C16orf80 Gene
protein-coding GIFtS: 46
GCID: GC16M058147
|
|
chromosome 16 open reading frame 80
| |
Aliases
for C16orf80 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 16 Open Reading Frame 801 2 | | EVORF2 | | GTL31 2 | | Functional Spliceosome-Associated Protein 232 | | FSAP231 | | Gene Trap Locus 32 | | Transcription Factor IIB2 3 | | UPF0468 Protein C16orf802 |
Export aliases for C16orf80 gene to outside databasesPrevious GC identifers: GC16M056704 GC16M044014 |
Summaries
for C16orf80 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C16orf80 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C16orf80 gene promoter:
AML1a FOXF2 ATF-2 FOXO3 FOXD1 Olf-1 MIF-1 IRF-1 RORalpha2 FOXO3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for C16orf80
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C16orf80 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q21 Ensembl cytogenetic band: 16q21 HGNC cytogenetic band: 16q21C16orf80 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M058147: view genomic region
(about GC identifiers)
Start:
|
58,147,496 bp from pter |
End:
|
58,163,354 bp from pter |
Size:
|
15,859 bases |
Orientation:
|
minus strand |
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Proteins
for C16orf80 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CP080_HUMAN, Q9Y6A4 (See
protein sequence)Recommended Name: UPF0468 protein C16orf80 Size: 193 amino acids; 22774 DaExplore the universe of human proteins at neXtProt for C16orf80: NX_Q9Y6A4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6A4
C16orf80 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037374.1
ENSEMBL proteins: ENSP00000262498 ENSP00000455220
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005929 | cilium |
IEA | -- |
C16orf80 for ontologies About GeneDecksing
C16orf80 Antibody Products:
Assay Products for C16orf80: |
Protein
Domains /
Families
for C16orf80 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C16orf80 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y6A4ProtoNet protein and cluster: Q9Y6A4 UniProtKB/Swiss-Prot: CP080_HUMAN, Q9Y6A4Similarity: Belongs to the UPF0468 family |
Function
for C16orf80 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf80 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf80
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: C16orf80 (NM_013242) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C16orf80 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf80 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf80 |
1 GenomeRNAi human phenotype for C16orf80:
|
Pathways & Interactions
for C16orf80 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C16orf80
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/6 Interacting proteins for C16orf80 (Q9Y6A42, 3 ENSP000002624984) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
TAS | 8688464 |
C16orf80 for ontologies About GeneDecksing
|
Drugs & Compounds
for C16orf80 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
C16orf80 for compounds About GeneDecksing
 Browse Tocris compounds for C16orf80
6 Novoseek chemical compound relationships for C16orf80 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tbps |
63.4 |
1 |
15289474 (1) |
| 1,25 dihydroxy vitamin d3 |
50.6 |
1 |
9169418 (1) |
| vitamin d |
26.4 |
3 |
9013769 (2), 10707958 (1) |
| alanine |
23.3 |
1 |
9325160 (1) |
| proline |
10.9 |
1 |
9325160 (1) |
| retinoic acid |
3.2 |
2 |
9808423 (2) |
Search CenterWatch for drugs/clinical trials and news about C16orf80 / CP080
|
Transcripts
for C16orf80 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C16orf80 gene: NM_013242.2 Unigene Cluster for C16orf80: Chromosome 16 open reading frame 80 Hs.532755 [show with all ESTs]Unigene Representative Sequence: NM_0132427 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262498(uc002enb.1) ENST00000562622(uc021tje.1) ENST00000564150
ENST00000562443 ENST00000565880 ENST00000567092 ENST00000567660
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf80 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf80
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C16orf80 (NM_013242) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C16orf80 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf80 |
Additional cDNA sequence: AF087845.1 AF093680.1 AK027099.1 AK297819.1 BC005152.2 10 DOTS entries: DT.446741 DT.95169711 DT.95318115 DT.100817172 DT.100817174 DT.99933427 DT.95169710 DT.91743811 DT.100817171 DT.120666634 24/290 AceView cDNA sequences (see all 290): BX374931 BM558871 CA430607 CA445778 BM561348 BM561760 AA306537 BM718998 AA287783 CR604557 BX367219 CR623489 AI303011 AI273666 BU730963 CR595445 BM708629 AI929160 BQ680316 CR613931 BG168024 CA487186 BM820528 NM_013242
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for C16orf80 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5 | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | | | | | - | | | | - | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C16orf80
|
Expression
for C16orf80 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C16orf80 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTTACAGA
About this image
See C16orf80 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C16orf80
SOURCE GeneReport for Unigene cluster: Hs.532755
SABiosciences Custom PCR Arrays for C16orf80
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C16orf80
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C16orf80 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C16orf80 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C16orf80 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf80 |
Orthologs
for C16orf80 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for C16orf80 gene from 9/32 species (see all 32) About this table
ENSEMBL Gene Tree for C16orf80 (if available)
TreeFam Gene Tree for C16orf80 (if available) |
Paralogs
for C16orf80 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C16orf80 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C16orf80 (58147496 - 58163354 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C16orf80
1 CNV: 102292 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for C16orf80 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C16orf80 for disorders About GeneDecksing
7  diseases for C16orf80: About MalaCardshepatitis e hepatitis b hepatocellular carcinoma hepatitis
immunodeficiency carcinoma malaria
Export disorders for C16orf80 gene to outside databases
|
Publications
for C16orf80 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C16orf80 gene, integrated from 9 sources (see all 76):
(articles sorted by number of sources associating them with C16orf80) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sequence and expression pattern of an evolutionarily conserved transcript identified by gene trapping. (PubMed id 8688464)1, 3 Rijkers T. and Ruther U. (1996)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. (PubMed id 17332742)1 Behzadnia N.... Luehrmann R. (2007)
- Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PubMed id 15324660)1 Jin J....Pawson T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for C16orf80 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C16orf80 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C16orf80 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C16orf80 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C16orf80 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C16orf80 gene:
Search GeneIP for patents involving C16orf80
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C16orf80 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C16orf80 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C16orf80 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C16orf80 | | | OriGene Protein Over-expression Lysate for C16orf80 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C16orf80 | | OriGene 3'-UTR Clone for C16orf80 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf80 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf80 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C16orf80 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C16orf80 | | OriGene Custom Protein Services for C16orf80 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C16orf80 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C16orf80 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C16orf80 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C16orf80 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C16orf80 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C16orf80 |
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 | | | C16orf80 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf80 |
|  |  |  | | | | Search ThermoFisher Antibodies for C16orf80 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf80 |
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