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Aliases for C16orf62 Gene

Aliases for C16orf62 Gene

  • Chromosome 16 Open Reading Frame 62 2 3 5
  • Esophageal Cancer-Associated Protein 4

External Ids for C16orf62 Gene

Previous GeneCards Identifiers for C16orf62 Gene

  • GC16P019475
  • GC16P019476
  • GC16P018103

Summaries for C16orf62 Gene

GeneCards Summary for C16orf62 Gene

C16orf62 (Chromosome 16 Open Reading Frame 62) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C16orf62 Gene

  • Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf62 Gene

Genomics for C16orf62 Gene

Regulatory Elements for C16orf62 Gene

Enhancers for C16orf62 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C16orf62 on UCSC Golden Path with GeneCards custom track

Promoters for C16orf62 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C16orf62 on UCSC Golden Path with GeneCards custom track

Genomic Location for C16orf62 Gene

19,555,073 bp from pter
19,706,793 bp from pter
151,721 bases
Plus strand

Genomic View for C16orf62 Gene

Genes around C16orf62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf62 Gene

Proteins for C16orf62 Gene

  • Protein details for C16orf62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0505 protein C16orf62
    Protein Accession:
    Secondary Accessions:
    • A8K2M1
    • O43329
    • Q69YI1
    • Q6PDA0
    • Q7L371
    • Q86W66
    • Q8WXA5
    • Q9H0L7
    • Q9H7C8

    Protein attributes for C16orf62 Gene

    963 amino acids
    Molecular mass:
    109563 Da
    Quaternary structure:
    • Interacts with COMMD1, CCDC93 and CCDC22; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22, CCDC93 and C16orf62. Interacts with FAM21C, WASH1 (PubMed:25355947).
    • Sequence=AAH14900.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97869.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C16orf62 Gene


neXtProt entry for C16orf62 Gene

Proteomics data for C16orf62 Gene at MOPED

Post-translational modifications for C16orf62 Gene

  • Ubiquitination at Lys 933
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C16orf62 Gene

Domains & Families for C16orf62 Gene

Protein Domains for C16orf62 Gene


Suggested Antigen Peptide Sequences for C16orf62 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0505 family.
  • Belongs to the UPF0505 family.
genes like me logo Genes that share domains with C16orf62: view

No data available for Gene Families for C16orf62 Gene

Function for C16orf62 Gene

Molecular function for C16orf62 Gene

UniProtKB/Swiss-Prot Function:
Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947).
genes like me logo Genes that share phenotypes with C16orf62: view

Animal Model Products

CRISPR Products

miRNA for C16orf62 Gene

miRTarBase miRNAs that target C16orf62

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf62 Gene

Localization for C16orf62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C16orf62 Gene

Membrane; Single-pass membrane protein. Early endosome.

Subcellular locations from

Jensen Localization Image for C16orf62 Gene COMPARTMENTS Subcellular localization image for C16orf62 gene
Compartment Confidence
endosome 4
plasma membrane 3
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C16orf62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with C16orf62: view

Pathways & Interactions for C16orf62 Gene

SuperPathways for C16orf62 Gene

No Data Available

Interacting Proteins for C16orf62 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000400815 for C16orf62 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C16orf62 Gene


No data available for Pathways by source and SIGNOR curated interactions for C16orf62 Gene

Drugs & Compounds for C16orf62 Gene

No Compound Related Data Available

Transcripts for C16orf62 Gene

Unigene Clusters for C16orf62 Gene

Chromosome 16 open reading frame 62:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf62 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: -
SP5: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP2: -

Relevant External Links for C16orf62 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C16orf62 Gene

mRNA expression in normal human tissues for C16orf62 Gene

Protein differential expression in normal tissues from HIPED for C16orf62 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C16orf62 Gene

SOURCE GeneReport for Unigene cluster for C16orf62 Gene Hs.654964

genes like me logo Genes that share expression patterns with C16orf62: view

Protein tissue co-expression partners for C16orf62 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C16orf62 Gene

Orthologs for C16orf62 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for C16orf62 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C25H16orf62 35
  • 91.87 (n)
  • 96.88 (a)
C16orf62 36
  • 97 (a)
(Canis familiaris)
Mammalia C6H16orf62 35
  • 88.89 (n)
  • 92.08 (a)
C16orf62 36
  • 96 (a)
(Mus musculus)
Mammalia 9030624J02Rik 35
  • 86.23 (n)
  • 92.31 (a)
9030624J02Rik 16
9030624J02Rik 36
  • 92 (a)
(Pan troglodytes)
Mammalia C16H16orf62 35
  • 98.93 (n)
  • 98.82 (a)
C16orf62 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC361635 35
  • 87.57 (n)
  • 93.7 (a)
(Monodelphis domestica)
Mammalia C16orf62 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
-- 36
  • 79 (a)
-- 36
  • 85 (a)
(Gallus gallus)
Aves C14H16ORF62 35
  • 76.22 (n)
  • 84.9 (a)
C16orf62 36
  • 84 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
-- 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c16orf62 35
  • 73.63 (n)
  • 81.62 (a)
Str.16226 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19623 35
(Danio rerio)
Actinopterygii zgc:163107 35
  • 68.89 (n)
  • 73.88 (a)
C12H16orf62 36
  • 74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12356 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001150 35
  • 53.14 (n)
  • 48.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8202 35
  • 52.42 (n)
  • 45.75 (a)
CG8202 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea F26G1.1 36
  • 19 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G50730 35
  • 43.57 (n)
  • 26.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for C16orf62:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C16orf62 Gene

Gene Tree for C16orf62 (if available)
Gene Tree for C16orf62 (if available)

Paralogs for C16orf62 Gene

No data available for Paralogs for C16orf62 Gene

Variants for C16orf62 Gene

Sequence variations from dbSNP and Humsavar for C16orf62 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs17854969 - 19,564,928(+) GGACT(A/G)TCACC reference, missense
rs7206637 - 19,581,571(+) CGTGA(A/T)CCGCA reference, missense, utr-variant-5-prime
rs17854970 - 19,629,783(+) TTGTG(C/T)CGAAG reference, missense
rs114443 -- 19,598,337(-) AGAGA(A/T)AAATA intron-variant
rs114444 -- 19,598,268(-) AGGTC(A/G)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf62 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv833163 CNV Gain 17160897
nsv520441 CNV Loss 19592680
nsv1756 CNV Insertion 18451855

Variation tolerance for C16orf62 Gene

Residual Variation Intolerance Score: 64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C16orf62 Gene

Disorders for C16orf62 Gene

Relevant External Links for C16orf62

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C16orf62 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf62 Gene

Publications for C16orf62 Gene

  1. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak C.A. … Burstein E. (Mol. Biol. Cell 2015) 2 3 4 67
  2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for C16orf62 Gene

Sources for C16orf62 Gene