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Aliases for C16orf58 Gene

Aliases for C16orf58 Gene

  • Chromosome 16 Open Reading Frame 58 2 3
  • UPF0420 Protein C16orf58 3
  • RUS 3

External Ids for C16orf58 Gene

Previous GeneCards Identifiers for C16orf58 Gene

  • GC16M031409
  • GC16M029061

Summaries for C16orf58 Gene

Entrez Gene Summary for C16orf58 Gene

  • This gene encodes a putative transmembrane protein containing a conserved DUF647 domain that may be involved in protein-protein interaction. The encoded protein is related to a plant protein that participates in ultraviolet B light-sensing during root morphogenesis. [provided by RefSeq, Feb 2013]

GeneCards Summary for C16orf58 Gene

C16orf58 (Chromosome 16 Open Reading Frame 58) is a Protein Coding gene. Diseases associated with C16orf58 include acute cystitis and bladder disease.

Gene Wiki entry for C16orf58 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf58 Gene

Genomics for C16orf58 Gene

Regulatory Elements for C16orf58 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C16orf58 Gene

31,489,469 bp from pter
31,509,309 bp from pter
19,841 bases
Minus strand

Genomic View for C16orf58 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C16orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf58 Gene

Proteins for C16orf58 Gene

  • Protein details for C16orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RUS1 family protein C16orf58
    Protein Accession:
    Secondary Accessions:
    • Q53GL8
    • Q8NAJ4
    • Q9BVY3
    • Q9H887

    Protein attributes for C16orf58 Gene

    468 amino acids
    Molecular mass:
    51018 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C16orf58 Gene


neXtProt entry for C16orf58 Gene

Proteomics data for C16orf58 Gene at MOPED

Post-translational modifications for C16orf58 Gene

  • Ubiquitination at Lys 297, Lys 376, Lys 433, Lys 436, and Lys 466
  • Modification sites at PhosphoSitePlus

Other Protein References for C16orf58 Gene

No data available for DME Specific Peptides for C16orf58 Gene

Domains & Families for C16orf58 Gene

Protein Domains for C16orf58 Gene


Suggested Antigen Peptide Sequences for C16orf58 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RUS1 family.
  • Belongs to the RUS1 family.
genes like me logo Genes that share domains with C16orf58: view

No data available for Gene Families for C16orf58 Gene

Function for C16orf58 Gene

Phenotypes for C16orf58 Gene

GenomeRNAi human phenotypes for C16orf58:
genes like me logo Genes that share phenotypes with C16orf58: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C16orf58

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf58 Gene

Localization for C16orf58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C16orf58 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for C16orf58 Gene COMPARTMENTS Subcellular localization image for C16orf58 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for C16orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C16orf58: view

Pathways & Interactions for C16orf58 Gene

SuperPathways for C16orf58 Gene

No Data Available

Interacting Proteins for C16orf58 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96GQ5-RUS1_HUMAN ENSP00000317579 for C16orf58 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for C16orf58 Gene


No data available for Pathways by source and SIGNOR curated interactions for C16orf58 Gene

Drugs & Compounds for C16orf58 Gene

No Compound Related Data Available

Transcripts for C16orf58 Gene

Unigene Clusters for C16orf58 Gene

Chromosome 16 open reading frame 58:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C16orf58

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf58 Gene

No ASD Table

Relevant External Links for C16orf58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C16orf58 Gene

mRNA expression in normal human tissues for C16orf58 Gene

Protein differential expression in normal tissues from HIPED for C16orf58 Gene

This gene is overexpressed in Nasal epithelium (53.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C16orf58 Gene

SOURCE GeneReport for Unigene cluster for C16orf58 Gene Hs.9003

genes like me logo Genes that share expression patterns with C16orf58: view

Protein tissue co-expression partners for C16orf58 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C16orf58 Gene

Orthologs for C16orf58 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for C16orf58 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C25H16orf58 35
  • 88.07 (n)
  • 83.68 (a)
C16orf58 36
  • 82 (a)
(Canis familiaris)
Mammalia C6H16orf58 35
  • 86.54 (n)
  • 85.47 (a)
C16orf58 36
  • 68 (a)
(Mus musculus)
Mammalia BC017158 35
  • 83.98 (n)
  • 81.33 (a)
BC017158 16
BC017158 36
  • 81 (a)
(Pan troglodytes)
Mammalia C16H16orf58 35
  • 99.43 (n)
  • 99.36 (a)
C16orf58 36
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1310127 35
  • 82.47 (n)
  • 80.9 (a)
(Monodelphis domestica)
Mammalia C16orf58 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia C16orf58 36
  • 70 (a)
(Anolis carolinensis)
Reptilia C16orf58 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732099 35
  • 61.32 (n)
  • 61.32 (a)
Str.20322 35
(Danio rerio)
Actinopterygii Dr.12463 35
zgc:162613 35
  • 57.04 (n)
  • 54.9 (a)
C3H16orf58 36
  • 50 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4481 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010020 35
  • 48.69 (n)
  • 43.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10338 35
  • 53.39 (n)
  • 44.29 (a)
CG10338 36
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RUS3 35
  • 48.65 (n)
  • 43.45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5264 35
Species with no ortholog for C16orf58:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C16orf58 Gene

Gene Tree for C16orf58 (if available)
Gene Tree for C16orf58 (if available)

Paralogs for C16orf58 Gene Pseudogenes for C16orf58 Gene

genes like me logo Genes that share paralogs with C16orf58: view

No data available for Paralogs for C16orf58 Gene

Variants for C16orf58 Gene

Sequence variations from dbSNP and Humsavar for C16orf58 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3934739 -- 31,501,765(+) GACCA(C/T)AGTGA intron-variant
rs4536493 -- 31,492,430(+) GCCCC(A/G)AGACC intron-variant
rs4889664 -- 31,504,889(+) cggtg(C/T)aggat intron-variant
rs6565234 -- 31,503,789(+) tcctg(C/T)gtagc intron-variant
rs6565235 -- 31,505,192(+) gatgt(C/T)tgggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf58 Gene

Variant ID Type Subtype PubMed ID
nsv833194 CNV Loss 17160897
nsv905747 CNV Gain 21882294
dgv2673n71 CNV Loss 21882294
nsv482193 CNV Gain 20164927

Variation tolerance for C16orf58 Gene

Residual Variation Intolerance Score: 58.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C16orf58 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf58 Gene

Disorders for C16orf58 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C16orf58 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute cystitis
  • urinary tract infection
bladder disease
  • urinary bladder disease
- elite association

Relevant External Links for C16orf58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C16orf58: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C16orf58 Gene

Publications for C16orf58 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 67
  4. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 67
  5. ROOT UV-B SENSITIVE2 acts with ROOT UV-B SENSITIVE1 in a root ultraviolet B-sensing pathway. (PMID: 19515790) Leasure C.D. … He Z.H. (Plant Physiol. 2009) 67

Products for C16orf58 Gene

Sources for C16orf58 Gene

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