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Aliases for C16orf72 Gene

Aliases for C16orf72 Gene

  • Chromosome 16 Open Reading Frame 72 2 3 5
  • UPF0472 Protein C16orf72 3
  • PRO0149 3

External Ids for C16orf72 Gene

Previous GeneCards Identifiers for C16orf72 Gene

  • GC16P009094
  • GC16P009185
  • GC16P009106

Summaries for C16orf72 Gene

GeneCards Summary for C16orf72 Gene

C16orf72 (Chromosome 16 Open Reading Frame 72) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf72 Gene

Genomics for C16orf72 Gene

Regulatory Elements for C16orf72 Gene

Enhancers for C16orf72 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G009126 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.6 +35.9 35874 3.0 PKNOX1 ATF1 MLX ARID4B SLC30A9 GLIS2 ZNF207 FOS SP5 MXD4 C16orf72 ENSG00000263244 ENSG00000260349 USP7 GC16P009141 PIR60317
GH16G008631 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.8 -458.9 -458888 2.0 ELF3 FOXA2 MLX ZSCAN9 RAD21 RARA TCF12 FOS CREM MIXL1 C16orf72 METTL22 TMEM114 USP7 GC16M008655
GH16G009046 1.3 Ensembl ENCODE 12.7 -43.0 -43028 4.2 FOXA2 ARNT ARID4B SIN3A YY1 SLC30A9 ZNF143 FOS ZHX2 MXD4 C16orf72 ENSG00000263244 ENSG00000260276 ENSG00000261392 GC16M008994
GH16G009122 1.3 Ensembl ENCODE dbSUPER 11.8 +32.1 32073 3.0 CTCF PKNOX1 ZMYM3 EBF1 ZIC2 POLR2A FOSL2 FOS IKZF2 PAF1 C16orf72 ENSG00000263244 ENSG00000260349 PIR60317 GC16P009141
GH16G009114 1.1 Ensembl ENCODE dbSUPER 11.8 +23.6 23599 2.2 AGO1 DNMT3B ZNF664 JUND POLR2A SCRT2 SPI1 SUPT5H C16orf72 CARHSP1 ENSG00000263244 PIR60317 GC16P009141
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C16orf72 on UCSC Golden Path with GeneCards custom track

Promoters for C16orf72 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000083058 752 4401 HDGF HNRNPUL1 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for C16orf72 Gene

Chromosome:
16
Start:
9,091,648 bp from pter
End:
9,121,640 bp from pter
Size:
29,993 bases
Orientation:
Plus strand

Genomic View for C16orf72 Gene

Genes around C16orf72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf72 Gene

Proteins for C16orf72 Gene

  • Protein details for C16orf72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CZ0-CP072_HUMAN
    Recommended name:
    UPF0472 protein C16orf72
    Protein Accession:
    Q14CZ0

    Protein attributes for C16orf72 Gene

    Size:
    275 amino acids
    Molecular mass:
    30926 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C16orf72 Gene

Post-translational modifications for C16orf72 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C16orf72 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C16orf72 Gene

Domains & Families for C16orf72 Gene

Protein Domains for C16orf72 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C16orf72 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14CZ0

UniProtKB/Swiss-Prot:

CP072_HUMAN :
  • Belongs to the UPF0472 family.
Family:
  • Belongs to the UPF0472 family.
genes like me logo Genes that share domains with C16orf72: view

No data available for Gene Families for C16orf72 Gene

Function for C16orf72 Gene

Gene Ontology (GO) - Molecular Function for C16orf72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C16orf72: view
genes like me logo Genes that share phenotypes with C16orf72: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf72 Gene

Localization for C16orf72 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf72 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C16orf72 Gene

Pathways & Interactions for C16orf72 Gene

SuperPathways for C16orf72 Gene

No Data Available

Interacting Proteins for C16orf72 Gene

Gene Ontology (GO) - Biological Process for C16orf72 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C16orf72 Gene

