Chromosome 16 Open Reading Frame 89) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf89 Gene

Genomics for C16orf89 Gene

Genomic Location for C16orf89 Gene

5,042,967 bp from pter
5,066,145 bp from pter
23,179 bases
Minus strand

Genomic View for C16orf89 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C16orf89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf89 Gene

Regulatory Elements for C16orf89 Gene

Proteins for C16orf89 Gene

  • Protein details for C16orf89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0764 protein C16orf89
    Protein Accession:
    Secondary Accessions:
    • B4DUM5
    • Q8N2I3
    • Q8N4T1

    Protein attributes for C16orf89 Gene

    402 amino acids
    Molecular mass:
    45391 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=AAH33681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ88847.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11494.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=EAW85244.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for C16orf89 Gene


neXtProt entry for C16orf89 Gene

Proteomics data for C16orf89 Gene at MOPED

Post-translational modifications for C16orf89 Gene

Other Protein References for C16orf89 Gene

No data available for DME Specific Peptides for C16orf89 Gene

Domains for C16orf89 Gene

Protein Domains for C16orf89 Gene



  • Belongs to the UPF0764 family.:
    • Q6UX73
genes like me logo Genes that share domains with C16orf89: view

No data available for Gene Families for C16orf89 Gene

Function for C16orf89 Gene

Gene Ontology (GO) - Molecular Function for C16orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IPI 20578903
genes like me logo Genes that share ontologies with C16orf89: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C16orf89 Gene

Localization for C16orf89 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C16orf89 Gene


Subcellular locations from

Jensen Localization Image for C16orf89 Gene COMPARTMENTS Subcellular localization image for C16orf89 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C16orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 20578903
GO:0016020 membrane IDA 20578903
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with C16orf89: view

Pathways for C16orf89 Gene

SuperPathways for C16orf89 Gene

No Data Available

Interacting Proteins for C16orf89 Gene

Gene Ontology (GO) - Biological Process for C16orf89 Gene


No data available for Pathways by source for C16orf89 Gene

Transcripts for C16orf89 Gene

Unigene Clusters for C16orf89 Gene

Chromosome 16 open reading frame 89:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf89 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for C16orf89 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C16orf89 Gene

mRNA expression in normal human tissues for C16orf89 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C16orf89 Gene

This gene is overexpressed in Thyroid (11.9), Stomach (4.9), and Lung (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C16orf89 Gene

SOURCE GeneReport for Unigene cluster for C16orf89 Gene Hs.11782

mRNA Expression by UniProt/SwissProt for C16orf89 Gene

Tissue specificity: Predominantly expressed in thyroid tissue.
genes like me logo Genes that share expressions with C16orf89: view

Orthologs for C16orf89 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C16orf89 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C16H16orf89 36
  • 98.79 (n)
  • 97.58 (a)
C16orf89 37
  • 88 (a)
(Bos Taurus)
Mammalia C16orf89 37
  • 70 (a)
C25H16orf89 36
  • 83.24 (n)
  • 76.18 (a)
(Canis familiaris)
Mammalia C16orf89 37
  • 69 (a)
C6H16orf89 36
  • 82.98 (n)
  • 77.81 (a)
(Mus musculus)
Mammalia AU021092 36
  • 78.02 (n)
  • 70.9 (a)
AU021092 16
AU021092 37
  • 58 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 52 (a)
-- 37
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia C16orf89 37
  • 46 (a)
(Rattus norvegicus)
Mammalia RGD1565166 36
  • 77.95 (n)
  • 72.62 (a)
(Gallus gallus)
Aves C14H16ORF89 36
  • 60.31 (n)
  • 50.17 (a)
C16orf89 37
  • 43 (a)
(Danio rerio)
Actinopterygii C3H16orf89 37
  • 34 (a)
si:ch211-76l23.7 36
  • 50.8 (n)
  • 42.17 (a)
Species with no ortholog for C16orf89:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C16orf89 Gene

Gene Tree for C16orf89 (if available)
Gene Tree for C16orf89 (if available)

Paralogs for C16orf89 Gene

Selected SIMAP similar genes for C16orf89 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C16orf89: view

No data available for Paralogs for C16orf89 Gene

Variants for C16orf89 Gene

Sequence variations from dbSNP and Humsavar for C16orf89 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs14295 -- 5,044,261(+) CCCAG(G/T)ATGTG utr-variant-3-prime, intron-variant
rs741163 -- 5,063,620(+) GCATT(C/T)GATTC intron-variant
rs741164 -- 5,056,183(-) AGGGG(A/G)TGCAC synonymous-codon, reference
rs741165 -- 5,055,485(+) AGAGG(A/C)GGGAA intron-variant
rs741166 -- 5,055,439(+) TGCCT(C/T)CATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf89 Gene

Variant ID Type Subtype PubMed ID
esv2422516 CNV Deletion 17116639
esv25186 CNV Gain 19812545
nsv905254 CNV Loss 21882294
dgv795e1 CNV Complex 17122850
nsv457360 CNV Loss 19166990
esv34300 CNV Gain 17911159
dgv796e1 CNV Complex 17122850
nsv817715 CNV Gain 17921354
nsv428318 CNV Gain 18775914
nsv1722 CNV Loss 18451855
nsv9340 CNV Loss 18304495
dgv477e199 CNV Deletion 23128226
nsv827532 CNV Loss 20364138

Relevant External Links for C16orf89 Gene

HapMap Linkage Disequilibrium report

Disorders for C16orf89 Gene

No disorders were found for C16orf89 Gene.

No data available for UniProtKB/Swiss-Prot for C16orf89 Gene

Publications for C16orf89 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Initial characterization of C16orf89, a novel thyroid-specific gene. (PMID: 20578903) Afink G.B. … Ris-Stalpers C. (Thyroid 2010) 2 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. A transcript finishing initiative for closing gaps in the human transcriptome. (PMID: 15197164) Sogayar M.C. … Zanette D.L. (Genome Res. 2004) 3

Products for C16orf89 Gene

Sources for C16orf89 Gene

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