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Aliases for C16orf70 Gene

Aliases for C16orf70 Gene

  • Chromosome 16 Open Reading Frame 70 2 3
  • C16orf6 3 4
  • Chromosome 16 Open Reading Frame 6 2
  • Lin-10 Homolog 3
  • LIN-10 3
  • LIN10 3

External Ids for C16orf70 Gene

Previous HGNC Symbols for C16orf70 Gene

  • C16orf6
  • LIN10

Previous GeneCards Identifiers for C16orf70 Gene

  • GC16P065703
  • GC16P053017

Summaries for C16orf70 Gene

GeneCards Summary for C16orf70 Gene

C16orf70 (Chromosome 16 Open Reading Frame 70) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf70 Gene

Genomics for C16orf70 Gene

Regulatory Elements for C16orf70 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C16orf70 Gene

67,109,898 bp from pter
67,148,539 bp from pter
38,642 bases
Plus strand

Genomic View for C16orf70 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C16orf70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf70 Gene

Proteins for C16orf70 Gene

  • Protein details for C16orf70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0183 protein C16orf70
    Protein Accession:
    Secondary Accessions:
    • Q9HA86

    Protein attributes for C16orf70 Gene

    422 amino acids
    Molecular mass:
    47524 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C16orf70 Gene


neXtProt entry for C16orf70 Gene

Proteomics data for C16orf70 Gene at MOPED

Post-translational modifications for C16orf70 Gene

  • Ubiquitination at Lys 231
  • Modification sites at PhosphoSitePlus

Other Protein References for C16orf70 Gene

No data available for DME Specific Peptides for C16orf70 Gene

Domains & Families for C16orf70 Gene

Protein Domains for C16orf70 Gene


Suggested Antigen Peptide Sequences for C16orf70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0183 family.
  • Belongs to the UPF0183 family.
genes like me logo Genes that share domains with C16orf70: view

No data available for Gene Families for C16orf70 Gene

Function for C16orf70 Gene

Gene Ontology (GO) - Molecular Function for C16orf70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16713569
genes like me logo Genes that share ontologies with C16orf70: view

Phenotypes for C16orf70 Gene

GenomeRNAi human phenotypes for C16orf70:
genes like me logo Genes that share phenotypes with C16orf70: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C16orf70

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf70 Gene

Localization for C16orf70 Gene

Subcellular locations from

Jensen Localization Image for C16orf70 Gene COMPARTMENTS Subcellular localization image for C16orf70 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C16orf70 Gene

Pathways & Interactions for C16orf70 Gene

SuperPathways for C16orf70 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C16orf70 Gene


No data available for Pathways by source and SIGNOR curated interactions for C16orf70 Gene

Drugs & Compounds for C16orf70 Gene

No Compound Related Data Available

Transcripts for C16orf70 Gene

Unigene Clusters for C16orf70 Gene

Chromosome 16 open reading frame 70:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C16orf70

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf70 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for C16orf70 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C16orf70 Gene

mRNA expression in normal human tissues for C16orf70 Gene

Protein differential expression in normal tissues from HIPED for C16orf70 Gene

This gene is overexpressed in Frontal cortex (13.0), Testis (8.0), Ovary (7.2), Retina (6.8), and Placenta (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C16orf70 Gene

SOURCE GeneReport for Unigene cluster for C16orf70 Gene Hs.513666

genes like me logo Genes that share expression patterns with C16orf70: view

Protein tissue co-expression partners for C16orf70 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C16orf70 Gene

Orthologs for C16orf70 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for C16orf70 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C18H16orf70 35
  • 92.42 (n)
  • 98.13 (a)
C16orf70 36
  • 97 (a)
(Canis familiaris)
Mammalia C5H16orf70 35
  • 94.71 (n)
  • 98.58 (a)
C16orf70 36
  • 99 (a)
(Mus musculus)
Mammalia D230025D16Rik 35
  • 92.02 (n)
  • 96.92 (a)
D230025D16Rik 16
D230025D16Rik 36
  • 97 (a)
(Pan troglodytes)
Mammalia C16H16orf70 35
  • 97.38 (n)
  • 96.9 (a)
C16ORF70 36
  • 100 (a)
(Rattus norvegicus)
Mammalia RGD621098 35
  • 92.18 (n)
  • 97.63 (a)
(Monodelphis domestica)
Mammalia C16orf70 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia C16orf70 36
  • 94 (a)
(Gallus gallus)
Aves C11H16ORF70 35
  • 83.57 (n)
  • 94.55 (a)
C11H16ORF70 36
  • 94 (a)
(Anolis carolinensis)
Reptilia C16orf70 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494115 35
  • 77.22 (n)
  • 85.48 (a)
(Danio rerio)
Actinopterygii si:dkey-102f14.5 35
  • 76.35 (n)
  • 88.1 (a)
C18H16orf70 36
  • 87 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003820 35
  • 58.66 (n)
  • 57.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7083 35
  • 57.17 (n)
  • 56.76 (a)
CG7083 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea T01G9.2 35
  • 46.38 (n)
  • 38.62 (a)
T01G9.2 36
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G51130 35
  • 49.86 (n)
  • 38.38 (a)
(Oryza sativa)
Liliopsida Os06g0714000 35
  • 49.28 (n)
  • 38.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.69 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
CSA.1238 36
  • 59 (a)
Species with no ortholog for C16orf70:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C16orf70 Gene

Gene Tree for C16orf70 (if available)
Gene Tree for C16orf70 (if available)

Paralogs for C16orf70 Gene Pseudogenes for C16orf70 Gene

genes like me logo Genes that share paralogs with C16orf70: view

No data available for Paralogs for C16orf70 Gene

Variants for C16orf70 Gene

Sequence variations from dbSNP and Humsavar for C16orf70 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs786359 -- 67,131,136(+) AGAAC(A/C)AAAGA intron-variant
rs810860 -- 67,139,222(+) cggcc(A/C)AGAAG intron-variant
rs964867 -- 67,132,017(-) AAAGG(A/G)AAGCC intron-variant
rs1152084 -- 67,137,959(+) TCCTT(C/T)CTTAT intron-variant
rs1811747 -- 67,136,505(-) TAAAT(G/T)CTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf70 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv906794 CNV Loss 21882294
nsv509627 CNV Insertion 20534489
dgv2886n71 CNV Loss 21882294
dgv2887n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138

Variation tolerance for C16orf70 Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C16orf70 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf70 Gene

Disorders for C16orf70 Gene

Relevant External Links for C16orf70

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C16orf70: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf70 Gene

Publications for C16orf70 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 67

Products for C16orf70 Gene

Sources for C16orf70 Gene

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