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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C16orf87 Gene

protein-coding   GIFtS: 39
GCID: GC16M046835          (predicted)

chromosome 16 open reading frame 87
  Search for C16orf87
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C16orf87    

Aliases
for C16orf87 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 16 Open Reading Frame 871 2
UPF0547 Protein C16orf872

External Ids:    HGNC: 337541   Entrez Gene: 3882722   Ensembl: ENSG000001553307   UniProtKB: Q6PH813   

Export aliases for C16orf87 gene to outside databases

Previous GC identifers: GC16M045394 GC16M032725


Summaries
for C16orf87 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C16orf87 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C16orf87 gene promoter:
         p53   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   YY1   CREB   POU2F1a   deltaCREB   HFH-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C16orf87

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C16orf87


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q11.2   Ensembl cytogenetic band:  16q11.2   HGNC cytogenetic band: 16q11.2

C16orf87 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C16orf87 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M046835:  view genomic region     (about GC identifiers)

Start:
 46,830,519 bp from pter      End:
 46,865,323 bp from pter
Size:
 34,805 bases      Orientation:
 minus strand

Proteins
for C16orf87 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CP087_HUMAN, Q6PH81 (See protein sequence)
Recommended Name: UPF0547 protein C16orf87  
Size: 154 amino acids; 17799 Da
Secondary accessions: Q63HN9
Alternative splicing: 2 isoforms:  Q6PH81-1   Q6PH81-2   

Explore the universe of human proteins at neXtProt for C16orf87: NX_Q6PH81

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6PH81

    • C16orf87 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001001436.1  
    ENSEMBL proteins: 
     ENSP00000378285   ENSP00000285697   ENSP00000455829  

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    Protein Domains /
    Families
    for C16orf87 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    C16orf87 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR018886 UPF0547

    Graphical View of Domain Structure for InterPro Entry Q6PH81

    ProtoNet protein and cluster: Q6PH81

    UniProtKB/Swiss-Prot: CP087_HUMAN, Q6PH81
    Similarity: Belongs to the UPF0547 family


    Function
    for C16orf87 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for C16orf87 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C16orf87

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for C16orf87 (ENSP000002856974) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Drugs & Compounds
    for C16orf87 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C16orf87
    Search CenterWatch for drugs/clinical trials and news about C16orf87 / CP087 

    Transcripts
    for C16orf87 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for C16orf87 gene: 
    NM_001001436.2  

    Unigene Cluster for C16orf87:

    Chromosome 16 open reading frame 87
    Hs.406551  [show with all ESTs]
    Unigene Representative Sequence: BX647945
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394806 ENST00000285697(uc002eek.1) ENST00000565112 ENST00000564250


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    Inhib. RNA
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    Additional cDNA sequence: 

    BC056676.1 BX647945.1 

    5 DOTS entries:

    DT.100694953  DT.86850873  DT.92427974  DT.100746084  DT.95175223 

    24/132 AceView cDNA sequences (see all 132):

    BM796892 BQ007535 AA733100 AI470958 AA233739 BG505112 AA383023 AA713526 
    AW161825 AI242243 AW157311 AW156889 AI127328 AI365157 H96793 BX332462 
    AA435821 AW157470 AI859089 AA397880 CR622077 AA383022 AI143280 AW162839 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for C16orf87    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:              -     -                           
    SP2:                                                
    SP3:              -     -           -               
    SP4:                    -                           


    ECgene alternative splicing isoforms for C16orf87

    Expression
    for C16orf87 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C16orf87 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAAAATATTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    C16orf87 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C16orf87 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C16orf87

    SOURCE GeneReport for Unigene cluster: Hs.406551
        SABiosciences Custom PCR Arrays for C16orf87
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    In Situ
    Assay Products:     
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    Orthologs
    for C16orf87 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for C16orf87 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia 4921524J17Rik1 , 5 RIKEN cDNA 4921524J17 gene1, 5 95.02(n)1
    98.7(a)1    		   8 (41.61 cM)5
    667141  NM_025722.31  NP_079998.11 
     854087595 
    chicken
    (Gallus gallus)    		 Aves C11H16orf871 chromosome 11 open reading frame, human C16orf87 86.58(n)
    91.56(a)    		   415747  XM_414112.3  XP_414112.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.148412 Transcribed sequence with moderate similarity to protein more 79.47(n)    57077196 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 18(a)
    		 1 ↔ 1
    		 GroupUn.89(80333-85435)


    ENSEMBL Gene Tree for C16orf87 (if available)
    TreeFam Gene Tree for C16orf87 (if available) 

    Paralogs
    for C16orf87 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C16orf87 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/367 NCBI SNPs in C16orf87 are shown (see all 367)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1822099471,2
    		--46835685(+) TCTCTC/TAAAAG 1 -- int10--------
    rs1852491201,2
    		--46835888(+) AAAAAG/TTAAGA 1 -- int10--------
    rs1462517211,2
    		--46836254(+) GTCTAC/GAAAGT 1 -- ut310--------
    rs1379751281,2
    		--46836455(+) TAAAAA/CTCACT 1 -- ut310--------
    rs1919268831,2
    		--46836528(+) TATTAA/CCCTAG 1 -- ut310--------
    rs1841739491,2
    		--46836546(+) ACCTAC/TCCCAT 1 -- ut310--------
    rs284470501,2
    		--46836742(+) ACAGGC/TGAGAA 1 -- ut31 ese30--------
    rs1439525751,2
    		--46836793(+) CCTGAG/TAGTCC 1 -- ut310--------
    rs1882772601,2
    		C,--46836824(+) TGATGC/TTATCC 1 -- ut310--------
    rs1144959741,2
    		--46837254(+) ATCTCC/TTCACT 1 -- int10--------

    HapMap Linkage Disequilibrium report for C16orf87 (46830519 - 46865323 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for C16orf87: --

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    Disorders / Diseases
    for C16orf87 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C16orf87 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C16orf87 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C16orf87)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for C16orf87 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C16orf87 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388272 HGNC: 33754 AceView: LOC388272 Ensembl:ENSG00000155330 euGenes: HUgn388272
    ECgene: C16orf87 H-InvDB: C16orf87

    Other Databases showing C16orf87 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C16orf87 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C16orf87 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C16orf87 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C16orf87 gene:
    Search GeneIP for patents involving C16orf87

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for C16orf87 gene

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    About This Section

     
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