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Aliases for C16orf58 Gene

Aliases for C16orf58 Gene

  • Chromosome 16 Open Reading Frame 58 2 3 5
  • RUS1 Homolog 2 3
  • RUS1 Family Protein C16orf58 3
  • UPF0420 Protein C16orf58 3
  • RUS 3

External Ids for C16orf58 Gene

Previous GeneCards Identifiers for C16orf58 Gene

  • GC16M031409
  • GC16M029061

Summaries for C16orf58 Gene

Entrez Gene Summary for C16orf58 Gene

  • This gene encodes a putative transmembrane protein containing a conserved DUF647 domain that may be involved in protein-protein interaction. The encoded protein is related to a plant protein that participates in ultraviolet B light-sensing during root morphogenesis. [provided by RefSeq, Feb 2013]

GeneCards Summary for C16orf58 Gene

C16orf58 (Chromosome 16 Open Reading Frame 58) is a Protein Coding gene. Diseases associated with C16orf58 include Acute Cystitis and Ureteral Disease.

Gene Wiki entry for C16orf58 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf58 Gene

Genomics for C16orf58 Gene

Regulatory Elements for C16orf58 Gene

Enhancers for C16orf58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G031535 0.8 ENCODE 12.6 -26.6 -26611 0.6 HDAC1 LEF1 PKNOX1 TAL1 TCF12 FOXM1 GATA3 GATA2 NCOR1 ADNP C16orf58 LOC105371171 GC16P031542 AHSP
GH16G031537 0.5 Ensembl 12.6 -28.3 -28265 0.9 ZNF740 RNF2 GABPB1 C16orf58 LINC02190 LOC105371171 ENSG00000260304 GC16P031542 AHSP
GH16G031507 1.1 ENCODE 0.7 +0.6 562 3.3 HNRNPUL1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 PRR14 ENSG00000260267 LINC02190 ITGAD TGFB1I1 ENSG00000235560 ENSG00000260625 C16orf58
GH16G031512 0.5 ENCODE 0.7 -4.0 -3951 1.3 ATM BCOR ZNF366 PRDM4 LOC105371171 C16orf58 GC16P031521
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C16orf58 on UCSC Golden Path with GeneCards custom track

Promoters for C16orf58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C16orf58 Gene

31,489,469 bp from pter
31,509,309 bp from pter
19,841 bases
Minus strand

Genomic View for C16orf58 Gene

Genes around C16orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf58 Gene

Proteins for C16orf58 Gene

  • Protein details for C16orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RUS1 family protein C16orf58
    Protein Accession:
    Secondary Accessions:
    • Q53GL8
    • Q8NAJ4
    • Q9BVY3
    • Q9H887

    Protein attributes for C16orf58 Gene

    468 amino acids
    Molecular mass:
    51018 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C16orf58 Gene


neXtProt entry for C16orf58 Gene

Post-translational modifications for C16orf58 Gene

  • Ubiquitination at posLast=297297, Lys376, posLast=433433, Lys436, and Lys466
  • Modification sites at PhosphoSitePlus

Other Protein References for C16orf58 Gene

No data available for DME Specific Peptides for C16orf58 Gene

Domains & Families for C16orf58 Gene

Protein Domains for C16orf58 Gene


Suggested Antigen Peptide Sequences for C16orf58 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RUS1 family.
  • Belongs to the RUS1 family.
genes like me logo Genes that share domains with C16orf58: view

No data available for Gene Families for C16orf58 Gene

Function for C16orf58 Gene

Phenotypes for C16orf58 Gene

genes like me logo Genes that share phenotypes with C16orf58: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf58 Gene

Localization for C16orf58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C16orf58 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf58 gene
Compartment Confidence
nucleus 3
cytosol 3
golgi apparatus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C16orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C16orf58: view

Pathways & Interactions for C16orf58 Gene

SuperPathways for C16orf58 Gene

No Data Available

Interacting Proteins for C16orf58 Gene

Gene Ontology (GO) - Biological Process for C16orf58 Gene


No data available for Pathways by source and SIGNOR curated interactions for C16orf58 Gene

