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Aliases for C15orf57 Gene

Aliases for C15orf57 Gene

  • Chromosome 15 Open Reading Frame 57 2 3 5
  • Coiled-Coil Domain Containing 32 2 3
  • CCDC32 3 4
  • Uncharacterized Protein C15orf57 3
  • Protein CCDC32 4

External Ids for C15orf57 Gene

Previous HGNC Symbols for C15orf57 Gene

  • CCDC32

Previous GeneCards Identifiers for C15orf57 Gene

  • GC15M038633
  • GC15M040845
  • GC15M017688
  • GC15M040820

Summaries for C15orf57 Gene

GeneCards Summary for C15orf57 Gene

C15orf57 (Chromosome 15 Open Reading Frame 57) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf57 Gene

Genomics for C15orf57 Gene

Regulatory Elements for C15orf57 Gene

Enhancers for C15orf57 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G040557 1.5 Ensembl ENCODE dbSUPER 52.7 +6.6 6562 2.8 HDGF ATF1 ARNT ZNF48 TCF12 SLC30A9 ZNF766 GATA2 SP5 JUNB C15orf57 RMDN3 KNSTRN PIR54978
GH15G040589 1.2 Ensembl ENCODE 65.8 -25.6 -25619 2.6 HDGF PKNOX1 ATF1 FOXA2 YBX1 ZNF2 ZNF48 YY1 ZNF121 GTF3C2 C15orf57 RAD51 DNAJC17 ENSG00000259211 BAHD1 RPAP1 RAD51-AS1 BMF RMDN3 GCHFR
GH15G040582 1.2 Ensembl ENCODE 54.9 -18.5 -18521 2.8 FOXA2 PKNOX1 ATF1 ARID4B YY1 GLIS2 FOS NFYC ZNF592 KAT8 C15orf57 RMDN3 ENSG00000203573 RPUSD2
GH15G040549 1.4 Ensembl ENCODE dbSUPER 46.6 +14.4 14418 2.3 HDAC1 TBP PKNOX1 TBL1XR1 BMI1 ZNF2 ZNF335 ELK1 RELB ETV6 C15orf57 RPL9P27 CHST14 PIR54978
GH15G040552 1.2 Ensembl ENCODE 53.9 +11.2 11211 2.0 TBP PKNOX1 FOXA2 ZSCAN4 KLF17 ARID4B SIN3A ZNF335 FOS RELB C15orf57 RMDN3 PIR54978
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C15orf57 on UCSC Golden Path with GeneCards custom track

Promoters for C15orf57 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075538 157 1401 HDGF PKNOX1 FOXA2 SIN3A ARID4B DMAP1 ZNF2 SLC30A9 ZNF143 ZNF207

Genomic Location for C15orf57 Gene

40,528,683 bp from pter
40,565,057 bp from pter
36,375 bases
Minus strand

Genomic View for C15orf57 Gene

Genes around C15orf57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf57 Gene

Proteins for C15orf57 Gene

  • Protein details for C15orf57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C15orf57
    Protein Accession:
    Secondary Accessions:
    • A8KAL4
    • Q86TC4
    • Q8N788
    • Q8NAR7

    Protein attributes for C15orf57 Gene

    185 amino acids
    Molecular mass:
    20656 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAD89911.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C15orf57 Gene


neXtProt entry for C15orf57 Gene

Post-translational modifications for C15orf57 Gene

  • Ubiquitination at Lys119
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C15orf57 Gene

Domains & Families for C15orf57 Gene

Protein Domains for C15orf57 Gene


Suggested Antigen Peptide Sequences for C15orf57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C15orf57: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C15orf57 Gene

Function for C15orf57 Gene

Gene Ontology (GO) - Molecular Function for C15orf57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with C15orf57: view
genes like me logo Genes that share phenotypes with C15orf57: view

