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Aliases for C15orf59 Gene

Aliases for C15orf59 Gene

  • Chromosome 15 Open Reading Frame 59 2 3 5

External Ids for C15orf59 Gene

Previous GeneCards Identifiers for C15orf59 Gene

  • GC15M071820
  • GC15M074032
  • GC15M050863

Summaries for C15orf59 Gene

GeneCards Summary for C15orf59 Gene

C15orf59 (Chromosome 15 Open Reading Frame 59) is a Protein Coding gene. GO annotations related to this gene include transferase activity and cofactor binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf59 Gene

Genomics for C15orf59 Gene

Regulatory Elements for C15orf59 Gene

Enhancers for C15orf59 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C15orf59 on UCSC Golden Path with GeneCards custom track

Promoters for C15orf59 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C15orf59 Gene

73,735,431 bp from pter
73,753,187 bp from pter
17,757 bases
Minus strand

Genomic View for C15orf59 Gene

Genes around C15orf59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf59 Gene

Proteins for C15orf59 Gene

  • Protein details for C15orf59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0583 protein C15orf59
    Protein Accession:

    Protein attributes for C15orf59 Gene

    293 amino acids
    Molecular mass:
    31928 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C15orf59 Gene

Post-translational modifications for C15orf59 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C15orf59 Gene

No data available for DME Specific Peptides for C15orf59 Gene

Domains & Families for C15orf59 Gene

Protein Domains for C15orf59 Gene


Suggested Antigen Peptide Sequences for C15orf59 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0583 family.
  • Belongs to the UPF0583 family.
genes like me logo Genes that share domains with C15orf59: view

No data available for Gene Families for C15orf59 Gene

Function for C15orf59 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf59 Gene

Localization for C15orf59 Gene

Subcellular locations from

Jensen Localization Image for C15orf59 Gene COMPARTMENTS Subcellular localization image for C15orf59 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C15orf59 Gene

Pathways & Interactions for C15orf59 Gene

SuperPathways for C15orf59 Gene

No Data Available

Interacting Proteins for C15orf59 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000369150 Q2T9L4-CO059_HUMAN for C15orf59 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C15orf59 Gene


No data available for Pathways by source and SIGNOR curated interactions for C15orf59 Gene

Drugs & Compounds for C15orf59 Gene

No Compound Related Data Available

Transcripts for C15orf59 Gene

mRNA/cDNA for C15orf59 Gene

Unigene Clusters for C15orf59 Gene

Chromosome 15 open reading frame 59:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf59 Gene

No ASD Table

Relevant External Links for C15orf59 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C15orf59 Gene

mRNA expression in normal human tissues for C15orf59 Gene

mRNA differential expression in normal tissues according to GTEx for C15orf59 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for C15orf59 Gene

This gene is overexpressed in Breast (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C15orf59 Gene

Protein tissue co-expression partners for C15orf59 Gene

NURSA nuclear receptor signaling pathways regulating expression of C15orf59 Gene:


SOURCE GeneReport for Unigene cluster for C15orf59 Gene:

genes like me logo Genes that share expression patterns with C15orf59: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C15orf59 Gene

Orthologs for C15orf59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf59 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C10H15orf59 34
  • 88.93 (n)
  • 91.78 (a)
C15orf59 35
  • 92 (a)
(Canis familiaris)
Mammalia C30H15orf59 34
  • 85.37 (n)
  • 85.02 (a)
C15orf59 35
  • 86 (a)
(Mus musculus)
Mammalia 6030419C18Rik 34
  • 86.99 (n)
  • 89.04 (a)
6030419C18Rik 16
6030419C18Rik 35
  • 89 (a)
(Pan troglodytes)
Mammalia C15H15orf59 34
  • 99.54 (n)
  • 99.66 (a)
C15orf59 35
  • 100 (a)
(Rattus norvegicus)
Mammalia RGD1562618 34
  • 86.48 (n)
  • 88.66 (a)
(Monodelphis domestica)
Mammalia C15orf59 35
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia C15orf59 35
  • 75 (a)
(Gallus gallus)
Aves C10H15ORF59 34
  • 69.26 (n)
  • 70.43 (a)
C15orf59 35
  • 62 (a)
(Anolis carolinensis)
Reptilia C15orf59 35
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf59 34
  • 64.57 (n)
  • 68.16 (a)
(Danio rerio)
Actinopterygii si:dkey-105e17.1 34
  • 60.27 (n)
  • 54.24 (a)
C18H15orf59 35
  • 51 (a)
Species where no ortholog for C15orf59 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf59 Gene

Gene Tree for C15orf59 (if available)
Gene Tree for C15orf59 (if available)

Paralogs for C15orf59 Gene

No data available for Paralogs for C15orf59 Gene

Variants for C15orf59 Gene

Sequence variations from dbSNP and Humsavar for C15orf59 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2601128 -- 73,739,577(+) GGCCA(C/G)GGCCA utr-variant-3-prime
rs3169102 -- 73,752,400(+) AGGTG(A/C)CCGGG upstream-variant-2KB, utr-variant-5-prime
rs4887111 -- 73,735,944(+) ATGCT(A/G)TGACT utr-variant-3-prime
rs4887114 -- 73,737,505(+) TAGAG(A/G)GGCTC utr-variant-3-prime
rs4887122 -- 73,742,907(+) CCTAG(C/T)GTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf59 Gene

Variant ID Type Subtype PubMed ID
esv2667170 CNV deletion 23128226
esv2749875 CNV deletion 23290073
esv2749876 CNV deletion 23290073
esv3552674 CNV deletion 23714750
nsv1121512 CNV deletion 24896259
nsv471252 CNV loss 18288195
nsv569970 CNV loss 21841781
nsv951991 CNV deletion 24416366

Variation tolerance for C15orf59 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C15orf59 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf59 Gene

Disorders for C15orf59 Gene

Relevant External Links for C15orf59

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C15orf59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf59 Gene

Publications for C15orf59 Gene

  1. Open reading frames associated with cancer in the dark matter of the human genome. (PMID: 25048349) Delgado A.P. … Narayanan R. (Cancer Genomics Proteomics 2014) 2 3 65
  2. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PMID: 23080069) Esteves S.L. … da Cruz e Silva E.F. (J. Mol. Neurosci. 2013) 3 65
  3. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M. … da Cruz e Silva E.F. (Biochem. Pharmacol. 2011) 3 65
  4. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PMID: 17903307) Wilk J.B. … O'Connor G.T. (BMC Med. Genet. 2007) 46 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65

Products for C15orf59 Gene

Sources for C15orf59 Gene

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