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C16orf11 Gene

protein-coding   GIFtS: 35
GCID: GC16P000610

Chromosome 16 Open Reading Frame 11

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 16 Open Reading Frame 111 2
Uncharacterized Protein RJD12 3
Uncharacterized Protein C16orf112

External Ids:    HGNC: 141391   Entrez Gene: 1463252   Ensembl: ENSG000001619927   UniProtKB: P0CG203   

Export aliases for C16orf11 gene to outside databases

Previous GC identifers: GC16U990161 GC16P000552


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C16orf11 Gene:
C16orf11 (chromosome 16 open reading frame 11) is a protein-coding gene. An important paralog of this gene is ZNF750.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C16orf11 gene promoter:
         ER-alpha   E2F-4   E2F-3a   E2F-5   E2F-2   AREB6   IRF-2   E2F   E2F-1   c-Myb   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C16orf11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C16orf11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

C16orf11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C16orf11 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000610:  view genomic region     (about GC identifiers)

Start:
610,422 bp from pter      End:
615,529 bp from pter
Size:
5,108 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CP011_HUMAN, P0CG20 (See protein sequence)
Recommended Name: Uncharacterized protein C16orf11  
Size: 571 amino acids; 59354 Da
Sequence caution: Sequence=AAK61234.1; Type=Erroneous gene model prediction;
Secondary accessions: B8ZZ27 Q8N233 Q96AX3 Q96S23

Explore the universe of human proteins at neXtProt for C16orf11: NX_P0CG20

Explore proteomics data for C16orf11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C16orf11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660313.1  
    ENSEMBL proteins: 
     ENSP00000386499  

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    antibodies-online proteins for C16orf11 (2 products) 

     
    antibodies-online peptides for C16orf11

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: P0CG20


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for C16orf11:
     Decreased nuclei size in G2M  Metaphase cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for C16orf11

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C16orf11
    Interactions:

        Search GeneGlobe Interaction Network for C16orf11

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C16orf11 (CP011)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C16orf11 gene: 
    NM_145270.2  

    Unigene Cluster for C16orf11:

    Chromosome 16 open reading frame 11
    Hs.632220  [show with all ESTs]
    Unigene Representative Sequence: BC016613
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000409413(uc002chk.3)
    miRNA
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    Additional mRNA sequence: BC016613.1 

    1 DOTS entry:

    DT.401668 

    7 AceView cDNA sequences:

    NM_145270 BC016613 H20980 BX281088 H50241 BE784253 AA757196 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C16orf11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGCCCTG
    C16orf11 Expression
    About this image

    C16orf11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C16orf11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632220
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C16orf11 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves C16orf116
    chromosome 16 open reading frame 11
    34(a)
    1 ↔ 1
    14(13482104-13485124)
    lizard
    (Anolis carolinensis)
    Reptilia C16orf116
    chromosome 16 open reading frame 11
    38(a)
    1 ↔ 1
    GL344114.1(22955-27362)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136812 Xenopus laevis transcribed sequence with weak similarity more 75.89(n)    BJ033142.1 
    zebrafish
    (Danio rerio)
    Actinopterygii C24H16orf116
    chromosome 16 open reading frame 11
    25(a)
    1 ↔ 1
    24(39499383-39515607) ENSDARG00000087663
            Species with no ortholog for C16orf11

    ENSEMBL Gene Tree for C16orf11 (if available)
    TreeFam Gene Tree for C16orf11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C16orf11 gene
    ZNF7502  

    Find genes that share paralogs with C16orf11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C16orf11 (see all 11)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839621761,2
    --610614(+) CGCCCC/TACACG 1 -- ut510--------
    rs1880246461,2
    C--610657(+) CCGGGA/CGCAGG 1 -- ut510--------
    rs112489381,2
    H--611117(+) TGCCCC/GGGGAG 1 -- int10--------
    rs562356301,2
    C--612506(+) GAGGC-/ACAACATG 1 -- cds10--------
    rs105819991,2
    C--612598(+) acaca-/CACA  
            
    ggcac
    1 -- int10--------
    rs105820001,2
    C--612609(+) cacac-/ACGCAGC 1 -- int10--------
    rs1114683651,2
    ----610479(+) CGGACC/GCGGGA 1 -- ut510--------
    rs80633391,2
    ----610770(+) gggcgC/Gccggg 1 -- int10--------
    rs3746819461,2
    ----610643(+) GGCTC-/CGCTCC
    CGGCCGGG
    CGCAG
    1 -- ut510--------
    rs3738847791,2
    ----610935(+) GTTCC-/GGGGGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for C16orf11 (610422 - 615529 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for C16orf11 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv2475n71CNV Loss21882294
    nsv904707CNV Loss21882294
    dgv2481n71CNV Loss21882294
    dgv2480n71CNV Loss21882294
    nsv904750CNV Loss21882294
    dgv2479n71CNV Loss21882294
    dgv2483n71CNV Loss21882294
    dgv2486n71CNV Loss21882294
    dgv2476n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C16orf11 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C16orf11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 146325 HGNC: 14139 AceView: LOC146325 Ensembl:ENSG00000161992 euGenes: HUgn146325
    ECgene: C16orf11 H-InvDB: C16orf11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C16orf11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C16orf11 gene:
    Search GeneIP for patents involving C16orf11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C16orf11
     Browse compounds at ApexBio
     Search Addgene for plasmids for C16orf11
      Search eBioscience for proteins for C16orf11
      Search eBioscience for elisas for C16orf11
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for C16orf11
     antibodies-online antibodies for C16orf11
     antibodies-online kits for C16orf11 (2 products)
     antibodies-online peptides for C16orf11
     antibodies-online proteins for C16orf11 (2 products)
           
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