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Aliases for C16orf45 Gene

Aliases for C16orf45 Gene

  • Chromosome 16 Open Reading Frame 45 2 3 5
  • Uncharacterized Protein C16orf45 3
  • Migration Inhibitory Protein 3
  • MINP 3

External Ids for C16orf45 Gene

Previous GeneCards Identifiers for C16orf45 Gene

  • GC16P015436
  • GC16P014921

Summaries for C16orf45 Gene

GeneCards Summary for C16orf45 Gene

C16orf45 (Chromosome 16 Open Reading Frame 45) is a Protein Coding gene. Diseases associated with C16orf45 include Corneal Dystrophy, Lisch Epithelial.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf45 Gene

Genomics for C16orf45 Gene

Regulatory Elements for C16orf45 Gene

Enhancers for C16orf45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G015519 1.7 FANTOM5 Ensembl ENCODE 35.8 +87.6 87641 4.5 HDGF PKNOX1 FOXA2 ARNT SIN3A ARID4B SLC30A9 ZNF766 KLF13 SP5 C16orf45 MARF1 NDE1 NPIPA2 LOC105371102 PIR54531
GH16G015517 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.8 +84.3 84338 1.9 YBX3 HDGF ZSCAN4 FEZF1 GLI4 ZNF2 RAD21 TCF12 EGR1 PCBP1 C16orf45 BFAR LOC100505915 PKD1P6 RRN3 ENSG00000183458 PKD1P1 ENSG00000183889 NPIPA1 LOC105371102
GH16G015487 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +56.9 56879 7.6 PKNOX1 FOXA2 ARID4B YBX1 YY1 ZNF766 FOS SP5 ZNF592 SREBF1 C16orf45 ENSG00000183889 ENSG00000183458 PKD1P1 NPIPA3 ENSG00000261819 LOC100505915 NPIPA5 ENSG00000227827 NPIPA2
GH16G015506 1.3 Ensembl ENCODE dbSUPER 19.1 +73.3 73278 2.0 BCOR ZMYM3 ZIC2 ZNF316 ADNP FOS NFE2 MAFK MIER1 MNT C16orf45 ENSG00000207425 LOC105371102
GH16G015481 1.6 Ensembl ENCODE dbSUPER 12.8 +48.3 48263 1.7 FOXA2 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 C16orf45 PLA2G10 LOC105371102
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C16orf45 on UCSC Golden Path with GeneCards custom track

Promoters for C16orf45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000083796 605 1401 PKNOX1 ZNF76 RAD21 GLIS2 EGR2 ZNF263 ZNF398 ZNF341 GLIS1 CEBPA

Genomic Location for C16orf45 Gene

Chromosome:
16
Start:
15,434,295 bp from pter
End:
15,625,028 bp from pter
Size:
190,734 bases
Orientation:
Plus strand

Genomic View for C16orf45 Gene

Genes around C16orf45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf45 Gene

Proteins for C16orf45 Gene

  • Protein details for C16orf45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MC5-CP045_HUMAN
    Recommended name:
    Uncharacterized protein C16orf45
    Protein Accession:
    Q96MC5
    Secondary Accessions:
    • O00223
    • O75769
    • Q8IZ36
    • Q96H25

    Protein attributes for C16orf45 Gene

    Size:
    204 amino acids
    Molecular mass:
    23732 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC31663.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C16orf45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C16orf45 Gene

Post-translational modifications for C16orf45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C16orf45 Gene

Domains & Families for C16orf45 Gene

Protein Domains for C16orf45 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C16orf45: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C16orf45 Gene

Function for C16orf45 Gene

Gene Ontology (GO) - Molecular Function for C16orf45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C16orf45: view

Phenotypes for C16orf45 Gene

GenomeRNAi human phenotypes for C16orf45:
genes like me logo Genes that share phenotypes with C16orf45: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf45 Gene

Localization for C16orf45 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf45 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
plasma membrane 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for C16orf45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015630 microtubule cytoskeleton IEA --
genes like me logo Genes that share ontologies with C16orf45: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C16orf45 Gene

Pathways & Interactions for C16orf45 Gene

SuperPathways for C16orf45 Gene

No Data Available

Interacting Proteins for C16orf45 Gene

Gene Ontology (GO) - Biological Process for C16orf45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007026 negative regulation of microtubule depolymerization IEA --
GO:0021822 negative regulation of cell motility involved in cerebral cortex radial glia guided migration IEA --
genes like me logo Genes that share ontologies with C16orf45: view

No data available for Pathways by source and SIGNOR curated interactions for C16orf45 Gene

