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Aliases for C15orf62 Gene

Aliases for C15orf62 Gene

  • Chromosome 15 Open Reading Frame 62 2 3 5

External Ids for C15orf62 Gene

Previous GeneCards Identifiers for C15orf62 Gene

  • GC15P038853
  • GC15P041062
  • GC15P017910

Summaries for C15orf62 Gene

GeneCards Summary for C15orf62 Gene

C15orf62 (Chromosome 15 Open Reading Frame 62) is a Protein Coding gene. GO annotations related to this gene include GTP-Rho binding.

Additional gene information for C15orf62 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf62 Gene

Genomics for C15orf62 Gene

Regulatory Elements for C15orf62 Gene

Enhancers for C15orf62 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H040791 1.5 Ensembl ENCODE dbSUPER 11.8 +24.5 24477 5 FOXA2 ARID4B FEZF1 BRCA1 YY1 FOS REST MIER2 PPARG KAT8 ZFYVE19 RMDN3 CCDC32 C15orf62 SPINT1 GCHFR RAD51 RAD51-AS1 RHOV RPUSD2
GH15H040742 1.3 Ensembl ENCODE 12.1 -24.0 -24038 7 PKNOX1 FOXA2 ATF1 ARID4B SIN3A TCF12 ZNF121 ZNF766 ELK1 ZNF143 CCDC32 RAD51 C15orf62 DNAJC17 ZFYVE19 RAD51-AS1 SPINT1 RHOV VPS18 ENSG00000251161
GH15H040589 1.2 Ensembl ENCODE 9.5 -179.3 -179286 2 HDGF PKNOX1 ATF1 FOXA2 YBX1 ZNF2 YY1 ZNF121 GTF3C2 ZNF143 CCDC32 INO80 RAD51 ENSG00000259211 DNAJC17 BAHD1 RPAP1 RAD51-AS1 BMF RMDN3
GH15H040789 0.5 dbSUPER 11.8 +20.3 20268 0 OSR2 CEBPB ZBTB33 C15orf62 GCHFR RMDN3 SPINT1 RAD51-AS1 RAD51 RHOV RPUSD2 PIR34167 GC15P040798
GH15H040633 0.5 ENCODE 10.7 -136.4 -136432 0 ZNF362 FOXA2 RFX1 SP7 FOXA1 CCDC32 RAD51 RAD51-AS1 C15orf62 ZFYVE19 DNAJC17 ENSG00000259254 RN7SL376P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C15orf62 on UCSC Golden Path with GeneCards custom track

Genomic Location for C15orf62 Gene

Chromosome:
15
Start:
40,769,961 bp from pter
End:
40,772,449 bp from pter
Size:
2,489 bases
Orientation:
Plus strand

Genomic View for C15orf62 Gene

Genes around C15orf62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf62 Gene

Proteins for C15orf62 Gene

  • Protein details for C15orf62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8K5M9-CO062_HUMAN
    Recommended name:
    Uncharacterized protein C15orf62, mitochondrial
    Protein Accession:
    A8K5M9
    Secondary Accessions:
    • A6NK01

    Protein attributes for C15orf62 Gene

    Size:
    175 amino acids
    Molecular mass:
    19679 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C15orf62 Gene

Post-translational modifications for C15orf62 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C15orf62 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C15orf62 Gene

Domains & Families for C15orf62 Gene

Gene Families for C15orf62 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C15orf62 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C15orf62: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C15orf62 Gene

Function for C15orf62 Gene

Gene Ontology (GO) - Molecular Function for C15orf62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0017049 GTP-Rho binding IBA --
genes like me logo Genes that share ontologies with C15orf62: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C15orf62
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf62 Gene

Localization for C15orf62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C15orf62 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C15orf62 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for C15orf62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with C15orf62: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C15orf62 Gene

Pathways & Interactions for C15orf62 Gene

SuperPathways for C15orf62 Gene

No Data Available

Interacting Proteins for C15orf62 Gene

Gene Ontology (GO) - Biological Process for C15orf62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007266 Rho protein signal transduction IBA --
GO:0008360 regulation of cell shape IBA --
GO:0030838 positive regulation of actin filament polymerization IBA --
GO:0031274 positive regulation of pseudopodium assembly IBA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with C15orf62: view

No data available for Pathways by source and SIGNOR curated interactions for C15orf62 Gene

Drugs & Compounds for C15orf62 Gene

No Compound Related Data Available

Transcripts for C15orf62 Gene

mRNA/cDNA for C15orf62 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C15orf62 Gene

Chromosome 15 open reading frame 62:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C15orf62
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf62 Gene

No ASD Table

Relevant External Links for C15orf62 Gene

GeneLoc Exon Structure for
C15orf62
ECgene alternative splicing isoforms for
C15orf62

Expression for C15orf62 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C15orf62 Gene

mRNA expression in normal human tissues for C15orf62 Gene

Protein differential expression in normal tissues from HIPED for C15orf62 Gene

This gene is overexpressed in Plasma (47.4) and Heart (21.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C15orf62 Gene



Protein tissue co-expression partners for C15orf62 Gene

NURSA nuclear receptor signaling pathways regulating expression of C15orf62 Gene:

C15orf62

SOURCE GeneReport for Unigene cluster for C15orf62 Gene:

Hs.631715
genes like me logo Genes that share expression patterns with C15orf62: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C15orf62 Gene

Orthologs for C15orf62 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf62 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf62 33
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia C15orf62 34
  • 89 (a)
OneToOne
C30H15orf62 33
  • 88.95 (n)
cow
(Bos Taurus)
Mammalia C10H15orf62 33
  • 86.27 (n)
C15orf62 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm14137 33 16 34
  • 85.33 (n)
rat
(Rattus norvegicus)
Mammalia LOC691418 33
  • 84.95 (n)
oppossum
(Monodelphis domestica)
Mammalia C15orf62 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5H15ORF62 33
  • 54.17 (n)
C15orf62 34
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C15orf62 34
  • 33 (a)
OneToOne
Species where no ortholog for C15orf62 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C15orf62 Gene

ENSEMBL:
Gene Tree for C15orf62 (if available)
TreeFam:
Gene Tree for C15orf62 (if available)

Paralogs for C15orf62 Gene

No data available for Paralogs for C15orf62 Gene

Variants for C15orf62 Gene

Sequence variations from dbSNP and Humsavar for C15orf62 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000210800 -- 40,771,255(+) ATGTT(-/G)GGGGG intron-variant, utr-variant-3-prime
rs1000581857 -- 40,768,519(+) TGCCC(A/G)GTGCC intron-variant, upstream-variant-2KB
rs1000599079 -- 40,771,403(+) ATCAG(A/G)GAGTG intron-variant, utr-variant-3-prime
rs1001431868 -- 40,771,135(+) GGCAG(A/G)GCTTC intron-variant, utr-variant-3-prime
rs1001635542 -- 40,772,359(+) TTCTA(C/T)GACCT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C15orf62 Gene

Variant ID Type Subtype PubMed ID
nsv827306 CNV loss 20364138

Variation tolerance for C15orf62 Gene

Gene Damage Index Score: 2.09; 38.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C15orf62 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C15orf62

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf62 Gene

Disorders for C15orf62 Gene

Relevant External Links for C15orf62

Genetic Association Database (GAD)
C15orf62
Human Genome Epidemiology (HuGE) Navigator
C15orf62
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C15orf62

No disorders were found for C15orf62 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf62 Gene

Publications for C15orf62 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  2. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for C15orf62 Gene

Sources for C15orf62 Gene

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