Animal Model Products

CRISPR Products

miRNA for C15orf57 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf57 Gene

Localization for C15orf57 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C15orf57 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C15orf57 Gene

Pathways & Interactions for C15orf57 Gene

SuperPathways for C15orf57 Gene

No Data Available

Interacting Proteins for C15orf57 Gene

Selected Interacting proteins: Q9BV29-CO057_HUMAN for C15orf57 Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for C15orf57 Gene


No data available for Pathways by source and SIGNOR curated interactions for C15orf57 Gene

Transcripts for C15orf57 Gene

Unigene Clusters for C15orf57 Gene

Chromosome 15 open reading frame 57:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf57 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - - - - -
SP2: - - - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - -
SP9: - - -
SP10: - -
SP11: - -
SP12: - - - - - - - -

Relevant External Links for C15orf57 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C15orf57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C15orf57 Gene

Protein differential expression in normal tissues from HIPED for C15orf57 Gene

This gene is overexpressed in Testis (28.2) and Fetal testis (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C15orf57 Gene

NURSA nuclear receptor signaling pathways regulating expression of C15orf57 Gene:


SOURCE GeneReport for Unigene cluster for C15orf57 Gene:


Evidence on tissue expression from TISSUES for C15orf57 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with C15orf57: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C15orf57 Gene

Orthologs for C15orf57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf57 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C15orf57 35
  • 100 (a)
C15H15orf57 34
  • 99.83 (n)
(Canis familiaris)
Mammalia C30H15orf57 34
  • 91.62 (n)
C15orf57 35
  • 90 (a)
(Bos Taurus)
Mammalia C10H15orf57 34
  • 90.32 (n)
CCDC32 35
  • 89 (a)
(Mus musculus)
Mammalia Ccdc32 34 16 35
  • 88.08 (n)
(Rattus norvegicus)
Mammalia Ccdc32 34
  • 87.34 (n)
(Monodelphis domestica)
Mammalia C15orf57 35
  • 71 (a)
(Gallus gallus)
Aves C5H15ORF57 34 35
  • 73.75 (n)
(Anolis carolinensis)
Reptilia C15orf57 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf57 34
  • 59.55 (n)
(Danio rerio)
Actinopterygii LOC564862 34
  • 59.02 (n)
C17H15orf57 35
  • 45 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2757 34
Species where no ortholog for C15orf57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf57 Gene

Gene Tree for C15orf57 (if available)
Gene Tree for C15orf57 (if available)

Paralogs for C15orf57 Gene

No data available for Paralogs for C15orf57 Gene

Variants for C15orf57 Gene

Sequence variations from dbSNP and Humsavar for C15orf57 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000006147 -- 40,544,734(+) TGGAT(A/T)TTTTT intron-variant
rs1000091456 -- 40,558,673(+) CCATA(A/G)GCAAC intron-variant
rs1000308421 -- 40,539,337(+) CCAGG(C/G)GTTCT intron-variant
rs1000318213 -- 40,534,063(+) AAAAT(A/T)TTAAT intron-variant, upstream-variant-2KB
rs1000394426 -- 40,539,902(+) TGATT(C/G)CATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf57 Gene

Variant ID Type Subtype PubMed ID
esv2664009 CNV deletion 23128226
esv2749601 CNV deletion 23290073
esv2749602 CNV deletion 23290073
esv2760026 CNV loss 17122850
esv34145 CNV loss 18971310
esv3552351 CNV deletion 23714750
esv3636227 CNV loss 21293372
nsv507777 OTHER sequence alteration 20534489
nsv832984 CNV loss 17160897
nsv930488 CNV insertion 23359205

Variation tolerance for C15orf57 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.57; 86.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C15orf57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf57 Gene

Disorders for C15orf57 Gene

Relevant External Links for C15orf57

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C15orf57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf57 Gene

Publications for C15orf57 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3 64
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64

Products for C15orf57 Gene

Sources for C15orf57 Gene

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