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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C16orf55 Gene

protein-coding GIFtS: 37
GCID: GC16P089724

chromosome 16 open reading frame 55

Search for C16orf55
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 16 Open Reading Frame 55¹ ²
FLJ31606¹
Uncharacterized Protein C16orf55²

External Ids:	HGNC: 26463¹	Entrez Gene: 124045²	Ensembl: ENSG00000167523⁷	UniProtKB: Q96N06³

Export aliases for C16orf55 gene to outside databases

Previous GC identifers: GC16P088252 GC16P075419

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010542.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C16orf55 gene promoter:
RFX1 USF1 SREBP-1c HNF-4alpha1 SREBP-1b E2F E2F-1 SREBP-1a USF-1 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C16orf55 promoter sequence

Search SABiosciences Chromatin IP Primers for C16orf55

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C16orf55

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3 Ensembl cytogenetic band: 16q24.3 HGNC cytogenetic band: 16q24.3

C16orf55 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C16orf55 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P089724: view genomic region (about GC identifiers)

Start:	89,724,210 bp from pter	End:	89,737,680 bp from pter
Size:	13,471 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP055_HUMAN, Q96N06 (See protein sequence)

Recommended Name: Uncharacterized protein C16orf55

Size: 139 amino acids; 15461 Da

Secondary accessions: A8WFL2

Explore the universe of human proteins at neXtProt for C16orf55: NX_Q96N06

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96N06

C16orf55 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001258836.1 NP_001258837.1 NP_001258838.1 NP_001258839.1 NP_694570.1

ENSEMBL proteins:

ENSP00000301031 ENSP00000461933 ENSP00000455761 ENSP00000462403 ENSP00000456696

ENSP00000462233 ENSP00000462319 ENSP00000462996

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96N06

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for C16orf55:

Decreased viability with pacli

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C16orf55

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C16orf55
Search CenterWatch for drugs/clinical trials and news about C16orf55 / CP055

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C16orf55 gene (5 alternative transcripts):

NM_001271907.1 NM_001271908.1 NM_001271909.1 NM_001271910.1 NM_153025.2

Unigene Cluster for C16orf55:

Chromosome 16 open reading frame 55

Hs.655171 [show with all ESTs]

Unigene Representative Sequence: BC045670

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000301031(uc002fnw.1 uc010vpk.1) ENST00000566204 ENST00000565890(uc002fny.2)

ENST00000457689 ENST00000567827 ENST00000564238(uc002fnx.4) ENST00000568929

ENST00000566857 ENST00000579310

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Additional cDNA sequence:

AK056168.1 AK125673.1 AK128803.1 AK303024.1 BC045670.1 BC148299.2 NR_073515.1 NR_073516.1

14 DOTS entries:

DT.100780802 DT.111391 DT.95296421 DT.95191930 DT.100780803 DT.97841569 DT.309564 DT.70103343

DT.91788666 DT.100702074 DT.120728246 DT.99930412 DT.87017080 DT.95250726

24/99 AceView cDNA sequences (see all 99):

AI024723 CR613671 CD369549 AW137815 AI969920 BM683984 AW274988 BU844820

H20390 AA319434 AI655320 AW298386 CR607009 AW002406 BM684785 CB216379

AW070989 BM853395 AA555330 CR606992 BM846416 H18097 AK125673 AI925029

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for C16orf55 (see all 11) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10a	·	10b	·	10c	·	10d	·	10e	·	10f
SP1:					-		-		-		-		-				-		-		-		-		-		-
SP2:							-		-		-		-				-		-		-		-		-		-
SP3:									-		-		-				-		-		-		-		-		-
SP4:									-		-		-						-		-		-		-
SP5:									-		-		-

ECgene alternative splicing isoforms for C16orf55

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C16orf55 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

C16orf55 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C16orf55 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C16orf55

SOURCE GeneReport for Unigene cluster: Hs.655171

SABiosciences Custom PCR Arrays for C16orf55

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for C16orf55 gene from 1/4 species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	4732415M23Rik^{1 , 5}	RIKEN cDNA 4732415M23 gene^{1, 5}	72.18(n)¹ 58.68(a)¹		8 (72.08 cM)⁵ 320869¹ NM_177279.4¹ NP_796253.2¹ 123212858⁵

ENSEMBL Gene Tree for C16orf55 (if available)
TreeFam Gene Tree for C16orf55 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7403983^1,2	C,A	--	89737965(+)	`cccctC/Tccccc`	1	--	ds500¹		0	--	--	--	--
rs58353331^1,2	C	--	89737965(+)	`CCCCC-/CTACCC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for C16orf55 (89724210 - 89737680 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C16orf55: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C16orf55 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C16orf55)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 124045	HGNC: 26463	AceView: FLJ31606	Ensembl:ENSG00000167523	euGenes: HUgn124045
ECgene: C16orf55	H-InvDB: C16orf55

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C16orf55	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C16orf55 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C16orf55 gene:
Search GeneIP for patents involving C16orf55

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	stable knockdown cell line services for C16orf55
	inducible knockdown cell line services for C16orf55
	design and validation of potent shRNA sequences against C16orf55
	adenovirus for potent knockdown of C16orf55
	adenovirus for overexpression of C16orf55
	stable overexpressing cell line services for C16orf55
	inducible overexpressing cell line services for C16orf55

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C16orf55 gene at Home site.

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C16orf55 Gene

chromosome 16 open reading frame 55

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C16orf55 Gene

chromosome 16 open reading frame 55

Aliasesfor C16orf55 gene

Summariesfor C16orf55 gene

Genomic Viewsfor C16orf55 gene

Proteinsfor C16orf55 gene

Protein Domains /Familiesfor C16orf55 gene

Functionfor C16orf55 gene

Pathways & Interactionsfor C16orf55 gene

Drugs & Compoundsfor C16orf55 gene

Transcriptsfor C16orf55 gene

Expression for C16orf55 gene

Orthologsfor C16orf55 gene

Paralogsfor C16orf55 gene

Genomic Variantsfor C16orf55 gene

Disorders / Diseasesfor C16orf55 gene

Publicationsfor C16orf55 gene

External Searches for C16orf55 gene

Genome Databases showing C16orf55 gene

Other Databases showing C16orf55 gene

Specialized Databases showing C16orf55 gene

Intellectual Propertyfor C16orf55 gene

Productsfor C16orf55 gene

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Aliases
for C16orf55 gene

Summaries
for C16orf55 gene

Genomic Views
for C16orf55 gene

Proteins
for C16orf55 gene

Protein Domains /
Families
for C16orf55 gene

Function
for C16orf55 gene

Pathways & Interactions
for C16orf55 gene

Drugs & Compounds
for C16orf55 gene

Transcripts
for C16orf55 gene

Expression
for C16orf55 gene

Orthologs
for C16orf55 gene

Paralogs
for C16orf55 gene

Genomic Variants
for C16orf55 gene

Disorders / Diseases
for C16orf55 gene

Publications
for C16orf55 gene

Intellectual Property
for C16orf55 gene

Products
for C16orf55 gene