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Aliases for C16orf62 Gene

Aliases for C16orf62 Gene

  • Chromosome 16 Open Reading Frame 62 2 3
  • Esophageal Cancer-Associated Protein 4

External Ids for C16orf62 Gene

Previous GeneCards Identifiers for C16orf62 Gene

  • GC16P019475
  • GC16P019476
  • GC16P018103

Summaries for C16orf62 Gene

GeneCards Summary for C16orf62 Gene

C16orf62 (Chromosome 16 Open Reading Frame 62) is a Protein Coding gene. Diseases associated with C16orf62 include esophageal cancer.

UniProtKB/Swiss-Prot for C16orf62 Gene

  • Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf62 Gene

Genomics for C16orf62 Gene

Regulatory Elements for C16orf62 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C16orf62 Gene

Start:
19,555,240 bp from pter
End:
19,706,793 bp from pter
Size:
151,554 bases
Orientation:
Plus strand

Genomic View for C16orf62 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C16orf62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf62 Gene

Proteins for C16orf62 Gene

  • Protein details for C16orf62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3J2-CP062_HUMAN
    Recommended name:
    UPF0505 protein C16orf62
    Protein Accession:
    Q7Z3J2
    Secondary Accessions:
    • A8K2M1
    • O43329
    • Q69YI1
    • Q6PDA0
    • Q7L371
    • Q86W66
    • Q8WXA5
    • Q9H0L7
    • Q9H7C8

    Protein attributes for C16orf62 Gene

    Size:
    963 amino acids
    Molecular mass:
    109563 Da
    Quaternary structure:
    • Interacts with COMMD1, CCDC93 and CCDC22; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22, CCDC93 and C16orf62. Interacts with FAM21C, WASH1 (PubMed:25355947).
    SequenceCaution:
    • Sequence=AAH14900.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97869.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C16orf62 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C16orf62 Gene

Proteomics data for C16orf62 Gene at MOPED

Post-translational modifications for C16orf62 Gene

  • Ubiquitination at Lys933
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C16orf62 Gene

Domains for C16orf62 Gene

Protein Domains for C16orf62 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C16orf62 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z3J2

UniProtKB/Swiss-Prot:

CP062_HUMAN :
  • Q7Z3J2
Family:
  • Belongs to the UPF0505 family.
genes like me logo Genes that share domains with C16orf62: view

No data available for Gene Families for C16orf62 Gene

Function for C16orf62 Gene

Molecular function for C16orf62 Gene

UniProtKB/Swiss-Prot Function: Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947).

Gene Ontology (GO) - Molecular Function for C16orf62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25355947
genes like me logo Genes that share ontologies with C16orf62: view

Phenotypes for C16orf62 Gene

GenomeRNAi human phenotypes for C16orf62:
genes like me logo Genes that share phenotypes with C16orf62: view

Animal Model Products

CRISPR Products

miRNA for C16orf62 Gene

miRTarBase miRNAs that target C16orf62

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C16orf62 Gene

Localization for C16orf62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C16orf62 Gene

Membrane; Single-pass membrane protein. Early endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C16orf62 Gene COMPARTMENTS Subcellular localization image for C16orf62 gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C16orf62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C16orf62: view

Pathways for C16orf62 Gene

SuperPathways for C16orf62 Gene

No Data Available

Interacting Proteins for C16orf62 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000400815%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000400815 for C16orf62 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for C16orf62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006893 Golgi to plasma membrane transport IMP 25355947
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with C16orf62: view

No data available for Pathways by source for C16orf62 Gene

Transcripts for C16orf62 Gene

Unigene Clusters for C16orf62 Gene

Chromosome 16 open reading frame 62:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C16orf62

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf62 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: -
SP4:
SP5: -
SP6:
SP7:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for C16orf62 Gene

GeneLoc Exon Structure for
C16orf62
ECgene alternative splicing isoforms for
C16orf62

Expression for C16orf62 Gene

mRNA expression in normal human tissues for C16orf62 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C16orf62 Gene

SOURCE GeneReport for Unigene cluster for C16orf62 Gene Hs.654964

genes like me logo Genes that share expressions with C16orf62: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C16orf62 Gene

Orthologs for C16orf62 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for C16orf62 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C16H16orf62 35
  • 98.93 (n)
  • 98.82 (a)
C16orf62 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C16orf62 36
  • 97 (a)
OneToOne
C25H16orf62 35
  • 91.87 (n)
  • 96.88 (a)
dog
(Canis familiaris)
Mammalia C16orf62 36
  • 96 (a)
OneToOne
C6H16orf62 35
  • 88.89 (n)
  • 92.08 (a)
mouse
(Mus musculus)
Mammalia 9030624J02Rik 35
  • 86.23 (n)
  • 92.31 (a)
9030624J02Rik 16
9030624J02Rik 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C16orf62 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC361635 35
  • 87.57 (n)
  • 93.7 (a)
chicken
(Gallus gallus)
Aves C14H16ORF62 35
  • 76.22 (n)
  • 84.9 (a)
C16orf62 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.19623 35
tropical clawed frog
(Silurana tropicalis)
Amphibia c16orf62 35
  • 73.63 (n)
  • 81.62 (a)
Str.16226 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12356 35
zebrafish
(Danio rerio)
Actinopterygii C12H16orf62 36
  • 74 (a)
OneToOne
zgc:163107 35
  • 68.89 (n)
  • 73.88 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001150 35
  • 53.14 (n)
  • 48.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8202 35
  • 52.42 (n)
  • 45.75 (a)
CG8202 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F26G1.1 36
  • 19 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G50730 35
  • 43.57 (n)
  • 26.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for C16orf62:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C16orf62 Gene

ENSEMBL:
Gene Tree for C16orf62 (if available)
TreeFam:
Gene Tree for C16orf62 (if available)

Paralogs for C16orf62 Gene

No data available for Paralogs for C16orf62 Gene

Variants for C16orf62 Gene

Sequence variations from dbSNP and Humsavar for C16orf62 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs114443 -- 19,598,337(-) AGAGA(A/T)AAATA intron-variant
rs114444 -- 19,598,268(-) AGGTC(A/G)TTTAC intron-variant
rs121235 -- 19,569,377(+) ACTGG(A/G)GAGAG intron-variant
rs170537 -- 19,585,079(+) tagtt(C/T)gttcc intron-variant
rs170538 -- 19,599,203(+) ctgca(C/G)attga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf62 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv833163 CNV Gain 17160897
nsv520441 CNV Loss 19592680
nsv1756 CNV Insertion 18451855

Relevant External Links for C16orf62 Gene

HapMap Linkage Disequilibrium report
C16orf62

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf62 Gene

Disorders for C16orf62 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for C16orf62 Gene including...

Search for C16orf62 Gene in MalaCards »

Relevant External Links for C16orf62

Genetic Association Database (GAD)
C16orf62
Human Genome Epidemiology (HuGE) Navigator
C16orf62
genes like me logo Genes that share disorders with C16orf62: view

No data available for UniProtKB/Swiss-Prot for C16orf62 Gene

Publications for C16orf62 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak C.A. … Burstein E. (Mol. Biol. Cell 2015) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for C16orf62 Gene

Sources for C16orf62 Gene

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