C16orf70 Gene
protein-coding GIFtS: 46
GCID: GC16P067143
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chromosome 16 open reading frame 70(Previous name: chromosome 16 open reading frame 6 )
(Previous symbols: C16orf6, LIN10)
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Aliases
for C16orf70 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 16 Open Reading Frame 701 2 | | FLJ120761 | | C16orf61 2 3 | | Chromosome 16 Open Reading Frame 61 | | LIN101 2 | | Lin-10 Homolog2 | | Lin-101 | | UPF0183 Protein C16orf702 |
Export aliases for C16orf70 gene to outside databasesPrevious GC identifers: GC16P065703 GC16P053017 |
Summaries
for C16orf70 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C16orf70 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C16orf70 gene promoter:
Nkx3-1 ISGF-3 Nkx3-1 v4 Nkx3-1 v1 Nkx3-1 v2 POU2F1 POU2F1a Nkx3-1 v3 FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C16orf70
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C16orf70 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1C16orf70 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P067143: view genomic region
(about GC identifiers)
Start:
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67,143,861 bp from pter |
End:
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67,182,442 bp from pter |
Size:
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38,582 bases |
Orientation:
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plus strand |
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Proteins
for C16orf70 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CP070_HUMAN, Q9BSU1 (See
protein sequence)Recommended Name: UPF0183 protein C16orf70 Size: 422 amino acids; 47524 Da
Caution: Was originally (Ref.1) thought to be a lin-10 homolog
Secondary accessions: Q9HA86Alternative splicing: 2 isoforms: Q9BSU1-1 Q9BSU1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C16orf70: NX_Q9BSU1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BSU1
C16orf70 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079463.2
ENSEMBL proteins: ENSP00000456688 ENSP00000456549 ENSP00000455182 ENSP00000219139 ENSP00000456154 ENSP00000464242
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
C16orf70 for ontologies About GeneDecksing
C16orf70 Antibody Products:
Assay Products for C16orf70: |
Protein
Domains /
Families
for C16orf70 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C16orf70 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BSU1ProtoNet protein and cluster: Q9BSU1 1 Blocks protein family: IPB005373 Protein of unknown function UPF0183
UniProtKB/Swiss-Prot: CP070_HUMAN, Q9BSU1Similarity: Belongs to the UPF0183 family |
Function
for C16orf70 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf70 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf70
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C16orf70 (NM_025187) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C16orf70 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf70 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf70 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
C16orf70 for ontologies About GeneDecksing
|
Pathways & Interactions
for C16orf70 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C16orf70
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/8 Interacting proteins for C16orf70 (Q9BSU11, 2, 3 ENSP000002191394) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0043001 | Golgi to plasma membrane protein transport |
-- | -- |
C16orf70 for ontologies About GeneDecksing
|
Drugs & Compounds
for C16orf70 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C16orf70
Search CenterWatch for drugs/clinical trials and news about C16orf70 / CP070
|
Transcripts
for C16orf70 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C16orf70 gene: NM_025187.3 Unigene Cluster for C16orf70: Chromosome 16 open reading frame 70 Hs.513666 [show with all ESTs]Unigene Representative Sequence: BC00455611 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000563853 ENST00000569914 ENST00000569600 ENST00000219139(uc002erc.3 uc002erd.3)
ENST00000569683 ENST00000566026 ENST00000569626(uc002ere.1) ENST00000565900
ENST00000561683 ENST00000567162 ENST00000569277
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf70 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf70
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C16orf70 (NM_025187) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C16orf70 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf70 |
Additional cDNA sequence: AF176088.1 AK022138.1 BC004556.2 15 DOTS entries: DT.315793 DT.95114678 DT.97805418 DT.100721424 DT.100740054 DT.307136 DT.70103743 DT.95096481 DT.91767275 DT.95114681 DT.95140381 DT.95217944 DT.97808949 DT.40108627 DT.99971070 24/112 AceView cDNA sequences (see all 112): BQ653132 AI336870 AI453251 BM693740 CB997191 BU176819 BQ653957 AU121257 BQ947236 AF176088 AL540304 BM555224 AI023696 CF265194 CB216088 AI805093 BC004556 AI493703 BQ028528 AI689566 AI401752 CA417705 BG697911 H12592
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for C16orf70 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C16orf70
|
Expression
for C16orf70 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C16orf70 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGTTGCT
About this image
See C16orf70 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C16orf70
SOURCE GeneReport for Unigene cluster: Hs.513666
SABiosciences Custom PCR Arrays for C16orf70
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C16orf70
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C16orf70 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C16orf70 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C16orf70 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf70 |
Orthologs
for C16orf70 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for C16orf70 gene from 8/27 species (see all 27) About this table
ENSEMBL Gene Tree for C16orf70 (if available)
TreeFam Gene Tree for C16orf70 (if available) |
Paralogs
for C16orf70 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C16orf70 gene
C16orf70 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for C16orf70
PGOHUM00000263224
|
Genomic Variants
for C16orf70 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C16orf70 (67143861 - 67182442 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C16orf70: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C16orf70 |
|
Disorders
/ Diseases
for C16orf70 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C16orf70 for disorders About GeneDecksing
4  diseases for C16orf70: About MalaCardschronic lymphocytic leukemia lymphocytic leukemia leukemia ataxia
Human Genome Epidemiology (HuGE) Navigator: C16orf70 (5 documents)
Export disorders for C16orf70 gene to outside databases
|
Publications
for C16orf70 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C16orf70 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with C16orf70) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
|
External Searches for C16orf70 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C16orf70 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C16orf70 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C16orf70 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C16orf70 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C16orf70 gene:
Search GeneIP for patents involving C16orf70
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C16orf70 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C16orf70 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C16orf70 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C16orf70 | | | OriGene Protein Over-expression Lysate for C16orf70 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C16orf70 | | OriGene 3'-UTR Clone for C16orf70 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf70 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf70 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C16orf70 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C16orf70 | | OriGene Custom Protein Services for C16orf70 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C16orf70 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C16orf70 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C16orf70 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C16orf70 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C16orf70 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C16orf70 |
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 | | | C16orf70 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf70 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf70 |
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