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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C15orf61 Gene

protein-coding   GIFtS: 32
GCID: GC15P067813

chromosome 15 open reading frame 61

  Search for C15orf61
in our new
 Human Malady Compendium 
Biological research products
for C15orf61
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chromosome 15 Open Reading Frame 611 2
LOC1458531
Uncharacterized Protein C15orf612

External Ids:    HGNC: 344531   Entrez Gene: 1458532   Ensembl: ENSG000001892277   UniProtKB: A6NNL53   

Export aliases for C15orf61 gene to outside databases

Previous GC identifers: GC15P065600 GC15P044649


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C15orf61 gene promoter:
         AP-1   ATF-2   IRF-1   Nkx2-5   c-Jun   POU3F2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C15orf61

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C15orf61


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q23

C15orf61 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C15orf61 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P067813:  view genomic region     (about GC identifiers)

Start:
67,813,406 bp from pter      End:
67,819,641 bp from pter
Size:
6,236 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CO061_HUMAN, A6NNL5 (See protein sequence)
Recommended Name: Uncharacterized protein C15orf61 precursor  
Size: 157 amino acids; 18091 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B4DFB2

Explore the universe of human proteins at neXtProt for C15orf61: NX_A6NNL5

C15orf61 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_001137408.1  
ENSEMBL proteins: 
 ENSP00000342254   ENSP00000453824  

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Uscn Proteins for C15orf61

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--


C15orf61 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: A6NNL5


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C15orf61

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C15orf61
Search CenterWatch for drugs/clinical trials and news about C15orf61 / CO061 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C15orf61 gene: 
NM_001143936.1  

Unigene Cluster for C15orf61:

Chromosome 15 open reading frame 61
Hs.438385  [show with all ESTs]
Unigene Representative Sequence: NM_001143936
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000342683(uc002aqs.3) ENST00000560041 ENST00000557807 ENST00000560547


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Inhib. RNA
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Additional cDNA sequence: 

AK294012.1 AY726587.1 

7 DOTS entries:

DT.101967301  DT.411237  DT.75104944  DT.40302164  DT.91714869  DT.423927  DT.92449192 

24/39 AceView cDNA sequences (see all 39):

AA932128 AA420989 AI972890 BI962974 BQ025984 CK903599 BM844502 BM701491 
BX115629 AJ346153 AI083721 AI204127 AI674485 CF144848 BG771448 BF438062 
BU568037 AJ707161 AI475694 AA412015 AA609146 BG189618 AA970879 AI003932 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C15orf61 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTGAAAGT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See C15orf61 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C15orf61

SOURCE GeneReport for Unigene cluster: Hs.438385
    SABiosciences Custom PCR Arrays for C15orf61
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf61

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for C15orf61 gene from 3/13 species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 2300009A05Rik1 , 5 RIKEN cDNA 2300009A05 gene1, 5 92.57(n)1
92.36(a)1
  9 (34.06 cM)5
694781  NM_027090.11  NP_081366.11 
 633944475 
zebrafish
(Danio rerio)
Actinopterygii zgc:1628981 zgc:162898 63.42(n)
64.94(a)
  100003490  NM_001082953.1  NP_001076422.1 
fruit fly
(Drosophila melanogaster)
Insecta CG341481 CG34148 56.33(n)
51.94(a)
  326250  NM_176531.2  NP_788708.2 


ENSEMBL Gene Tree for C15orf61 (if available)
TreeFam Gene Tree for C15orf61 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/126 NCBI SNPs in C15orf61 are shown (see all 126    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1460611721,2
--67811681(+) GGCTAA/GTTTTT 6 -- us2k1 int10--------
rs1137187461,2
C,--67811959(+) GAGGCG/-GGCGG 6 -- int1 us2k11Minor allele frequency- -:0.50CSA 2
rs590760751,2
C,F,--67812048(+) CAGCCG/AAGTGT 6 -- int1 us2k13Minor allele frequency- A:0.12WA NA EA 358
rs1931644731,2
--67812114(+) CTTGAA/GCCCAG 6 -- int1 us2k10--------
rs1169091561,2
F,--67812146(+) CGAGAT/CCGAGC 6 -- int1 us2k11Minor allele frequency- C:0.21EA 120
rs1437406691,2
--67812284(+) TCGGCA/GTATGT 6 -- us2k1 int10--------
rs1851366701,2
--67812346(+) GCTCAC/TGCCTG 6 -- int1 us2k10--------
rs1468096361,2
--67812368(+) CTTTGA/GGAGGC 6 -- us2k1 int10--------
rs1900354711,2
--67812443(+) CTCTAC/TTAAAA 6 -- us2k1 int10--------
rs1466684221,2
C,--67812630(+) AAAAC-/AAAA  
        
AACTG
6 -- int1 us2k10--------

HapMap Linkage Disequilibrium report for C15orf61 (67813406 - 67819641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for C15orf61: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C15orf61 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C15orf61)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (2006)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 145853 HGNC: 34453 AceView: LOC145853 Ensembl:ENSG00000189227 euGenes: HUgn145853
ECgene: C15orf61 H-InvDB: C15orf61

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C15orf61 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C15orf61 gene:
Search GeneIP for patents involving C15orf61

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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