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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C16orf74 Gene

protein-coding   GIFtS: 39
GCID: GC16M085741

Chromosome 16 Open Reading Frame 74

  Search for C16orf74
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 16 Open Reading Frame 741 2
Uncharacterized Protein C16orf742

External Ids:    HGNC: 233621   Entrez Gene: 4045502   Ensembl: ENSG000001541027   UniProtKB: Q96GX83   

Export aliases for C16orf74 gene to outside databases

Previous GC identifers: GC16M084299 GC16M071483


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C16orf74 Gene: 
C16orf74 (chromosome 16 open reading frame 74) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C16orf74 gene promoter:
         TBP   Nkx3-1   Nkx3-1 v2   Nkx3-1 v4   NRSF form 1   IRF-7A   Nkx3-1 v3   Nkx3-1 v1   NRSF form 2   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C16orf74

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C16orf74


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24.1

C16orf74 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C16orf74 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M085741:  view genomic region     (about GC identifiers)

Start:
85,723,690 bp from pter      End:
85,784,735 bp from pter
Size:
61,046 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CP074_HUMAN, Q96GX8 (See protein sequence)
Recommended Name: Uncharacterized protein C16orf74  
Size: 76 amino acids; 8118 Da
Sequence caution: Sequence=BC009078; Type=Miscellaneous discrepancy; Note=Intron retention;

Explore the universe of human proteins at neXtProt for C16orf74: NX_Q96GX8

Explore proteomics data for C16orf74 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96GX8

  • C16orf74 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C16orf74 Protein Expression
    REFSEQ proteins: NP_996850.1  
    ENSEMBL proteins: 
     ENSP00000473398   ENSP00000473536   ENSP00000473306   ENSP00000284245   ENSP00000473676  
     ENSP00000473366  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96GX8


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf74


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C16orf74

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for C16orf74 (Q96GX82, 3 ENSP000002842454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP3CAQ082092, 3, ENSP000003783234MINT-67845 I2D: score=4 STRING: ENSP00000378323
    UNC119Q134322, 3, ENSP000003370404MINT-66726 I2D: score=4 STRING: ENSP00000337040
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C16orf74 (CP074)

    Search CenterWatch for drugs/clinical trials and news about C16orf74 / CP074

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C16orf74 gene: 
    NM_206967.2  

    Unigene Cluster for C16orf74:

    Chromosome 16 open reading frame 74
    Hs.461655  [show with all ESTs]
    Unigene Representative Sequence: BE872965
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602758 ENST00000602719 ENST00000602583 ENST00000602675 ENST00000284245(uc002fjc.4)
    ENST00000602914 ENST00000602766
    miRNA
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    hsa-miR-3607-3p hsa-miR-3613-3p hsa-miR-340
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for C16orf74
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C16orf74
    Clone
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    OriGene ORF clones in mouse, rat for C16orf74
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    GenScript: all cDNA clones in your preferred vector: C16orf74 (NM_206967)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C16orf74
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf74
    Sirion Biotech Customized lentivirus for stable overexpression of C16orf74 
                         Customized lentivirus expression plasmids for stable overexpression of C16orf74 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C16orf74
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C16orf74

    8 DOTS entries:

    DT.97840876  DT.100022026  DT.100752149  DT.100676943  DT.120657810  DT.100714926  DT.100809917  DT.100728663 

    24/330 AceView cDNA sequences (see all 330):

    CR592948 BM833306 AI221443 BM681000 AI828992 BQ671560 BE513254 AI638280 
    BU631364 BM832087 BX344766 BC010164 AI583174 AI824062 BU597296 AI910385 
    BQ637460 AF201939 BU184963 BE218516 BU729618 CR600014 BE262182 BU527159 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for C16orf74    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                                -               
    SP2:                          -                     
    SP3:                          -     -     -         


    ECgene alternative splicing isoforms for C16orf74

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C16orf74 expression in normal human tissues (normalized intensities)      C16orf74 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCTGCCAT
    C16orf74 Expression
    About this image


    C16orf74 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter

    See C16orf74 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C16orf74

    SOURCE GeneReport for Unigene cluster: Hs.461655
        SABiosciences Custom PCR Arrays for C16orf74
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C16orf74
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf74

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for C16orf74 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1190005I06Rik1 , 5 RIKEN cDNA 1190005I06 gene1, 5 79.39(n)1
    75(a)1
      8 (69.92 cM)5
    689181  NM_197988.11  NP_932105.21 
     1206086025 


    ENSEMBL Gene Tree for C16orf74 (if available)
    TreeFam Gene Tree for C16orf74 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1321 SNPs in C16orf74 are shown (see all 1321)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349145791,2
    C,F--71482738(+) GTGACC/TGCAGA 1 -- int14Minor allele frequency- T:0.21WA NA CSA 124
    rs1875440351,2
    C--71528352(+) CCTGGC/TGCCAA 1 -- int10--------
    rs758307521,2
    F--71528353(+) CTGGCG/ACCAAC 1 -- int11Minor allele frequency- A:0.12WA 118
    rs1920562791,2
    --71528368(+) CAGGCA/GGCCCT 1 -- int10--------
    rs1880417341,2
    C--85740626(+) CCGCAC/GAGCCC 1 -- int10--------
    rs1430921081,2
    C--85740665(+) GCAGAA/CTGAAA 1 -- int10--------
    rs1920856001,2
    --85740682(+) GGGCTC/TGAGAC 1 -- int10--------
    rs1508821541,2
    --85740714(+) CCAGAC/TTGGCT 1 -- int10--------
    rs116441221,2
    C,F,H--85740750(+) ACCCAC/TGCTTT 1 -- int124Minor allele frequency- N:0.00NS EA NA 2574
    rs1831234221,2
    --85740751(+) CCCACA/GCTTTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for C16orf74 (85723690 - 85784735 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for C16orf74:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1023256CNV Deletion17803354
    esv2714855CNV Deletion23290073
    nsv833316CNV Loss17160897
    nsv907090CNV Loss21882294
    nsv510693CNV Loss20534489
    nsv527240CNV Loss19592680
    esv4262CNV Complex18987735

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C16orf74 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C16orf74)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Identification of C16orf74 as a marker of progression in primary non-muscle invasive bladder cancer. (PubMed id 21203532)1 Kim W.T....Kim W.J. (2010)
    3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    4. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    6. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107413)1 Wistow G.... Peterson K. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 404550 HGNC: 23362 AceView: Pfs2andMGC17624 Ensembl:ENSG00000154102 euGenes: HUgn404550
    ECgene: C16orf74 H-InvDB: C16orf74

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C16orf74 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C16orf74 gene:
    Search GeneIP for patents involving C16orf74

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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