C15orf57 Gene
protein-coding GIFtS: 39
GCID: GC15M040845
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|
chromosome 15 open reading frame 57(Previous name: coiled-coil domain containing 32 )
(Previous symbol: CCDC32)
| |
Aliases
for C15orf57 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 15 Open Reading Frame 571 2 | | CCDC321 2 3 | | Coiled-Coil Domain Containing 321 2 | | MGC204811 | | Uncharacterized Protein C15orf572 | | Protein CCDC323 |
Export aliases for C15orf57 gene to outside databasesPrevious GC identifers: GC15M038633 GC15M017688 |
Summaries
for C15orf57 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C15orf57 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C15orf57 gene promoter:
Egr-3 C/EBPbeta AML1a Pax-5 NF-kappaB HEN1 NF-kappaB2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C15orf57
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C15orf57 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.1 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q15.1C15orf57 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M040845: view genomic region
(about GC identifiers)
Start:
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40,820,882 bp from pter |
End:
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40,857,256 bp from pter |
Size:
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36,375 bases |
Orientation:
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minus strand |
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Proteins
for C15orf57 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CO057_HUMAN, Q9BV29 (See
protein sequence)Recommended Name: Uncharacterized protein C15orf57 Size: 185 amino acids; 20656 Da
Sequence caution: Sequence=CAD89911.1; Type=Erroneous initiation;
Secondary accessions: A8KAL4 Q86TC4 Q8N788 Q8NAR7Alternative splicing: 3 isoforms: Q9BV29-1 Q9BV29-2 Q9BV29-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C15orf57: NX_Q9BV29
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BV29
C15orf57 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001074260.1 NP_001074261.1 NP_443081.1
ENSEMBL proteins: ENSP00000453429 ENSP00000453607 ENSP00000454049 ENSP00000453226 ENSP00000453544 ENSP00000453221 ENSP00000350695 ENSP00000397515 ENSP00000452773 ENSP00000453274 ENSP00000453899 ENSP00000452657
Human Recombinant Protein Products:
C15orf57 Antibody Products:
Assay Products for C15orf57: |
Protein
Domains /
Families
for C15orf57 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9BV29 |
Function
for C15orf57 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf57 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf57 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): C15orf57 (NM_001080792) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C15orf57 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C15orf57 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf57 |
|
Pathways & Interactions
for C15orf57 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C15orf57
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for C15orf57 (ENSP000003975154) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C15orf57 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C15orf57
Search CenterWatch for drugs/clinical trials and news about C15orf57 / CO057
|
Transcripts
for C15orf57 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C15orf57 gene (3 alternative transcripts): NM_001080791.1 NM_001080792.1 NM_052849.2 Unigene Cluster for C15orf57: Chromosome 15 open reading frame 57 Hs.654661 [show with all ESTs]Unigene Representative Sequence: NM_00108079114 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000560305 ENST00000559153 ENST00000561011(uc001zly.3) ENST00000559291
ENST00000559911 ENST00000558113 ENST00000358005(uc001zmc.1 uc001zma.1 uc001zmb.1)
ENST00000416810 ENST00000558750 ENST00000558918 ENST00000559103 ENST00000558871(uc010bbr.3)
ENST00000560109 ENST00000560535
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf57 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf57 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): C15orf57 (NM_001080792) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C15orf57 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C15orf57 |
Additional cDNA sequence: AK092214.1 AK293079.1 AK312842.1 BC001673.2 17 DOTS entries: DT.100803916 DT.100032015 DT.315172 DT.100060851 DT.100803917 DT.121041568 DT.75103618 DT.91950246 DT.100888411 DT.97796639 DT.87078071 DT.95174321 DT.100803910 DT.101976396 DT.121041450 DT.121041574 DT.95199735 24/193 AceView cDNA sequences (see all 193): CB242454 AI202924 AW591037 BI771595 BI766474 AI967928 BI255064 AA476574 BI832599 CR594644 AW575737 BM833342 BU657434 AI419568 NM_052849 BC001673 AI149374 AI816509 BF115434 AI469664 CR617997 CR613762 BI793179 T66934
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for C15orf57 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 |
|---|
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| SP1: | | | | | | | | | | | | | - | | - | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | - | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for C15orf57
|
Expression
for C15orf57 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C15orf57 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCAGTATGT
About this image
See C15orf57 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C15orf57
SOURCE GeneReport for Unigene cluster: Hs.654661
SABiosciences Custom PCR Arrays for C15orf57
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C15orf57
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C15orf57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C15orf57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C15orf57 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf57 |
Orthologs
for C15orf57 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C15orf57 gene from 5/11 species (see all 11) About this table
ENSEMBL Gene Tree for C15orf57 (if available)
TreeFam Gene Tree for C15orf57 (if available) |
Paralogs
for C15orf57 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C15orf57 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C15orf57 (40820882 - 40857256 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for C15orf57
3 CNVs: 47928 33964 3959 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C15orf57 |
|
Disorders
/ Diseases
for C15orf57 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C15orf57 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C15orf57 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C15orf57) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Identification of cellular factors binding to acetylat ed HIV-1 integrase. (PubMed id 20016921)1 Allouch A. and Cereseto A. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for C15orf57 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C15orf57 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C15orf57 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C15orf57 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C15orf57 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C15orf57 gene:
Search GeneIP for patents involving C15orf57
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C15orf57 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C15orf57 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C15orf57 | | | OriGene Protein Over-expression Lysate for C15orf57 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for C15orf57 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf57 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf57 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C15orf57 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C15orf57 | | OriGene Custom Protein Services for C15orf57 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C15orf57 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C15orf57 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C15orf57 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C15orf57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C15orf57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C15orf57 |
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 | | | C15orf57 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf57 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C15orf57 |
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