Transcripts for C16orf45 Gene

Unigene Clusters for C16orf45 Gene

Chromosome 16 open reading frame 45:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf45 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: - - - -
SP4:
SP5:

Relevant External Links for C16orf45 Gene

GeneLoc Exon Structure for
C16orf45
ECgene alternative splicing isoforms for
C16orf45

Expression for C16orf45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf45 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C16orf45 Gene

This gene is overexpressed in Brain (36.2), Heart (12.1), Frontal cortex (8.7), and Fetal Brain (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C16orf45 Gene



Protein tissue co-expression partners for C16orf45 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C16orf45 Gene:

C16orf45

SOURCE GeneReport for Unigene cluster for C16orf45 Gene:

Hs.401798

Evidence on tissue expression from TISSUES for C16orf45 Gene

  • Nervous system(4.8)
  • Muscle(4.6)
  • Stomach(4.2)
  • Lung(3)
  • Heart(2.8)
  • Kidney(2.6)
  • Gall bladder(2.5)
  • Liver(2.5)
  • Blood(2.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with C16orf45: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf45 Gene

Orthologs for C16orf45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C16orf45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C16ORF45 35
  • 100 (a)
OneToOne
C16H16orf45 34
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia C16orf45 35
  • 97 (a)
OneToOne
C6H16orf45 34
  • 92.48 (n)
oppossum
(Monodelphis domestica)
Mammalia C16orf45 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C25H16orf45 34
  • 93.65 (n)
MGC140681 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2900011O08Rik 34 16 35
  • 91.46 (n)
rat
(Rattus norvegicus)
Mammalia RGD1305733 34
  • 91.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C16orf45 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves C16ORF45 34 35
  • 77.12 (n)
lizard
(Anolis carolinensis)
Reptilia C16orf45 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c16orf45 34
  • 73.1 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:114175 34
  • 65.58 (n)
C6H16orf45 35
  • 60 (a)
OneToOne
Species where no ortholog for C16orf45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C16orf45 Gene

ENSEMBL:
Gene Tree for C16orf45 (if available)
TreeFam:
Gene Tree for C16orf45 (if available)

Paralogs for C16orf45 Gene

No data available for Paralogs for C16orf45 Gene

Variants for C16orf45 Gene

Sequence variations from dbSNP and Humsavar for C16orf45 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000024287 -- 15,587,867(+) TGTGT(A/G)TGTGT intron-variant, utr-variant-3-prime
rs1000027925 -- 15,528,908(+) TGTGA(A/G)GACAC intron-variant
rs1000029509 -- 15,493,410(+) AAAAG(A/G)ACATT intron-variant
rs1000036730 -- 15,504,750(+) ATCCA(C/G)CCACA intron-variant, nc-transcript-variant
rs1000036995 -- 15,535,462(+) CCAAC(A/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf45 Gene

Variant ID Type Subtype PubMed ID
dgv4924n54 CNV gain 21841781
esv2671884 CNV deletion 23128226
esv2678976 CNV deletion 23128226
esv2714015 CNV deletion 23290073
esv2714016 CNV deletion 23290073
esv3638032 CNV gain 21293372
esv3638033 CNV gain 21293372
esv3638034 CNV gain 21293372
esv3638035 CNV loss 21293372
esv3638036 CNV gain 21293372
esv3638037 CNV loss 21293372
nsv1035393 CNV gain 25217958
nsv1040547 CNV gain 25217958
nsv1045440 CNV gain 25217958
nsv1047898 CNV loss 25217958
nsv1049647 CNV gain+loss 25217958
nsv1125134 CNV deletion 24896259
nsv435664 CNV deletion 17901297
nsv457428 CNV gain 19166990
nsv510677 CNV deletion 20534489
nsv827568 CNV loss 20364138
nsv833147 CNV loss 17160897
nsv974766 CNV duplication 23825009
nsv977122 CNV duplication 23825009

Variation tolerance for C16orf45 Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C16orf45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C16orf45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf45 Gene

Disorders for C16orf45 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C16orf45 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
corneal dystrophy, lisch epithelial
  • lisch epithelial corneal dystrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C16orf45

Genetic Association Database (GAD)
C16orf45
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C16orf45
genes like me logo Genes that share disorders with C16orf45: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C16orf45 Gene

Publications for C16orf45 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 3 4 64
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64
  5. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. (PMID: 24823311) Guan W. … Steffen L.M. (Circ Cardiovasc Genet 2014) 3 64

Products for C16orf45 Gene

Sources for C16orf45 Gene

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