C16orf46 Gene
protein-coding GIFtS: 40
GCID: GC16M081087
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chromosome 16 open reading frame 46
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Aliases
for C16orf46 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 16 Open Reading Frame 461 2 | | FLJ327021 | | Uncharacterized Protein C16orf462 |
Export aliases for C16orf46 gene to outside databasesPrevious GC identifers: GC16M079653 GC16M066843 |
Summaries
for C16orf46 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C16orf46 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C16orf46 gene promoter:
ATF-2 FOXD1 CBF-C CBF-A FOXO4 FOXJ2 (long isoform) FOXJ2 NF-kappaB1 MRF-2 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for C16orf46
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C16orf46 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q23.2 Ensembl cytogenetic band: 16q23.2 HGNC cytogenetic band: 16q23.2C16orf46 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M081087: view genomic region
(about GC identifiers)
Start:
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81,087,102 bp from pter |
End:
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81,110,872 bp from pter |
Size:
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23,771 bases |
Orientation:
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minus strand |
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Proteins
for C16orf46 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CP046_HUMAN, Q6P387 (See
protein sequence)Recommended Name: Uncharacterized protein C16orf46 Size: 395 amino acids; 43418 Da
Secondary accessions: Q96MA7Alternative splicing: 2 isoforms: Q6P387-1 Q6P387-2 Explore the universe of human proteins at neXtProt for C16orf46: NX_Q6P387
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P387
C16orf46 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001094343.1 NP_689550.2
ENSEMBL proteins: ENSP00000367874 ENSP00000299578 ENSP00000455877
Human Recombinant Protein Products for C16orf46:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
C16orf46 for ontologies About GeneDecksing
C16orf46 Antibody Products:
Assay Products for C16orf46: |
Protein
Domains /
Families
for C16orf46 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6P387 |
Function
for C16orf46 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf46 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf46 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): C16orf46 (NM_001100873) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C16orf46 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf46 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf46 |
|
Pathways & Interactions
for C16orf46 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C16orf46
|
Drugs & Compounds
for C16orf46 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C16orf46
Search CenterWatch for drugs/clinical trials and news about C16orf46 / CP046
|
Transcripts
for C16orf46 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C16orf46 gene (2 alternative transcripts): NM_001100873.1 NM_152337.2 Unigene Cluster for C16orf46: Chromosome 16 open reading frame 46 Hs.658684 [show with all ESTs]Unigene Representative Sequence: AK1284674 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378611(uc010chf.3) ENST00000299578(uc002fgc.4 uc010vno.2)
ENST00000444657 ENST00000565253
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf46 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf46 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C16orf46 (NM_001100873) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C16orf46 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf46 |
Additional cDNA sequence: AK057264.1 AK128467.1 AK295411.1 BC064143.1 7 DOTS entries: DT.99944493 DT.40229554 DT.100775253 DT.99990752 DT.92009263 DT.40268560 DT.95272855 24/237 AceView cDNA sequences (see all 237): BI094355 N63246 AI952820 AA304964 BM756167 BF448093 AI650884 AI432670 BG528603 CA777840 BC000790 CR603107 CR603013 AW194585 BI093591 N72768 AA905107 NM_004483 BX111930 CR606547 BI091245 CR601763 BG576993 AA307978
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for C16orf46 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 |
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| SP1: | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | | |
ECgene alternative splicing isoforms for C16orf46
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Expression
for C16orf46 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C16orf46 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTCCCAAA
About this image
See C16orf46 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C16orf46
SOURCE GeneReport for Unigene cluster: Hs.658684
SABiosciences Custom PCR Arrays for C16orf46
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C16orf46
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C16orf46 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C16orf46 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C16orf46 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf46 |
Orthologs
for C16orf46 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for C16orf46 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for C16orf46 (if available)
TreeFam Gene Tree for C16orf46 (if available) |
Paralogs
for C16orf46 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C16orf46 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C16orf46 (81087102 - 81110872 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for C16orf46
3 CNVs: 8830 53839 5331 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C16orf46 |
|
Disorders
/ Diseases
for C16orf46 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C16orf46 for disorders About GeneDecksing
2  diseases for C16orf46: About MalaCardsconduct disorder adhd
Human Genome Epidemiology (HuGE) Navigator: C16orf46 (1 document)
Export disorders for C16orf46 gene to outside databases
|
Publications
for C16orf46 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C16orf46 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C16orf46) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)1 Anney R.J....Gill M. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for C16orf46 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing C16orf46 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C16orf46 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C16orf46 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C16orf46 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C16orf46 gene:
Search GeneIP for patents involving C16orf46
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C16orf46 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C16orf46 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C16orf46 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C16orf46 | | | OriGene Protein Over-expression Lysate for C16orf46 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C16orf46 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf46 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C16orf46 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C16orf46 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C16orf46 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C16orf46 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C16orf46 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C16orf46 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C16orf46 |
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 | | | C16orf46 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C16orf46 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for C16orf46 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf46 |
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