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Aliases for C16orf74 Gene

Aliases for C16orf74 Gene

  • Chromosome 16 Open Reading Frame 74 2 3 5

External Ids for C16orf74 Gene

Previous GeneCards Identifiers for C16orf74 Gene

  • GC16M084299
  • GC16M085741
  • GC16M071483
  • GC16M085726

Summaries for C16orf74 Gene

GeneCards Summary for C16orf74 Gene

C16orf74 (Chromosome 16 Open Reading Frame 74) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf74 Gene

Genomics for C16orf74 Gene

Regulatory Elements for C16orf74 Gene

Promoters for C16orf74 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C16orf74 on UCSC Golden Path with GeneCards custom track

Genomic Location for C16orf74 Gene

Chromosome:
16
Start:
85,690,084 bp from pter
End:
85,751,129 bp from pter
Size:
61,046 bases
Orientation:
Minus strand

Genomic View for C16orf74 Gene

Genes around C16orf74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf74 Gene

Proteins for C16orf74 Gene

  • Protein details for C16orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GX8-CP074_HUMAN
    Recommended name:
    Uncharacterized protein C16orf74
    Protein Accession:
    Q96GX8

    Protein attributes for C16orf74 Gene

    Size:
    76 amino acids
    Molecular mass:
    8118 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC009078; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for C16orf74 Gene

Proteomics data for C16orf74 Gene at MOPED

Post-translational modifications for C16orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C16orf74 Gene

No data available for DME Specific Peptides for C16orf74 Gene

Domains & Families for C16orf74 Gene

Protein Domains for C16orf74 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C16orf74: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C16orf74 Gene

Function for C16orf74 Gene

Phenotypes for C16orf74 Gene

genes like me logo Genes that share phenotypes with C16orf74: view

Animal Model Products

CRISPR Products

miRNA for C16orf74 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf74 Gene

Localization for C16orf74 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C16orf74 Gene COMPARTMENTS Subcellular localization image for C16orf74 gene
Compartment Confidence
cytoskeleton 2
extracellular 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C16orf74 Gene

Pathways & Interactions for C16orf74 Gene

SuperPathways for C16orf74 Gene

No Data Available

Interacting Proteins for C16orf74 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000284245%0d%0a9606.ENSP00000378323%0d%0a9606.ENSP00000337040%0d%0a
Selected Interacting proteins: Q96GX8-CP074_HUMAN ENSP00000284245 for C16orf74 Gene via I2D STRING MINT

Gene Ontology (GO) - Biological Process for C16orf74 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C16orf74 Gene

Drugs & Compounds for C16orf74 Gene

No Compound Related Data Available

Transcripts for C16orf74 Gene

mRNA/cDNA for C16orf74 Gene

Unigene Clusters for C16orf74 Gene

Chromosome 16 open reading frame 74:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf74 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -
SP3: - - -

Relevant External Links for C16orf74 Gene

GeneLoc Exon Structure for
C16orf74
ECgene alternative splicing isoforms for
C16orf74

Expression for C16orf74 Gene

mRNA expression in normal human tissues for C16orf74 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C16orf74 Gene

This gene is overexpressed in Bladder (x5.2).

Protein differential expression in normal tissues from HIPED for C16orf74 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C16orf74 Gene



SOURCE GeneReport for Unigene cluster for C16orf74 Gene Hs.461655

genes like me logo Genes that share expression patterns with C16orf74: view

Protein tissue co-expression partners for C16orf74 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for C16orf74 Gene

Orthologs for C16orf74 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C16orf74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C16H16orf74 35
  • 99.56 (n)
  • 98.68 (a)
C16orf74 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C18H16orf74 35
  • 82.67 (n)
  • 76 (a)
dog
(Canis familiaris)
Mammalia C5H16orf74 35
  • 89.91 (n)
  • 85.53 (a)
C16orf74 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1190005I06Rik 36
  • 51 (a)
OneToMany
Gm27021 36
  • 37 (a)
OneToMany
1190005I06Rik 16
1190005I06Rik 35
  • 79.39 (n)
  • 75 (a)
oppossum
(Monodelphis domestica)
Mammalia C16orf74 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C16orf74 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1309651 35
  • 80 (n)
  • 76 (a)
Species with no ortholog for C16orf74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C16orf74 Gene

ENSEMBL:
Gene Tree for C16orf74 (if available)
TreeFam:
Gene Tree for C16orf74 (if available)

Paralogs for C16orf74 Gene

No data available for Paralogs for C16orf74 Gene

Variants for C16orf74 Gene

Sequence variations from dbSNP and Humsavar for C16orf74 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs377473 -- 85,711,112(+) agttc(A/G)agacc intron-variant
rs388140 -- 85,738,204(+) cgtgc(C/T)acttc intron-variant, upstream-variant-2KB
rs440642 -- 85,730,448(+) ATTCC(A/C)AGACT intron-variant
rs442069 -- 85,724,841(+) GGGAT(C/G)AAAAA intron-variant
rs390924 -- 85,733,278(+) ACCAC(A/G)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf74 Gene

Variant ID Type Subtype PubMed ID
nsv907090 CNV Loss 21882294
esv4262 CNV Complex 18987735
nsv833316 CNV Loss 17160897
nsv527240 CNV Loss 19592680
esv1023256 CNV Deletion 17803354
nsv510693 CNV Loss 20534489
esv2714855 CNV Deletion 23290073

Variation tolerance for C16orf74 Gene

Gene Damage Index Score: 1.39; 27.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C16orf74 Gene

HapMap Linkage Disequilibrium report
C16orf74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf74 Gene

Disorders for C16orf74 Gene

Relevant External Links for C16orf74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C16orf74

No disorders were found for C16orf74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf74 Gene

Publications for C16orf74 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  4. Identification of C16orf74 as a marker of progression in primary non-muscle invasive bladder cancer. (PMID: 21203532) Kim W.T. … Kim W.J. (PLoS ONE 2010) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for C16orf74 Gene

Sources for C16orf74 Gene

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