C15orf52 Gene
protein-coding GIFtS: 38
GCID: GC15M040624
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chromosome 15 open reading frame 52
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Aliases
for C15orf52 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 15 Open Reading Frame 521 2 | | FLJ433391 | | Uncharacterized Protein C15orf522 |
Export aliases for C15orf52 gene to outside databasesPrevious GC identifers: GC15M038411 GC15M017467 |
Summaries
for C15orf52 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C15orf52 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C15orf52 gene promoter:
E2F-3a E2F-4 E2F-5 RelA E2F-2 Nkx2-5 NF-kappaB E2F-1 E2F NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C15orf52
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C15orf52 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.1 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q15.1C15orf52 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M040624: view genomic region
(about GC identifiers)
Start:
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40,623,653 bp from pter |
End:
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40,633,168 bp from pter |
Size:
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9,516 bases |
Orientation:
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minus strand |
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Proteins
for C15orf52 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CO052_HUMAN, Q6ZUT6 (See
protein sequence)Recommended Name: Uncharacterized protein C15orf52 Size: 534 amino acids; 57325 Da
Sequence caution: Sequence=CAH18251.1; Type=Erroneous initiation;
Secondary accessions: B9EIQ8 Q68DG9 Q6ZTM3 Q6ZU22Alternative splicing: 4 isoforms: Q6ZUT6-1 Q6ZUT6-2 Q6ZUT6-3 Q6ZUT6-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C15orf52: NX_Q6ZUT6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZUT6
C15orf52 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997263.2
ENSEMBL proteins: ENSP00000380670 ENSP00000453969 ENSP00000452677 ENSP00000453500
Human Recombinant Protein Products:
C15orf52 Antibody Products:
Assay Products for C15orf52: |
Protein
Domains /
Families
for C15orf52 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6ZUT6 |
Function
for C15orf52 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf52 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf52
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C15orf52 (NM_207380) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C15orf52 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C15orf52 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf52 |
|
Pathways & Interactions
for C15orf52 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C15orf52
|
Drugs & Compounds
for C15orf52 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C15orf52
Search CenterWatch for drugs/clinical trials and news about C15orf52 / CO052
|
Transcripts
for C15orf52 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C15orf52 gene: NM_207380.2 Unigene Cluster for C15orf52: Chromosome 15 open reading frame 52 Hs.32433 [show with all ESTs]Unigene Representative Sequence: NM_2073807 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397536(uc010ucn.2) ENST00000382688(uc001zlh.4) ENST00000559313
ENST00000558858 ENST00000558912(uc001zli.1) ENST00000560922 ENST00000557973
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf52 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf52
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C15orf52 (NM_207380) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C15orf52 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C15orf52 |
Additional cDNA sequence: AK124643.1 AK126035.1 BC015670.2 BC140897.1 BC140902.1 CR749408.1 3 DOTS entries: DT.110239 DT.75191167 DT.100744681 24/70 AceView cDNA sequences (see all 70): BU618720 BX479476 BX490063 AA939115 BE223099 BM792659 BM797258 BQ690903 BX391563 CA423451 BX488617 AK125329 BQ894659 BQ673040 AK124643 CA446467 BM712833 BQ717122 CR749408 BC015670 BG478086 BX641759 BF338229 NM_207380
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for C15orf52 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
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| SP1: | | | | | - | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | |
| SP3: | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C15orf52
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Expression
for C15orf52 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C15orf52 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTTTGATG
About this image
See C15orf52 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C15orf52
SOURCE GeneReport for Unigene cluster: Hs.32433
SABiosciences Custom PCR Arrays for C15orf52
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C15orf52
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C15orf52 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C15orf52 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C15orf52 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf52 |
Orthologs
for C15orf52 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C15orf52 gene from 1/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
CR759892.16 |
-- |
19(a) |
1 ↔ 1 |
17(2222357-2311535) |
ENSEMBL Gene Tree for C15orf52 (if available)
TreeFam Gene Tree for C15orf52 (if available) |
Paralogs
for C15orf52 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C15orf52 gene
- CCDC92
C15orf52 for paralogs About GeneDecksing
|
Genomic Variants
for C15orf52 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C15orf52 (40623653 - 40633168 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C15orf52
1 CNV: 47928 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C15orf52 |
|
Disorders
/ Diseases
for C15orf52 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C15orf52 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C15orf52 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C15orf52) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for C15orf52 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing C15orf52 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C15orf52 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C15orf52 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C15orf52 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C15orf52 gene:
Search GeneIP for patents involving C15orf52
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C15orf52 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C15orf52 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C15orf52 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C15orf52 | | | OriGene Protein Over-expression Lysate for C15orf52 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C15orf52 | | OriGene 3'-UTR Clone for C15orf52 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf52 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf52 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C15orf52 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C15orf52 | | OriGene Custom Protein Services for C15orf52 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C15orf52 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C15orf52 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C15orf52 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C15orf52 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C15orf52 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C15orf52 |
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 | | | C15orf52 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf52 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C15orf52 |
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