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Aliases for C16orf46 Gene

Aliases for C16orf46 Gene

  • Chromosome 16 Open Reading Frame 46 2 3 5

External Ids for C16orf46 Gene

Previous GeneCards Identifiers for C16orf46 Gene

  • GC16M079653
  • GC16M081087
  • GC16M066843

Summaries for C16orf46 Gene

GeneCards Summary for C16orf46 Gene

C16orf46 (Chromosome 16 Open Reading Frame 46) is a Protein Coding gene.

Additional gene information for C16orf46 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf46 Gene

Genomics for C16orf46 Gene

Regulatory Elements for C16orf46 Gene

Enhancers for C16orf46 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H081841 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -764.8 -764833 1.9 HDGF ZFP64 BATF ATF7 ETV6 RUNX3 IKZF2 EGR2 CBFB ZC3H11A PLCG2 ENSG00000261141 ENSG00000260213 C16orf46 ENSG00000260495 CMIP GC16M081818 GC16P081959
GH16H081136 0.6 ENCODE 6.7 -59.8 -59808 2 ZNF687 FOXA2 RFX1 NRF1 HLF MAX HNF4A MYC FOXA1 C16orf46 GCSH RNU6-1191P PKD1L2
GH16H081138 0.5 ENCODE 5.3 -62.1 -62083 1.4 CTCF ESRRA ZBTB33 C16orf46 GCSH RNU6-1191P PKD1L2
GH16H080736 0.6 FANTOM5 4 +341.2 341205 0.1 GATAD2A TFAP4 NFIA HNF4A YY1 DYNLRB2 CDYL2 C16orf46 ENSG00000260594 ENSG00000260064
GH16H080752 0.6 FANTOM5 3.9 +324.5 324486 0.2 ZNF629 CREB1 FEZF1 CREM ZXDB ZNF112 DYNLRB2 ENSG00000261141 C16orf46 ENSG00000260594 CDYL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C16orf46 on UCSC Golden Path with GeneCards custom track

Promoters for C16orf46 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000088406 167 1401 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF143

Genomic Locations for C16orf46 Gene

Genomic Locations for C16orf46 Gene
chr16:81,053,497-81,077,267
(GRCh38/hg38)
Size:
23,771 bases
Orientation:
Minus strand
chr16:81,087,102-81,110,872
(GRCh37/hg19)

Genomic View for C16orf46 Gene

Genes around C16orf46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf46 Gene

Proteins for C16orf46 Gene

  • Protein details for C16orf46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P387-CP046_HUMAN
    Recommended name:
    Uncharacterized protein C16orf46
    Protein Accession:
    Q6P387
    Secondary Accessions:
    • Q96MA7

    Protein attributes for C16orf46 Gene

    Size:
    395 amino acids
    Molecular mass:
    43418 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C16orf46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C16orf46 Gene

Post-translational modifications for C16orf46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C16orf46 Gene

Domains & Families for C16orf46 Gene

Gene Families for C16orf46 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C16orf46 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C16orf46: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C16orf46 Gene

Function for C16orf46 Gene

Phenotypes From GWAS Catalog for C16orf46 Gene

genes like me logo Genes that share phenotypes with C16orf46: view

miRNA for C16orf46 Gene

miRTarBase miRNAs that target C16orf46

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf46 Gene

Localization for C16orf46 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf46 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C16orf46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with C16orf46: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C16orf46 Gene

Pathways & Interactions for C16orf46 Gene

SuperPathways for C16orf46 Gene

No Data Available

Interacting Proteins for C16orf46 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000299578%0d%0a9606.ENSP00000367049%0d%0a
Selected Interacting proteins: ENSP00000299578 for C16orf46 Gene via STRING

Symbol External ID(s) Details
MZT1

Gene Ontology (GO) - Biological Process for C16orf46 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C16orf46 Gene

Drugs & Compounds for C16orf46 Gene

No Compound Related Data Available

Transcripts for C16orf46 Gene

Unigene Clusters for C16orf46 Gene

Chromosome 16 open reading frame 46:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf46 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2:
SP3: - - - -

Relevant External Links for C16orf46 Gene

GeneLoc Exon Structure for
C16orf46
ECgene alternative splicing isoforms for
C16orf46

Expression for C16orf46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf46 Gene

Protein differential expression in normal tissues from HIPED for C16orf46 Gene

This gene is overexpressed in Monocytes (55.3) and Lung (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C16orf46 Gene



Protein tissue co-expression partners for C16orf46 Gene

NURSA nuclear receptor signaling pathways regulating expression of C16orf46 Gene:

C16orf46

SOURCE GeneReport for Unigene cluster for C16orf46 Gene:

Hs.658684
genes like me logo Genes that share expression patterns with C16orf46: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf46 Gene

Orthologs for C16orf46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C16orf46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C16H16orf46 33
  • 98.82 (n)
C16orf46 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H16orf46 33
  • 82.05 (n)
C16orf46 34
  • 71 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C18H16orf46 33
  • 79.09 (n)
C16orf46 34
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700030J22Rik 33 16 34
  • 69.29 (n)
rat
(Rattus norvegicus)
Mammalia LOC687399 33
  • 68.45 (n)
oppossum
(Monodelphis domestica)
Mammalia C16orf46 34
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C16orf46 34
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487055 33
  • 43.34 (n)
Species where no ortholog for C16orf46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C16orf46 Gene

ENSEMBL:
Gene Tree for C16orf46 (if available)
TreeFam:
Gene Tree for C16orf46 (if available)

Paralogs for C16orf46 Gene

No data available for Paralogs for C16orf46 Gene

Variants for C16orf46 Gene

Sequence variations from dbSNP and Humsavar for C16orf46 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000002000 -- 81,055,090(+) CTGAA(A/G)TTTAG intron-variant
rs1000038060 -- 81,055,419(+) TTGGG(C/T)ATGGG intron-variant
rs1000116315 -- 81,079,080(+) CCAGC(C/T)CAGCC upstream-variant-2KB
rs1000192021 -- 81,071,830(+) GCAGG(A/T)AGGTG intron-variant, nc-transcript-variant
rs1000215805 -- 81,076,772(+) CTCCC(C/T)TTATG intron-variant, downstream-variant-500B, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C16orf46 Gene

Variant ID Type Subtype PubMed ID
nsv573346 CNV loss 21841781
nsv573338 CNV loss 21841781
nsv1897 CNV deletion 18451855
nsv1062724 CNV gain 25217958
esv3639308 CNV loss 21293372
esv3639307 CNV loss 21293372
esv2751615 CNV gain 17911159
esv2422360 CNV duplication 17116639
dgv356n27 CNV loss 19166990

Variation tolerance for C16orf46 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C16orf46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C16orf46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf46 Gene

Disorders for C16orf46 Gene

Relevant External Links for C16orf46

Genetic Association Database (GAD)
C16orf46
Human Genome Epidemiology (HuGE) Navigator
C16orf46
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C16orf46

No disorders were found for C16orf46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf46 Gene

Publications for C16orf46 Gene

  1. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60
  5. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PMID: 20235792) Uhl GR … Munafò MR (Pharmacogenomics 2010) 45 60

Products for C16orf46 Gene

Sources for C16orf46 Gene

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