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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C16orf80 Gene

protein-coding   GIFtS: 46
GCID: GC16M058147

Chromosome 16 Open Reading Frame 80

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 16 Open Reading Frame 801 2     GTL32
Functional Spliceosome-Associated Protein 231 2     fSAP232
Transcription Factor IIB2 3     Gene Trap Locus 32
EVORF2     UPF0468 Protein C16orf802

External Ids:    HGNC: 295231   Entrez Gene: 291052   Ensembl: ENSG000000707617   UniProtKB: Q9Y6A43   

Export aliases for C16orf80 gene to outside databases

Previous GC identifers: GC16M056704 GC16M044014


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C16orf80 Gene: 
C16orf80 (chromosome 16 open reading frame 80) is a protein-coding gene. Diseases associated with C16orf80 include hepatitis e, and hepatitis b.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C16orf80 gene promoter:
         AML1a   FOXF2   ATF-2   FOXO3   FOXD1   Olf-1   MIF-1   IRF-1   RORalpha2   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC16orf80 promoter sequence
   Search SABiosciences Chromatin IP Primers for C16orf80

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C16orf80


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q21

C16orf80 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C16orf80 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M058147:  view genomic region     (about GC identifiers)

Start:
58,147,496 bp from pter      End:
58,163,354 bp from pter
Size:
15,859 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CP080_HUMAN, Q9Y6A4 (See protein sequence)
Recommended Name: UPF0468 protein C16orf80  
Size: 193 amino acids; 22774 Da

Explore the universe of human proteins at neXtProt for C16orf80: NX_Q9Y6A4

Explore proteomics data for C16orf80 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6A4

  • C16orf80 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C16orf80 Protein Expression
    REFSEQ proteins: NP_037374.1  
    ENSEMBL proteins: 
     ENSP00000262498   ENSP00000455220  

    Human Recombinant Protein Products for C16orf80: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005929cilium IEA--

    C16orf80 for ontologies           About GeneDecksing



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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007714 DUF667

    Graphical View of Domain Structure for InterPro Entry Q9Y6A4

    ProtoNet protein and cluster: Q9Y6A4

    UniProtKB/Swiss-Prot: CP080_HUMAN, Q9Y6A4
    Similarity: Belongs to the UPF0468 family


    C16orf80 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for C16orf80:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for C16orf80 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C16orf80 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf80


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C16orf80

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for C16orf80 (Q9Y6A42, 3 ENSP000002624984) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50833 I2D: score=4 STRING: ENSP00000306330
    SF3A2Q154282, 3, ENSP000002214944MINT-5206313 I2D: score=1 STRING: ENSP00000221494
    CLUAP1Q96AJ13I2D: score=5 
    SFSWAPQ128723I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development TAS8688464

    C16orf80 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    C16orf80 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C16orf80 (CP080)

    6 Novoseek inferred chemical compound relationships for C16orf80 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tbps 63.4 1 15289474 (1)
    1,25 dihydroxy vitamin d3 50.6 1 9169418 (1)
    vitamin d 26.4 3 9013769 (2), 10707958 (1)
    alanine 23.3 1 9325160 (1)
    proline 10.9 1 9325160 (1)
    retinoic acid 3.2 2 9808423 (2)

    Search CenterWatch for drugs/clinical trials and news about C16orf80 / CP080

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C16orf80 gene: 
    NM_013242.2  

    Unigene Cluster for C16orf80:

    Chromosome 16 open reading frame 80
    Hs.532755  [show with all ESTs]
    Unigene Representative Sequence: NM_013242
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262498(uc002enb.1) ENST00000562622(uc021tje.1) ENST00000564150
    ENST00000562443 ENST00000565880 ENST00000567092 ENST00000567660
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate C16orf80:
    hsa-miR-3163 hsa-miR-664
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    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AF087845.1 AF093680.1 AK027099.1 AK297819.1 BC005152.2 

    10 DOTS entries:

    DT.446741  DT.95169711  DT.95318115  DT.100817172  DT.100817174  DT.99933427  DT.95169710  DT.91743811 
    DT.100817171  DT.120666634 

    24/290 AceView cDNA sequences (see all 290):

    CR623489 AI273666 CA445778 CA441250 BI823257 BM561348 CR626042 BU730963 
    AI200535 NM_013242 CR612011 BX374931 BM467844 AA297805 BF347467 CB241837 
    BI819715 BQ680316 BI492769 CR596631 CR604557 AI146475 AI147193 BM849335 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for C16orf80 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b
    SP1:                                -           -     -                       -                     
    SP2:                                -           -     -                                             
    SP3:                                -           -     -     -                                       
    SP4:                                                                          -                     
    SP5:                                -                                                               


