C15orf55 Gene
protein-coding GIFtS: 49
GCID: GC15P034635
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chromosome 15 open reading frame 55
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Aliases
for C15orf55 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 15 Open Reading Frame 551 2 | | FAM22H1 2 | | NUT1 2 | | Nuclear Protein In Testis2 3 | | DKFZp434O1921 | | Protein NUT2 |
Export aliases for C15orf55 gene to outside databasesPrevious GC identifers: GC15P032426 GC15P011501 |
Summaries
for C15orf55 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C15orf55 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C15orf55 gene promoter:
Max1 MyoD Lmo2 MIF-1 CUTL1 C/EBPalpha PPAR-alpha PPAR-gamma1 SEF-1 (1) PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for C15orf55
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C15orf55 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q14 Ensembl cytogenetic band: 15q14 HGNC cytogenetic band: 15q14C15orf55 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P034635: view genomic region
(about GC identifiers)
Start:
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34,635,516 bp from pter |
End:
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34,649,938 bp from pter |
Size:
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14,423 bases |
Orientation:
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plus strand |
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Proteins
for C15orf55 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NUT_HUMAN, Q86Y26 (See
protein sequence)Recommended Name: Protein NUT Size: 1132 amino acids; 120314 Da
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm
Sequence caution: Sequence=AAO22237.1; Type=Erroneous initiation;
Secondary accessions: Q86YS8 Q8N7F2 Q9NTB3Alternative splicing: 2 isoforms: Q86Y26-1 Q86Y26-2 Explore the universe of human proteins at neXtProt for C15orf55: NX_Q86Y26
Post-translational modifications:
Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86Y26
C15orf55 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_786883.1
ENSEMBL proteins: ENSP00000444896 ENSP00000407031 ENSP00000329448
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
C15orf55 for ontologies About GeneDecksing
C15orf55 Antibody Products:
Assay Products for C15orf55: |
Protein
Domains /
Families
for C15orf55 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C15orf55 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86Y26ProtoNet protein and cluster: Q86Y26 UniProtKB/Swiss-Prot: NUT_HUMAN, Q86Y26Similarity: Belongs to the FAM22 family |
Function
for C15orf55 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf55 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf55
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: C15orf55 (NM_175741) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf55 |
2 GenomeRNAi human phenotypes for C15orf55:
|
Pathways & Interactions
for C15orf55 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chromatin Regulation / Acetylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for C15orf55
C15orf55 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C15orf55
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/15 Interacting proteins for C15orf55 (Q86Y263 ENSP000003294484) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
|
Drugs & Compounds
for C15orf55 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C15orf55
Search CenterWatch for drugs/clinical trials and news about C15orf55 / NUT
|
Transcripts
for C15orf55 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C15orf55 gene: NM_175741.1 Unigene Cluster for C15orf55: Chromosome 15 open reading frame 55 Hs.525769 [show with all ESTs]Unigene Representative Sequence: AK3026563 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000537011(uc010ucc.2 uc010ucd.2) ENST00000438749 ENST00000333756(uc001zif.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf55 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf55
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C15orf55 (NM_175741) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C15orf55 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C15orf55 |
Additional cDNA sequence: AF482429.1 AK098568.1 AK302656.1 AK302680.1 AL137416.1 BC033392.1 BC114518.1 BC114567.1 4 DOTS entries: DT.40126418 DT.100821652 DT.100018691 DT.121064595 23 AceView cDNA sequences: AL043527 AL043575 AL040313 AI656084 BX117628 AW183828 AF482429 AL040312 NM_175741 AL137416 AI989606 AI824990 BC033392 AI962801 AK098568 BX281944 AA868866 AI797944 BI830646 AW196973 BG771892 AI041285 AY166680
GeneLoc Exon Structure
|
Expression
for C15orf55 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C15orf55 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGGCAGGA
About this image
See C15orf55 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C15orf55
SOURCE GeneReport for Unigene cluster: Hs.525769
UniProtKB/Swiss-Prot: NUT_HUMAN, Q86Y26Tissue specificity: Specifically expressed in testis
SABiosciences Custom PCR Arrays for C15orf55
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C15orf55
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C15orf55 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C15orf55 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C15orf55 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf55 |
Orthologs
for C15orf55 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C15orf55 gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
55(a) |
1 → many |
GL343220.1(852503-857458) |
ENSEMBL Gene Tree for C15orf55 (if available)
TreeFam Gene Tree for C15orf55 (if available) |
Paralogs
for C15orf55 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C15orf55 gene
- FAM22G2 FAM22A2 FAM22D2 FAM22B2 FAM22F2 FAM22E2
7 SIMAP similar genes for C15orf55 using alignment to 2 protein entries: E7EVE8_HUMAN (see all proteins):NUT FAM22F FAM22G FAM22B FAM22E FAM22D
FAM22A
C15orf55 for paralogs About GeneDecksing
|
Genomic Variants
for C15orf55 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C15orf55 (34635516 - 34649938 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for C15orf55
6 CNVs: 0783 0187 3957 2192 7058 49528 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C15orf55 |
|
Disorders
/ Diseases
for C15orf55 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C15orf55 for disorders About GeneDecksing
OMIM gene information: 608963
OMIM disorders: --
UniProtKB/Swiss-Prot: NUT_HUMAN, Q86Y26
Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising inmidline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising inmidline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein
1  disease for C15orf55: About MalaCardscarcinoma
2 diseases from the University of Copenhagen DISEASES database for C15orf55:Carcinoma Extragonadal seminoma Export disorders for C15orf55 gene to outside databases
|
Publications
for C15orf55 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C15orf55 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with C15orf55) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. (PubMed id 12543779)1, 2, 3 French C.A....Fletcher J.A. (2003)
- BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. (PubMed id 17934517)1, 2 French C.A.... Aster J.C. (2008)
- NUT rearrangement is uncommon in human thymic epitheli al tumors. (PubMed id 22425924)1 Petrini P....Giaccone G. (2012)
- NUT midline carcinoma: report of 2 cases suggestive of pulmonary origin. (PubMed id 22301500)1 Tanaka M....Tanaka Y. (2012)
- Perturbation of BRD4 protein function by BRD4-NUT pro tein abrogates cellular differentiation in NUT midline carcinoma. (PubMed id 21652721)1 Yan J....You J. (2011)
- Long-term survival of a patient with squamous cell ca rcinoma harboring NUT gene rearrangement. (PubMed id 20871268)1 Fujioka N....Kratzke R.A. (2010)
- Oncogenesis by sequestration of CBP/p300 in transcrip tionally inactive hyperacetylated chromatin domains. (PubMed id 20676058)1 Reynoird N....Khochbin S. (2010)
- Carcinomas of the upper aerodigestive tract with rear rangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinom as). (PubMed id 19550370)1 Stelow E.B. and French C.A. (2009)
- NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract. (PubMed id 18391746)1 Stelow E.B....French C.A. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for C15orf55 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C15orf55 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C15orf55 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C15orf55 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for C15orf55 gene:
Search GeneIP for patents involving C15orf55
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C15orf55 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C15orf55 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C15orf55 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C15orf55 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C15orf55 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf55 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf55 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C15orf55 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C15orf55 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C15orf55 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C15orf55 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C15orf55 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C15orf55 |
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 | | | C15orf55 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf55 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C15orf55 |
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