Drugs & Compounds for C16orf72 Gene

No Compound Related Data Available

Transcripts for C16orf72 Gene

mRNA/cDNA for C16orf72 Gene

Unigene Clusters for C16orf72 Gene

Chromosome 16 open reading frame 72:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf72 Gene

No ASD Table

Relevant External Links for C16orf72 Gene

GeneLoc Exon Structure for
C16orf72
ECgene alternative splicing isoforms for
C16orf72

Expression for C16orf72 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf72 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C16orf72 Gene

This gene is overexpressed in Whole Blood (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of C16orf72 Gene:

C16orf72

SOURCE GeneReport for Unigene cluster for C16orf72 Gene:

Hs.221497

Evidence on tissue expression from TISSUES for C16orf72 Gene

  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with C16orf72: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf72 Gene

Orthologs for C16orf72 Gene

This gene was present in the common ancestor of animals.

Orthologs for C16orf72 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C25H16ORF72 35
  • 100 (a)
OneToOne
C25H16orf72 34
  • 97.7 (n)
chimpanzee
(Pan troglodytes)
Mammalia C16H16orf72 34
  • 99.24 (n)
C16orf72 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1810013L24Rik 34 16 35
  • 97.09 (n)
oppossum
(Monodelphis domestica)
Mammalia C16orf72 35
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1309748 34
  • 96.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C16orf72 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C16orf72 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves C16orf72 35
  • 94 (a)
OneToOne
LOC416639 34
  • 88.03 (n)
lizard
(Anolis carolinensis)
Reptilia C16orf72 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c16orf72 34
  • 84.38 (n)
Str.5950 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68553 34
zebrafish
(Danio rerio)
Actinopterygii C3H16orf72 35
  • 83 (a)
OneToOne
zgc:77849 34
  • 75.63 (n)
wufb59e09 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3294 34
fruit fly
(Drosophila melanogaster)
Insecta CG4768 35
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11201 35
  • 44 (a)
OneToOne
Species where no ortholog for C16orf72 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C16orf72 Gene

ENSEMBL:
Gene Tree for C16orf72 (if available)
TreeFam:
Gene Tree for C16orf72 (if available)

Paralogs for C16orf72 Gene

Pseudogenes.org Pseudogenes for C16orf72 Gene

genes like me logo Genes that share paralogs with C16orf72: view

No data available for Paralogs for C16orf72 Gene

Variants for C16orf72 Gene

Sequence variations from dbSNP and Humsavar for C16orf72 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000030161 -- 9,099,861(+) TTAGC(A/T)CAAGT intron-variant
rs1000100711 -- 9,103,139(+) CACCA(C/T)GAAAC reference, stop-gained
rs1000142569 -- 9,117,643(+) TTTTA(A/G)GACAA utr-variant-3-prime
rs1000146903 -- 9,111,615(+) TTGGA(A/C)TTTTT intron-variant, utr-variant-3-prime
rs1000177771 -- 9,094,849(+) TTGTC(C/G)TCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf72 Gene

Variant ID Type Subtype PubMed ID
dgv2725n100 CNV gain 25217958
dgv2726n100 CNV gain 25217958
esv3892788 CNV gain 25118596
nsv1040937 CNV gain 25217958
nsv1070322 CNV deletion 25765185
nsv457400 CNV gain 19166990
nsv457401 CNV gain 19166990
nsv457402 CNV gain 19166990
nsv519065 CNV gain 19592680
nsv525864 CNV loss 19592680
nsv571430 CNV gain 21841781
nsv571431 CNV gain 21841781
nsv571432 CNV gain 21841781
nsv952918 CNV duplication 24416366

Variation tolerance for C16orf72 Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C16orf72 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C16orf72

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf72 Gene

Disorders for C16orf72 Gene

Relevant External Links for C16orf72

Genetic Association Database (GAD)
C16orf72
Human Genome Epidemiology (HuGE) Navigator
C16orf72
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C16orf72

No disorders were found for C16orf72 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf72 Gene

Publications for C16orf72 Gene

  1. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 2 3 64
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64
  5. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3 64

Products for C16orf72 Gene

Sources for C16orf72 Gene

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