Drugs & Compounds for C16orf58 Gene

No Compound Related Data Available

Transcripts for C16orf58 Gene

Unigene Clusters for C16orf58 Gene

Chromosome 16 open reading frame 58:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf58 Gene

No ASD Table

Relevant External Links for C16orf58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C16orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf58 Gene

Protein differential expression in normal tissues from HIPED for C16orf58 Gene

This gene is overexpressed in Nasal epithelium (53.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C16orf58 Gene

Protein tissue co-expression partners for C16orf58 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C16orf58 Gene:


SOURCE GeneReport for Unigene cluster for C16orf58 Gene:


Evidence on tissue expression from TISSUES for C16orf58 Gene

  • Nervous system(4.7)
  • Kidney(4.6)
  • Thyroid gland(4.3)
  • Intestine(2.4)
  • Gall bladder(2.2)
  • Lung(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with C16orf58: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf58 Gene

Orthologs for C16orf58 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for C16orf58 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C16H16orf58 34
  • 99.43 (n)
C16orf58 35
  • 99 (a)
(Bos Taurus)
Mammalia C25H16orf58 34
  • 88.07 (n)
C16orf58 35
  • 82 (a)
(Canis familiaris)
Mammalia C6H16orf58 34
  • 86.54 (n)
C16orf58 35
  • 68 (a)
(Mus musculus)
Mammalia BC017158 34 16 35
  • 83.98 (n)
(Rattus norvegicus)
Mammalia RGD1310127 34
  • 82.47 (n)
(Ornithorhynchus anatinus)
Mammalia C16orf58 35
  • 70 (a)
(Monodelphis domestica)
Mammalia C16orf58 35
  • 68 (a)
(Anolis carolinensis)
Reptilia C16orf58 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732099 34
  • 61.32 (n)
Str.20322 34
(Danio rerio)
Actinopterygii zgc:162613 34
  • 57.04 (n)
C3H16orf58 35
  • 50 (a)
Dr.12463 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4481 34
fruit fly
(Drosophila melanogaster)
Insecta CG10338 34 35
  • 53.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010020 34
  • 48.69 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RUS3 34
  • 48.65 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5264 34
Species where no ortholog for C16orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C16orf58 Gene

Gene Tree for C16orf58 (if available)
Gene Tree for C16orf58 (if available)

Paralogs for C16orf58 Gene

No data available for Paralogs for C16orf58 Gene

Variants for C16orf58 Gene

Sequence variations from dbSNP and Humsavar for C16orf58 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_036485 A breast cancer sample
rs387906682 Pathogenic 31,489,034(+) TGCCG(C/G)GCGTT intron-variant, downstream-variant-500B, reference, missense
rs61742739 Pathogenic 31,490,477(+) GGTCA(A/G)CCTCA nc-transcript-variant, reference, missense, utr-variant-3-prime
rs61741237 Likely benign 31,490,401(+) CCCTT(A/G)CCCAG nc-transcript-variant, reference, missense, utr-variant-3-prime
rs114517938 Uncertain significance 31,490,598(+) CTGCG(A/C/G)TGCTC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C16orf58 Gene

Variant ID Type Subtype PubMed ID
esv3570465 CNV gain 25503493
nsv1060240 CNV gain 25217958
nsv482193 CNV gain 20164927
nsv833194 CNV loss 17160897

Variation tolerance for C16orf58 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C16orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf58 Gene

Disorders for C16orf58 Gene

MalaCards: The human disease database

(3) MalaCards diseases for C16orf58 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute cystitis
  • urinary tract infection
ureteral disease
  • ureteral disorders
bladder disease
  • urinary bladder disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C16orf58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C16orf58: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C16orf58 Gene

Publications for C16orf58 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for C16orf58 Gene

Sources for C16orf58 Gene

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