C16orf89 Gene
protein-coding GIFtS: 41
GCID: GC16M005035
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|
chromosome 16 open reading frame 89
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Aliases
for C16orf89 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 16 Open Reading Frame 891 2 | | MGC454381 | | UPF0764 Protein C16orf892 |
Export aliases for C16orf89 gene to outside databases |
Summaries
for C16orf89 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for C16orf89:
This gene is expressed predominantly in the thyroid. Based on expression patterns similar to thyroid transcriptionfactors and proteins, this gene may function in the development and function of the thyroid. Multiple transcriptvariants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)
|
Genomic Views
for C16orf89 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C16orf89 gene promoter:
STAT1 p53 STAT4 STAT1beta STAT5A XBP-1 STAT1alpha Zic1 STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for C16orf89
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C16orf89 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3C16orf89 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M005035: view genomic region
(about GC identifiers)
Start:
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5,094,123 bp from pter |
End:
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5,116,111 bp from pter |
Size:
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21,989 bases |
Orientation:
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minus strand |
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Proteins
for C16orf89 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CP089_HUMAN, Q6UX73 (See
protein sequence)Recommended Name: UPF0764 protein C16orf89 precursor Size: 402 amino acids; 45391 Da
Subunit: Homodimer
Subcellular location: Secreted
Sequence caution: Sequence=AAH33681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAQ88847.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC11494.1;Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=EAW85244.1; Type=Erroneous initiation;Note=Translation N-terminally shortened;
Secondary accessions: B4DUM5 Q8N2I3 Q8N4T1Alternative splicing: 2 isoforms: Q6UX73-1 Q6UX73-2 (Major isoform, represents 80% of transcripts)Explore the universe of human proteins at neXtProt for C16orf89: NX_Q6UX73
Post-translational modifications:
Glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UX73
C16orf89 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001091984.2 NP_689672.4
ENSEMBL proteins: ENSP00000417158 ENSP00000420566 ENSP00000324672 ENSP00000390402 ENSP00000283478
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
C16orf89 for ontologies About GeneDecksing
C16orf89 Antibody Products:
Assay Products for C16orf89: |
Protein
Domains /
Families
for C16orf89 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6UX73 1 Blocks protein family: IPB001545 Gonadotropin
UniProtKB/Swiss-Prot: CP089_HUMAN, Q6UX73Similarity: Belongs to the UPF0764 family |
Function
for C16orf89 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf89 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf89 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf89 |
Animal Models:
Mouse knock-out AU021092tm1Lex for C16orf89
1 MGI phenotypic allele  for AU021092 (no phenotypes)
C16orf89 for phenotypes About GeneDecksing
|
Pathways & Interactions
for C16orf89 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C16orf89
|
Drugs & Compounds
for C16orf89 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C16orf89
Search CenterWatch for drugs/clinical trials and news about C16orf89 / CP089
|
Transcripts
for C16orf89 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C16orf89 gene (2 alternative transcripts): NM_001098514.2 NM_152459.4 Unigene Cluster for C16orf89: Chromosome 16 open reading frame 89 Hs.11782 [show with all ESTs]Unigene Representative Sequence: NM_1524598 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000586629 ENST00000474471 ENST00000472572 ENST00000315997 ENST00000592343
ENST00000591875 ENST00000422873(uc002cyk.4) ENST00000350219(uc010bud.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf89 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf89 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C16orf89 (NM_152459) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C16orf89 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf89 |
Additional cDNA sequence: AK075242.1 AK300708.1 AY358483.1 BC033681.1 4 DOTS entries: DT.100741932 DT.97793329 DT.210110 DT.75165060 24/69 AceView cDNA sequences (see all 69): BQ917270 BF871511 BF871021 BI771576 AK075242 AW070501 BM906008 BC033681 BI760173 AI479299 BQ067424 BM921619 BU632344 BM706955 AI673086 BX090681 BG702313 N44000 N44008 AI373281 BP349238 AI823572 AY358483 BI765378
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for C16orf89 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
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| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | - | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C16orf89
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Expression
for C16orf89 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C16orf89 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGCTGCCT
About this image
See C16orf89 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C16orf89
SOURCE GeneReport for Unigene cluster: Hs.11782
UniProtKB/Swiss-Prot: CP089_HUMAN, Q6UX73Tissue specificity: Predominantly expressed in thyroid tissue
SABiosciences Custom PCR Arrays for C16orf89
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C16orf89
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C16orf89 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C16orf89 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C16orf89 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf89 |
Orthologs
for C16orf89 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C16orf89 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for C16orf89 (if available)
TreeFam Gene Tree for C16orf89 (if available) |
Paralogs
for C16orf89 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C16orf89 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C16orf89 (5094123 - 5116111 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for C16orf89
7 CNVs: 9755 8811 5436 3101 3989 72444 32079 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C16orf89 |
|
Disorders
/ Diseases
for C16orf89 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C16orf89 for disorders About GeneDecksing
1  disease for C16orf89: About MalaCardsthyroiditis
Export disorders for C16orf89 gene to outside databases
|
Publications
for C16orf89 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C16orf89 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C16orf89) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Initial characterization of C16orf89, a novel thyroid -specific gene. (PubMed id 20578903)1, 2, 3 Afink G.B....Ris-Stalpers C. (2010)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- A transcript finishing initiative for closing gaps in the human transcriptome. (PubMed id 15197164)1 Sogayar M.C....Zanette D.L. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for C16orf89 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C16orf89 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C16orf89 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C16orf89 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C16orf89 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C16orf89 gene:
Search GeneIP for patents involving C16orf89
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C16orf89 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C16orf89 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C16orf89 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C16orf89 | | | OriGene Protein Over-expression Lysate for C16orf89 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C16orf89 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf89 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf89 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C16orf89 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | C16orf89 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf89 |
|  |  |  | | | | Search ThermoFisher Antibodies for C16orf89 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf89 |
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