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Aliases for C16orf59 Gene

Aliases for C16orf59 Gene

  • Chromosome 16 Open Reading Frame 59 2 3 5

External Ids for C16orf59 Gene

Previous GeneCards Identifiers for C16orf59 Gene

  • GC16P002451
  • GC16P002512

Summaries for C16orf59 Gene

GeneCards Summary for C16orf59 Gene

C16orf59 (Chromosome 16 Open Reading Frame 59) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf59 Gene

Genomics for C16orf59 Gene

Regulatory Elements for C16orf59 Gene

Enhancers for C16orf59 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G002467 1.7 FANTOM5 ENCODE dbSUPER 3.9 +9.6 9615 5.4 HDGF PKNOX1 AGO1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 ERVK13-1 NME3 ENSG00000260646 MTCO1P28 SNORD60 SNHG19 ZNF205 ENSG00000261123 NTN3 RAB26
GH16G002459 1.1 ENCODE 0.7 +0.1 74 1.5 HDGF PKNOX1 MLX CREB3L1 AGO1 ARID4B SIN3A ZNF2 ZNF143 ZNF548 ZNF263 CCNF SNORA64 ENSG00000260954 ENSG00000255513 LOC105371055 JPT2 ABCA3 ABCA17P ZNF597
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C16orf59 on UCSC Golden Path with GeneCards custom track

Promoters for C16orf59 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082477 120 801 HDGF PKNOX1 MLX CREB3L1 AGO1 ARID4B SIN3A ZNF2 ZNF143 ZNF548

Genomic Location for C16orf59 Gene

2,460,080 bp from pter
2,464,963 bp from pter
4,884 bases
Plus strand

Genomic View for C16orf59 Gene

Genes around C16orf59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf59 Gene

Proteins for C16orf59 Gene

  • Protein details for C16orf59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C16orf59
    Protein Accession:
    Secondary Accessions:
    • B4DXD7
    • Q96H61
    • Q9H872

    Protein attributes for C16orf59 Gene

    433 amino acids
    Molecular mass:
    46402 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C16orf59 Gene


neXtProt entry for C16orf59 Gene

Post-translational modifications for C16orf59 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C16orf59 Gene

No data available for DME Specific Peptides for C16orf59 Gene

Domains & Families for C16orf59 Gene

Protein Domains for C16orf59 Gene


Suggested Antigen Peptide Sequences for C16orf59 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C16orf59: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C16orf59 Gene

Function for C16orf59 Gene

Gene Ontology (GO) - Molecular Function for C16orf59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C16orf59: view
genes like me logo Genes that share phenotypes with C16orf59: view

Animal Model Products

CRISPR Products

miRNA for C16orf59 Gene

miRTarBase miRNAs that target C16orf59

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf59 Gene

Localization for C16orf59 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf59 gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C16orf59 Gene

Pathways & Interactions for C16orf59 Gene

SuperPathways for C16orf59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C16orf59 Gene


No data available for Pathways by source and SIGNOR curated interactions for C16orf59 Gene

Transcripts for C16orf59 Gene

Unigene Clusters for C16orf59 Gene

Chromosome 16 open reading frame 59:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf59 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - -
SP8: -

Relevant External Links for C16orf59 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C16orf59 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf59 Gene

mRNA differential expression in normal tissues according to GTEx for C16orf59 Gene

This gene is overexpressed in Testis (x5.0).

Protein differential expression in normal tissues from HIPED for C16orf59 Gene

This gene is overexpressed in Lung (37.0), Saliva (18.3), and Heart (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C16orf59 Gene

Protein tissue co-expression partners for C16orf59 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C16orf59 Gene:


SOURCE GeneReport for Unigene cluster for C16orf59 Gene:

genes like me logo Genes that share expression patterns with C16orf59: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf59 Gene

Orthologs for C16orf59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C16orf59 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C16H16orf59 34
  • 98.69 (n)
C16orf59 35
  • 98 (a)
(Bos Taurus)
Mammalia C25H16orf59 34
  • 79.76 (n)
C16orf59 35
  • 67 (a)
(Canis familiaris)
Mammalia C6H16orf59 34
  • 78.38 (n)
C16orf59 35
  • 74 (a)
(Rattus norvegicus)
Mammalia LOC100158225 34
  • 73.11 (n)
(Mus musculus)
Mammalia 1600002H07Rik 34 16 35
  • 72.69 (n)
(Monodelphis domestica)
Mammalia C16orf59 35
  • 36 (a)
(Gallus gallus)
Aves C16orf59 35
  • 34 (a)
(Anolis carolinensis)
Reptilia C16orf59 35
  • 32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485766 34
  • 44.74 (n)
Species where no ortholog for C16orf59 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C16orf59 Gene

Gene Tree for C16orf59 (if available)
Gene Tree for C16orf59 (if available)

Paralogs for C16orf59 Gene

No data available for Paralogs for C16orf59 Gene

Variants for C16orf59 Gene

Sequence variations from dbSNP and Humsavar for C16orf59 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000288682 -- 2,465,120(+) CACCA(C/T)GCCTG nc-transcript-variant, downstream-variant-500B
rs1000319816 -- 2,460,643(+) CCGGG(C/G)TTTGA upstream-variant-2KB, reference, missense
rs1000430269 -- 2,464,931(+) GAGCC(A/G)CTTGT downstream-variant-500B, utr-variant-3-prime
rs1000681638 -- 2,460,115(+) GAGGC(A/G)GCAAA upstream-variant-2KB, utr-variant-5-prime
rs1001729051 -- 2,461,507(+) AGGGC(A/G)TGGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C16orf59 Gene

Variant ID Type Subtype PubMed ID
dgv4864n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1052260 CNV gain 25217958
nsv571205 CNV gain 21841781
nsv827513 CNV gain 20364138
nsv833121 CNV loss 17160897
nsv952903 CNV deletion 24416366

Variation tolerance for C16orf59 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C16orf59 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf59 Gene

Disorders for C16orf59 Gene

Relevant External Links for C16orf59

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C16orf59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf59 Gene

Publications for C16orf59 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for C16orf59 Gene

Sources for C16orf59 Gene

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