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Aliases for C16orf54 Gene

Aliases for C16orf54 Gene

  • Chromosome 16 Open Reading Frame 54 2 3 5

External Ids for C16orf54 Gene

Previous GeneCards Identifiers for C16orf54 Gene

  • GC16M029662
  • GC16M029663
  • GC16M029753
  • GC16M027414

Summaries for C16orf54 Gene

GeneCards Summary for C16orf54 Gene

C16orf54 (Chromosome 16 Open Reading Frame 54) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf54 Gene

Genomics for C16orf54 Gene

Regulatory Elements for C16orf54 Gene

Enhancers for C16orf54 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G029700 1.5 FANTOM5 Ensembl ENCODE 15 +44.4 44405 3.6 SIN3A ARID4B ZBTB7B CBX5 ZNF143 DEK REST TBX21 ZNF592 MIER3 NPIPB13 C16orf54 MVP DOC2A ENSG00000198106 NPIPB11 ENSG00000260853 ENSG00000235560 RN7SKP127 CORO1A
GH16G029742 1.5 FANTOM5 ENCODE dbSUPER 8.9 +1.2 1197 5.4 HDGF YY1 ZNF121 CBX5 ELK1 ZNF207 JUNB REST TBX21 PPARG RN7SKP127 C16orf54 TBX6 YPEL3 MYLPF CORO1A PPP4C ENSG00000260719
GH16G029828 1.2 Ensembl ENCODE 10.9 -83.7 -83701 3.4 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 SP5 KAT8 MIER3 RCOR2 CDIPT-AS1 CDIPT C16orf92 FAM57B DOC2A TMEM219 HIRIP3 INO80E C16orf54 ZNF689
GH16G029876 1.1 Ensembl ENCODE 10.7 -130.8 -130780 1.9 HDGF PKNOX1 KLF1 CBX3 SAP30 ZNF140 ZMYM3 ZNF384 FOXK2 POLR2A MVP SEZ6L2 ASPHD1 TMEM219 TAOK2 DOC2A HIRIP3 INO80E C16orf92 FAM57B
GH16G029699 0.9 ENCODE 12.2 +47.1 47095 0.2 ARID4B GATA2 FOS MXD4 REST ZNF592 NBN KDM1A SP7 CTCF C16orf54 MVP RN7SKP127 GC16P029695 GC16M029709
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C16orf54 on UCSC Golden Path with GeneCards custom track

Promoters for C16orf54 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085101 629 1001 HDGF MXI1 BACH1 MAX BMI1 EBF1 ZBTB40 ARID3A EGR1 POLR2A

Genomic Location for C16orf54 Gene

Chromosome:
16
Start:
29,742,463 bp from pter
End:
29,746,329 bp from pter
Size:
3,867 bases
Orientation:
Minus strand

Genomic View for C16orf54 Gene

Genes around C16orf54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf54 Gene

Proteins for C16orf54 Gene

  • Protein details for C16orf54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWD8-CP054_HUMAN
    Recommended name:
    Transmembrane protein C16orf54
    Protein Accession:
    Q6UWD8
    Secondary Accessions:
    • A6NJR6
    • Q8NAB0

    Protein attributes for C16orf54 Gene

    Size:
    224 amino acids
    Molecular mass:
    24360 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C16orf54 Gene

Post-translational modifications for C16orf54 Gene

Other Protein References for C16orf54 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C16orf54 Gene

Domains & Families for C16orf54 Gene

Protein Domains for C16orf54 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C16orf54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C16orf54: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C16orf54 Gene

Function for C16orf54 Gene

Phenotypes for C16orf54 Gene

GenomeRNAi human phenotypes for C16orf54:
genes like me logo Genes that share phenotypes with C16orf54: view

Animal Model Products

CRISPR Products

miRNA for C16orf54 Gene

miRTarBase miRNAs that target C16orf54

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf54 Gene

Localization for C16orf54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C16orf54 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf54 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C16orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C16orf54: view

Pathways & Interactions for C16orf54 Gene

SuperPathways for C16orf54 Gene

No Data Available

Interacting Proteins for C16orf54 Gene

Gene Ontology (GO) - Biological Process for C16orf54 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C16orf54 Gene

Transcripts for C16orf54 Gene

mRNA/cDNA for C16orf54 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C16orf54 Gene

Chromosome 16 open reading frame 54:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf54 Gene

No ASD Table

Relevant External Links for C16orf54 Gene

GeneLoc Exon Structure for
C16orf54
ECgene alternative splicing isoforms for
C16orf54

Expression for C16orf54 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf54 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C16orf54 Gene

This gene is overexpressed in Whole Blood (x38.9).

Protein differential expression in normal tissues from HIPED for C16orf54 Gene

This gene is overexpressed in CD8 Tcells (17.3), Plasma (11.5), Peripheral blood mononuclear cells (10.9), Monocytes (8.5), NK cells (7.6), and Platelet (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C16orf54 Gene



Protein tissue co-expression partners for C16orf54 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C16orf54 Gene:

C16orf54

SOURCE GeneReport for Unigene cluster for C16orf54 Gene:

Hs.331095

Evidence on tissue expression from TISSUES for C16orf54 Gene

  • Spleen(4.2)
genes like me logo Genes that share expression patterns with C16orf54: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf54 Gene

Orthologs for C16orf54 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C16orf54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C16H16orf54 34
  • 99.26 (n)
C16orf54 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C25H16orf54 34
  • 82.26 (n)
C16orf54 35
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C6H16orf54 34
  • 81.55 (n)
C16orf54 35
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI467606 34 16 35
  • 76.53 (n)
rat
(Rattus norvegicus)
Mammalia LOC308990 34
  • 76.38 (n)
oppossum
(Monodelphis domestica)
Mammalia C16orf54 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
Species where no ortholog for C16orf54 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C16orf54 Gene

ENSEMBL:
Gene Tree for C16orf54 (if available)
TreeFam:
Gene Tree for C16orf54 (if available)

Paralogs for C16orf54 Gene

No data available for Paralogs for C16orf54 Gene

Variants for C16orf54 Gene

Sequence variations from dbSNP and Humsavar for C16orf54 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000595169 -- 29,743,035(+) TGAGC(C/T)CAGGA utr-variant-3-prime
rs1000639186 -- 29,746,141(+) ACTGC(A/G)GTGAG upstream-variant-2KB
rs1000755061 -- 29,746,404(+) AAAAT(A/T)AGCTG upstream-variant-2KB
rs1000985062 -- 29,747,297(+) ATAGA(C/T)AGAAA upstream-variant-2KB
rs1001253009 -- 29,745,771(+) GCCTC(C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf54 Gene

Variant ID Type Subtype PubMed ID
dgv34n68 CNV loss 17160897
nsv1063706 CNV gain 25217958
nsv833186 CNV loss 17160897

Variation tolerance for C16orf54 Gene

Gene Damage Index Score: 2.08; 38.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C16orf54 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C16orf54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf54 Gene

Disorders for C16orf54 Gene

Relevant External Links for C16orf54

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C16orf54

No disorders were found for C16orf54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf54 Gene

Publications for C16orf54 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. (PMID: 22171320) Halim A. … Larson G. (Mol. Cell. Proteomics 2011) 4 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for C16orf54 Gene

Sources for C16orf54 Gene

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