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Aliases for C15orf59 Gene

Aliases for C15orf59 Gene

  • Chromosome 15 Open Reading Frame 59 2 3

External Ids for C15orf59 Gene

Summaries for C15orf59 Gene

GeneCards Summary for C15orf59 Gene

C15orf59 (Chromosome 15 Open Reading Frame 59) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf59 Gene

Genomics for C15orf59 Gene

Genomic Location for C15orf59 Gene

Start:
73,735,431 bp from pter
End:
73,753,153 bp from pter
Size:
17,723 bases
Orientation:
Minus strand

Genomic View for C15orf59 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C15orf59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf59 Gene

Regulatory Elements for C15orf59 Gene

Proteins for C15orf59 Gene

  • Protein details for C15orf59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2T9L4-CO059_HUMAN
    Recommended name:
    UPF0583 protein C15orf59
    Protein Accession:
    Q2T9L4
    Secondary Accessions:

    Protein attributes for C15orf59 Gene

    Size:
    293 amino acids
    Molecular mass:
    31928 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C15orf59 Gene

Proteomics data for C15orf59 Gene at MOPED

Post-translational modifications for C15orf59 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C15orf59 Gene

No data available for DME Specific Peptides for C15orf59 Gene

Domains for C15orf59 Gene

Protein Domains for C15orf59 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C15orf59 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2T9L4

UniProtKB/Swiss-Prot:

CO059_HUMAN
Family:
  • Belongs to the UPF0583 family.:
    • Q2T9L4
genes like me logo Genes that share domains with C15orf59: view

No data available for Gene Families for C15orf59 Gene

Function for C15orf59 Gene

Gene Ontology (GO) - Molecular Function for C15orf59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity --
GO:0048037 cofactor binding --
genes like me logo Genes that share ontologies with C15orf59: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C15orf59 Gene

Localization for C15orf59 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C15orf59 Gene COMPARTMENTS Subcellular localization image for C15orf59 gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C15orf59 Gene

Pathways for C15orf59 Gene

SuperPathways for C15orf59 Gene

No Data Available

Interacting Proteins for C15orf59 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369150%0d%0a9606.ENSP00000335084%0d%0a
Selected Interacting proteins: ENSP00000369150 for C15orf59 Gene via STRING

Symbol External ID(s) Details
PPP1CC

Gene Ontology (GO) - Biological Process for C15orf59 Gene

None

No data available for Pathways by source for C15orf59 Gene

Transcripts for C15orf59 Gene

mRNA/cDNA for C15orf59 Gene

Unigene Clusters for C15orf59 Gene

Chromosome 15 open reading frame 59:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf59 Gene

No ASD Table

Relevant External Links for C15orf59 Gene

GeneLoc Exon Structure for
C15orf59
ECgene alternative splicing isoforms for
C15orf59

Expression for C15orf59 Gene

mRNA expression in normal human tissues for C15orf59 Gene

mRNA differential expression in normal tissues according to GTEx for C15orf59 Gene

This gene is overexpressed in Heart - Left Ventricle (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C15orf59 Gene

SOURCE GeneReport for Unigene cluster for C15orf59 Gene Hs.40794

genes like me logo Genes that share expressions with C15orf59: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C15orf59 Gene

Orthologs for C15orf59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf59 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf59 35
  • 99.54 (n)
  • 99.66 (a)
C15orf59 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C10H15orf59 35
  • 88.93 (n)
  • 91.78 (a)
C15orf59 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C15orf59 36
  • 86 (a)
OneToOne
C30H15orf59 35
  • 85.37 (n)
  • 85.02 (a)
mouse
(Mus musculus)
Mammalia 6030419C18Rik 35
  • 86.99 (n)
  • 89.04 (a)
6030419C18Rik 16
6030419C18Rik 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C15orf59 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C15orf59 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562618 35
  • 86.48 (n)
  • 88.66 (a)
chicken
(Gallus gallus)
Aves C10H15ORF59 35
  • 69.26 (n)
  • 70.43 (a)
C15orf59 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C15orf59 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf59 35
  • 64.57 (n)
  • 68.16 (a)
zebrafish
(Danio rerio)
Actinopterygii C18H15orf59 36
  • 51 (a)
OneToOne
si:dkey-105e17.1 35
  • 60.27 (n)
  • 54.24 (a)
Species with no ortholog for C15orf59:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf59 Gene

ENSEMBL:
Gene Tree for C15orf59 (if available)
TreeFam:
Gene Tree for C15orf59 (if available)

Paralogs for C15orf59 Gene

No data available for Paralogs for C15orf59 Gene

Variants for C15orf59 Gene

Sequence variations from dbSNP and Humsavar for C15orf59 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs751033 -- 73,750,156(+) AACGC(C/T)GGTCA intron-variant
rs896598 -- 73,744,288(+) ATGCC(A/G)GGCCT intron-variant
rs896599 -- 73,747,207(+) ACTTG(A/T)ATCCT intron-variant
rs1047399 -- 73,752,625(+) CGCCC(A/G)GGACG upstream-variant-2KB, utr-variant-5-prime
rs1129484 -- 73,752,565(+) CCGTG(C/T)TCCGC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C15orf59 Gene

Variant ID Type Subtype PubMed ID
nsv471252 CNV Loss 18288195
esv2667170 CNV Deletion 23128226
esv2749875 CNV Deletion 23290073
esv2749876 CNV Deletion 23290073

Relevant External Links for C15orf59 Gene

HapMap Linkage Disequilibrium report
C15orf59

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf59 Gene

Disorders for C15orf59 Gene

Relevant External Links for C15orf59

Genetic Association Database (GAD)
C15orf59
genes like me logo Genes that share disorders with C15orf59: view

No data available for UniProtKB/Swiss-Prot for C15orf59 Gene

Publications for C15orf59 Gene

  1. Open reading frames associated with cancer in the dark matter of the human genome. (PMID: 25048349) Delgado A.P. … Narayanan R. (Cancer Genomics Proteomics 2014) 2 3
  2. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PMID: 17903307) Wilk J.B. … O'Connor G.T. (BMC Med. Genet. 2007) 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M. … da Cruz e Silva E.F. (Biochem. Pharmacol. 2011) 3

Products for C15orf59 Gene

Sources for C15orf59 Gene

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