    ECgene alternative splicing isoforms for C16orf80

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C16orf80 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTACAGA
    C16orf80 Expression
    About this image


    See C16orf80 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C16orf80

    SOURCE GeneReport for Unigene cluster: Hs.532755
        SABiosciences Custom PCR Arrays for C16orf80
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for C16orf80 gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gtl31 , 5 gene trap locus 31, 5 91.02(n)1
    99.48(a)1
      8 (47.12 cM)5
    148941  NM_008187.21  NP_032213.21 
     954202525 
    chicken
    (Gallus gallus)
    Aves C11H16orf801 chromosome 11 open reading frame, human C16orf80 85.32(n)
    98.96(a)
      415627  NM_001005833.1  NP_001005833.1 
    lizard
    (Anolis carolinensis)
    Reptilia C16ORF806
    Uncharacterized protein
    95(a)
    1 ↔ 1
    GL344501.1(5522-5635)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.166542 Xenopus laevis transcribed sequence with strong similarity more 82.48(n)    BM262586.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733802 similar to transcription factor IIB 83.02(n)   393784  BC059688.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG53431 CG5343 76.86(n)
    92.23(a)
      34429  NM_135558.3  NP_609402.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C54C6.61 Protein C54C6.6 65.61(n)
    77.37(a)
      353416  NM_181977.1  NP_871706.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G123001 hypothetical protein 66.49(n)
    77.13(a)
      820410  NM_112066.4  NP_566418.1 
    rice
    (Oryza sativa)
    Liliopsida Os.64242 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.61(n)    AK108370.1 


    ENSEMBL Gene Tree for C16orf80 (if available)
    TreeFam Gene Tree for C16orf80 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/379 SNPs in C16orf80 are shown (see all 379)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1930784781,2
    --58147126(+) AAAACA/GTTATT 1 -- int10--------
    rs1852427791,2
    --58147145(+) CATAAA/CGAAGA 1 -- int10--------
    rs1881616951,2
    --58147288(+) GCAGAA/GGTGGA 1 -- int10--------
    rs1918007561,2
    --58147319(+) GACCCA/GCACAG 1 -- int10--------
    rs169596941,2
    C,F,H--58147378(+) TTAGAT/CACTTA 1 -- int112Minor allele frequency- C:0.06NA NS EA WA 652
    rs1485926471,2
    --58147549(+) TGACAC/TAGCAT 1 -- ut310--------
    rs118596001,2
    C,F,H--58147595(+) AAACCG/ACAGGA 1 -- ut31 ese38Minor allele frequency- A:0.01NS EA NA 816
    rs795123321,2
    --58147621(+) GAATTA/CCTTAT 1 -- ut310--------
    rs142721,2
    C,F--58147687(+) CAGGCG/AGCGGA 1 -- ut315Minor allele frequency- A:0.03MN NA CSA EA 428
    rs10519181,2
    C,F,H--58147713(+) CATGCG/ACCACT 1 -- ut31 ese38Minor allele frequency- A:0.03MN NS EA NA CSA 718

    HapMap Linkage Disequilibrium report for C16orf80 (58147496 - 58163354 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for C16orf80:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2714547CNV Deletion23290073
    esv2714546CNV Deletion23290073
    esv2618354CNV Insertion19546169

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for C16orf80

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for C16orf80:    About MalaCards
    hepatitis e    hepatitis b    hepatitis    hepatocellular carcinoma


    C16orf80 for disorders           About GeneDecksing


    Export disorders for C16orf80 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C16orf80 gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with C16orf80)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and expression pattern of an evolutionarily conserved transcript identified by gene trapping. (PubMed id 8688464)1, 3 Rijkers T. and Ruther U. (1996)
    2. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. (PubMed id 17332742)1 Behzadnia N.... Luehrmann R. (2007)
    9. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PubMed id 15324660)1 Jin J....Pawson T. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29105 HGNC: 29523 AceView: GTL3 Ensembl:ENSG00000070761 euGenes: HUgn29105
    ECgene: C16orf80 H-InvDB: C16orf80

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C16orf80 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C16orf80 gene:
    Search GeneIP for patents involving C16orf80

    GeneCards and IP:
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